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    1. Montage Images of Spectral-Domain Optical Coherence Tomography in Eyes with Idiopathic Macular Holes

      Montage Images of Spectral-Domain Optical Coherence Tomography in Eyes with Idiopathic Macular Holes

      Purpose To describe the morphologic and anatomic relationships at the vitreoretinal interface, from the macula into the periphery, in patients with idiopathic macular hole. Montaged images of posterior and peripheral spectral-domain (SD) optical coherence tomography (OCT) studies were used to describe the anatomic vitreoretinal relationships. Design Prospective, consecutive, observational case series. Participants Forty-six eyes of thirty-six consecutive patients with idiopathic macular hole and their fellow eyes. Methods Montage images of 4 radial OCT scans (horizontal, vertical, and 2 oblique scans) through the fovea were obtained in each case. Main Outcome Measures Montage SD OCT images. Results In fellow eyes, potential ...

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    2. Diagnosing Preperimetric Glaucoma with Spectral Domain Optical Coherence Tomography

      Diagnosing Preperimetric Glaucoma with Spectral Domain Optical Coherence Tomography

      Purpose: To evaluate the diagnostic accuracy of spectral domain optical coherence tomography (SD-OCT) for detection of preperimetric glaucoma and compare it with the performance of confocal scanning laser ophthalmoscopy (CSLO).Design: Cohort study.Participants: A cohort of 134 eyes of 88 glaucoma suspects based on the appearance of the optic disc.Methods: Patients were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS). All eyes underwent retinal nerve fiber layer (RNFL) imaging with Spectralis SD-OCT (Heidelberg Engineering, Carlsbad, CA) and topographic imaging with Heidelberg Retinal Tomograph III (HRT-III) (Heidelberg Engineering) CSLO within 6 months of each other. All patients had ...

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    3. Ability and Reproducibility of Fourier-Domain Optical Coherence Tomography to Detect Retinal Nerve Fiber Layer Atrophy in Parkinson's Disease

      Ability and Reproducibility of Fourier-Domain Optical Coherence Tomography to Detect Retinal Nerve Fiber Layer Atrophy in Parkinson's Disease

      Purpose To evaluate and compare the ability of 3 protocols of Fourier-domain optical coherence tomography (OCT) to detect retinal thinning and retinal nerve fiber layer (RNFL) atrophy in patients with Parkinson's disease (PD) compared with healthy subjects. To test the intrasession reproducibility of RNFL thickness measurements in patients with PD and healthy subjects using the Cirrus (Carl Zeiss Meditec Inc., Dublin, CA) and Spectralis (Heidelberg Engineering, Inc., Heidelberg, Germany) OCT devices. Design Observational, cross-sectional study. Participants Patients with PD (n = 75) and age-matched healthy subjects (n = 75) were enrolled. Methods All subjects underwent three 360-degree circular scans centered on ...

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    4. Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography: Patterns of Retinal Nerve Fiber Layer Progression

      Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography: Patterns of Retinal Nerve Fiber Layer Progression

      Objective To examine the use of the retinal nerve fiber layer (RNFL) thickness map generated by a spectral-domain optical coherence tomography (OCT) to detect RNFL progression and identify the pattern of progressive changes of RNFL defects in glaucoma. Design Prospective, longitudinal study. Participants One hundred eighty-six eyes of 103 glaucoma patients. Methods Patients were followed at 4-month intervals for ≥36 months for RNFL imaging and visual field examination. Both eyes were imaged by the Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA) and had visual field testing at the same visits. We defined RNFL progression by Guided Progression Analysis (Carl ...

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    5. Choroidal Thickness Measurements

      Choroidal Thickness Measurements

      We read with interest recent article by Branchini et al, entitled “Reproducibility of choroidal thickness measurements across 3 spectral domain optical coherence tomography systems.” We commend the authors for their efforts in comparing these instruments, but we feel that their statistical methods may lead to invalid conclusions. The authors claimed to have investigated the reproducibility of choroidal thickness measurements by 3 different spectral domain optical coherence tomography devices, stating there is “good reproducibility among choroidal thickness measurements of images acquired with Cirrus, Spectralis, and RTVue.” The conclusion was based upon the result that there was a high correlation between repeated ...

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    6. Visual Acuity, Optical Components, and Macular Abnormalities in Patients with a History of Retinopathy of Prematurity

      Visual Acuity, Optical Components, and Macular Abnormalities in Patients with a History of Retinopathy of Prematurity

      Purpose: To examine the optical components and spectral-domain optical coherence tomography (OCT) findings in children with a history of retinopathy of prematurity (ROP) and to identify any associations between the OCT findings and the visual acuities of the patients.Design: Prospective, case-controlled study.Participants and Controls: Children who were between 6 and 14 years of age were divided into the following 4 groups: Patients with a history of threshold ROP who had been treated using laser therapy or cryotherapy (group 1), patients with regressed ROP who had not received any treatment (group 2), patients who were born prematurely but who ...

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    7. Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Objective To evaluate the agreement of optic disc measurements obtained with the Cirrus high-density optical coherence tomography (HD-OCT) and the Heidelberg retina tomograph (HRT) and compare the intervisit, test–retest variability between the instruments. Design Prospective, cross-sectional study. Participants Two hundred seven subjects (109 glaucoma and 98 normal subjects). Methods One eye from each individual was selected randomly for optic disc imaging by the Cirrus HD-OCT and the HRT. Areas of the optic disc and the cup, cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio were compared between the instruments. The OCT measurements were corrected for ocular magnification using ...

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    8. Assessment of Macular Choroidal Thickness by Optical Coherence Tomography and Angiographic Changes in Central Serous Chorioretinopathy

      Assessment of Macular Choroidal Thickness by Optical Coherence Tomography and Angiographic Changes in Central Serous Chorioretinopathy

      Objective To investigate the relationship between macular choroidal thickness measured by high-penetrating swept-source optical coherence tomography (SS-OCT) and angiographic findings in central serous chorioretinopathy (CSC). Design Prospective cross-sectional case series. Participants and Controls Thirty-four patients with CSC (44 eyes) and 17 volunteer subjects (17 normal eyes). Methods All subjects underwent a comprehensive ophthalmologic and SS-OCT prototype examination. All patients with CSC also underwent simultaneous fluorescein angiography (FA) and indocyanine green angiography (IA). Mean regional choroidal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout and squared sector grids were obtained by 3-dimensional raster scanning using SS-OCT. Main Outcome ...

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    9. Diagnostic Ability of a Linear Discriminant Function for Spectral-Domain Optical Coherence Tomography in Patients with Multiple Sclerosis

      Diagnostic Ability of a Linear Discriminant Function for Spectral-Domain Optical Coherence Tomography in Patients with Multiple Sclerosis

      Purpose To calculate and validate a linear discriminant function (LDF) for spectral-domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal nerve fiber layer (RNFL) thickness parameters for the detection of multiple sclerosis (MS). Design Observational cross-sectional study. Participants Patients with multiple sclerosis (n = 115) and age-matched healthy subjects (n = 115) were enrolled in the study. Methods The Spectralis OCT system (Heidelberg Engineering, Heidelberg, Germany) was used to obtain the circumpapillary RNFL thickness in both eyes of each participant. Main Outcome Measures A validating set including 60% of the study subjects (69 healthy individuals and 69 patients with ...

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    10. Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Changes in Anterior Segment Morphology after Laser Peripheral Iridotomy: An Anterior Segment Optical Coherence Tomography Study

      Purpose Novel anterior segment optical coherence tomography (ASOCT) parameters associated with angle closure include anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and iris curvature (I-curv). We aimed to investigate changes in these parameters after laser peripheral iridotomy (LPI) in a cohort of primary angle-closure suspects (PACS). Design Prospective observational study. Participants and Controls A total of 176 PACS aged ≥50 years who underwent LPI in 1 eye. Methods We analyzed ASOCT images (Visante, Carl Zeiss Meditec, Dublin, CA) from all subjects using customized software before and ...

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    11. Glaucoma Diagnostic Accuracy of Ganglion Cell–Inner Plexiform Layer Thickness: Comparison with Nerve Fiber Layer and Optic Nerve Head

      Glaucoma Diagnostic Accuracy of Ganglion Cell–Inner Plexiform Layer Thickness: Comparison with Nerve Fiber Layer and Optic Nerve Head

      Purpose To determine the diagnostic performance of macular ganglion cell–inner plexiform layer (GCIPL) thickness measured with the Cirrus high-definition optical coherence tomography (HD-OCT) ganglion cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements. Design Evaluation of diagnostic test or technology. Participants Fifty-eight patients with early glaucoma and 99 age-matched normal subjects. Methods Macular GCIPL and peripapillary RNFL thicknesses and ONH parameters were measured in each participant, and their diagnostic abilities ...

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    12. Correlation of Fundus Autofluorescence with Spectral Domain Optical Coherence Tomography and Vision in Diabetic Macular Edema

      Correlation of Fundus Autofluorescence with Spectral Domain Optical Coherence Tomography and Vision in Diabetic Macular Edema

      Purpose To investigate the correlation between fundus autofluorescence (FAF) and the results of spectral-domain optical coherence tomography (SD-OCT) as well as visual acuity (VA) in patients with diabetic macular edema (DME) and to determine the visual prognostic factors. Design Retrospective, interventional case series. Participants Sixty-one patients with DME who underwent intravitreal injection of bevacizumab (IVB) as their first treatment. Methods An assessment of VA and FAF and SD-OCT images were obtained before and after IVB (pre- and post-IVB). Foveal FAF was graded on a scale of 1 to 4. The presence or absence of FAF at the foveola was also ...

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    13. Detection of New-Onset Choroidal Neovascularization Using Optical Coherence Tomography: The Amd Doc Study

      Detection of New-Onset Choroidal Neovascularization Using Optical Coherence Tomography: The Amd Doc Study

      Purpose To determine the sensitivity of time domain optical coherence tomography (OCT) in detecting conversion to neovascular age-related macular degeneration (AMD) in eyes at high risk for choroidal neovascularization (CNV), compared with detection using fluorescein angiography (FA) as the gold standard. Design Prospective, multicenter, observational study. Participants Individuals aged ≥50 years with nonneovascular AMD at high risk of progressing to CNV in the study eye and evidence of neovascular AMD in the fellow eye. Methods At study entry and every 3 months through 2 years, participants underwent best-corrected visual acuity, supervised Amsler grid testing, preferential hyperacuity perimetry (PHP) testing, stereoscopic ...

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    14. Probing the Floor of the Optic Nerve Head in Glaucoma

      Probing the Floor of the Optic Nerve Head in Glaucoma
      Spectral domain optical coherence tomography (SD-OCT) applied to the eye is rapidly expanding its scope of usefulness. In this issue of Ophthalmology, the respective authors of 2 different articles describe the use of “enhanced depth imaging” (EDI) to explore the optic disc, and in particular the lamina cribrosa, in the context of glaucoma. The lamina cribrosa is of special interest because the excavation of the optic nerve head, so characteristic of glaucoma in contrast to other optic atrophies, is related to the collapse and posterior bowing of the lamina cribrosa with widening of the scleral opening.
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    15. Evaluation of Macular Thickness by SD-OCT

      Evaluation of Macular Thickness by SD-OCT

      Our objective is to evaluate serial macular thickness changes and their effect on visual acuity following uncomplicated phacoemulsification surgery using spectral domain optical coherence tomography (SD-OCT). Spectral domain is a new generation of OCT machines that provide faster speed of data acquisition, which provide better axial resolution and improve visualization of the retina. This study was approved by the Medical Ethics Committee of the University of Malaya Medical Centre (Reference Number 739.14) and it adhered to the tenets of Declaration of Helsinki.

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    16. Progression Detection Capability of Macular Thickness in Advanced Glaucomatous Eyes

      Progression Detection Capability of Macular Thickness in Advanced Glaucomatous Eyes
      Purpose To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). Design Longitudinal, observational study. Participants A total of 98 eyes of 98 patients with advanced glaucoma (visual field [VF] mean deviation [MD] <−10 dB) with a mean follow-up time of 2.2 years. Methods Three glaucoma experts independently reviewed optic disc and RNFL photographs and classified patients into 3 groups: progressed, stable, and undetermined (criterion 1). Patients in the undetermined group could not be evaluated because of ...
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    17. Ultra-High Resolution Optical Coherence Tomography for Differentiation of Ocular Surface Squamous Neoplasia and Pterygia

      Ultra-High Resolution Optical Coherence Tomography for Differentiation of Ocular Surface Squamous Neoplasia and Pterygia
      Objective To assess the use of an ultra–high-resolution (UHR) optical coherence tomography (OCT) as an adjuvant diagnostic tool in distinguishing ocular surface squamous neoplasia (OSSN) and pterygia. Design Prospective case series. Participants Thirty-four eyes of 34 patients with conjunctival lesions clinically suspicious for OSSN or pterygia. Methods All patients were photographed and then imaged with a custom-built UHR OCT device. Subsequently, each patient underwent excisional or incisional biopsy with histopathologic diagnosis. Main Outcome Measures Comparison of preoperative UHR OCT images and the corresponding histopathologic specimen; comparison of epithelial thickness between the 2 groups as measured by UHR OCT. Results ...
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    18. Highly Reflective Foveal Region in Optical Coherence Tomography in Eyes with Vitreomacular Traction or Epiretinal Membrane

      Highly Reflective Foveal Region in Optical Coherence Tomography in Eyes with Vitreomacular Traction or Epiretinal Membrane
      Objective: To report the optical coherence tomography (OCT) findings in eyes with vitreomacular traction (VMT) or with an epiretinal membrane (ERM).Design: Retrospective case series.Participants: Fifty-four eyes of 45 consecutive patients with subjective visual disturbances resulting from VMT or idiopathic ERM were studied.Methods: The morphologic features of the photoreceptor layer at the foveal center were determined and the central foveal thickness (CFT) was measured by spectral-domain (SD) OCT.Main Outcome Measures: The morphologic characteristics of the foveal region observed by SD OCT.Results: A roundish or diffuse highly reflective region was observed between the photoreceptor inner segment/outer ...
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    19. Enhanced Depth Imaging Detects Lamina Cribrosa Thickness Differences in Normal Tension Glaucoma and Primary Open-Angle Glaucoma

      Enhanced Depth Imaging Detects Lamina Cribrosa Thickness Differences in Normal Tension Glaucoma and Primary Open-Angle Glaucoma
      Objective: To confirm the advantages of the enhanced depth imaging (EDI) mode over the standard mode of the Heidelberg Spectralis spectral domain optical coherence tomography (SD-OCT) for imaging of the lamina cribrosa, and to compare laminar thicknesses of various glaucoma types with or without disc hemorrhage in a similar state of visual field loss. Design Cross-sectional, case-control design. Participants We included 137 glaucoma patients and 49 healthy controls. Methods Optic nerve head B-scans were obtained by both the standard and EDI modes of the Spectralis OCT. Laminar thickness was measured at the center of mid-superior, central, and mid-inferior horizontal B-scans ...
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    20. Enhanced Depth Imaging Optical Coherence Tomography of Deep Optic Nerve Complex Structures in Glaucoma

      Enhanced Depth Imaging Optical Coherence Tomography of Deep Optic Nerve Complex Structures in Glaucoma
      Objective: To assess the usefulness of enhanced depth imaging (EDI) optical coherence tomography (OCT) for evaluating deep structures of the optic nerve complex (ONC; optic nerve head and peripapillary structures) in glaucoma.Design: Prospective, observational study.Participants: Seventy-three established glaucoma patients (139 eyes) with a range of glaucomatous damage.Methods: Serial horizontal and vertical EDI OCT images of the ONC were obtained from both eyes of each participant. Deep ONC structures, including the lamina cribrosa (LC), short posterior ciliary artery (SPCA), central retinal artery (CRA), central retinal vein (CRV), peripapillary choroid and sclera, and subarachnoid space around the optic nerve ...
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    21. Reproducibility of Choroidal Thickness Measurements Across Three Spectral Domain Optical Coherence Tomography Systems

      Reproducibility of Choroidal Thickness Measurements Across Three Spectral Domain Optical Coherence Tomography Systems
      Purpose: To investigate the reproducibility of choroidal thickness measurements in normal subjects on 3 spectral domain optical coherence tomography (SD-OCT) instruments: Zeiss Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA), Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany), and Optovue RTVue (Optovue Inc., Fremont, CA).Design: Cross-sectional non-interventional study.Participants: Images were obtained in 28 eyes of 28 healthy undilated volunteers without ocular pathology in a clinical setting.Methods: All subjects were imaged on the fovea using Cirrus HD 1-line raster, Spectralis enhanced depth imaging (EDI), and RTVue retina-cross.Main Outcome Measures: The choroid was measured subfoveally, 750 μm temporal, and 750 ...
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    22. Dynamics of Human Foveal Development after Premature Birth

      Dynamics of Human Foveal Development after Premature Birth
      Purpose: To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT).Design: Prospective, observational case series.Paticipants: Thirty-one prematurely born neonates, 9 children, and 9 adults.Methods: Sixty-two neonates were enrolled in this study. After examination for retinopathy of prematurity (ROP), SD-OCT imaging was performed at the bedside in nonsedated infants aged 31 to 41 weeks postmenstrual age (PMA) (= gestational age in weeks + chronologic age) and at outpatient follow-up ophthalmic examinations. Thirty-one neonates met eligibility criteria. Nine children and nine adults without ocular pathology served as control groups. Semiautomatic retinal layer ...
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    23. Macular Ganglion Cell Layer Imaging in Preperimetric Glaucoma with Speckle Noise–Reduced Spectral Domain Optical Coherence Tomography

      Macular Ganglion Cell Layer Imaging in Preperimetric Glaucoma with Speckle Noise–Reduced Spectral Domain Optical Coherence Tomography

      ObjectiveTo visualize the macular ganglion cell layer (GCL) and measure its thickness in normal eyes and eyes with preperimetric glaucoma, using speckle noise–reduced spectral domain optical coherence tomography (SD-OCT).DesignRetrospective consecutive case series.ParticipantsThirty-seven eyes of 37 patients with preperimetric glaucoma and 39 normal eyes of 39 volunteers.MethodsVertical and horizontal SD-OCT B-scan images were acquired with minimal speckle noise by using eye-tracking to obtain and average 50 B-scans at each identical location of interest. B-scan images were manually analyzed for GCL, retinal nerve fiber layer (RNFL), and inner plexiform layer shapes and thicknesses in the macula.Main Outcome ...

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    24. Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography

      Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography
      Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer, and macular measurements with spectral-domain optical coherence tomography (SD OCT).Design: Cross-sectional observational study.Participants: Three hundred fifty adult subjects without ocular disease.Methods: Data from SD OCT imaging of the optic nerve head, peripapillary retinal nerve fiber layer (RNFL), and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula.Main Outcome Measures: Optic nerve, RNFL, and ...
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    1-24 of 112 1 2 3 4 5 »
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