1. 1-17 of 17
    1. Quantifying the Pattern of Retinal Vascular Orientation in Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Quantifying the Pattern of Retinal Vascular Orientation in Diabetic Retinopathy Using Optical Coherence Tomography Angiography

      Quantitative imaging using optical coherence tomography angiography (OCTA) could provide objective tools for the detection and characterization of diabetic retinopathy (DR). In this study, we developed a novel quantitative approach using OCTA images to delineate the vessel orientation pattern of a specific region of interest, which is an orientation distribution curve depicting the probability of vessels at each angle from 0 to 360 degrees. Three quantitative metrics including vessel preferred orientation, vessel anisotropy and vessel mass were extracted from the orientation pattern and analyzed in each of eight 45° sectors at the macula. Differential retinal microvascular orientation patterns were observed ...

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    2. Acute Symptomatic Vitreous Floaters Assessed With Ultra-Wide Field Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

      Acute Symptomatic Vitreous Floaters Assessed With Ultra-Wide Field Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography

      Purpose: To describe the eyes with vitreous floaters and to analyze the development of acute symptomatic posterior vitreous detachment (PVD). Methods: A retrospective review of medical records was performed on patients with the vitreous floater developed for the first time of their life. Peripapillary vitreous opacity (pVO) was searched in Ultra-wide field (UWF) scanning laser ophthalmoscopy and PVD stage was assessed through spectral-domain optical coherence tomography (SD-OCT). Results: 196 patients (55 males and 141 females), who were 58.4(±9.1) on years old, visited a retinal clinic 9.4 (±9.1) days after they experienced vitreous floaters. (pVO) was ...

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    3. Automated Measurement of Iris Surface Smoothness Using Anterior Segment Optical Coherence Tomography

      Automated Measurement of Iris Surface Smoothness Using Anterior Segment Optical Coherence Tomography

      Fuchs uveitis (FU) is a chronic and often unilateral ocular inflammation and characteristic iris atrophic changes, other than heterochromia, are common in FU and are key to the correct diagnosis in many cases. With the advent of anterior segment optical coherence tomography (AS-OCT), some investigators attempted to quantitatively study these atrophic changes; mostly by introducing various methods to measure iris thickness in AS-OCT images. We aimed to present an automated method in a observational case series to measure the smoothness index (SI) of iris surface in AS-OCT images. The ratio of the length of the straight line connecting the most ...

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    4. Comparison of Quantitative Parameters in Diabetics Without Clinical Signs of Diabetic Retinopathy and Healthy Individuals Using Swept-source Optical Coherence Tomography Angiography

      Comparison of Quantitative Parameters in Diabetics Without Clinical Signs of Diabetic Retinopathy and Healthy Individuals Using Swept-source Optical Coherence Tomography Angiography

      Automated image analysis is the future for retinal imaging in order to early diagnose retinal diseases like diabetic retinopathy. Swept source coherence tomography angiography offers new insights in retinal vascularization. Data sets for each stage of diabetic retinopathy are crucial to compare findings to the healthy population and to develop further algorithms. We recruited 39 eyes of Type-2 diabetics without diabetic retinopathy comparing them to 43 eyes of age and gender matched individuals using swept source coherence tomography angiography. Vessel and perfusion density in the superficial and deep retinal plexus, as well foveal-avascular zone expansion, using Macular Density V 0 ...

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    5. Peripapillary Vessel Density Measurement of Quadrant and Clock-Hour Sectors in Primary Angle Closure Glaucoma Using Optical Coherence Tomography Angiography

      Peripapillary Vessel Density Measurement of Quadrant and Clock-Hour Sectors in Primary Angle Closure Glaucoma Using Optical Coherence Tomography Angiography

      Background: The purpose of this study was to investigate peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors, and the diagnostic ability of peripapillary vessel density was also studied. Methods: This was a cross-sectional study on forty-one PACG patients(50 eyes)and twenty-seven healthy subjects(27 eyes). The optic disc was imaged using a 1050-nm-wavelength swept-source optical coherence tomography system (DRI OCT Triton, TOPCON). Peripapillary vessel density was quantified by imageJ software. Characteristics of peripapillary vessel density of quadrant and clock-hour sectors were analyzed, and diagnostic capability was evaluated by areas under the receiver ...

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    6. Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

      Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

      Purpose : To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19). Methods : In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls. Results : Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 ...

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    7. Comparison of Optical Coherence Tomography Angiography Metrics in Primary Angle-Closure Glaucoma and Normal-Tension Glaucoma

      Comparison of Optical Coherence Tomography Angiography Metrics in Primary Angle-Closure Glaucoma and Normal-Tension Glaucoma

      Purpose: To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). Methods: One or both eyes of each subjects were imaged for a 3x3mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Results: Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of ...

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    8. Structural Alterations of the Choroid Evaluated by Enhanced-Depth Imaging Optical Coherence Tomography in Patients with COVID-19

      Structural Alterations of the Choroid Evaluated by Enhanced-Depth Imaging Optical Coherence Tomography in Patients with COVID-19

      Background: To assess alterations of choroid by enhanced depth imaging optical coherence tomography (EDI-OCT) in coronavirus disease 2019 (COVID-19). Methods: Thirty-two patients with COVID-19 infection (group 1) and 34 healthy subjects (group 2) were included in this study. The choroidal thickness was measured at three points: Subfoveal, 1500 mm nasal from the fovea, and 1500 mm temporal from the fovea. Total choroidal area, luminal area, stromal area and choroidal vascular index (CVI) was measured by Image-J. Results: In group 1, subfoveal, nasal, and temporal choroid thicknesses were thinner compared to group 2. However, there was no statistical significance (p=0 ...

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    9. A New Optical Coherence Tomography Method for Subfoveal Choroidal Thickness Measurement: A Singlecenter Observational Study

      A New Optical Coherence Tomography Method for Subfoveal Choroidal Thickness Measurement: A Singlecenter Observational Study

      Background : Several macular pathologies are associated with choroidal vascular supply, and thus require choroidal thickness evaluation. However, there is no standard subfoveal choroidal thickness (SFCT) measuring method. This study investigated a new method to measure the SFCT, using optical coherence tomography. Methods : This is a single-center observational study. Eighty-two senior medical students participated as observers and independently measured the SFCT on five standard optical coherence tomography images of healthy adults in a tertiary care setting. They used three different methods: (1) the observer’s own method, (2) the conventional method, perpendicular to the retinal pigment epithelium, and (3) the new ...

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    10. Optical Coherence Tomography Observed Fundus Changes of Hypertensive Disorders Complicating Pregnancy

      Optical Coherence Tomography Observed Fundus Changes of Hypertensive Disorders Complicating Pregnancy

      Background By optical coherence tomography(OCT) observed fundus changes of hypertensive disorders complicating pregnancy. Methods Inspected patients with hypertensive disorders complicating pregnancy accepted eye examination including corrected visual acuity, slit lamp examination, fundus examination, OCT Results 1.OCT examination results of abnormal 148, which neurosensory serous retinal detachment 84eyes (56.76%), pigment epithelium and the IS / OS layer change 38 eyes (25.68%), optic disc oedema and retinal haemorrhage and other changes of 26 eyes (17.56%). 2. Between different phenotypes OCT of Patients with oedema, proteinuria, blood pressure and course had differences (P <0.05), and had a correlation ...

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    11. Quantitative Evaluation of Vascular Density inDiabetic Retinopathy Subtypes using Optical Coherence Tomography Angiography

      Quantitative Evaluation of Vascular Density inDiabetic Retinopathy Subtypes using Optical Coherence Tomography Angiography

      Background: To determine the discrepancy between quantitative measurement of retinal and choriocapillaris (CC) vascular density (VD) in diabetic retinopathy (DR) stages using spectral domain optical coherence tomography angiography (SD OCTA) and compare it with normal subjects. Methods: 188 eyes of 97 participants were recruited in this cross-sectional study. Macular OCTA (3x3mm) scan was performed and VD at the level of superficial capillary plexus (SCP), deep capillary plexus (DCP) and CC were measured with the device software. Results: In normal subjects, VD in SCP, DCP, and CC were higher in all subsegments. In retinal VD, all calculated parameters were reduced in ...

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    12. An Assessment of Band Keratopathy Depth With Anterior Segment Optical Coherence Tomography

      An Assessment of Band Keratopathy Depth With Anterior Segment Optical Coherence Tomography

      Background: To describe the anterior segment optical coherence tomography (AS-OCT) findings in a series of patients with band keratopathy (BK) and discuss its possible clinical utility. Methods: A retrospective review of 31 eyes from 31 consecutive patients with BK from November 2013 to October 2018. Lesion depth and central corneal thickness (CCT) were outputted from AS-OCT (RS-3000 Advance, NAVIS-EX 1.5.5 Nidek CO LTD, Japan). Results: There were 20 cases of ocular trauma, 3 cases of retinal detachment, 2 cases of glaucoma, 2 cases of uveitis, 1 case of Coats’ disease, 1 case of complicated cataract surgery, 1 case ...

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    13. Early Diagnostic Value of Spectral Domain-optical Coherence Tomography for Optic Nerve Injury in Sellar-occupied Patients

      Early Diagnostic Value of Spectral Domain-optical Coherence Tomography for Optic Nerve Injury in Sellar-occupied Patients

      Background: To investigate the value of spectral domain-optical coherence tomography (SD-OCT) in the early diagnosis of optic nerve injury in patients with occupying lesion in sellar region. Methods: A case-control study was conducted for patients who were diagnosed as the occupying lesion in sellar region in the Department of Ophthalmology. The general routine examination and visual field examination were performed in the ophthalmology department. A total of 22 patients(44 eyes) with no abnormalities were selected, and 22 healthy controls (44 eyes) were enrolled. SD-OCT was used to detect the average thickness of peripapillary retinal nerve fiber layer (pRNFL) and ...

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    14. Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study

      Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes with Exudative Circumscribed Choroidal Haemangioma : An Optical Coherence Tomography Angiography Study

      Background : To quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma (CCH) compared with age- and gender-controlled healthy eyes. Methods : This was a cross-sectional, case-control study. 82 eyes of eighty-two subjects including 41 eyes of forty-one subjects in the exudative CCH group and 41 eyes of forty-one subjects in the age- and gender-controlled healthy eye group were enrolled in this study. Optical coherence tomography angiography (OCTA) was performed in each subject, and the capillary density (CD) of superficial plexus, deep capillary plexus, and the choriocapillaris as well as the area of foveal avascular zone (FAZ) were ...

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    15. Quantitative Assessment of Retinal Thickness and Vessel Density Using Optical Coherence Tomography Angiography in Patients with Alzheimer’s Disease and Glaucoma

      Quantitative Assessment of Retinal Thickness and Vessel Density Using Optical Coherence Tomography Angiography in Patients with Alzheimer’s Disease and Glaucoma

      Background Retinal imaging using optical coherence tomography (OCT) and OCT angiography (OCTA) may serve as an alternative approach to monitoring and diagnosing neurodegenerative diseases such as Alzheimer's disease (AD) and primary open-angle glaucoma (POAG). In this study, we performed direct comparisons of retinal vessel density with the thickness of inner retinal layer (IRL) and outer retinal layer (ORL) in patients with AD and POAG. Methods In this cross-sectional study, we analyzed data from 48 eyes of healthy control (HC) participants, 71 eyes of POAG patients, and 49 eyes of AD patients with confirmed presence of fibrillar brain amyloid on ...

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    16. The optical coherence tomography angiography manifestation of strabismus amblyopia with eccentric fixation

      The optical coherence tomography angiography manifestation of strabismus amblyopia with eccentric fixation

      Background To explore the application value of optical coherence tomography angiography (OCTA) in patients with strabismus amblyopia accompanied by eccentric fixation. Methods The following data were collected from patients with strabismus amblyopia accompanied by eccentric fixation: best corrected visual acuity (BCVA); spherical equivalent (SE) and deviation angle; eccentric fixation distance using OCTA system software tools, with µm as the unit of measurement of the distance between the retinal fixed point and the macular fovea; macular fovea vessel length density (VLD); perfusion density (PD); foveal avascular zone (FAZ) area; and perimeter and circularity of the superficial retinal vascular plexus. The entry ...

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    17. Consistency Between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes

      Consistency Between Optical Coherence Tomography and Humphrey Visual Field for Evaluating Glaucomatous Defects in High Myopic Eyes

      Background: The study is to investigate the influence of high myopia on the consistency between optical coherence tomography (OCT) and visual field in primary open-angle glaucoma (POAG). Methods: We enrolled 37 patients with POAG with high myopia (POAG-HM group), 27 patients with POAG without high myopia (POAG group), and 29 controls with high myopia (HM group). All subjects underwent Humphrey perimetry (30-2 and 10-2 algorithms). The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured using Cirrus HD-OCT. Spearman’s rank correlation analysis was used to determine correlations between OCT and perimetric parameters ...

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    1-17 of 17
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