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    1. A review of optical coherence tomography in breast cancer

      A review of optical coherence tomography in breast cancer

      Optical coherence tomography (OCT) is a medical imaging modality that opens up new opportunities for imaging in breast cancer. It provides two- and three-dimensional micro-scale images of tissue structure from bulk tissue, in vivo or freshly excised without labeling or staining, is capable of video-rate acquisition speeds, and is compatible with compact imaging probes. In this paper, the authors briefly describe OCT technology and describe in detail its capabilities for imaging breast cancer. Potential applications identified in current research are discussed, particularly in the assessment of excised breast tumors. It is concluded that OCT shows promise for margin assessment and ...

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    2. High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography

      High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography

      Optical coherence tomography (OCT), a spectroscopy technique, has been used in biomedical applications for about 20 years. It has evolved to a standard non-invasive examination procedure yielding detail-rich cross-sectional images of living tissue. With longer wavelengths in the IR spectrum and the availability of InGaAs detectors and cameras, OCT scanners now penetrate even deeper into the human tissue. This article presents technical improvements on an IR line-scan camera, which specifically benefits OCT applications.

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      Mentions: Xenics
    3. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at days 7 and 21 after implantation and post mortem on the day of noticeable inflammation. A Fourier-domain OCT was programmed for spoke pattern scanning schemes centered at the implant midpoint ...

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    4. Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      In Fourier domain optical coherence tomography (FDOCT) coherence noise is caused by interference of light waves back-reflected or scattered from different spots within a measuring depth or from optical components within the OCT system such as a bended optical fibre. This coherence noise appears as periodic stripe patterns along the axial direction in resulting images. Background subtraction and physical segmentation are used to degrade the periodic coherence noise in previous studies. Here we utilise a post-processing method by applying a frequency domain filter to reduce the periodic coherence noise. Even though the approach taken is a very simple one, it ...

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    5. Optical coherence tomography - from research to routine medical diagnostics

      Optical coherence tomography - from research to routine medical diagnostics

      In the field of biomedical optics, Optical Coherence Tomography (OCT) is one of the success stories of transition from research to routine medical diagnostics. This talk will focus on OCT as an interesting case study for successful technologies in the medical field, in particular in ophthalmology. Despite being a unique solution for the technical problems of imaging into the eye, it took more than 15 years to establish OCT as a routine diagnostic tool in ophthalmology. The presentation will highlight the technical and clinical milestones that drove this development. One of the technical milestones was the transition from time-domain OCT ...

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    6. Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      The development of protective ventilation strategies for patients suffering from life-threatening lung diseases and the promotion of numerical simulation of lung tissue mechanics requires detailed knowledge about the three-dimensional alveolar micro-structure, their dynamics and elastic properties. Subpleural lung tissue can be observed in animal models utilizing optical coherence tomography (OCT) with a high spatial resolution. We present four-dimensional high-speed OCT imaging of single alveoli as a suitable technique for the visualization of the temporal changes of the three-dimensional structure during the ventilation with a temporal resolution of 17 stacks per ventilation cycle. The acquired four-dimensional information allows a quantitative evaluation ...

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    7. A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      We present a novel hybrid system that allows simultaneous high-resolution spectral domain optical coherence tomography (OCT) in the near-infrared and single-photon excited fluorescence (SPEF) detection in the green and red visible wavelength range for non-invasive multimodal imaging of the retina in small in vivo animal models such as zebrafish.

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    1-9 of 9
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