1. 1-24 of 995 1 2 3 4 ... 40 41 42 »
    1. Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study

      Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study

      Purpose: To investigate the association of the degree of stent expansion, as assessed by optical coherence tomography (OCT), following stent implantation, and clinical outcomes in ST-segment elevation myocardial infarction (STEMI) patients. Methods: STEMI patients from the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and angioX) OCT study were selected; Clinical outcomes were collected through 1 year. Stent expansion index is a minimum stent area (MSA) divided by average lumen area (average of proximal and distal reference lumen area). The following variables were measured: MSA (< 4.5mm 2 ), dissection (> 200 µm in width and < 5 mm from stent segment ...

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    2. DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

      OCTA imaging is an emerging modality for the discovery of retinal biomarkers in systemic disease. Several studies have already shown the potential of deep learning algorithms in the medical domain. However, they generally require large amount of manually graded images which may not always be available. In our study, we aim to investigate whether transfer learning can help in identifying patient status from a relatively small dataset. Additionally, we explore if data augmentation may help in improving our classification accuracy. Finally, for the first time, we propose a validation of our model on OCTA images acquired with a different device ...

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    3. Quantification of calcium burden by coronary CT angiography compared to optical coherence tomography

      Quantification of calcium burden by coronary CT angiography compared to optical coherence tomography

      Coronary artery calcifications (CAC) are frequently observed in patients referred for coronary CT angiography (CTA). Calcification volume (in mm 3 ) can accurately be assessed during catheterization by optical coherence tomography (OCT). The aim of the present study was to investigate the accuracy of CTA-derived assessment of calcification volume as compared with OCT. 66 calcified plaques (32 vessels) from 31 patients undergoing OCT-guided PCI with coronary CT acquired as a standard of care were included. Coronary CT and OCT images were matched using fiduciary points. Calcified plaques were reconstructed in three dimensions to calculate calcium volume. A Passing-Bablok regression analysis and ...

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    4. The effect of epiretinal membrane surgery on macular microvasculature: an optical coherence tomography angiography study

      The effect of epiretinal membrane surgery on macular microvasculature: an optical coherence tomography angiography study

      Purpose To investigate both the possible effects of both idiopathic epiretinal membrane (IERM) itself and surgery on macular microvascular structure using optical coherence tomography angiography (OCT-A) and to determine the associations with structural and visual outcomes. Methods Twenty-four eyes of 24 patients with IERM and 24 eyes of 12 healthy controls were included. Vascular parameters, including the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were evaluated by OCT-A prior to and 6 months after ERM removal. The foveal avascular zone (FAZ, mm 2 ) area, parafoveal vascular density (VD, %) and flow area (mm 2 ) measurements were used to evaluate ...

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    5. Long-term follow up of en face optical coherence tomography of the inner retinal surface following internal limiting membrane peeling for idiopathic macular holes

      Long-term follow up of en face optical coherence tomography of the inner retinal surface following internal limiting membrane peeling for idiopathic macular holes

      Purpose To evaluate sequential changes in the inner retinal surface using en face spectral domain optical coherence tomography (SD-OCT) following internal limiting membrane (ILM) peeling for idiopathic full thickness macular holes. Methods Retrospective, interventional study on 45 eyes of 42 patients with type 1 macular hole closure after a single procedure and a minimum post-operative follow up of 6 months. Best corrected visual acuity (BCVA), fundus photographs, B scan and en face SD-OCT scans were analysed pre-operatively, at 2, 6, 12 months post-operatively and then yearly. The presence or absence of concentric macular dark spots (CMDS) on the ILM slab ...

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    6. Thinner temporal peripapillary retinal nerve fibre layer in Stargardt disease detected by optical coherence tomography

      Thinner temporal peripapillary retinal nerve fibre layer in Stargardt disease detected by optical coherence tomography

      Purpose To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness measured by spectral domain optical coherence tomography (OCT) in patients with Stargardt disease (STGD). Methods A cross-sectional, monocentric, observational case-control study. Twenty patients (39 eyes) with ABCA4 mutations graded according to the Fishman STGD classification were included. RNFL measurement was performed using Heidelberg Spectralis SD-OCT. RNFL thickness in STGD patients was compared to age-matched data of healthy individuals provided by the device’s manufacturer. A manual readjustment of the optic disc-fovea angle was performed when needed. Results The mean age at first diagnosis of STGD was 22.9 years (range ...

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    7. Uveitic macular edema response to intravitreal dexamethasone implant is independent of optical coherence tomography findings

      Uveitic macular edema response to intravitreal dexamethasone implant is independent of optical coherence tomography findings

      Purpose To identify predictive response optical coherence tomography (OCT) findings in uveitic macular edema (UME) treated with intravitreal dexamethasone implant (DEX). Methods Retrospective study of 66 eyes (53 patients) treated with DEX for UME. SD-OCT macular scans were collected prior to DEX treatment and 6 weeks and 3 months after the DEX implant. OCT images were evaluated for qualitative and quantitative characteristics (central retinal thickness, CRT and macular volume, MV). A multivariate analysis of covariance (ANCOVA) was carried out to study the predictive influence of OCT and clinical covariates on outcomes. The main outcome was a composite endpoint based on ...

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    8. Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion

      Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion

      Purpose Juvenile open angle glaucoma (JOAG) is a type of glaucoma that occurs in patients younger than 40 years. Only a few studies have assessed vascular perfusion in JOAG and correlated it with structural damage. The aim of this study is to investigate vascular perfusion in JOAG by optical coherence tomography angiography (OCTA) and correlate it with structural damage, represented by retinal nerve fiber layer (RNFL) thinning. Methods This is a cross-sectional observational study of 25 eyes of patients with JOAG. All patients underwent full ocular examination and scanning by OCTA to measure parameters such as RNFL thickness, peripapillary and ...

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    9. Optical coherence tomography indices in the diagnosis and discrimination of stages of primary open-angle glaucoma in an African population

      Optical coherence tomography indices in the diagnosis and discrimination of stages of primary open-angle glaucoma in an African population

      Purpose The objective of this study was to determine the structure–function association of the optical coherence tomography (OCT) indices (retinal nerve fibre layer (RNFL), ganglion cell complex (GCC) and optic nerve head (ONH) parameters) with the visual field sensitivity and their diagnostic ability at different stages of primary open-angle glaucoma (POAG) among a population West-African descent. Methods The study was a clinic-based prospective study which employed purposive sampling in the recruitment of clinically diagnosed POAG and non-glaucoma patients. OCT and visual field test (VFT) results were collated. Classification of the POAG cases was done using the Hodapp–Parrish–Anderson ...

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    10. Diagnostics in Ocular Imaging

      Diagnostics in Ocular Imaging

      This book presents a new avenue in the field of ophthalmology and sheds light on the field of eye imaging. With the increasing availability of electronic devices and their important role in both personal and professional aspects of human life, there is a growing need for perfect vision. Ophthalmic imaging is a major tool for screening and documenting eye diseases in both medical and surgical fields of ophthalmology and is also of use for ophthalmologists around the globe. The number of eye-imaging devices has increased dramatically, however undiagnosed or poorly managed eye diseases remain a significant cause of ocular and ...

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    11. Difference of vascular healing between bioabsorbable-polymer and durable-polymer new generation drug-eluting stents: an optical coherence tomographic analysis

      Difference of vascular healing between bioabsorbable-polymer and durable-polymer new generation drug-eluting stents: an optical coherence tomographic analysis

      The comparison of bioabsorbable-polymer and durable-polymer stents has continued to be debated, and there is ongoing concern regarding vascular healing and late stent thrombosis. This study compared the vascular healing at 8-month follow-up by optical coherence tomography (OCT) between 4 different kinds of new generation drug-eluting stents (DESs). We enrolled 112 patients (112 de novo lesions) who underwent OCT guided percutaneous coronary intervention with 4 kinds of new generation DESs including bioabsorbable-polymer everolimus-eluting stents (BP-EESs), bioabsorbable-polymer sirolimus-eluting stents (BP-SESs), durable-polymer everolimus-eluting stents (DP-EESs), and durable-polymer zotarolimus-eluting stents (DP-ZESs) and an 8-month follow-up angiogram and OCT were performed between July 2016 ...

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    12. Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography

      Imaging of a retinal pigment epithelium aperture using polarization-sensitive optical coherence tomography

      Purpose: To evaluate cases with a retinal pigment epithelium (RPE) aperture using polarization-sensitive optical coherence tomography (PS-OCT). Study design: Retrospective consecutive case series. Methods: A retrospective study that included three eyes (three patients) with RPE aperture and age-related macular degeneration (AMD) evaluated at the Macular Clinic in Tokyo University Hospital. A three-dimensional dataset of depolarization information was obtained with a clinical prototype of PS-OCT. Results: All patients were categorized as intermediate AMD. RPE apertures were identified with PS-OCT as discontinuities of depolarization in the RPE layer of the pigment epithelial detachment (PED). A nonuniform decrease of depolarization in the RPE ...

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    13. Investigation of macular and optic nerve head structural changes using spectral domain optical coherence tomography in internal carotid artery stenosis

      Investigation of macular and optic nerve head structural changes using spectral domain optical coherence tomography in internal carotid artery stenosis

      Purpose To demonstrate differences in optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular thickness in patients with internal carotid artery (ICA) stenosis using spectral domain optical coherence tomography (SD-OCT). Methods A case-controlled study was conducted in 31 patients with a diagnosis of unilateral ICA stenosis (the percentage of stenosis was between 65 and 85%), and 53 age- and sex-matched healthy subjects (control group) from March 2016 to April 2018. The ONH parameters, RNFL, and macular thicknesses in the nine macular quadrants according to the Early Treatment Diabetic Retinopathy Study (ETDRS) were measured using SD-OCT. Results The average ...

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    14. Effects of age and binarising area on choroidal vascularity index in healthy eyes: an optical coherence tomography study

      Effects of age and binarising area on choroidal vascularity index in healthy eyes: an optical coherence tomography study

      Purpose: To investigate the changes in the choroidal vascularity index (CVI) with age and to compare the effect of the binarised area on CVI in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). Materials and methods: Two hundred and twenty-four eyes of 224 healthy subjects were included in this prospective cross-sectional study. The eyes were divided into different age groups to analyse the possible age-related choroidal structural changes. Subfoveal choroidal thickness (SFCT), CVI, total choroidal area (TCA), stromal area (SA), luminal area (LA), and CVI within the central 1500 µm of the macula were analysed using enhanced depth imaging SD-OCT ...

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    15. Foveal avascular zone analysis by optical coherence tomography angiography in patients with type 1 and 2 diabetes and without clinical signs of diabetic retinopathy

      Foveal avascular zone analysis by optical coherence tomography angiography in patients with type 1 and 2 diabetes and without clinical signs of diabetic retinopathy

      Purpose To analyze the early macular microvascular alterations in patients with type 1 and 2 diabetes mellitus (DM) without diabetic retinopathy (DR), using optical coherence tomography angiography (OCT-A), and compare these with nondiabetic patients. Methods This prospective study involved 93 patients with type 1 diabetes (DM1), 104 patients with type 2 diabetes (DM2) without signs of DR, and 71 healthy subjects for the control group. The foveal avascular zone (FAZ) area and the vessel density (VD) at the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were evaluated. Results The SCP and DCP FAZ areas were significantly larger in ...

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    16. Feasibility of morphological assessment of coronary artery calcification with electrocardiography-gated non-contrast computed tomography: a comparative study with optical coherence tomography

      Feasibility of morphological assessment of coronary artery calcification with electrocardiography-gated non-contrast computed tomography: a comparative study with optical coherence tomography

      To investigate the feasibility of pre-procedural morphological assessment of coronary artery calcification in severely calcified lesions with electrocardiography (ECG)-gated non-contrast computed tomography (CT). Severely calcified coronary arteries in patients who underwent ECG-gated non-contrast CT prior to optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) were studied retrospectively. CT and OCT data were co-registered by marking landmark structures such as side branches and reviewed side by side with cross-sectional images. The maximum calcium angle (MCA) and presence of nodular calcification (NC) were evaluated. A total of 496 cross-sections in 16 lesions were included in this analysis. The Pearson correlation ...

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    17. Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography is organized into comprehensive chapters on the following topics: fundamentals, technologies and technological differences among platforms, application of OCT, corneal OCT angiography, as well as case-based chapters. Numerous highly-detailed figures, illustrations and photographs make this an ideal resource for the corneal specialist seeking further instruction on this cutting-edge technology. The case-based chapters include such conditions as bowman dystrophies, trauma, cataract, glaucoma, sclera, refractive surgery, ocular infections, and are structured to facilitate the consultant surgeon by providing practical information applicable to practical cases in their practice.

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    18. Spectral-domain OCT changes in retina and optic nerve in children with hypoxic-ischaemic encephalopathy

      Spectral-domain OCT changes in retina and optic nerve in children with hypoxic-ischaemic encephalopathy

      Purpose To evaluate the effect of neonatal hypoxic–ischaemic injury on the retina and the optic nerve and to correlate ocular damage with systemic parameters, laboratory tests, neurological imaging and therapeutic hypothermia at birth. Methods Forty-one children with hypoxic–ischaemic encephalopathy (HIE) at birth (9.09 ± 3.78 years) and a control group of 38 healthy subjects (9.57 ± 3.47 years) were enrolled in a cohort study. The HIE population was divided into three subgroups, based on the degree of encephalopathy according to Sarnat score and the treatment with therapeutic hypothermia (TH): Sarnat score I not treated with hypothermia ...

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    19. Macular Surgery Current Practice and Trends (Textbook)

      Macular Surgery Current Practice and Trends (Textbook)

      Recent technological advances in the diagnosis of macular disorders have enhanced our understanding of these diseases. At the same time, advances in small-gauge vitrectomy instrumentation and techniques have improved the safety and efficiency of surgery, allowing macular conditions that would have otherwise resulted in blindness to be treated effectively, preserving patients’ sight. Macular surgery continues to evolve rapidly, thanks to exciting future technology trends. This book provides a detailed and up-to-date overview of the field. It begins with essential information on macular anatomy and pathophysiology, examination techniques, and surgical instrumentation. In turn, it discusses a broad range of disease processes ...

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    20. Clinical impact of a new optical coherence tomography-derived volumetric method for evaluating stent expansion

      Clinical impact of a new optical coherence tomography-derived volumetric method for evaluating stent expansion

      The aim of this study was to investigate the impact of a new optical coherence tomography (OCT)-derived volumetric method for stent expansion (new-OCT method) to predict the target lesion revascularization (TLR) and compare the expansion findings between this new method and the conventional method because, in the real world, there are few clinical data on the new-OCT-method for stent expansion. One hundred forty lesions in 135 patients who underwent OCT-guided percutaneous coronary intervention were enrolled. We compared the new-OCT-method and conventional method to predict the TLR at 1 year. A total of 7 lesions (5.0% of treated lesions ...

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      Mentions: Osaka University
    21. Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      Multi-directional Morphological Assessment of Single Bacterial Colonies Through Non-invasive Optical Imaging

      A bacterium in bacterial colony is a basal component of bacterial studies and is therefore of considerable importance. The morphological characteristics of a single colony have been widely used as the standard to identify diverse bacterial species. However, the conventional methods for obtaining morphological information, such as microscopic techniques, cannot provide tomographic views. This study utilizes spectral-domain optical coherence tomography (SD-OCT) to observe both external and internal structures for single colonies. OCT imaging provided a clear top (projection) and lateral (cross-sectional) images, which can identify distinct features in the fifteen different bacterial species examined. Through the acquired OCT images, the ...

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    22. Relationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy

      Relationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy

      Purpose To describe the structure–function relationship in birdshot chorioretinopathy (BSCR) using visual field data and peri-papillary retinal nerve fiber thickness (RNFL). Methods A total of 21 patients (34 eyes) with BSCR were evaluated prospectively from 2014 to 2018 (IMAGE-EYE cohort). Functional tests included measurement of visual acuity and visual field (30-2 SITA standard). Anatomical tests included fluorescein angiography, indocyanine green angiography, and spectral domain optical coherence tomography. Results Most of the patients were female (57%) with a mean age of 62 ± 8 years. Mean follow-up was 2.3 ± 0.6 years. Structural examination results were significantly modified in contrast ...

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    23. Long-Term Arterial Remodeling After Bioresorbable Scaffold Implantation 4-Year Follow-up of Quantitative Coronary Angiography, Histology and Optical Coherence Tomography

      Long-Term Arterial Remodeling After Bioresorbable Scaffold Implantation 4-Year Follow-up of Quantitative Coronary Angiography, Histology and Optical Coherence Tomography

      Purpose Our previous studies have confirmed the safety and efficacy of the novel fully bioresorbable PLLA scaffold (PowerScaffold®) at 12 months implantation. In the present study, the scaffold absorption and coronary vessel remodeling at 4 years were evaluated. Methods After PowerScaffold® were implanted into 13 coronary arteries of 6 miniature pigs, quantitative coronary angiography (QCA) was performed at 15 days and 4 years follow-up to measure the mean lumen diameter (MLD), late lumen loss (LLL), and % stenosis of the coronary arteries. Optical coherence tomography (OCT) was performed to obtain the strut footprints at 4 years before euthanization for histological analysis ...

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    24. Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography

      Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography

      Optical imaging for early disease diagnosis, especially cancer, has created significant interest. Label-free methods have gained attention in this regard. The light–matter interaction means that the combination of more than one optical modality for imaging can lead to enhanced specificity and sensitivity. Here we describe efforts using inelastic scattering (Raman) analysis for molecular fingerprinting of tissue combined with morphological information obtained from optical coherence tomography (OCT). This chapter focuses on innovations in these systems that allow us to co-register images at depth simultaneously for both these imaging modes and potential applications for disease diagnosis.

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