1. Articles from OphSource


  2. 73-96 of 112 « 1 2 3 4 5 »
    1. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Study on Diagnostic Agreement with Heidelberg Retinal Tomograph

      Objective To evaluate and compare the diagnostic agreement and performance for glaucoma detection between a confocal scanning laser ophthalmoscope and a spectral-domain optical coherence tomograph (OCT). Design Prospective, cross-sectional study. Participants One hundred fifty-five subjects (79 glaucoma and 76 normal subjects). Methods One eye from each individual was selected randomly for optic disc and retinal nerve fiber layer (RNFL) imaging by the Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, GmbH, Dossenheim, Germany) and the Spectralis OCT (Heidelberg Engineering), respectively. Glaucoma was defined based on the presence of visual field defects with the Humphrey visual field analyzer (Carl Zeiss Meditec, Dublin, CA ...
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    2. Optical Coherence Tomography Quantitative Analysis of Iris Volume Changes after Pharmacologic Mydriasis

      Purpose To describe a method using anterior segment optical coherence tomography (AS OCT) for estimating iris volume. To quantify changes in iris volume induced by pharmacologic mydriasis in narrow-angle eyes predisposed to angle-closure compared with normal open-angle eyes. Design Cross-sectional study. Participants Thirty fellow eyes of 30 patients who had an episode of primary acute angle-closure and 30 eyes of 30 normal age- and gender-matched subjects with open angles. All fellow eyes had a patent laser peripheral iridotomy. Methods Iris volume and all biometric measurements were performed before and after instillation of 1% tropicamide and at least 1 week later ...
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    3. Optical Coherence Tomography: Pathology Correlation of Optic Disc Melanocytoma

      Objective: To correlate combined optical coherence tomography (OCT) and scanning laser ophthalmoscope (SLO) imaging to clinical and histopathologic characteristics of optic disc melanocytoma (ODM).Design: Retrospective, consecutive clinical case analysis.Participants: Twenty patients with ODM were evaluated.Testing: All underwent ophthalmic examinations including a best-corrected visual acuity, slit-lamp examination, dilated ophthalmoscopy, fundus photography with angiography, B-scan ultrasonography, and combined OCT and SLO imaging.Main Outcome Measures: One eye, treated by enucleation, was evaluated by pathologic analysis and was correlated to its combined OCT and SLO images. These findings were correlated to clinical and OCT information from 19 patients with ODM ...

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    4. Sensitivity and Specificity of Time-Domain versus Spectral-Domain Optical Coherence Tomography in Diagnosing Early to Moderate Glaucoma

      Purpose: To evaluate the sensitivity and specificity of measurements of retinal nerve fiber layer (RNFL) thickness in early to moderate glaucoma using Stratus time-domain and Cirrus spectral-domain optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA).Design: Evaluation of diagnostic test or technology.Participants: Fifty-four glaucoma subjects with early to moderate visual field defects and 50 age-matched normal subjects.Testing: Three peripapillary RNFL scans of 1 eye of each subject using Stratus and Cirrus OCT.Main Outcome Measures: Sensitivity and specificity of average, quadrant, and clock-hour RNFL thickness.Results: The average age±standard deviation in the normal and glaucoma groups ...
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    5. Insights into Advanced Retinopathy of Prematurity Using Handheld Spectral Domain Optical Coherence Tomography Imaging

      Purpose To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT). Design Prospective, observational case series. Participants Three low-birth-weight, severely premature infants. Methods Clinical examination was performed using a portable slit lamp and indirect ophthalmoscope. Imaging was performed by using a handheld SD OCT device and Retcam (Clarity Medical Systems, Pleasanton, CA) or video-indirect recording. Spectral domain optical coherence tomography imaging was conducted without sedation at the bedside in the neonatal intensive care unit on 1 patient. The other 2 patients had an examination under anesthesia with SD OCT imaging in the ...
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    6. Detection of Macular Ganglion Cell Loss in Glaucoma by Fourier-Domain Optical Coherence Tomography

      Detection of Macular Ganglion Cell Loss in Glaucoma by Fourier-Domain Optical Coherence Tomography
      Purpose: To map ganglion cell complex (GCC) thickness with high-speed Fourier-domain optical coherence tomography (FD-OCT) and compute novel macular parameters for glaucoma diagnosis.Design: Observational, cross-sectional study.Participants: One hundred seventy-eight participants in the Advanced Imaging for Glaucoma Study, divided into 3 groups: 65 persons in the normal group, 78 in the perimetric glaucoma group (PG), and 52 in the preperimetric glaucoma group (PPG).Methods: The RTVue FD-OCT system was used to map the macula over a 7×6 mm region. The macular OCT images were exported for automatic segmentation using software we developed. The program measured macular retinal (MR ...
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    7. Foveal Ganglion Cell Layer Damage in Ischemic Diabetic Maculopathy: Correlation of Optical Coherence Tomographic and Anatomic Changes

      Purpose: To describe the morphologic features of ischemic diabetic maculopathy by high-resolution optical coherence tomography (OCT) and their correlation with the damaged foveal avascular zone (FAZ) on fluorescein angiography (FA).Design: Observational case series.Participants: One hundred twenty-four eyes of 63 patients with diabetic retinopathy and acceptable FA and OCT images were studied. Twenty-three normal fellow eyes of 23 nondiabetic patients with unilateral acute central serous choroidopathy also were studied.Methods: High-speed Fourier-domain OCT was used with a speckle noise-reduction technique to obtain detailed horizontal and vertical images through the center of the fovea and horizontal raster scans every 100 ...
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    8. Acute Vogt–Koyanagi–Harada Disease in Enhanced Spectral-Domain Optical Coherence Tomography

      Objective To demonstrate unique membranous structures seen on enhanced spectral domain optical coherence tomography (SD-OCT) images of eyes with acute Vogt–Koyanagi–Harada (VKH) disease. Design Retrospective, observational case series. Participants Twenty eyes of 10 consecutive patients diagnosed with acute VKH disease. Methods We reviewed fundus photographs, conventional OCT images, fluorescein angiograms (FA), and enhanced SD-OCT images, including serial sections through the macula, obtained at the initial visit and periodically after steroid treatment until complete resolution of serous retinal detachment. Main Outcome Measures Findings on enhanced SD-OCT imaging and FA in eyes with VKH disease. Results All 20 eyes had ...
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    9. Correlation between Metamorphopsia and Epiretinal Membrane Optical Coherence Tomography Findings

      Purpose: To examine the retinal morphologic features of metamorphopsia caused by epiretinal membrane (ERM) and to determine whether spectral-domain optical coherence tomography (SD-OCT) correlated with metamorphopsia.Design: Retrospective case series.Participants: This study included 19 eyes of 19 patients with ERM diagnosed by clinical ophthalmic findings and SD-OCT.Methods: The 19 eyes were classified into 3 groups based on Amsler chart results: no metamorphopsia (n = 4), local metamorphopsia (n = 8), and broad metamorphopsia (n = 7). The thickness of the 3 inner retinal layers: inner nuclear layer (INL), outer plexiform layer (Opl), and outer nuclear layer (ONL), on 5 horizontal SD-OCT ...
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    10. Spectral Domain Optical Coherence Tomography Imaging of Geographic Atrophy Margins

      Objective: To test in vivo whether spectral domain optical coherence tomography (SD-OCT) provides adequate resolution for reproducible measurement of photoreceptor (PR) layer at the margins of geographic atrophy (GA), and if it delineates the relationship between PR layer and retinal pigment epithelium at the margins of GA.Design: Prospective consecutive case series.Participants: Patients with GA secondary to nonneovascular age-related macular degeneration (AMD) identified during routine follow-up at Duke Eye Center between January 3, 2006, and June 3, 2007, and who consented to participate in this study.Methods: We used SD-OCT to image eyes. Multiple B-scans from each eye were ...
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    11. Evaluation of Injection Frequency and Visual Acuity Outcomes for Ranibizumab Monotherapy in Exudative Age-related Macular Degeneration

      Objective: To evaluate the visual outcomes for intravitreal ranibizumab administered on an as-needed basis for exudative age-related macular degeneration (AMD) and to investigate the relationship between injection frequency and visual outcome in this setting.Design: Retrospective, interventional case series.Participants: A total of 131 eyes with treatment-naïve, exudative AMD undergoing ranibizumab monotherapy.Methods: Intravitreal ranibizumab was administered on an as-needed basis guided by clinical examination and optical coherence tomography (OCT). The OCT scans were evaluated by the treating physicians for the presence of intraretinal fluid, subretinal fluid, intraretinal cysts, or increasing pigment epithelial detachment size. Clinical data including visual ...

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    12. Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices

      Purpose: To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.Design: Prospective, noncomparative, noninterventional case series.Participants: Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.Methods: Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc ...
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    13. Macular and Nerve Fiber Layer Thickness in Amblyopia: The Sydney Childhood Eye Study

      Purpose: To examine macular and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopia.Design: Population-based cross-sectional study.Participants: Of 4118 children examined in the Sydney Childhood Eye Study (incorporating the Sydney Myopia Study) from 34 randomly selected primary schools and 21 secondary schools from 2003 to 2005, 3529 (85.7%) were included in this analysis. The median age of the 2 samples was 6 years (n = 1395) and 12 years (n = 2134), respectively.Methods: A detailed eye examination was conducted on all children, including determination of best-corrected visual acuity (logarithm of the minimum angle of resolution [logMAR]), autorefraction (RK-F1 ...
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    14. Incidence of Postvitrectomy Macular Edema Using Optical Coherence Tomography

      Objective: To evaluate the incidence, effect on visual recovery, and predisposing risk factors of postvitrectomy macular edema (ME).Design: Prospective cohort study.Participants: One-hundred nine eyes undergoing nonemergent vitrectomy surgery.Methods: Eyes were evaluated for postoperative day 1 inflammation, 1-month retinal thickness using optical coherence tomography, and preoperative and 1-month postoperative best-corrected visual acuity (BCVA). Macular edema was defined as central subfield thickness ≥272 μm.Main Outcome Measures: Retinal thickness, inflammation, and BCVA.Results: Incidence of ME on optical coherence tomography was 47% (95% confidence interval [CI], 37%–56%). Mean 1-month visual acuity improved 3.3 lines (0.33 logarithm ...
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    15. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Variability and Diagnostic Performance Study

      Objective: To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure–function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.).Design: Prospective, cross-sectional study.Participants: Ninety-seven normal subjects and 83 glaucoma patients.Methods: One eye from each subject was imaged with Cirrus HD-OCT and Stratus OCT. Sixteen and 31 normal eyes were selected randomly to evaluate intravisit repeatability and intervisit reproducibility, respectively. The agreement of ...
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    16. Accommodation Measured with Optical Coherence Tomography in Patients with Marfan's Syndrome

      Purpose To evaluate accommodation in patients with Marfan's syndrome using optical coherence tomography (OCT). Design Clinical case-control study. Participants and Controls The study included 31 eyes of 31 patients with Marfan's syndrome and 31 eyes of 31 unaffected controls. Subgroups of eyes of patients with Marfan's syndrome with and without a subluxated lens also were compared. Methods The changes in the anterior segment during accommodation and cycloplegia were studied with OCT. Main Outcome Measures Accommodative power, anterior chamber depth (ACD), lens thickness, and pupil diameter. Results No difference in accommodative power or ACD were found between the ...
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    17. Comparison of Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD and Stratus Optical Coherence Tomography

      To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT). Design Cross-sectional study. Participants Sixty healthy participants, 48 glaucoma suspects, and 55 subjects with glaucoma. Methods Participants were imaged by a single trained operator using the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) at the same visit. Main Outcome Measures The RNFL thickness as measured by the Stratus OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) was compared (paired t test). The relationship between RNFL ...
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    18. In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Cornea in Nephropathic Cystinosis

      Objective: To analyze the corneas of patients with nephropathic cystinosis using in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT).Design: Prospective case series.Participants: Sixteen eyes of 8 patients with nephropathic cystinosis aged 8 to 21 years.Methods: The ophthalmologic evaluation included best-corrected visual acuity, evaluation of photophobia (0–4), slit-lamp biomicroscopy analysis, intraocular pressure measurement, evaluation of crystal density using a slit-lamp–based scoring of the cornea, as well as AS-OCT and IVCM analysis.Main Outcome Measures: The depth of crystal deposition (DCD) in the central cornea and the central cornea thickness (CCT) were assessed ...
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    19. Anterior Ocular Biometry Using 3-Dimensional Optical Coherence Tomography

      Purpose: To evaluate anterior ocular biometry by comparing the measurements of central corneal thickness (CCT) and anterior chamber depth (ACD) with 3-dimensional corneal and anterior segment optical coherence tomography (CAS-OCT) and other methods. Design: Cross-sectional study.Participants: Forty eyes of 40 normal subjects.Methods: The CCT was measured by 4 methods (CAS-OCT, Scheimpflug camera, scanning-slit topography, and ultrasonic pachymetry), and the ACD was measured by 3 methods (CAS-OCT, Scheimpflug camera, and scanning-slit topography). The anterior chamber volume (ACV) was calculated with CAS-OCT. Repeatability and reproducibility of CAS-OCT measurements were evaluated.Main Outcome Measurements: The CCT and ACD were measured and ...
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    20. Optical Coherence Tomographic Hyperreflective Foci: A Morphologic Sign of Lipid Extravasation in Diabetic Macular Edema

      Purpose: To analyze hyperreflective foci typically seen in diabetic macular edema (DME) in optical coherence tomography (OCT).Design: Prospective clinical trial.Participants: Twelve consecutive patients with treatment-naïve, clinically significant DME.Methods: During a same-day examination, a standardized visual acuity assessment (Early Treatment of Diabetic Retinopathy Study protocol), infrared fundus imaging, color fundus photography, and biomicroscopy were performed. Additionally, all patients were scanned using Stratus, Cirrus, and Spectralis OCT and results correlated.Main Outcome Measures: Morphologic changes secondary to DME.Results: In all eyes with DME, distinct hyperreflective foci distributed throughout all retinal layers were found in the OCT scans ...

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    21. High-speed Ultrahigh Resolution Optical Coherence Tomography before and after Ranibizumab for Age-related Macular Degeneration

      Objective: To evaluate intraretinal anatomy in patients with exudative age-related macular degeneration (AMD) using high-speed ultrahigh resolution optical coherence tomography (hsUHR-OCT) before and 1 month after intravitreal injection of ranibizumab.Design: Retrospective case series.Participants: Twelve eyes of 12 patients.Methods: A broad bandwidth superluminescent diode laser light source and spectral/Fourier domain signal detection were used to create a prototype hsUHR-OCT instrument with 3.5 μm axial image resolution and approximately 25,000 lines/second acquisition speed. Twelve eyes of 12 patients with exudative AMD were imaged with hsUHR-OCT before and 1 month after intravitreal ranibizumab injection. High pixel ...

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    22. Comparing Retinal Thickness Measurements Using Automated Fast Macular Thickness Map versus Six-Radial Line Scans with Manual Measurements

      Purpose: To compare automated retinal thickness values generated by the fast macular thickness maps (FMTM) and customized 6-radial line scans (RLS) versus manual retinal measurements on Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA). Design: Prospective, observational case series. Participants: Patients with subfoveal choroidal neovascularization (CNV) caused by age-related macular degeneration (AMD), diabetic macular edema (DME), or branch/central retinal vein occlusion (RVO). Methods: Patients were prospectively imaged using the FMTM and customized RLS patterns on Stratus OCT at the same sitting. Each scan was evaluated for errors in retinal segmentation (i.e., correct retinal boundaries [CRB]). Automated ...

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    23. Correlation between Spectral Domain Optical Coherence Tomography Findings and Fluorescein Angiography Patterns in Diabetic Macular Edema

      Objective: To study the relationship between spectral domain optical coherence tomography (SD-OCT) findings and fluorescein angiography (FA) patterns in patients with diabetic macular edema (DME). Design: Retrospective, observational, cross-sectional study. Participants: We included 59 eyes from 59 patients with DME that had SD-OCT/scanning laser ophthalmoscope (SLO) and FA performed on the same day. Eyes with macular edema owing to other ocular diseases were excluded. Methods: The relationship between SD-OCT and FA findings was evaluated by superimposing and aligning the SLO images onto the FA photos. The SLO image of the OPKO/OTI Spectral OCT/SLO (OPKO-OTI, Miami, FL) corresponds ...
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    24. Effects of Age on Optical Coherence Tomography Measurements of Healthy Retinal Nerve Fiber Layer, Macula, and Optic Nerve Head

      Purpose: To determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses, and optic nerve head (ONH) parameters in healthy subjects using optical coherence tomography (OCT). Design: Retrospective, cross-sectional observational study. Participants: A total of 226 eyes from 124 healthy subjects were included. Methods: Healthy subjects were scanned using the Fast RNFL, Fast Macula, and Fast ONH scan patterns on a Stratus OCT (Carl Zeiss Meditec, Dublin, CA). All global and sectoral RNFL and macular parameters and global ONH parameters were modeled in terms of age using linear mixed effects models. Normalized slopes ...
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    73-96 of 112 « 1 2 3 4 5 »
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