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    1. Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

      Doppler optical coherence tomography as a promising tool for detecting fluid in the human middle ear

      The treatment of otitis media requires classifying the effusion in the tympanic cavity for choosing appropriate therapeutic strategies. Otoscopic examination of the middle ear depends on the expertise of the physician and is often hampered in case of inflammatory alterations of the tympanic membrane. In otologic research, optical coherence tomography is an innovative non-invasive imaging technique utilized for visualizing the tympanic membrane. This ex vivo study presents the possibility of OCT and Doppler-OCT for the detection of effusions in the tympanic cavity. Structural OCT imaging allows the direct visualization of scattering fluids behind the tympanic membrane. In addition, the measurement ...

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    2. Discrepancies between Spectral Domain Optical Coherence Tomography and Fluorescein Angiography in Detecting Uveitic Macular Edema

      Discrepancies between Spectral Domain Optical Coherence Tomography and Fluorescein Angiography in Detecting Uveitic Macular Edema

      AIM: To compare spectral-domain optical coherence tomography (SD-OCT) with fluorescein angiography (FA) in detecting macular edema in patients with uveitis and analyse discrepancies in the findings obtained by the two methods. METHODS: The study included 133 eyes from 117 patients with uveitis that had SD-OCT (RTVue-100/ Optovue) and FA (Topcon TRC 50DX) scans performed to detect or rule out macular edema. RESULTS: Macular edema was found in 57 (42.9%) of the 133 surveyed eyes. In 37 eyes (27.8%) macular edema was confirmed by both imaging methods. In 17 eyes (12.8%) macular edema was detected on SD-OCT but ...

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    3. Effect of temperature regime and compression in OCT imaging of skin in vivo

      Effect of temperature regime and compression in OCT imaging of skin in vivo

      Optical coherence tomography (OCT) is a modern technique for imaging of internal structures of biotissue of up to several millimeters in depth with a resolution of several micrometers. However, various external conditions can distort the diagnostic capabilities of an OCT image. Mechanical compression and temperature regime are the two conditions which mostly affect the diagnostic OCT images obtained with a contact probe. It is shown here that the application of compression to human skin induces a decrease in contrast of the stratum corneum-epidermis junction and an increase in contrast of the epidermis-dermis junction. With regard to these junctions, a preliminary ...

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    4. Quantitative assessment of oral microstructural and microvascular changes in late oral radiation toxicity, using noninvasive in-vivo optical coherence tomography

      Quantitative assessment of oral microstructural and microvascular changes in late oral radiation toxicity, using noninvasive in-vivo optical coherence tomography

      Background and objectives: About half of the head and neck cancer patients treated with radiotherapy suffer from late radiation effects months to years after the treatment. The most common diagnosis and monitoring methods for such oral toxicities are based on surface examination of the oral tissue, which is subjective. Therefore, subsurface imaging and image quantification tools can be highly useful for monitoring these late effects as these approaches are more robust and objective. In this study, we demonstrate the ability of optical coherence tomography (OCT) technology and its newly developed quantitative imaging platform to reveal subsurface microstructural and microvascular changes ...

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    5. Imaging of aortic valve dynamics in 4D OCT New insights into murine aortic valve diseases

      Imaging of aortic valve dynamics in 4D OCT  New insights into murine aortic valve diseases

      The mechanical components of the heart, especially the valves and leaflets, are enormous stressed during lifetime. Therefore, those structures undergo different pathophysiological tissue transformations which affect cardiac output and in consequence living comfort of affected patients. These changes may lead to calcific aortic valve stenosis (AVS), the major heart valve disease in humans. The knowledge about changes of the dynamic behaviour during the course of this disease and the possibility of early stage diagnosis is of particular interest and could lead to the development of new treatment strategies and drug based options of prevention or therapy. 4D optical coherence tomography ...

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    6. Towards contactless optical coherence elastography with acoustic tissue excitation

      Towards contactless optical coherence elastography with acoustic tissue excitation

      Elastography presents an interesting approach to complement image data with mechanical tissue properties. Typically, the tissue is excited by direct contact to a probe. We study contactless elastography based on optical coherence tomography (OCT) and dynamic acoustic tissue excitation with airborne sound. We illustrate the principle and an implementation using sound waves of 135 Hz to excite the tissue. The displacement is measured and results of several tests indicate the feasibility to obtain a qualitative measure of the mechanical tissue properties. The approach is interesting for optical palpation, e.g., to enhance navigation and tissue characterization in minimally invasive and ...

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    7. Intravascular optical coherence tomography (OCT) as an additional tool for the assessment of stent structures

      Intravascular optical coherence tomography (OCT) as an additional tool for the assessment of stent structures

      Evaluation of the vascular stent position, shape and correct expansion has a high relevance in therapy and diagnosis. Hence, the wall apposition in vessel areas with differing diameters and the appearance of torsions or structural defects of the implant body caused by catheter based device dropping are of special interest. Neurovascular implants like braided flow diverter and laser cut stents consist of metal struts and wires with diameters of about 40 μm. Depending on the implants material composition, visibility is poor with conventional 2D X-ray fluoroscopic and radiographic imaging. The metal structures of the implants also lead to artifacts in ...

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    8. Can optical coherence tomography predict early retinal microvascular pathology in type 1 diabetic adolescents without minimal diabetic retinopathy? A single-centre study

      Can optical coherence tomography predict early retinal microvascular pathology in type 1 diabetic adolescents without minimal diabetic retinopathy? A single-centre study

      Background: Optical coherence tomography (OCT) has been proven useful in measuring retinal thickness and volumes in patients with diabetes. Objective: To test whether OCT is able to identify early retinal changes and its potential correlations with metabolic parameters and other microvascular complications. Patients and methods: Thirty patients with type 1 diabetes without minimal diabetic retinopathy (MDR) (17 males, 13 females, aged 14.3±2.4 years) compared with age-matched healthy volunteers were examined with OCT. Diabetes duration, anthropometric measurements, HbA 1c , other microvascular complications (nephropathy, autonomic and peripheral neuropathy) and total serum cholesterol were determined. Results: No statistically significant differences ...

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    9. A review of optical coherence tomography in breast cancer

      A review of optical coherence tomography in breast cancer

      Optical coherence tomography (OCT) is a medical imaging modality that opens up new opportunities for imaging in breast cancer. It provides two- and three-dimensional micro-scale images of tissue structure from bulk tissue, in vivo or freshly excised without labeling or staining, is capable of video-rate acquisition speeds, and is compatible with compact imaging probes. In this paper, the authors briefly describe OCT technology and describe in detail its capabilities for imaging breast cancer. Potential applications identified in current research are discussed, particularly in the assessment of excised breast tumors. It is concluded that OCT shows promise for margin assessment and ...

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    10. High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography

      High-resolution InGaAs sensor pushing biomedical infrared optical coherence tomography

      Optical coherence tomography (OCT), a spectroscopy technique, has been used in biomedical applications for about 20 years. It has evolved to a standard non-invasive examination procedure yielding detail-rich cross-sectional images of living tissue. With longer wavelengths in the IR spectrum and the availability of InGaAs detectors and cameras, OCT scanners now penetrate even deeper into the human tissue. This article presents technical improvements on an IR line-scan camera, which specifically benefits OCT applications.

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      Mentions: Xenics
    11. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at days 7 and 21 after implantation and post mortem on the day of noticeable inflammation. A Fourier-domain OCT was programmed for spoke pattern scanning schemes centered at the implant midpoint ...

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    12. Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering

      In Fourier domain optical coherence tomography (FDOCT) coherence noise is caused by interference of light waves back-reflected or scattered from different spots within a measuring depth or from optical components within the OCT system such as a bended optical fibre. This coherence noise appears as periodic stripe patterns along the axial direction in resulting images. Background subtraction and physical segmentation are used to degrade the periodic coherence noise in previous studies. Here we utilise a post-processing method by applying a frequency domain filter to reduce the periodic coherence noise. Even though the approach taken is a very simple one, it ...

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    13. Optical coherence tomography - from research to routine medical diagnostics

      Optical coherence tomography - from research to routine medical diagnostics

      In the field of biomedical optics, Optical Coherence Tomography (OCT) is one of the success stories of transition from research to routine medical diagnostics. This talk will focus on OCT as an interesting case study for successful technologies in the medical field, in particular in ophthalmology. Despite being a unique solution for the technical problems of imaging into the eye, it took more than 15 years to establish OCT as a routine diagnostic tool in ophthalmology. The presentation will highlight the technical and clinical milestones that drove this development. One of the technical milestones was the transition from time-domain OCT ...

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    14. Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      Four-dimensional optical coherence tomography imaging of subpleural alveoli in mice

      The development of protective ventilation strategies for patients suffering from life-threatening lung diseases and the promotion of numerical simulation of lung tissue mechanics requires detailed knowledge about the three-dimensional alveolar micro-structure, their dynamics and elastic properties. Subpleural lung tissue can be observed in animal models utilizing optical coherence tomography (OCT) with a high spatial resolution. We present four-dimensional high-speed OCT imaging of single alveoli as a suitable technique for the visualization of the temporal changes of the three-dimensional structure during the ventilation with a temporal resolution of 17 stacks per ventilation cycle. The acquired four-dimensional information allows a quantitative evaluation ...

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    15. A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      A hybrid imaging system for simultaneous ophthalmic optical coherence tomography and dual-channel fluorescence detection in small animal models

      We present a novel hybrid system that allows simultaneous high-resolution spectral domain optical coherence tomography (OCT) in the near-infrared and single-photon excited fluorescence (SPEF) detection in the green and red visible wavelength range for non-invasive multimodal imaging of the retina in small in vivo animal models such as zebrafish.

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    1-17 of 17
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