1. 121-144 of 169 « 1 2 3 4 5 6 7 »
    1. Imaging the Iris with Swept-Source Optical Coherence Tomography: Relationship between Iris Volume and Primary Angle Closure

      Imaging the Iris with Swept-Source Optical Coherence Tomography: Relationship between Iris Volume and Primary Angle Closure

      Objective To measure iris volume and anterior segment parameters using a swept-source anterior segment optical coherence tomography (OCT) and investigate factors associated with iris volume and iris volume change after pupil dilation in eyes with open angles and angle closure. Design Cross-sectional study. Participants A total of 86 eyes, including 31 eyes from 21 patients with primary angle closure (PAC) or PAC suspect, 31 eyes from 20 patients with primary open-angle glaucoma (POAG), and 24 eyes from 15 normal subjects, were included. Methods The anterior segment parameters and iris were imaged and measured by the Casia SS-1000 OCT (Tomey, Nagoya ...

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    2. Optical Coherence Tomography–Based Observation of the Natural History of Drusenoid Lesion in Eyes with Dry Age-Related Macular Degeneration

      Optical Coherence Tomography–Based Observation of the Natural History of Drusenoid Lesion in Eyes with Dry Age-Related Macular Degeneration

      Purpose To use spectral domain optical coherence tomography (SD-OCT) to investigate risk factors predictive for the development of atrophy of drusenoid lesions (DLs) (drusen and drusenoid pigment epithelium detachment) in eyes with non-neovascular age-related macular degeneration (NNVAMD). Design Cohort study. Participants Forty-one eyes from 29 patients with NNVAMD. Methods Patients with NNVAMD who underwent registered SD-OCT imaging over a minimum period of 6 months were reviewed. Drusenoid lesions that were accompanied by new atrophy onset at 6 months or last follow-up (FUL) were further analyzed. Detailed lesion change was described throughout the study period. Odds ratios (ORs) and risk for ...

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    3. Optical Coherence Tomography in Eyes with Vitreomacular Traction

      Optical Coherence Tomography in Eyes with Vitreomacular Traction

      We read with interest the article “Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane” by Tsunoda et al. The authors reported the presence of a highly reflective deposit (named “cotton ball sign”) on spectral-domain optical coherence tomography (SD-OCT) scanning in 63.8% of the eyes (30/47) with an epiretinal membrane (ERM) and in 100% (7/7) of eyes with vitreomacular traction (VMT). They stated that related articles were searched on PubMed and none was found describing the same feature. We believe the so-called “cotton ball sign” related to ERM or VMT ...

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    4. Assessment of Circumferential Angle-Closure by the Iris–Trabecular Contact Index with Swept-Source Optical Coherence Tomography

      Assessment of Circumferential Angle-Closure by the Iris–Trabecular Contact Index with Swept-Source Optical Coherence Tomography

      Purpose To evaluate the diagnostic performance of the iris–trabecular contact (ITC) index, a measure of the degree of angle-closure, using swept-source optical coherence tomography (SSOCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) in comparison with gonioscopy. Design Prospective observational study. Participants A total of 108 normal subjects and 32 subjects with angle-closure. Methods The SSOCT 3-dimensional angle scans, which obtain radial scans for the entire circumference of the angle, were performed under dark conditions and analyzed using customized software by a single examiner masked to the subjects' clinical details. The ITC index was calculated as a percentage of the angle ...

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    5. Spectral-Domain Optical Coherence Tomographic Findings at Each Stage of Punctate Inner Choroidopathy

      Spectral-Domain Optical Coherence Tomographic Findings at Each Stage of Punctate Inner Choroidopathy

      Purpose To describe the natural course of punctate inner choroidopathy (PIC) using spectral-domain optical coherence tomography (SD-OCT). Design Prospective observational case series. Participants Forty-two consecutive patients (60 eyes) with PIC with at least 3 months of follow-up. Methods Serial SD-OCT images were obtained from both eyes of each participant at each visit. Main Outcome Measures The morphologic characteristics of each stage of PIC lesions observed by SD-OCT. Results Continued stage progression of PIC lesions was observed in 27 eyes (45%), among which choroidal thickness changes were observed in 8 eyes (30%). Stage I lesion showed a normal appearance or slight ...

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    6. Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers - Corrected Proof

      Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers - Corrected Proof

      Objective: To demonstrate a novel swept source optical coherence tomography (SS-OCT) imaging device using a vertical cavity surface-emitting laser (VCSEL) capable of imaging the full eye length and to introduce a method using this device for noncontact ocular biometry. To compare the measurements of intraocular distances using this SS-OCT instrument with commercially available optical and ultrasound biometers. To evaluate the intersession reproducibility of measurements of intraocular distances using SS-OCT.Design: Evaluation of technology.Participants: Twenty eyes of 10 healthy subjects imaged at the New England Eye Center at Tufts Medical Center and Massachusetts Institute of Technology between May and September ...

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    7. Recognition of Henle's Fiber Layer on OCT Images

      Recognition of Henle's Fiber Layer on OCT Images

      Monés et al made an important observation about how important is to recognize the normal anatomy of the Henle's fiber layer in the optical coherence tomography images (OCT). Spectral-domain (SD) OCT offers the possibility of evaluating retinal architecture at near-histologic levels of resolution. However, clinicians should be aware that optical variations induced by examination conditions might alter the reflectivity of the retinal layers. This consideration is particularly true when imaging the outer plexiform layer (OPL) within the central macula.

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    8. Diagnostic Potential of Iris Cross-sectional Imaging in Albinism Using Optical Coherence Tomography

      Diagnostic Potential of Iris Cross-sectional Imaging in Albinism Using Optical Coherence Tomography

      Purpose To characterize in vivo anatomic abnormalities of the iris in albinism compared with healthy controls using anterior segment optical coherence tomography (AS-OCT) and to explore the diagnostic potential of this technique for albinism. We also investigated the relationship between iris abnormalities and other phenotypical features of albinism. Design Prospective cross-sectional study. Participants A total of 55 individuals with albinism and 45 healthy controls. Methods We acquired 4.37×4.37-mm volumetric scans (743 A-scans, 50 B-scans) of the nasal and temporal iris in both eyes using AS-OCT (3-μm axial resolution). Iris layers were segmented and thicknesses were measured ...

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    9. Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema

      Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema

      Objective To evaluate agreement between fluorescein angiography (FA) and optical coherence tomography (OCT) results for diagnosis of macular edema in patients with uveitis. Design Multicenter cross-sectional study. Participants Four hundred seventy-nine eyes with uveitis from 255 patients. Methods The macular status of dilated eyes with intermediate uveitis, posterior uveitis, or panuveitis was assessed via Stratus-3 OCT and FA. To evaluate agreement between the diagnostic approaches, κ statistics were used. Main Outcome Measures Macular thickening (MT; center point thickness, ≥240 μm per reading center grading of OCT images) and macular leakage (ML; central subfield fluorescein leakage, ≥0.44 disc areas per reading ...

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    10. The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings

      Purpose To report and analyze the spectral-domain optical coherence tomography (SD-OCT) features of the posterior pole and papillomacular fold (PMF) in posterior microphthalmos (PM) in relation to axial length of the globe and corneal power. Design Comparative case series. Participants Forty eyes of 20 PM patients and 70 eyes of 35 age-matched controls. Methods All PM and control eyes underwent a full biometric evaluation, including axial length and corneal power measurements, and macular SD-OCT. In addition, a novel SD-OCT marker of the posterior pole curvature, termed the posterior pole curvature index (PPCI), was measured along both the vertical and horizontal ...

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    11. Choroidal Thickness Measurement in Myopic Eyes by Enhanced Depth Optical Coherence Tomography

      Choroidal Thickness Measurement in Myopic Eyes by Enhanced Depth Optical Coherence Tomography

      Purpose To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI). Design A cross-sectional study. Participants Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated. Methods Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm ...

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    12. Subclinical Macular Findings in Infants Screened for Retinopathy of Prematurity with Spectral-Domain Optical Coherence Tomography

      Subclinical Macular Findings in Infants Screened for Retinopathy of Prematurity with Spectral-Domain Optical Coherence Tomography

      Objective To evaluate subclinical macular findings in premature patients at risk of retinopathy of prematurity (ROP) with the use of handheld spectral-domain optical coherence tomography (SD-OCT). Design Prospective, observational case series. Participants Forty-nine prematurely born neonates. Methods Forty-nine infants were imaged using a handheld SD-OCT. Images were acquired in nonsedated infants in the neonatal intensive care unit (NICU). Some patients were followed and reimaged over the course of several weeks. A total of 300 total images were acquired and evaluated for cystoid macular edema (CME) and persistence of inner retinal layers. Main Outcome Measures In vivo determination of foveal retinal ...

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    13. Differentiation of Parapapillary Atrophy Using Spectral-Domain Optical Coherence Tomography

      Differentiation of Parapapillary Atrophy Using Spectral-Domain Optical Coherence Tomography

      Purpose To develop a classification of parapapillary atrophy (PPA) based on its relationship with the location of Bruch's membrane (BM) termination in primary open-angle glaucoma (POAG) patients. Design Cross-sectional observational study. Participants This study analyzed 161 eyes from 161 POAG patients who had temporal β-zone PPA, the width of which was more than 200 μm on at least 1 horizontal scan image obtained by spectral-domain optical coherence tomography within the mid horizontal one third of the optic nerve. Methods Based on the extent of BM within the PPA area, eyes were categorized as group A (intact BM; 76 eyes ...

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    14. A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      Purpose To assess the repeatability and reproducibility of 3 rotating Scheimpflug cameras, the Pentacam (Oculus, Wetzlar, Germany), Sirius (Costruzione Strumenti Oftalmici, Florence, Italy), and Galilei (Ziemer, Biel, Switzerland), and 1 Fourier-domain optical coherence tomography (FD-OCT) system, the RTvue-100 OCT (Optovue Inc., Fremont, CA), in measuring corneal thickness. Design Evaluation of diagnostic test. Participants Sixty-six right eyes of 66 healthy volunteers, whose mean age ± standard deviation (SD) was 35.39±10.06 years (range, 18–55 years). Methods Corneal thickness measurements obtained by each system included central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT), measured at ...

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    15. Analysis of Choroidal Morphologic Features and Vasculature in Healthy Eyes Using Spectral-Domain Optical Coherence Tomography

      Analysis of Choroidal Morphologic Features and Vasculature in Healthy Eyes Using Spectral-Domain Optical Coherence Tomography

      Objective: To analyze the morphologic features and vasculature of the choroid in healthy eyes using spectral-domain (SD) optical coherence tomography (OCT).Design: Cross-sectional retrospective review.Participants: Forty-two healthy subjects (42 eyes) with no ocular disease who underwent high-definition scanning with Cirrus high-definition OCT (Carl Zeiss Meditec, Inc., Dublin, CA) at the New England Eye Center, Boston, Massachusetts, between November 2009 and September 2010.Methods: The SD OCT images were evaluated for morphologic features of the choroid, including the shape of the choroid–scleral border, location of the thickest point of choroid, and regions of focal choroidal thinning. Total choroidal thickness ...

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    16. Evaluation of Lamina Cribrosa in Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging - Corrected Proof

      Evaluation of Lamina Cribrosa in Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography Enhanced Depth Imaging - Corrected Proof

      Purpose To evaluate the features of the lamina cribrosa (LC) in pseudoexfoliation glaucoma (PXG) patients using enhanced depth imaging (EDI) of spectral-domain optical coherence tomography (SD OCT). The results were compared with those of patients with primary open-angle glaucoma (POAG). Design Cross-sectional study. Participants Patients with PXG (n = 21) and POAG (n = 35) matched for age and visual field mean deviation (VF MD). Methods Participants were imaged using SD OCT. Lamina cribrosa thickness (LT) and anterior lamina cribrosa depth (ALD) were determined at 3 areas (mid superior, center, and mid inferior) by 2 examiners using an EDI mode of the ...

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    17. Graft Orientation, Optical Coherence Tomography, and Endothelial Keratoplasty

      Graft Orientation, Optical Coherence Tomography, and Endothelial Keratoplasty

      Many believe that Descemet's membrane endothelial keratoplasty (DMEK) surgery, as first described by Melles et al, provides faster and better visual rehabilitation compared with other posterior lamellar keratoplasty techniques. DMEK allows transplantation of the endothelium–Descemet's membrane layer with reconstruction of the corneal anatomy. An endothelium–Descemet's membrane layer stained with trypan blue usually displays a characteristic appearance with rolled edges indicating endothelial cells on the outside of the curved edge (, available at http://aaojournal.org). However, this may be difficult to observe during surgery while manipulating the graft in the anterior chamber, especially in patients with ...

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    18. Ability of Cirrus High-Definition Spectral-Domain Optical Coherence Tomography Clock-Hour, Deviation, and Thickness Maps in Detecting Photographic Retinal Nerve Fiber Layer Abnormalities - Corrected Proof

      Ability of Cirrus High-Definition Spectral-Domain Optical Coherence Tomography Clock-Hour, Deviation, and Thickness Maps in Detecting Photographic Retinal Nerve Fiber Layer Abnormalities - Corrected Proof

      Purpose To investigate the ability of clock-hour, deviation, and thickness maps of Cirrus high-definition spectral-domain optical coherence tomography (HD-OCT) in detecting retinal nerve fiber layer (RNFL) defects identified in red-free fundus photographs in eyes with early glaucoma (mean deviation >–6.0 dB). Design Cross-sectional study. Participants Two hundred ninety-five eyes with glaucomatous RNFL defects with clear margins observed in red-free fundus photographs and 200 age-, sex-, and refractive error–matched healthy eyes were enrolled. Methods The width and location of RNFL defects were evaluated by using the red-free fundus photograph. When a RNFL defect detected by red-free fundus photograph did ...

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    19. Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: Measuring Peripheral Anterior Synechia in Glaucoma

      Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: Measuring Peripheral Anterior Synechia in Glaucoma

      Objective To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. Design Cross-sectional study. Participants Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and Axenfeld–Rieger syndrome [n = 1]). Methods The anterior chamber angles were evaluated with indentation gonioscopy and imaged by swept-source OCT (Casia OCT, Tomey, Nagoya, Japan) in room light and in the dark using the ...

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    20. Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Objective To assess the value of enhanced depth imaging optical coherence tomography (EDI OCT) in diagnosing and evaluating optic nerve head drusen (ONHD) compared with conventional diagnostic methods. Design Prospective, comparative, cross-sectional study. Participants Thirty-four patients with clinically visible or suspected ONHD in either eye based on dilated optic disc examination or optic disc stereophotography and without ocular comorbidity. Methods Spectral-domain OCT of the optic nerve head in both conventional (non-EDI) and EDI modes, ultrasound B-scan, and standard automated perimetry were performed on both eyes of all participants. Main Outcome Measures Detection and findings of ONHD between EDI OCT and ...

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    21. Epimacular Brachytherapy for Neovascular Age-Related Macular Degeneration (CABERNET) Fluorescein Angiography and Optical Coherence Tomography

      Epimacular Brachytherapy for Neovascular Age-Related Macular Degeneration (CABERNET) Fluorescein Angiography and Optical Coherence Tomography

      Purpose To report the fluorescein angiography (FA) and optical coherence tomography (OCT) results of a clinical trial of epimacular brachytherapy (EMBT) used for the treatment of neovascular age-related macular degeneration (AMD). Design Pivotal multicenter, active-controlled, randomized clinical trial. Participants A total of 494 participants with treatment-naïve, neovascular AMD. Methods Participants with classic, minimally classic, and occult lesions were randomized to receive (a) EMBT and 2 mandated monthly ranibizumab injections followed by pro re nata (PRN) ranibizumab or (b) 3 mandated monthly ranibizumab injections followed by mandated quarterly plus PRN ranibizumab. Participants underwent FA at screening and at months 1 ...

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    22. Detection of Glaucomatous Progression by Spectral-Domain Optical Coherence Tomography

      Detection of Glaucomatous Progression by Spectral-Domain Optical Coherence Tomography

      Purpose To compare the rate of change of circumpapillary retinal nerve fiber layer (cRNFL) thickness, macular volume and thickness, and optic nerve head (ONH) parameters assessed using spectral-domain optical coherence tomography (SD-OCT) between eyes with progressing and nonprogressing glaucoma. Design Longitudinal, observational study. Participants Two hundred seventy-nine eyes from 162 glaucoma patients followed for an average of 2.2 years. Methods Eyes were classified as progressors and nonprogressors according to assessment of optic disc and RNFL photographs and visual field progression analysis. Linear mixed effects models were used to evaluate the overall rate of change of cRNFL thickness, macular volume ...

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    23. Predictive Value in Retinal Vein Occlusions of Early Versus Late or Incomplete Ranibizumab Response Defined by Optical Coherence Tomography - Corrected Proof

      Predictive Value in Retinal Vein Occlusions of Early Versus Late or Incomplete Ranibizumab Response Defined by Optical Coherence Tomography - Corrected Proof

      Purpose To determine if optical coherence tomography (OCT) at baseline or month 3 in the Treatment of Macular Edema following Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety (BRAVO) and Treatment of Macular Edema following Central Retinal Vein Occlusion: Evaluation of Efficacy and Safety (CRUISE) studies provides information that predicts visual outcome. Design Post hoc analysis from 2 prospective, randomized, controlled clinical trials. Participants Three hundred ninety-seven patients from the BRAVO study and 392 patients from the CRUISE study. Methods Time-domain OCT imaging data were analyzed. Main Outcome Measures Mean change from baseline best-corrected visual acuity (BCVA) letter score ...

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