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    1. Familial Exudative Vitreoretinopathy: Spectral-Domain Optical Coherence Tomography of the Vitreoretinal Interface, Retina, and Choroid

      Familial Exudative Vitreoretinopathy:  Spectral-Domain Optical Coherence Tomography of the Vitreoretinal Interface, Retina, and Choroid

      Purpose The in vivo microstructural features of familial exudative vitreoretinopathy (FEVR) have not been well described. We present new anatomic features of FEVR with functional and genetic correlations. Design Consecutive, retrospective, observational case series. Participants Patients with FEVR treated from 2009 to 2014. Methods We identified 346 patients with FEVR. Those imaged with spectral-domain optical coherence tomography (SD OCT) with or without enhanced depth imaging (EDI) were included, and images were correlated with best-corrected visual acuity (BCVA), widefield angiography, fundus autofluorescence (AF), and wnt signaling pathway mutations. Main Outcome Measures Exploratory SD OCT findings and BCVA. Results A total of ...

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    2. Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2

      Volume-Rendering Optical Coherence Tomography Angiography of Macular Telangiectasia Type 2

      Purpose To evaluate the vascular structure of eyes with macular telangiectasia type 2 (MacTel2) using volume-rendered optical coherence tomography angiography (OCTA). Design Retrospective cross-sectional study. Participants A total of 14 consecutive patients (20 eyes) with MacTel2 who had a signal strength score ≥55 and could maintain fixation during the scan process. Methods The eyes were scanned using optical coherence tomography with split-spectrum amplitude decorrelation techniques to derive flow information. Data were extracted and used to create volume-rendered images of the retinal vasculature that could be rotated about 3 different axes for evaluation. Main Outcome Measures Descriptive appraisal of the vascular ...

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    3. En Face Optical Coherence Tomography of Subfoveal Perfluorocarbon Liquid

      En Face Optical Coherence Tomography of Subfoveal Perfluorocarbon Liquid

      A 49-year-old man with history of complicated tractional retinal detachment repair presented with long-standing 20/400 visual acuity in the right eye. Ophthalmoscopy revealed subfoveal perfluorocarbon liquid (PFCL) bubbles (top left). En face optical coherence tomography (OCT; Avanti RTVue XR, Optovue, Fremont, CA) at the level of the middle retina demonstrated large areas of hyporeflectivity corresponding to the PFCL with surrounding stippled hyporeflectivity likely representing inner nuclear layer microcysts.

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    4. Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Purpose To describe the characteristics as well as the sensitivity and specificity of detection of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) using spectral-domain optical coherence tomography. Design Observational, retrospective study. Participants Seventy-two eyes of 61 subjects (48 eyes of 43 subjects with CNV, 24 eyes of 18 subjects without CNV). Methods Patients imaged using the prototype AngioVue OCTA system (Optovue, Inc, Fremont, CA) between August 2014 and October 2014 at New England Eye Center were assessed. Patients in whom CNV was identified on OCTA were evaluated to define characteristics of CNV on OCTA: size using greatest linear ...

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    5. Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial

      Papilledema Outcomes from the Optical Coherence Tomography Substudy of the Idiopathic Intracranial Hypertension Treatment Trial

      Purpose To assess treatment efficacy using spectral-domain (SD) optical coherence tomography (OCT) measurements of papilledema in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), which evaluated the effects of acetazolamide and weight management and of placebo and weight management in eyes with mild visual loss. Design Randomized double-masked control clinical trial of acetazolamide plus weight management compared with placebo plus weight management in subjects with mild visual field loss and previously untreated idiopathic intracranial hypertension (IIH). Participants Eighty-nine (43 acetazolamide treated, 46 placebo treated) of 165 subjects meeting IIHTT entry criteria. Methods Subjects underwent perimetry, papilledema grading (Frisén method), high- ...

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    6. Estimating the Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects

      Estimating the Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects

      Purpose To estimate the diagnostic accuracy and lead time gained by retinal nerve fiber layer (RNFL) thickness measurements from optical coherence tomography (OCT) for detecting glaucoma before the development of visual field defects. Design Observational cohort study. Participants The study group included 75 eyes of 75 patients suspected of having glaucoma. These eyes had normal standard automated perimetry (SAP) at baseline and demonstrated repeatable (3 consecutive) abnormal tests during a median follow-up of 6.3 years. A control group of 75 eyes of 75 healthy subjects matched by age and number of OCT tests during follow-up was included. Methods The ...

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    7. Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging

      Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging

      Purpose To evaluate the application of an optical coherence tomography angiography (OCTA) system adapted for the assessment of anterior segment vasculature. Design Cross-sectional, observational study. Participants Consecutive subjects with normal eyes on slit-lamp clinical examination and patients with abnormal corneal neovascularization. Methods All scans were performed using a commercially available AngioVue OCTA system (Optovue, Inc., Fremont, CA) using an anterior segment lens adapter and the split-spectrum amplitude decorrelation angiography algorithm. Each subject underwent scans from 4 quadrants (superior, inferior, nasal, and temporal) in each eye by 2 trained, independent operators. Main Outcome Measures Analysis of signal strength, image quality, and ...

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    8. Optical Coherence Tomography Imaging of Human Lacrimal Glands: An In Vivo Study

      Optical Coherence Tomography Imaging of Human Lacrimal Glands: An In Vivo Study

      Humans have main lacrimal glands and accessory lacrimal glands. The main lacrimal glands comprise the orbital and palpebral lobes, which are located in the superotemporal area of the orbit. The palpebral lobe lies below the aponeurosis of the levator palpebrae superioris and is in contact with the superior and lateral conjunctival fornices. 1 Even in healthy subjects, the palpebral lobe is seen through the conjunctiva when the eyelid is elevated. Therefore, optical coherence tomography (OCT) scanning of the exposed palpebral lobe can be used to visualize the parenchyma of the palpebral lobe just beneath the conjunctiva.

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    9. Spectral-Domain Optical Coherence Tomography in Acute Posterior Vitreous Detachment

      Spectral-Domain Optical Coherence Tomography in Acute Posterior Vitreous Detachment

      Posterior vitreous detachment (PVD) is a physiologic process that occurs with aging, having a reported incidence of 53% in patients >50 years old. 1 With advancing age, the vitreous progressively liquefies and its extracellular matrix undergoes remodeling, facilitating the eventual formation of a PVD. 1 Although usually a benign event, complications such as macular traction, macular hole, vitreous hemorrhage, retinal tears, and retinal detachment may arise.

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    10. Optical Coherence Tomography of Chorioretinopathy Caused by Mucopolysaccharidoses

      Optical Coherence Tomography of Chorioretinopathy Caused by Mucopolysaccharidoses

      Ocular changes in some types of the mucopolysaccharidoses (MPS) include corneal clouding, glaucoma, pigmentary retinopathy, optic disc edema, and optic atrophy. 1,2 Pigmentary retinopathy has been reported in MPS I (Hurler disease), MPS I-S (Scheie syndrome), MPS I-H/S (Hurler/Scheie), MPS II (Hunter disease), MPS III (Sanfilippo syndrome), and MPS IV A (Morquio A syndrome). 1,2 Clinical signs of retinopathy include atrophy of the retinal pigment epithelium (RPE), arteriolar narrowing, and later bone spicules.

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    11. Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Purpose This study was designed to determine the feasibility of anterior segment optical coherence tomography (AS-OCT) to objectively image and quantify the degree of AC inflammation. Design Prospective evaluation of a diagnostic test. Participants Patients with anterior segment involving uveitis. Methods Observational case series of patients with uveitis. Single-line and 3-dimensional (3D) volume AS-OCT scans were manually graded to evaluate for the presence or absence of cells in the AC. Clinical grading scores were correlated to the number of cells seen in each line scan. An automated algorithm was developed to measure the number of cells seen in the 3D ...

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    12. Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Spectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization

      Purpose To describe the characteristics as well as the sensitivity and specificity of detection of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) using spectral-domain optical coherence tomography. Design Observational, retrospective study. Participants Seventy-two eyes of 61 subjects (48 eyes of 43 subjects with CNV, 24 eyes of 18 subjects without CNV). Methods Patients imaged using the prototype AngioVue OCTA system (Optovue, Inc, Fremont, CA) between August 2014 and October 2014 at New England Eye Center were assessed. Patients in whom CNV was identified on OCTA were evaluated to define characteristics of CNV on OCTA: size using greatest linear ...

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    13. Comparison of Intraoperative Aberrometry, OCT-Based IOL Formula, Haigis-L, and Masket Formulae for IOL Power Calculation after Laser Vision Correction

      Comparison of Intraoperative Aberrometry, OCT-Based IOL Formula, Haigis-L, and Masket Formulae for IOL Power Calculation after Laser Vision Correction

      Purpose To compare the accuracy of intraoperative aberrometry technology and the Fourier-domain optical coherence tomography (OCT)–based intraocular lens (IOL) formula for IOL power calculation in eyes undergoing cataract surgery after previous laser vision correction (LVC) compared with established methods. Design Retrospective consecutive case series. Participants Patients undergoing cataract surgery with a history of LASIK or photorefractive keratectomy. Methods The IOL power was estimated preoperatively using the IOLMaster 500 (Carl Zeiss Meditec, Dublin, CA) to calculate the Haigis-L and Masket regression formulae (when prior data were available), and the Optovue RTVue (Optovue Inc, Fremont, CA) spectral domain OCT was used ...

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    14. The Application of Extended Field Imaging to Optical Coherence Tomography

      The Application of Extended Field Imaging to Optical Coherence Tomography

      Since its invention, optical coherence tomography (OCT) has made remarkable advancements in both image resolution and acquisition speed. 1,2 With improvements in both hardware and software, higher resolution and less noisy retinal cross-sectional images can be obtained noninvasively. 3 Recent improvements to commercially available OCT systems have also included increasing scan length. For example, most spectral-domain OCT machines provide line scans that are approximately 9 mm in length. Therefore, a single scan can include the macula and part of the optic disc.

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    15. Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      Optical Coherence Tomography, Fluorescein Angiography, and the Management of Neovascular Age-Related Macular Degeneration

      In the article by Castillo et al 1 (see page 399 ), the authors provide a thoughtful review of “the accuracy of optical coherence tomography (OCT) [compared] with alternative tests for monitoring neovascular age-related macular degeneration (nAMD) and detecting disease activity among eyes previously treated for this condition.” The topic is important. The article focuses mainly on whether OCT can replace fluorescein angiography (FA) because OCT is safer, more convenient, and less costly. Their conclusion is that OCT cannot replace FA: “There is a substantial disagreement between OCT and FA findings in detecting active disease in patients with nAMD who are ...

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    16. Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Re: Mwanza et al.: Diagnostic performance of optical coherence tomography ganglion cell–inner plexiform layer thickness measurements in early glaucoma (Ophthalmology 2014;121:849-54)

      Mwanza et al 1 evaluated the performance of ganglion cell inner-plexiform layer (GCIPL) parameters used alone or in combination with retinal nerve fiber layer (RNFL) and optic nerve head parameters for the early diagnosis of glaucoma. They also provide positive (PLR) and negative (NLR) likelihood ratios (LR) that are valuable for clinical use.

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    17. The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

      The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

      Purpose To describe the prevalence and interrelationships of epiretinal membranes (ERMs), vitreomacular traction (VMT), macular cysts, paravascular cysts (PVCs), lamellar macular holes (LMHs), full-thickness macular holes (FTMHs), and visual impairment in a population-based study of older adults. Design Cross-sectional study. Participants There were 1913 participants aged 63 to 102 years at the 20-year Beaver Dam Eye Study follow-up examination in 2008–2010, of whom 1540 (2980 eyes) had gradable spectral-domain optical coherence tomography (SD OCT) scans of the macula in at least 1 eye. Methods The presence of ERMs and other retinal lesions was determined by standardized grading of macular ...

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    18. Rates of Decline in Regions of the Visual Field Defined by Frequency-Domain Optical Coherence Tomography in Patients with -Mediated X-Linked Retinitis Pigmentosa

      Rates of Decline in Regions of the Visual Field Defined by Frequency-Domain Optical Coherence Tomography in Patients with -Mediated X-Linked Retinitis Pigmentosa

      Purpose To determine whether annual decline in visual field sensitivity is greater in the transition zone at the edge of the frequency-domain optical coherence tomography (fdOCT) inner segment ellipsoid zone (EZ) than at other locations in the visual field. Design Prospective, longitudinal, observational study. Participants Forty-four patients with X-linked retinitis pigmentosa (XLRP) resulting from a mutation in the RPGR gene. Methods Static perimetric fields (Humphrey 30-2; Carl Zeiss Meditec, Dublin, CA) were obtained annually for 4 years. Beginning with year 2, fdOCT scans were obtained annually with a Heidelberg Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany). Main Outcome Measures The ...

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    19. Spectral-Domain Optical Coherence Tomography in Hydroxychloroquine Retinopathy

      Spectral-Domain Optical Coherence Tomography in Hydroxychloroquine Retinopathy

      In 2011, revised guidelines for screening chloroquine and hydroxychloroquine (HCQ) retinopathy recommended spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence, or multifocal electroretinogram in addition to ophthalmologic examination and 10-2 perimetry. 1 To date, the qualitative features of SD OCT in chloroquine and HCQ retinopathy have been reported in <60 patients, most of whom had established retinopathy. Also, thinning of parafoveal retina has been documented, 2,3 occurring even when cross-sectional scans are equivocal.

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    20. Longitudinal Evaluation of Posterior Corneal Elevation after Laser Refractive Surgery Using Swept-Source Optical Coherence Tomography

      Longitudinal Evaluation of Posterior Corneal Elevation after Laser Refractive Surgery Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the change in posterior corneal elevation up to 1 year after myopic femtosecond-assisted LASIK and photorefractive keratectomy (PRK). Design Prospective, longitudinal, comparative study. Participants Patients undergoing femtosecond-assisted LASIK or PRK. Methods Corneal imaging was performed using swept-source optical coherence tomography at baseline and at each postoperative follow-up. A 2-way analysis of variance model with repeated measures and a linear mixed effect model were used to compare the differences in posterior corneal elevation between LASIK and PRK at different points after adjusting for the preoperative spherical equivalent (SEQ), central corneal thickness (CCT), thinnest corneal thickness (TCT), residual bed ...

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    21. Optical Coherence Tomography Accurately Measures Corneal Power Change from Laser Refractive Surgery

      Optical Coherence Tomography Accurately Measures Corneal Power Change from Laser Refractive Surgery

      Purpose To determine the ability of motion-corrected optical coherence tomography (OCT) to measure the corneal refractive power change due to LASIK. Design Evaluation of a diagnostic test or technology in a cohort. Subjects A total of 70 eyes from 37 subjects undergoing LASIK were measured preoperatively. A total of 39 eyes from 22 subjects were measured postoperatively and completed the study. Methods Consecutive patients undergoing LASIK at the Duke Eye Center who consented to participate were imaged with Placido-ring topography, Scheimpflug photography, and OCT on the day of their surgery. Patients were then reimaged with the same imaging systems at ...

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    22. Retinal Nerve Fiber Layer Thickness Measurements

      Retinal Nerve Fiber Layer Thickness Measurements

      Objective To evaluate optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) measurements in patients with active and quiescent uveitis with and without glaucoma and compare results to the published age-adjusted normative data. Design Comparative, retrospective pilot study. Participants Consecutive patients with uveitis who underwent OCT RNFL measurements between December 2011 and October 2012 were identified: 76 uveitic eyes without glaucoma and 135 uveitic eyes with glaucoma. Intervention We conducted OCT of the RNFL. Main Outcome Measures Global and sectoral RNFL thickness measurements. Results In 19 nonglaucomatous, uveitic eyes with active inflammation, mean global and all sectoral RNFL measurements were ...

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    23. Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography

      With great interest we read the article by Garcia-Martin et al.1 The authors were able to include an impressively large number of patients and this dataset provides an excellent opportunity to evaluate retinal layer affection in multiple sclerosis. However, after carefully reading the article, we are concerned that there are discrepancies in the document that require clarification.

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    1-24 of 116 1 2 3 4 5 »
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