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    1. Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

      Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

      Purpose To describe swept source-OCT (SS-OCT) and swept source-OCT angiography (SS-OCTA) findings in eyes with posterior microphthalmos (PM). Methods Twelve eyes (six patients) with PM were evaluated using SS-OCT and SS-OCTA. Structural changes, subfoveal choroidal thickness (SFCT), and perifoveal capillary changes with qualitative and quantitative assessments were analyzed. Twenty eyes served as control group. Results SS-OCT findings included elevated retinal papillo-macular fold (75%), retinal pigment epithelium folds (83%), macular cystoid spaces (42%), subretinal fluid (17%), and increased visibility of posterior vitreous cortex and hyaloid (42%). Mean SFCT in PM and in control eyes were 430.33 ± 157.48 µm and ...

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    2. Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Retinal perfusion 6 months after trabeculectomy as measured by optical coherence tomography angiography

      Purpose To investigate potential changes of vessel density (VD) at the optic nerve head (ONH) and the macula 6 months after trabeculectomy (TE). Methods In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE + MMC (mitomycin C). At four different time points multiple morphological papillary parameters were measured by OCT, and the ONH VD in the radial peripapillary capillary layer and the superficial and deep plexuses of the macula was determined by OCTA (optical coherence tomography angiography, RTVue-XR, Optovue). The mean defect was determined by visual field examination (mode 30-2, Humphrey Field Analyzer). The duration of ...

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    3. Geometrical characterization of the corneo-scleral transition in normal patients with Fourier domain optical coherence tomography

      Geometrical characterization of the corneo-scleral transition in normal patients with Fourier domain optical coherence tomography

      Purpose To characterize the geometry at the corneo-scleral transition for a normal population and its correlation with other anatomic parameters of the eyeball. Methods Transversal epidemiologic study on a sample of 100 individuals (right eye) in different ethnic groups (Africans and Caucasians). All of them were examined with Fourier domain optical coherence tomography, auto-refractometer, topographer, and biometer to obtain the corneo-scleral angle (CSA) and additional clinical parameters. The dataset was analyzed to determine correlations between different anatomical parameters and nasal (CSAn) and temporal CSA (CSAt) values. Results The CSAt presents a significant but low correlation with the anterior chamber depth ...

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    4. OCT angiography-based monitoring of neovascular regression on fibrovascular membrane after preoperative intravitreal conbercept injection

      OCT angiography-based monitoring of neovascular regression on fibrovascular membrane after preoperative intravitreal conbercept injection

      Purpose To quantify the preoperative neovascular change pattern on the fibrovascular membrane (FVM) within 7 days after intravitreal injection of conbercept (IVC) using optical coherence tomography angiography (OCTA) in proliferative diabetic retinopathy (PDR). Methods Prospective, observational study of PDR patients with visible FVM receiving or not receiving IVC. Neovascular changes were assessed by OCTA pre-IVC and 1, 3, 5, and 7 days post-IVC. Vessel skeleton density (SD) and vessel density (VD) were quantified by an intensity-based optical microangiography algorithm. The interclass correlation coefficient (ICC) was calculated to assess the agreement between measurements. The SD and VD were compared between follow-ups ...

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    5. Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients

      Correlation between B-scan optical coherence tomography, en face thickness map ring and hyperautofluorescent ring in retinitis pigmentosa patients

      Objective To evaluate and compare the B-scan OCT loss of ellipsoid zone, OCT en face thickness map constriction, and hyperautofluorescent ring constriction in RP patients. Methods Retrospective case series study. Forty-eight eyes of 24 RP patients with a parafoveal hyperautofluorescent ring were studied. The diagnosis of RP was established by the presence of rod response impairment and a prevalent decrease of scotopic over photopic responses on electroretinography. The FAF and spectral-domain optical coherence tomography (SD-OCT) images were obtained from 24 patients with RP. The measurements of the EZ line width on B-scan OCT, hyperautofluorescent ring area on FAF, and hyperautofluorescent ...

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    6. Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy

      Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy

      Purpose To study the changes in the choroidal vascular pattern of the deep choroidal layer and choriocapillaris in the eyes with central serous chorioretinopathy (CSC) before versus after photodynamic therapy (PDT) as visualized by optical coherence tomography angiography (OCTA). Methods This comparative case series study included patients who underwent a half-dose of PDT as a therapy for CSC. Using OCTA and manually shifting the reference level into the deep choroidal layer, we assessed the density of the deep choroidal vascular layer and choriocapillaris. Results The study included 20 patients (17 men; mean age, 43.3 ± 10.9 years), with two ...

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    7. Clinical evaluation of neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by swept source optical coherence tomography angiography (SS OCTA)

      Clinical evaluation of neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by swept source optical coherence tomography angiography (SS OCTA)

      Purpose To evaluate the clinical characteristics of eyes with chronic central serous chorioretinopathy based on swept source optical coherence tomography angiography (SS OCTA). Methods Twenty-nine eyes presenting with chronic central serous chorioretinopathy (CSC) were examined with the Topcon SS OCTA, using the DRI optical coherence tomography (OCT) Triton machine, and were classified as neovascular or non-neovascular CSC depending on whether a vascular pattern was detected in the outer retina on OCT angiogram. The two groups were compared based on the following clinical findings: best corrected distance and reading visual acuity (BCDVA, best corrected reading acuity (BCRA)), rate of subretinal fluid ...

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    8. Combination of Enhanced Depth Imaging Optical Coherence Tomography and Fundus Images for Glaucoma Screening

      Combination of Enhanced Depth Imaging Optical Coherence Tomography and Fundus Images for Glaucoma Screening

      Glaucoma is an eye disease that damages the optic nerve and can lead to irreversible loss of peripheral vision gradually and even blindness without treatment. Thus, diagnosing glaucoma in the early stage is essential for treatment. In this paper, an automatic method for early glaucoma screening is proposed. The proposed method combines structural parameters and textural features extracted from enhanced depth imaging optical coherence tomography (EDI-OCT) images and fundus images. The method first segments anterior the lamina cribrosa surface (ALCS) based on region-aware strategy and residual U-Net and then extracts structural features of the lamina cribrosa, such as lamina cribrosa ...

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    9. Influence of optic media of the human eye on the imaging of Argus® II retinal prosthesis with intraoperative spectral-domain optical coherence tomography

      Influence of optic media of the human eye on the imaging of Argus® II retinal prosthesis with intraoperative spectral-domain optical coherence tomography

      Background This study aimed to evaluate the influence of the optic media of the human eye on intraoperative spectral-domain optical coherence tomography (iSD-OCT) of an Argus® II retinal prosthesis (AIIRP) during its implantation. Methods One AIIRP was implanted in a human eye with end-stage retinitis pigmentosa and another one in a test eye. Intraoperative imaging was performed using the Rescan™ 700, a microscope-integrated iSD-OCT system. The feasibility of iSD-OCT imaging for AIIRP implantation was assessed during different surgical steps. Data were post-processed postoperatively using the ImageJ graphic software. Results The quality of imaging of the AIIRP during its implantation was ...

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    10. Spectral composition of low-coherence interferograms at high numerical apertures

      Spectral composition of low-coherence interferograms at high numerical apertures

      Interference signals in coherence scanning interferometry at high numerical apertures and narrow bandwidth illumination are spectrally broadened. This enables phase analysis within a spectral range much wider than the spectral distribution of the light emitted by the light source. Consequently, different surface features can be resolved depending on the wavelength used for phase analysis of the interference signals. In addition, the surface topography itself affects the spectral composition of interference signals in different ways. Signals related to tilted surfaces or step height structures show special spectral characteristics. Thus, spectral amplitude and phase analysis enables a better understanding of the underlying ...

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    11. Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann–Pick disease

      Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann–Pick disease

      Purpose To evaluate accumulation patterns of deposits in retinal layers of type B Niemann–Pick patients by multimodal imaging. Methods Seven patients with type B Niemann–Pick disease were included in this study. All participants underwent a complete ophthalmologic evaluation, high-resolution digital colour imaging, spectral-domain optical coherence tomography, blue light fundus autofluorescence and optical coherence tomography angiography (OCTA). Results We demonstrated different accumulation patterns in the retinal ganglion cell layer, the retinal nerve fibre layer and the subfoveolar region by multimodal imaging. Local retinal capillary nonflow areas in the superficial plexus, increased vascular tortuosity and deformed foveal avascular areas were ...

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    12. A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field

      A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field

      Purpose To compare the retinal area measured on a panoramic en face optical coherence tomography angiography (OCTA) image with that on an ultra-widefield fluorescein angiography (UWF FA) image. Methods Sixteen eyes (11 with branch retinal vein occlusion, 2 with central retinal vein occlusion, 1 with branch retinal artery occlusion, and 2 with hypertensive retinopathy) were included in this study. A panoramic en face OCTA image was created from five single non-panoramic en face OCTA 12 × 12-mm images. The panoramic OCTA image was superimposed on the corresponding UWF FA image after image registration; the total retinal area was measured using the ...

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    13. Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report

      Enhanced depth imaging and swept-source optical coherence tomography findings in choroidal osteoma: a case report

      Purpose The aim of this study was to report the findings from enhanced depth imaging (EDI) and swept-source optical coherence tomography (OCT) in a choroidal osteoma. Methods A case study of a patient with choroidal osteoma is presented and discussed. Results A 25-year-old woman presented with an asymptomatic peripapillary mass. Fundus examination revealed a yellow–orange, well-defined geographical lesion. B‑scan ultrasonography, corroborated by fundus autofluorescence (FAF) and OCT findings, pointed to the diagnosis of choroidal osteoma. Calcified areas of the tumor were iso-autofluorescent on FAF and hyporeflective on OCT, revealing the morphological patterns of cancellous bone, including a sponge-like ...

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    14. Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width

      Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width

      Purpose The assessment of cup-disc ratio as a surrogate parameter for the neuroretinal rim width (NRW) of the optic nerve is well established, but prone to human error and imprecision. Objective assessment of the NRW is provided by spectral domain optical coherence tomography (SD-OCT). This study is the first to systematically compare NRW measurements acquired with the Carl Zeiss Meditech Cirrus HD-OCT 5000 and the Heidelberg Engineering Spectralis SD-OCT. Methods In this cross-sectional study, 20 eyes of each 20 glaucoma patients and 20 age-matched healthy controls underwent ophthalmic examination, SD-OCT imaging, and computer perimetry. Regression analyses were performed for the ...

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    15. Efficacy of the proximal optimization technique on crossover stenting in coronary bifurcation lesions in the 3D-OCT bifurcation registry

      Efficacy of the proximal optimization technique on crossover stenting in coronary bifurcation lesions in the 3D-OCT bifurcation registry

      Aim We sought to investigate the efficacy of the proximal optimization technique (POT) on crossover stenting followed by side branch (SB) dilation under optical coherence tomography guidance in a multicenter registry study. Methods and results A total of 135 bifurcation lesions in 134 patients were divided into POT (n = 52) and non-POT groups (n = 83). The POT was performed before SB dilatation (pre-POT; n = 26), finally (final-POT; n = 12), at both timing (re-POT; n = 13), and uncertain (n = 1). There were no significant intergroup differences in the success rate of guide wire re-crossing (GWR) into the optimal cell (72% vs ...

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    16. Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

      Pearls and Pitfalls of Optical Coherence Tomography Angiography Imaging: A Review

      Optical coherence tomography angiography (OCTA) has significantly expanded our knowledge of the ocular vasculature. Furthermore, this imaging modality has been widely adopted to investigate different ocular and systemic diseases. In this review, a discussion of the fundamental principles of OCTA is followed by the application of this imaging modality to study the retinal and choroidal vessels. A proper comprehension of this imaging modality is essential for the interpretation of OCTA imaging applications in retinal and choroidal disorders.

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    17. Enlargement of the foveal avascular zone detected by optical coherence tomography angiography in diabetic children without diabetic retinopathy

      Enlargement of the foveal avascular zone detected by optical coherence tomography angiography in diabetic children without diabetic retinopathy

      Purpose Evaluation of foveal avascular zone (FAZ) in children with diabetes (DM) using OCTA. Methods We examined 112 diabetic children without DR aged 6–18 years and 30 age-matched controls using Topcon OCT Angiography and measured FAZ in superficial (SCP) and deep capillary plexus (DCP). The study group was divided into three subgroups depending on DM duration group 1: < 5 years ( n  = 40), group 2: 5–10 years ( n  = 42), group 3: > 10 years ( n  = 30). Results The mean DCP FAZ increased with DM duration from 502.2 μm 2 (SD 137.8) in group 1 to 523.9 μm ...

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    18. Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment

      Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment

      Purpose To explore macular perfusion changes in patients with rhegmatogenous retinal detachment (RRD) involved the macula following successful surgery and to evaluate the correlation between macular blood flow density and visual outcomes using optical coherence tomography angiography (OCTA). Methods This retrospective study included 14 eyes (14 patients) with macular-off RRD that underwent a standard three-port 23-gauge pars plana vitrectomy (PPV) and intraocular gas tamponade combined with phacoemulsification, aspiration, and intraocular lens implantation. OCTA was used to evaluate the macular perfusion changes throughout postoperative 12 weeks in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary plexus (CCP). The ...

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    19. Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant

      Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant

      Purpose The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls. Methods A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). We evaluated the conjunctival morphology of the eyes using AS-OCT. The main parameters evaluated were bleb height, sub-epithelial fibrosis, epithelial thickness, and changes in intraocular pressure (IOP). Results We found ...

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    20. Assessment of strut coverage of everolimus-eluting platinum chromium stent 2 weeks after implantation by optical coherence tomography

      Assessment of strut coverage of everolimus-eluting platinum chromium stent 2 weeks after implantation by optical coherence tomography

      The SYNERGY coronary stent is new-generation drug-eluting stents, which has a thin-strut platinum–chromium platform with everolimus in a biodegradable polymer applied to the abluminal surface. It would be speculated that favorable arterial healing with early strut coverage could be achieved. The present study investigated the degree of strut coverage using optical coherence tomography (OCT) 2 weeks after SYNERGY implantation and clinical factors contributing to strut coverage. A total of 29 patients who underwent staged percutaneous coronary intervention (PCI) to residual lesions 2 weeks after the index PCI with SYNERGY stent implantation were enrolled. At the time of staged PCI ...

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      Mentions: Kenichi Fujii
    21. Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography

      Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography

      Purpose To investigate the validity of a multiple regression equation to predict postoperative corneal curvature radius (K) in simultaneous cataract and pterygium surgery using preoperative factors, including preoperative K. Study design Retrospective study. Methods Seventy eyes of 58 patients who had undergone initial pterygium removal at the Hayashi Eye Hospital between June 2014 and December 2017 were included in this study. In all eyes, the shape of the cornea could be measured using anterior segment optical coherence tomography 2 months after surgery. The independent variables were determined using a multiple regression equation that predicted the average postoperative K on the ...

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    22. Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

      Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

      Aims To describe optical coherence tomography (OCT) findings in patients with in-stent restenosis (ISR) and determine predictors of neointimal patterns and neoatherosclerosis. Methods and results Patients undergoing OCT prior to PCI for ISR in three European centres were included. Analyses were performed in a core laboratory. Qualitative and quantitative [gray-scale signal intensity (GSI)] neointima analyses were performed on a per quadrant basis. A total of 107 patients were included. Predominantly homogeneous lesions included 4.5% (0.0–14.3) non-homogeneous quadrants, while predominantly non-homogeneous ones included 28.1% (20.3–37.5) homogeneous quadrants. Mean GSI values differed significantly between ...

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    23. Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging

      Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging

      Purpose To determine the effects of averaging five en face optical coherence tomography angiographic (OCTA) images on the quality of the images in eyes with a choroidal neovascularization (CNV). Methods Twenty-seven eyes of 25 patients (18 men, 7 women; average age 71.0 years) with a CNV were examined by OCTA (OCT HS-100, Canon. Japan). A 3 × 3-mm image including the CNV was recorded and automatically segmented between the retinal outer layers. Analyses were performed on a single image (S-image) and the average of five single images of the same area (A-images). The region of the CNV was selected by ...

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