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    1. Optical Coherence Tomography of Chorioretinopathy Caused by Mucopolysaccharidoses

      Optical Coherence Tomography of Chorioretinopathy Caused by Mucopolysaccharidoses

      Ocular changes in some types of the mucopolysaccharidoses (MPS) include corneal clouding, glaucoma, pigmentary retinopathy, optic disc edema, and optic atrophy. 1,2 Pigmentary retinopathy has been reported in MPS I (Hurler disease), MPS I-S (Scheie syndrome), MPS I-H/S (Hurler/Scheie), MPS II (Hunter disease), MPS III (Sanfilippo syndrome), and MPS IV A (Morquio A syndrome). 1,2 Clinical signs of retinopathy include atrophy of the retinal pigment epithelium (RPE), arteriolar narrowing, and later bone spicules.

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    2. Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Purpose This study was designed to determine the feasibility of anterior segment optical coherence tomography (AS-OCT) to objectively image and quantify the degree of AC inflammation. Design Prospective evaluation of a diagnostic test. Participants Patients with anterior segment involving uveitis. Methods Observational case series of patients with uveitis. Single-line and 3-dimensional (3D) volume AS-OCT scans were manually graded to evaluate for the presence or absence of cells in the AC. Clinical grading scores were correlated to the number of cells seen in each line scan. An automated algorithm was developed to measure the number of cells seen in the 3D ...

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    3. Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Purpose To describe the characteristics as well as the sensitivity and specificity of detection of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) using spectral-domain optical coherence tomography. Design Observational, retrospective study. Participants Seventy-two eyes of 61 subjects (48 eyes of 43 subjects with CNV, 24 eyes of 18 subjects without CNV). Methods Patients imaged using the prototype AngioVue OCTA system (Optovue, Inc, Fremont, CA) between August 2014 and October 2014 at New England Eye Center were assessed. Patients in whom CNV was identified on OCTA were evaluated to define characteristics of CNV on OCTA: size using greatest linear ...

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    4. Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Purpose To describe the characteristics as well as the sensitivity and specificity of detection of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) using spectral-domain optical coherence tomography. Design Observational, retrospective study. Participants Seventy-two eyes of 61 subjects (48 eyes of 43 subjects with CNV, 24 eyes of 18 subjects without CNV). Methods Patients imaged using the prototype AngioVue OCTA system (Optovue, Inc, Fremont, CA) between August 2014 and October 2014 at New England Eye Center were assessed. Patients in whom CNV was identified on OCTA were evaluated to define characteristics of CNV on OCTA: size using greatest linear ...

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    5. Comparison of Intraoperative Aberrometry, OCT-Based IOL Formula, Haigis-L, and Masket Formulae for IOL Power Calculation after Laser Vision Correction

      Comparison of Intraoperative Aberrometry, OCT-Based IOL Formula, Haigis-L, and Masket Formulae for IOL Power Calculation after Laser Vision Correction

      Purpose To compare the accuracy of intraoperative aberrometry technology and the Fourier-domain optical coherence tomography (OCT)–based intraocular lens (IOL) formula for IOL power calculation in eyes undergoing cataract surgery after previous laser vision correction (LVC) compared with established methods. Design Retrospective consecutive case series. Participants Patients undergoing cataract surgery with a history of LASIK or photorefractive keratectomy. Methods The IOL power was estimated preoperatively using the IOLMaster 500 (Carl Zeiss Meditec, Dublin, CA) to calculate the Haigis-L and Masket regression formulae (when prior data were available), and the Optovue RTVue (Optovue Inc, Fremont, CA) spectral domain OCT was used ...

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    6. The Application of Extended Field Imaging to Optical Coherence Tomography

      The Application of Extended Field Imaging to Optical Coherence Tomography

      Since its invention, optical coherence tomography (OCT) has made remarkable advancements in both image resolution and acquisition speed. 1,2 With improvements in both hardware and software, higher resolution and less noisy retinal cross-sectional images can be obtained noninvasively. 3 Recent improvements to commercially available OCT systems have also included increasing scan length. For example, most spectral-domain OCT machines provide line scans that are approximately 9 mm in length. Therefore, a single scan can include the macula and part of the optic disc.

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    7. Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      In the article by Castillo et al 1 (see page 399 ), the authors provide a thoughtful review of “the accuracy of optical coherence tomography (OCT) [compared] with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition.” The topic is important. The article focuses mainly on whether OCT can replace fluorescein angiography (FA) because OCT is safer, more convenient, and less costly. Their conclusion is that OCT cannot replace FA: “There is a substantial disagreement between OCT and FA findings in detecting active disease in patients with nAMD who are ...

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    8. Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Mwanza et al 1 evaluated the performance of ganglion cell inner-plexiform layer (GCIPL) parameters used alone or in combination with retinal nerve fiber layer (RNFL) and optic nerve head parameters for the early diagnosis of glaucoma. They also provide positive (PLR) and negative (NLR) likelihood ratios (LR) that are valuable for clinical use.

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    9. The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

      The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

      Purpose To describe the prevalence and interrelationships of epiretinal membranes (ERMs), vitreomacular traction (VMT), macular cysts, paravascular cysts (PVCs), lamellar macular holes (LMHs), full-thickness macular holes (FTMHs), and visual impairment in a population-based study of older adults. Design Cross-sectional study. Participants There were 1913 participants aged 63 to 102 years at the 20-year Beaver Dam Eye Study follow-up examination in 2008–2010, of whom 1540 (2980 eyes) had gradable spectral-domain optical coherence tomography (SD OCT) scans of the macula in at least 1 eye. Methods The presence of ERMs and other retinal lesions was determined by standardized grading of macular ...

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    10. Rates of Decline in Regions of the Visual Field Defined by Frequency-Domain Optical Coherence Tomography in Patients with -Mediated X-Linked Retinitis Pigmentosa

      Rates of Decline in Regions of the Visual Field Defined by Frequency-Domain Optical Coherence Tomography in Patients with -Mediated X-Linked Retinitis Pigmentosa

      Purpose To determine whether annual decline in visual field sensitivity is greater in the transition zone at the edge of the frequency-domain optical coherence tomography (fdOCT) inner segment ellipsoid zone (EZ) than at other locations in the visual field. Design Prospective, longitudinal, observational study. Participants Forty-four patients with X-linked retinitis pigmentosa (XLRP) resulting from a mutation in the RPGR gene. Methods Static perimetric fields (Humphrey 30-2; Carl Zeiss Meditec, Dublin, CA) were obtained annually for 4 years. Beginning with year 2, fdOCT scans were obtained annually with a Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany). Main Outcome Measures The ...

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    11. Spectral-Domain Optical Coherence Tomography in Hydroxychloroquine Retinopathy

      Spectral-Domain Optical Coherence Tomography in Hydroxychloroquine Retinopathy

      In 2011, revised guidelines for screening chloroquine and hydroxychloroquine (HCQ) retinopathy recommended spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence, or multifocal electroretinogram in addition to ophthalmologic examination and 10-2 perimetry. 1 To date, the qualitative features of SD OCT in chloroquine and HCQ retinopathy have been reported in <60 patients, most of whom had established retinopathy. Also, thinning of parafoveal retina has been documented, 2,3 occurring even when cross-sectional scans are equivocal.

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    12. Longitudinal Evaluation of Posterior Corneal Elevation after Laser Refractive Surgery Using Swept-Source Optical Coherence Tomography

      Longitudinal Evaluation of Posterior Corneal Elevation after Laser Refractive Surgery Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the change in posterior corneal elevation up to 1 year after myopic femtosecond-assisted LASIK and photorefractive keratectomy (PRK). Design Prospective, longitudinal, comparative study. Participants Patients undergoing femtosecond-assisted LASIK or PRK. Methods Corneal imaging was performed using swept-source optical coherence tomography at baseline and at each postoperative follow-up. A 2-way analysis of variance model with repeated measures and a linear mixed effect model were used to compare the differences in posterior corneal elevation between LASIK and PRK at different points after adjusting for the preoperative spherical equivalent (SEQ), central corneal thickness (CCT), thinnest corneal thickness (TCT), residual bed ...

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    13. Optical Coherence Tomography Accurately Measures Corneal Power Change from Laser Refractive Surgery

      Optical Coherence Tomography Accurately Measures Corneal Power Change from Laser Refractive Surgery

      Purpose To determine the ability of motion-corrected optical coherence tomography (OCT) to measure the corneal refractive power change due to LASIK. Design Evaluation of a diagnostic test or technology in a cohort. Subjects A total of 70 eyes from 37 subjects undergoing LASIK were measured preoperatively. A total of 39 eyes from 22 subjects were measured postoperatively and completed the study. Methods Consecutive patients undergoing LASIK at the Duke Eye Center who consented to participate were imaged with Placido-ring topography, Scheimpflug photography, and OCT on the day of their surgery. Patients were then reimaged with the same imaging systems at ...

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    14. Retinal Nerve Fiber Layer Thickness Measurements

      Retinal Nerve Fiber Layer Thickness Measurements

      Objective To evaluate optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurements in patients with active and quiescent uveitis with and without glaucoma and compare results to the published age-adjusted normative data. Design Comparative, retrospective pilot study. Participants Consecutive patients with uveitis who underwent OCT RNFL measurements between December 2011 and October 2012 were identified: 76 uveitic eyes without glaucoma and 135 uveitic eyes with glaucoma. Intervention We conducted OCT of the RNFL. Main Outcome Measures Global and sectoral RNFL thickness measurements. Results In 19 nonglaucomatous, uveitic eyes with active inflammation, mean global and all sectoral RNFL measurements were ...

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    15. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

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    16. Optical Coherence Tomography for the Monitoring of Neovascular Age-Related Macular Degeneration

      Optical Coherence Tomography for the Monitoring of Neovascular Age-Related Macular Degeneration

      Topic To compare the accuracy of optical coherence tomography (OCT) with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition. Clinical Relevance Traditionally, fundus fluorescein angiography (FFA) has been considered the reference standard to detect nAMD activity, but FFA is costly and invasive. Replacement of FFA by OCT can be justified if there is a substantial agreement between tests. Methods Systematic review and meta-analysis. The index test was OCT. The comparator tests were visual acuity, clinical evaluation (slit lamp), Amsler chart, color fundus photographs, infrared reflectance, red-free images and ...

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    17. Retinal Imaging in the Twenty-First Century: State of the Art and Future Directions

      Retinal Imaging in the Twenty-First Century: State of the Art and Future Directions

      Assessment of chorioretinal disease is dependent on the ability to visualize pathologic changes occurring in the posterior segment of the eye using optical instruments, termed ophthalmoscopy . Ophthalmoscopy, in turn, has been enhanced greatly by the development of techniques that allow recording of these changes, termed retinal imaging . As well as documenting pathologic features, retinal and fundal imaging facilitates the identification of morphologic features not visible to the clinician on biomicroscopy. As such, advances in retinal imaging have proven fundamental to many paradigm shifts in our understanding and treatment of ocular disease. In the 1950s, with the advent of electronic flashes ...

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    18. Anterior Segment Optical Coherence Tomography in the Long-Term Follow-up and Detection of Glaucoma in Boston Type I Keratoprosthesis

      Anterior Segment Optical Coherence Tomography in the Long-Term Follow-up and Detection of Glaucoma in Boston Type I Keratoprosthesis

      Purpose To evaluate the role of anterior segment (AS) optical coherence tomography (OCT) as a standardized method of imaging Boston type I keratoprosthesis (KPro) after surgery, particularly in the visualization of iris and angle structures. Design Prospective case series. Participants Twenty patients who underwent KPro implantation in 1 eye. Methods Patients underwent AS OCT imaging before surgery. After KPro implantation, patients were imaged using the AS single, dual, and quad scans to obtain transverse images of the eye every 15° over 360°. High-resolution, corneal quad, and anterior chamber scans were also obtained. This imaging protocol allowed juxtaposition and comparison of ...

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    19. Assessment of Retinal Alterations after Intravitreal Ocriplasmin with Spectral Domain-Optical Coherence Tomography

      Assessment of Retinal Alterations after Intravitreal Ocriplasmin with Spectral Domain-Optical Coherence Tomography

      Ocriplasmin (Jetrea, Thrombogenics, Leuven, Belgium) was recently approved by the United States Food and Drug Administration for the treatment of symptomatic vitreomacular traction (VMT). The MIVI-TRUST phase III randomized, controlled trials revealed that intravitreal ocriplasmin had superior efficacy for VMT resolution compared with placebo vehicle injection. 1 Qualitative identification of outer retinal changes after ocriplasmin injection that were not previously recognized in the MIVI-TRUST trials have recently been described.

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    20. Long-term Assessment of Tilt of Glued Intraocular Lenses An Optical Coherence Tomography Analysis 5 Years after Surgery

      Long-term Assessment of Tilt of Glued Intraocular Lenses  An Optical Coherence Tomography Analysis 5 Years after Surgery

      Purpose Long-term assessment of the optic position of glued transscleral fixated intraocular lens (IOL) with optical coherence tomography (OCT). Design Prospective observational case series. Participants Patients with a minimum 5 years' follow-up after glued IOL surgery were included. Methods Postoperatively, IOL position was examined by anterior segment OCT (Carl Zeiss Meditec) and the scans were analyzed in 2 axes (180°–0° and 270°–90°) using MatLab (Mathworks). Best-corrected visual acuity (BCVA; Snellen's charts), Orbscan, retinoscopy, refraction, and slit-lamp biomicroscopy were performed. Main Outcome Measures The distance between the iris margin and the anterior IOL optic (D1, D2), slope of ...

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    21. Imaging of the Temporal Raphe with Optical Coherence Tomography

      Imaging of the Temporal Raphe with Optical Coherence Tomography

      There has been considerable debate about the arrangement and composition of the temporal raphe in the human retina. In postmortem studies, Vrabec 1 showed that axons of retinal ganglion cells temporal to the fovea are forced to take an arched course above and below the papillomacular bundle and that the temporal raphe generally represents a watershed midline. However, there is scarce published literature on the relationship between the orientation of the papillomacular bundle and the temporal raphe.

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    22. Optical Coherence Tomography–Defined Changes Preceding the Development of Drusen-Associated Atrophy in Age-Related Macular Degeneration

      Optical Coherence Tomography–Defined Changes Preceding the Development of Drusen-Associated Atrophy in Age-Related Macular Degeneration

      Purpose To characterize the pathological changes preceding the development of drusen-associated atrophy in eyes with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT). Design Longitudinal and cross-sectional retrospective observational study. Participants A total of 181 participants with intermediate AMD in at least 1 eye (141 unilateral, 40 bilateral) were assessed longitudinally. A total of 230 participants with bilateral intermediate AMD (40 longitudinal participants with an additional 190 participants) were analyzed cross-sectionally. Methods Spectral-domain OCT, color fundus photography (CFP), near-infrared reflectance, and fundus autofluorescence imaging were performed in all participants at cross-section and every 3 months for up to ...

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    23. Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Optical Coherence Tomography Angiography of Optic Disc Perfusion in Glaucoma

      Purpose To compare optic disc perfusion between normal subjects and subjects with glaucoma using optical coherence tomography (OCT) angiography and to detect optic disc perfusion changes in glaucoma. Design Observational, cross-sectional study. Participants Twenty-four normal subjects and 11 patients with glaucoma were included. Methods One eye of each subject was scanned by a high-speed 1050-nm–wavelength swept-source OCT instrument. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute 3-dimensional optic disc angiography. A disc flow index was computed from 4 registered scans. Confocal scanning laser ophthalmoscopy (cSLO) was used to measure disc rim area, and stereo photography was used ...

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    24. Glaucoma Diagnostic Accuracy of Optical Coherence Tomography Parameters in Early Glaucoma with Different Types of Optic Disc Damage

      Glaucoma Diagnostic Accuracy of Optical Coherence Tomography Parameters in Early Glaucoma with Different Types of Optic Disc Damage

      Purpose To compare the initial visual field (VF) defect pattern and the spectral-domain optical coherence tomography (OCT) parameters and investigate the effects of distinct types of optic disc damage on the diagnostic performance of these OCT parameters in early glaucoma. Design Retrospective, observational study. Participants A total of 138 control eyes and 160 eyes with early glaucoma were enrolled. The glaucomatous eyes were subdivided into 4 groups according to the type of optic disc damage: focal ischemic (FI) group, myopic (MY) group, senile sclerotic (SS) group, and generalized enlargement (GE) group. Methods The values of total deviation (TD) maps were ...

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    1-24 of 107 1 2 3 4 5 »
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