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    1. Quantification of Macular Perfusion in Healthy Children Using Optical Coherence Tomography Angiography

      Quantification of Macular Perfusion in Healthy Children Using Optical Coherence Tomography Angiography

      Background: Variations in vessel density (VD) patterns of the macula in children of different ages are unknown. Methods: In this cross-sectional study, subjects with normal eyes aged 3–18 years were enrolled. The macula was scanned by optical coherence tomography angiography (OCTA). Four age groups as under 7 years, 7-10 years, 11-14 years and more than 14 years of age were defined. The influences of age, gender, and body mass index on VD were analyzed. Results : A total of 108 normal eyes from 54 participants with a mean age of 10.9 years were enrolled in the study. At the ...

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    2. Reproducibility of Choroidal Thickness Measurements in Hemodialysis Patients. A Spectral Domain Optical Coherence Tomography Study

      Reproducibility of Choroidal Thickness Measurements in Hemodialysis Patients. A Spectral Domain Optical Coherence Tomography Study

      To investigate the effects of hemodialysis (HD) on the reproducibility of subfoveal choroidal thickness (SFCT) as measured by spectral domain-optical coherence tomography (SD-OCT) Methods In this study, 26 HD (26 eyes) patients had their pre- and post-HD SFCT measured, and the results were compared for reproducibility. Following a thorough ophthalmic examination, SD-OCT was performed three times in a row during a single session. The same physician measured SFCT after automatically identifying choroid with a software caliper. The reproducibility parameters, including intra-class correlation coefficients (ICCs), coefficients of variation (COV), and test-retest variability (TRTV) were then calculated. Results Males made up 53 ...

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    3. Investigation of Optic Disc and Retinal Microvasculature by Optical Coherence Tomography Angiography in Children with Asthma

      Investigation of Optic Disc and Retinal Microvasculature by Optical Coherence Tomography Angiography in Children with Asthma

      Purpose To investigate the optic disc and retinal microvasculature by optical coherence tomography angiography (OCTA) in children with asthma and compare them with healthy ones. Methods Sixty eyes of 30 asthmatic children (asthma group), 60 eyes of 30 control age- and sex- matched healthy subjects (control group) were included to this study, prospectively. Demographic features and ophthalmological examination including OCTA measurements were evaluated. The OCTA was performed with 6x6 mm sections for macula and 4.5x4.5 mm sections for optic disc in all eyes. Retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of retina, and optic ...

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    4. Effect of Alirocumab on Coronary Plaque in Patients With Coronary Artery Disease Assessed by Optical Coherence Tomography

      Effect of Alirocumab on Coronary Plaque in Patients With Coronary Artery Disease Assessed by Optical Coherence Tomography

      Background Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been demonstrated with significant greater reduction of LDL cholesterol levels and cardiovascular events, compared with standard statin therapy. However, the evidence on the impact of PCSK9 inhibitors on coronary plaque composition and morphology are limited. Methods In this prospective, open-label, randomized study, eligible patients with intermediate coronary lesions and elevated LDL cholesterol values were randomized to either alirocumab 75 mg Q2W plus statin therapy (alirocumab arm) or statin therapy (standard care arm). Optical coherence tomography (OCT) assessment for target lesions were obtained at the baseline and at 36 weeks of ...

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    5. Aqueous Humor Cytokine Levels Through Microarray Analysis and a Sub-Analysis Based on Optical Coherence Tomography in Wet Age-Related Macular Degeneration Patients

      Aqueous Humor Cytokine Levels Through Microarray Analysis and a Sub-Analysis Based on Optical Coherence Tomography in Wet Age-Related Macular Degeneration Patients

      Purpose: To evaluate the magnitude of change in optic disc, peripapillary retinal nerve fiber layer (RNFL) and macular parameters measured by swept-source optical coherence tomography (SS-OCT) in glaucomatous eyes after filtration surgery, and to determine any possible relationship between these measurements and baseline factors. Patients and Methods: This multicenter, prospective, consecutive observational study included patients with open-angle glaucoma who required glaucoma filtering surgery (surgical group, 29 eyes) and those with stable disease (control group, 25 eyes). Patients from the surgical group underwent measurement of optic disc, peripapillary retinal nerve fiber layer (RNFL) and macular parameters before and after surgery. Results ...

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    6. Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

      Retinal Optical Coherence Tomography Angiography Findings of Acute Anterior Uveitis

      Purpose: To evaluate the changes in retinal microvasculature in eyes with anterior uveitis (AU) using optical coherence tomography angiography. Methods: Foveal avascular zone (FAZ) of superficial capillary plexus (SCP) and deep capillary plexus (DCP), vessel density (VD) of SCP, DCP, and choriocapillaris, and central macular thickness (CMT) and central foveal thickness (CFT) were calculated from 34 healthy and 41 uveitic eyes. The parameters were compared between the two groups. Results: The deep FAZ was significantly lower in the eyes with AU during the attack than after recovery and the control group (p=0.001 and p=0.003, respectively). The ...

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    7. COVID-19: More than a Respiratory Virus, An Optical Coherence Tomography Study

      COVID-19: More than a Respiratory Virus, An Optical Coherence Tomography Study

      Purpose: The purpose of this study is to investigate anatomic and morphologic features of inner and outer retinal layers in patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT), whwther correlate with any symptoms during disease process. Methods : 32 patients recovered from COVID-19; age and gender matched 36 healthy controls were included in this cross-sectional study. Ganglion cell-inner plexiform layer, macular and periapiller retinal nerve fiber layer (RNFL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL) and the outer retinal hyperreflective bands including external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ ...

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    8. Detection of choroidal neovascularisation in flat irregular pigment epithelial detachment in central serous chorioretinopathy using optical coherence tomography angiography: en-face image combined with cross-sectional image

      Detection of choroidal neovascularisation in flat irregular pigment epithelial detachment in central serous chorioretinopathy using optical coherence tomography angiography: en-face image combined with cross-sectional image

      Background: This study investigated choroidal neovascularisation (CNV) in FIPED by two methods: en-face OCTA and cross-sectional OCTA. We intended to evaluate the incidence of CNV and compare the efficacy of each imaging modalities. Methods: We retrospectively studied OCT and OCTA images of 328 eyes with CSC. OCTA B-scans and macular cube scans were primarily reviewed for the detection of FIPED and CNV. En-face OCTA and cross-sectional OCTA with Angio-B view, which is an image that combines an OCT B-scan with a flow signal were analysed to evaluate the presence of CNV in FIPED. Results: Among 93 eyes of 88 patients ...

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    9. Livelayer: A Semi-Automatic Software Program for Segmentation of Layers and Diabetic Macular Edema in Optical Coherence Tomography Images

      Livelayer: A Semi-Automatic Software Program for Segmentation of Layers and Diabetic Macular Edema in Optical Coherence Tomography Images

      Given the capacity of Optical Coherence Tomography (OCT) imaging to display symptoms of a wide variety of eye diseases and neurological disorders, the need for OCT image segmentation and the corresponding data interpretation is latterly felt more than ever before. In this paper, we wish to address this need by designing a semi-automatic software program for applying reliable segmentation of 8 different macular layers as well as outlining retinal pathologies such as diabetic macular edema. The software accommodates a novel graph-based semi-automatic method, called “Livelayer” which is designed for straightforward segmentation of retinal layers and fluids. This method is chiefly ...

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    10. Prognostic Utility of Optical Coherence Tomography for Visual Outcome After Extended Endoscopic Endonasal Surgery for Adult Craniopharyngiomas

      Prognostic Utility of Optical Coherence Tomography for Visual Outcome After Extended Endoscopic Endonasal Surgery for Adult Craniopharyngiomas

      Optical coherence tomography (OCT) serving as a novel high resolution imaging technique can assess the retinal morphology. At present, a few studies are reported with limited evidence on the predictive value of OCT for visual outcome after optic nerve decompression. This study aims to utilize the largest series of adult craniopharyngiomas to evaluate the association between OCT parameters and visual outcome following the extended endoscopic endonasal surgery (EEES). From October 2018 to October 2020, one hundred and seventy eyes in 88 adult patients with craniopharyngiomas were retrospectively reviewed. Gross total resection was performed in 82 (93.2%) patients. The median ...

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    11. Capsular Blockage Syndrome: Clinical and Anterior Segment Optical Coherence Tomography (OCT) Characteristics

      Capsular Blockage Syndrome: Clinical and Anterior Segment Optical Coherence Tomography (OCT) Characteristics

      Background: CBS is a rare phenomenon which is found during and after cataract surgery. The mechanism, OCT presentation and clinical characteristics are not well studied. Methods: Document patients with CBS who underwent examination, including refraction, best-corrected visual acuity, slit lamp, anterior segment OCT, and onset after cataract surgery. All patients underwent Nd:YAG laser capsulotomy and were prescribed a low-dose topical steroid for seven days. Post-capsulotomy refraction and visual acuity were recorded. Results: This study included 18 eyes. Patients’ mean age was 80 (range, 54–92). The duration between cataract surgery and CBS diagnosis ranged 15–136 months. According to ...

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    12. Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Purpose: To investigate choroidal neovascularization (CNV) activity after anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD) by optical coherence tomography angiography (OCTA) and to determine whether combined qualitative and quantitative biomarkers can achieve high predictive accuracy to guide treatment decisions. Methods: Patients diagnosed with type 1 or type 2 CNV via multimodal imaging who had received anti-VEGF treatmentwere retrospectively reviewed. Qualitative and quantitative CNV responses on OCTA after serial injections were analyzed, and the assessment was correlated with their structural OCT scans. The enrolled eyes were divided into two groups: eyes with exudative signs ...

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    13. Evaluation of the Optic Nerve Head Using Optical Coherence Tomography Angiography in Systemic Sclerosis Patients

      Evaluation of the Optic Nerve Head Using Optical Coherence Tomography Angiography in Systemic Sclerosis Patients

      Introduction This study aims to quantify retinal microvascular vessel density using optical coherence tomography angiography (OCTA) in patients with systemic sclerosis (SS), whether there is a difference in values ​​with the controls and to correlate it with the disease activity, damage risk and drug usage. Material- method SSc patients were enrolled, and age- and gender-matched controls underwent OCTA, after basic ophthalmological and rheumatological examinations in this cross-sectional, prospective study. Results 61 eyes of 61 consecutive SSc patients with a median age 52 years were investigeted. There was no statistically significant difference between patients and control groups regarding RNFL and OCTA ...

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    14. Non-invasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography

      Non-invasive Estimation of Pulsatile and Static Intracranial Pressure by Optical Coherence Tomography

      This study examined whether optical coherence tomography (OCT) can be used to estimate the pulsatile and static intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Continuous overnight monitoring of the pulsatile and static ICP and a single OCT examination were performed in 20 patients with IIH and in 12 reference subjects without cerebrospinal fluid disturbances. The ICP measurements were obtained using a parenchymal sensor. The pulsatile ICP was determined as the mean ICP wave amplitude (MWA) and the static ICP was determined as the mean ICP. The IIH group had increased overnight MWA and mean ICP scores, and ...

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    15. Retinal Nerve Fiber Layer Analysis in Children with Migraine with and without Aura using Optical Coherence Tomography: A Case-Control Study

      Retinal Nerve Fiber Layer Analysis in Children with Migraine with and without Aura using Optical Coherence Tomography: A Case-Control Study

      Purpose To evaluate retinal nerve fiber layer (RNFL) thickness in children with migraine, with and without aura, compared to healthy controls using optical coherence tomography (OCT). Methods Cross-sectional case-control study. Peripapillary RNFL thickness was measured using optical coherence tomography (OCT) in a group of children diagnosed with migraine with aura (MwA) (n=9) and migraine without aura (MwoA) (n=11), and in a group of healthy controls (n=20). Age, sex, duration of migraine in months, number of episodes per month, duration of episodes in hours, and use of prophylactic treatment with magnesium were recorded. Groups were matched by age ...

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    16. Retinal Morphological Alterations in Polycythemia Vera: An Optical Coherence Tomography Angiography Study

      Retinal Morphological Alterations in Polycythemia Vera: An Optical Coherence Tomography Angiography Study

      Purpose Investigation of retinal morphological alterations in patients with polycythemia vera (PV) using optical coherence tomography angiography (OCTA). Materials and Methods Thirty PV patients (group 1) who were followed-up at Afyonkarahisar Health Sciences University Hospital, Department of Hematology, and 30 normal subjects (group 2) who applied to Ophthalmology Department for routine eye examination were enrolled in this cross-sectional, single-centered study. Following a comprehensive ophthalmological examination, all participants underwent spectral-domain OCTA examination with Angio Retina mode (6x6 mm). Data were compared between groups for statistical significance. RESULTS The male-to-female ratio was 1:1. Mean ages were 46.97±3.20 and ...

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    17. Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

      Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

      Objective To compare fixation deviation and stability with soft contact lens correction and device built-in auto-focus system during optical coherence tomography angiography (OCTA). Methods This observational study measured OCTA metrics first with contact lens correction, followed by removal of contact lenses, using the device auto-focus system at a University Optometry Clinic, Hong Kong. All participants were habitual soft contact lens wearers with either low or high myopia. OCTA measurements were obtained using a spectral domain OCTA. Fixation deviation was distance (in pixels) of the fovea to the center of the OCTA measurement grid. Fixation stability was test-retest repeatability (TRR) and ...

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    18. Evaluation of Possible Changes in Intraocular Pressure and Optical Coherence Tomography Measurements in Severe OSAS Patients After 3 Month Positive Airway Pressure Treatment

      Evaluation of Possible Changes in Intraocular Pressure and Optical Coherence Tomography Measurements in Severe OSAS Patients After 3 Month Positive Airway Pressure Treatment

      Purpose: To identify and compare possible changes in intraocular pressure (IOP), macular and peripapillary retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) before and after 3 months of positive airway pressure (PAP) in patients with severe OSAS. Materials and Methods: Twenty-five patients diagnosed with severe OSAS in the neurology sleep outpatient clinic were included in the study. Ophthalmologic examinations were performed at the time of diagnosis and after 3 months of PAP treatment. Statistical analysis of comparisons of IOP and OCT measurements taken before and after PAP treatment was performed. Before treatment, the correlations between central corneal ...

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    19. Macula and Optic Disc Characteristics in Methamphetamine and Crystal Methamphetamine Abusers Using Optical Coherence Tomography

      Macula and Optic Disc Characteristics in Methamphetamine and Crystal Methamphetamine Abusers Using Optical Coherence Tomography

      Purpose Methamphetamine and Crystal Methamphetamine abusers were compared with healthy subjects using optical coherence tomography to assess their retinal nerve fiber layer, macula, and optic disc characteristics. Methods Forty-one Methamphetamine and Crystal Methamphetamine abusers and 42 healthy subjects (mean ± SD of age: 35.82 ± 8.6 and 37.67 ± 9.1 years, respectively) were incorporated in this cross sectional study. The drug abusers had a history of at least five years of substance use through smoking. Fourier-domain optical coherence tomography was used to image and assess the characteristics of retinal nerve fiber layer, macular thickMisness, and optic disc in the ...

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    20. Decreased Central and Limbal Epithelium Thickness After Corneal Crosslinking Evaluated by Anterior Segment Optic Coherence Tomography

      Decreased Central and Limbal Epithelium Thickness After Corneal Crosslinking Evaluated by Anterior Segment Optic Coherence Tomography

      Aim : To Investigate the central cornea, limbal epithelium thickness and stroma thickness after corneal cross-linking by Anterior Segment Optical Coherence Tomography (AS-OCT) and Scheimpflug topography. Methods: Fifteen keratoconus patients treated with cross-linking(CXL) and fifteen untreated keratoconus patients was included to the study. Corneal central, limbal epithelial, stromal and total thickness with was analyzed by using Anterior Segment Optical Coherence Topography (AS-OCT) and keratometric values ​​were analyzed by Scheimpflug topography. Results: There was a statisticallly significant difference between treated and untreated keratoconus patients according to limbal epithelial thickness (LET). Limbal epithelial thickness was 30.7 ± 5.5µm in the ...

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    21. Measurement of the Active Toxoplasma Retinochoroiditis Lesion Size During the Disease Course With Swept Source Optical Coherence Tomography Angiography: A Retrospective Image Analysis

      Measurement of the Active Toxoplasma Retinochoroiditis Lesion Size During the Disease Course With Swept Source Optical Coherence Tomography Angiography: A Retrospective Image Analysis

      Purpose To measure the lesion size reduction in eyes with active toxoplasma retinochoroiditis during the disease course with swept- source optical coherence tomography angiography (SS-OCTA). Methods We retrospectively analyzed the chorioretinal lesion size in a group of 14 eyes with a single active toxoplasma retinochoroiditis lesion.SS-OCTA was performed at the baseline and follow -up in all eyes. The 6x6 mm choriocapillaris slab images were evaluated with an image analysis (Matlab). The number of black and white pixels in a 1500µm-diameter circle centered on each active lesion was counted at the time of baseline examination and at the first ...

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    22. Optical Coherence Tomography Biomarkers of Photoreceptor Degeneration in Retinitis Pigmentosa

      Optical Coherence Tomography Biomarkers of Photoreceptor Degeneration in Retinitis Pigmentosa

      Purpose: Several parameters on optical coherence tomography (OCT) have been suggested as biomarkers for photoreceptor degeneration in retinitis pigmentosa (RP). This study is to investigate which OCT parameters can serve as the earliest biomarkers in RP. Methods: OCT line scans of the horizontal meridian were conducted in 22 eyes of 22 RP patients and 30 eyes of 30 healthy controls. Longitudinal reflectance profiles were obtained using ImageJ at every 5 pixels. The following parameters on OCT were quantitatively measured: 1) relative optical intensity (ROI) of ellipsoid zone (EZ) and interdigitation zone (IZ); 2) thickness of outer nuclear layer (ONLT), photoreceptor ...

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    23. Morpho-molecular Signal Correlation between Optical Coherence Tomography and Raman Spectroscopy for Superior Image Interpretation and Clinical Diagnosis

      Morpho-molecular Signal Correlation between Optical Coherence Tomography and Raman Spectroscopy for Superior Image Interpretation and Clinical Diagnosis

      The combination of manifold optical imaging modalities resulting in multimodal optical systems allows to discover a larger number of biomarkers than using a single modality. The goal of multimodal imaging systems is to increase the diagnostic performance through the combination of complementary modalities, e.g. optical coherence tomography (OCT) and Raman spectroscopy (RS). The physical signal origins of OCT and RS are distinctly different, i.e. in OCT it is elastic back scattering of photons, due to a change in refractive index, while in RS, it is the inelastic scattering between photons and molecules. Despite those diverse characteristics both modalities ...

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    24. Choroidal Thickness in Children With Type 1 Diabetes Depending On the Pubertal Status and Metabolic Parameters Analyzed By Optical Coherence Tomography

      Choroidal Thickness in Children With Type 1 Diabetes Depending On the Pubertal Status and Metabolic Parameters Analyzed By Optical Coherence Tomography

      cing this parameter, using optical coherence tomography (OCT). Material and methods: 333 eyes out of 167 children with T1D without symptoms of diabetic retinopathy (mean age 12,81±3,63 years, diabetes duration 4,59±3,71 years) were enrolled. CT in all quadrants was evaluated. The studied population was divided into three groups: prepubertal, pubertal and postpubertal. The multivariate regression model was carried out using all metabolic parameter and then it was built using only the significant ones. Results: Significant differences in CT between males and females, except nasal and superior quadrants were observed. We revealed significant differences in ...

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