1. 1-12 of 12
    1. Comparison of Quantitative Imaging Devices and Subjective Optic Nerve Head Assessment by General Ophthalmologists to Differentiate Normal From Glaucomatous Eyes

      Purpose: To compare the ability of subjective assessment of optic nerve head (ONH) and retinal nerve fiber layer (RNFL) by general ophthalmologists and by a glaucoma expert with objective measurements by optical coherence tomography (Stratus OCT, Carl Zeiss Meditec Inc), confocal scanning laser ophthalmoscope (HRT III; Heidelberg Engineering, Heidelberg, Germany), and scanning laser polarimetry (GDx enhanced corneal compensation; Carl Zeiss Meditec Inc, Dublin, CA) in discriminating glaucomatous and normal eyes. Methods: Sixty-one glaucomatous and 57 normal eyes of 118 subjects were included in the study. Three independent general ophthalmologists and 1 glaucoma expert evaluated ONH stereophotographs. Receiver operating characteristic curves ...
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    2. Artifacts on the Optic Nerve Head Analysis of the Optical Coherence Tomography in Glaucomatous and Nonglaucomatous Eyes

      Purpose: To determine the frequency and type of imaging artifacts in the optic nerve head (ONH) analysis protocol of the optical coherence tomograph (Stratus OCT) in healthy and glaucomatous eyes. Design: Retrospective study. Methods: Two experienced operators reviewed imaging obtained in 264 eyes from 264 participants (146 controls, 118 glaucoma patients). Each participant had a minimum of 3 scans using fast ONH protocol. Only scans with good quality were included in the study. Results: Thirty-two eyes (12%) had imaging artifacts in at least one of the radial scans distributed as follows: 12 eyes showed incorrect identification of vitreous-retinal surface plane ...
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    3. Signal Strength is an Important Determinant of Accuracy of Nerve Fiber Layer Thickness Measurement by Optical Coherence Tomography.

      Purpose: To investigate the effect of signal strength on the measurement of the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT). Methods: Eyes with known or suspected glaucoma or nonglaucomatous optic atrophy were scanned twice within the same visit using Stratus OCT's Fast Nerve Fiber Layer Thickness protocol. Only those eyes with 2 high-quality scans (signal strengths of at least 5 and different from each other, no error messages, and no obvious segmentation errors) were included in the study. The RNFL thickness measurements from the initial and the repeat scans were compared and then correlated with the ...
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    4. Detectability of Glaucomatous Changes Using SAP, FDT, Flicker Perimetry, and OCT

      Purpose: To compare the detectability between glaucomatous visual field changes using standard automated perimetry (SAP), frequency doubling technology (FDT), short-wavelength automated perimetry (SWAP), and flicker perimetry and structural changes using optical coherence tomography (OCT). Participants: Fifty-nine eyes of fifty-nine patients with open-angle glaucoma, 24 eyes of 24 glaucoma suspects (GSs), and 40 eyes of 40 healthy age-matched subjects. Methods: All subjects underwent Humphrey visual field analyzer II 24-2 full threshold (SAP), Swedish interactive threshold algorithm-SWAP, FDT (30-1, 30-5, 24-2-1, 24-2-5), flicker perimetry on Octopus 311 (4-zone probability 38S), and Stratus OCT [fast retinal nerve fiber layer thickness (NFLT) and fast ...
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    5. Longitudinal Evaluation of Optic Disc Measurement Variability With Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy.

      Purpose: To evaluate and compare the longitudinal variability of optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO) optic disc measurements. Methods: A total of 25 normal and 50 glaucomatous eyes from 75 subjects were included in the analysis. The optic disc was measured by OCT and CSLO. Three separate measurements collected over an average period of 8.5±0.9 months were used to evaluate reproducibility. Univariate and multivariate regression analyses were performed to evaluate the associations between age, refraction, diagnosis (glaucoma or normal), visual field mean deviation, optic disc area, signal strength variance (OCT), optic disc area ...
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    6. Scan Tracking Coordinates for Improved Centering of Stratus OCT Scan Pattern.

      Objective: To describe and evaluate a technique to optimize scan centering during the Stratus optical coherence tomography (OCT) image acquisition process using currently available scan tracking coordinates. Design: Observational clinical study. Participants: Twelve eyes of six normal subjects were examined using the Fast retinal nerve fiber layer (RNFL) thickness and the Fast Optic Disc acquisition protocols. Methods: At visit 1, 3 consecutive measurements (trials) were taken by 2 different operators with the scan subjectively centered on the optic disc for the Fast RNFL thickness protocol and Fast Optic Disc protocol. At visit 2, 3 consecutive measurements were taken by positioning ...
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    7. The Correlation Between Visual Field Defects and Focal Nerve Fiber Layer Thickness Measured With Optical Coherence Tomography in the Evaluation of Glaucoma.

      Purpose: To study the correlation between known visual field defects and retinal nerve fiber layer (RNFL) thickness detected by optical coherence tomography (OCT) in glaucomatous eyes. Materials and Methods: Visual field parameters and OCT RNFL measurements of 28 eyes of 28 glaucoma patients with various stages of glaucoma were compared with 38 eyes of 38 normal age-matched controls. A perimetric nerve fiber bundle map was built by dividing the visual field area into 21 zones. Mean deviation and pattern standard deviation values within these 21 zones were compared with OCT RNFL thickness measurements in 12 sectors and the results were ...
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    8. Visualization of Changes of the Iris Configuration After Peripheral Laser Iridotomy in Primary Melanin Dispersion Syndrome Using Optical Coherence Tomography.

      Pigment or melanin dispersion syndrome is characterized by radial iris transillumination defects, retrocorneal Krukenberg spindle, and dense trabecular pigmentation. Reverse pupillary block has been presumed as one possible pathogenetic mechanism for backward bowing of the iris leading to iris-zonular rubbing and distribution of melanin granules in the anterior chamber. Laser iridotomy is recommended as a treatment to prevent further melanin dispersion and development of pigmentary glaucoma. The effect of Nd:YAG laser iridotomy as a prophylactic and potentially causal treatment in melanin dispersion syndrome can be easily visualized by optical coherence tomography as a fast and noncontact procedure.
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    9. Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography.

      Purpose: To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Subjects and Methods: RNFL thickness profiles were measured by OCT in 16 control individuals and 16 patients. The patients had advanced glaucoma defined by abnormal disc appearance, abnormal visual fields, and a mean visual field deviation worse than -10 dB. Results: In general, the OCT RNFL thickness profiles showed 4 local maxima, with the peak amplitudes in the superior and inferior regions occurring in the temporal (peripapillary) disc region. There was ...
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    10. Changes in Angle Configuration After Phacoemulsification Measured by Anterior Segment Optical Coherence Tomography.

      Purpose: To measure changes in angle width after phacoemulsification and intraocular lens (IOL) implantation using anterior segment optical coherence tomography (AS-OCT). Materials and Methods: Twenty-one patients undergoing cataract surgery were recruited from the National University Hospital, Singapore. AS-OCT images were obtained of nasal and temporal angle quadrants before and at 1-month after surgery. Optical measurements of central anterior chamber depth were obtained, and gonioscopic measurement of angle width was recorded. AS-OCT angle width parameters measured in the nasal and temporal quadrants included the angle opening distance at 500 [mu]m (AOD500) anterior to the scleral spur and the trabecular iris ...

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    11. An Analysis of Normal Variations in Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence Tomography.

      Purpose: To assess the normal variations in retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Subjects and Methods: Both eyes of 48 individuals (age 56.4+/-9.5 y) with normal vision and refractive errors between +/-6.0 D were tested with the fast RNFL scan protocol of the OCT3 (Zeiss Meditech). Their 256-point RNFL profiles were exported for analysis. The location and peak amplitude of the maxima of the RNFL profiles were measured. Intersubject and interocular variations were assessed with a coefficient of determination, R2. An R2 of 1.0 indicated that the average profile ...
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    1-12 of 12
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