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    1. Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography

      Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography

      AIM : To evaluate the ability of macular ganglion cell complex (GCC) thickness using Fourier domain optical coherence tomography (FD-OCT) to detect glaucoma in highly myopic eyes. METHODS : Cross-sectional study. A total of 114 participants, consecutively were enrolled. Macular GCC thickness and peripapillary retinal nerve fiber layer (RNFL) thickness were obtained with RTVue FD-OCT. Receiver operating characteristics curves were constructed for each measurement parameter, and areas under the curves (AUCs) were compared. RESULTS : Both the average GCC and average RNFL thickness showed negative correlations with axial length (rGCC=-0.404, P=0.001; rRNFL=-0.561, P<0.001). The largest ...

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    2. Comparison of choroidal vessel thickness in children and adult eyes by enhanced-depth imaging optical coherence tomography imaging

      Comparison of choroidal vessel thickness in children and adult eyes by enhanced-depth imaging optical coherence tomography imaging

      AIM : To evaluate choroidal thickness, medium choroidal vessel thickness (MCVT) and large choroidal vessel thickness (LCVT) in normal children and adult subjects. METHODS : Manual measurements of subfoveal choroidal thickness (SFCT), MCVT and LCVT at subfoveal and 750 μm nasal and temporal to fovea locations were completed on enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of normal children and adult subjects. RESULTS : Fifty adult and fifty-seven child subjects were included in the study (including 80 adult and 103 child eyes). Mean (±SD) SFCT of adult and children eyes in the study was 309.3±95.7 μm and 279.3±50 ...

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    3. The optic nerve head perfusion and its correlation with the macular blood perfusion in unilateral idiopathic macular hole: an optical coherence tomography angiography study

      The optic nerve head perfusion and its correlation with the macular blood perfusion in unilateral idiopathic macular hole: an optical coherence tomography angiography study

      AIM : To compare the optic nerve head (ONH) perfusion in both eyes of unilateral idiopathic macular hole (IMH) with normal control group by using optical coherence tomography angiography (OCTA) and investigate its correlationship with the macular blood perfusion. METHODS : We performed a prospective and cross-sectional study that included 19 patients with full-thickness unilateral IMH and 24 age- and sex-matched controls. All participants received OCTA test. The ONH perfusion was evaluated by the regions of peripapillary and whole en face (the sum of peripapillary and optic disc). The potential correlationship between ONH and parafovea were implied. All the data were performed ...

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    4. Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls

      Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls

      AIM : To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls. METHODS : This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3.0 D, up to -6.0 D) and high myopia (HM; SE greater than -6.0 D). The control group consisted of emmetropic (EM) patients ...

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    5. Optical coherence tomography angiography in retinal cavernous hemangioma

      Optical coherence tomography angiography in retinal cavernous hemangioma

      Cavernous hemangiomas of the retina are rare benign vascular tumors, commonly diagnosed in children and young adults. They are characterized by dilated blood vessels that form cavities or caverns through which the blood flow is very low or virtually absent [1] . Retinal lesions may be associated with cerebral hemangiomas [1] , which conversely, do not harbor any tissue within the malformation, the smooth muscle is impaired and there is no capsule surrounding the caverns. Cavernous hemangioma has also been associated with choroidal hemangioma [2] and ocular melanocytosis [3] . Retinal lesions vary in size and location, and generally follow the course of ...

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    6. Optical coherence tomography changes following vitrectomy for long standing premacular hemorrhage in Valsalva retinopathy

      Optical coherence tomography changes following vitrectomy for long standing premacular hemorrhage in Valsalva retinopathy

      Dear Editor, Premacular hemorrhage is a common cause of sudden profound visual loss in otherwise healthy eye. One of the commonest causes of premacular hemorrhage in clinical practice is Valsalva retinopathy, which was first described by Thomas Duane in 1972 [1] . In the setting of Valsalva retinopathy these hemorrhages are a result of ruptured perifoveal capillaries because of raised intravenous pressure of the eye. This happens when the raised intra-thoracic pressure due to Valsalva maneuver is transmitted to the ocular venous system because of valve-less nature of the later. While the exact location of these hemorrhages has been disputed, they ...

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    7. Optical coherence tomography with or without enhanced depth imaging for peripapillary retinal nerve fiber layer and choroidal thickness

      Optical coherence tomography with or without enhanced depth imaging for peripapillary retinal nerve fiber layer and choroidal thickness

      AIM : To assess peripapillary retinal nerve fiber layer (RNFL) and choroidal thickness obtained with enhanced depth imaging (EDI) mode compared with those obtained without EDI mode using Heidelberg Spectralis optical coherence tomography (OCT). METHODS : Fifty eyes of 25 normal healthy subjects and 32 eyes of 20 patients with different eye diseases were included in the study. All subjects underwent 3.4 mm diameter peripapillary circular OCT scan centered on the optic disc using both the conventional and the EDI OCT protocols. The visualization of RNFL and choroidoscleral junction was assessed using an ordinal scoring scale. The paired t-test, intraclass correlation ...

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    8. Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

      Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

      AIM : To investigate foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and to assess the reproducibility of FAZ and PRVD measurements. METHODS : Sixty diabetic patients (60 eyes) with different stage of DR (graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners. FAZ area in all patients was also assessed using fluorescein angiography (FA). RESULTS : In subject with proliferative DR and with moderate-severe non proliferative DR ...

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    9. Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

      Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

      The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography. Thirteen right eyes were included in the study. The device used for the measurement was the Visante® omni system. The stimuli were set up at different vergences (0.0 D, -1.5 D, and -3.0 D). The angle opening distance 500 and 750, the trabecular iris space area 500 and 750, and the scleral spur angle parameters were assessed at the nasal and temporal regions. The results in the iridotrabecular angle comparing the three accommodative states of the eye did ...

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    10. Influence of corneal power on circumpapillary retinal nerve fiber layer and optic nerve head measurements by spectral-domain optical coherence tomography

      Influence of corneal power on circumpapillary retinal nerve fiber layer and optic nerve head measurements by spectral-domain optical coherence tomography

      AIM : To evaluate the influence of corneal power on circumpapillary retinal nerve fiber layer (cpRNFL) and optic nerve head (ONH) measurements by spectral-domain optical coherence tomography (SD-OCT). METHODS : Twenty-five eyes of 25 healthy participants (mean age 23.6±3.6y) were imaged by SD-OCT using horizontal raster scans. Disposable soft contact lenses of different powers (from ?11 to +5 diopters including 0 diopter) were worn to induce 2-diopter changes in corneal power. Differences in the cpRNFL and ONH measurements per diopter of change in corneal power were analyzed. RESULTS : As corneal power increased by 1 diopter, total and quadrant cpRNFL ...

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    11. Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy

      Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy

      AIM : To compare the optic disc blood flow of non-arteritic ischemic optic neuropathy (NAION) eyes with normal eyes. METHODS : The optic disc blood flow densities of diagnosed non-acute phase NAION eyes (21 eyes, 14 individuals) and normal eyes (19 eyes, 12 individuals) were detected via Optovue optical coherence tomography angiography (OCTA). The optic disc blood flow was measured via Image J software. Correlations between optic disc perfusion and visual function variables were assessed by linear regression analysis. RESULTS : The average percentage of the optic disc non-perfusion areas in the non-acute phase NAION patients (17.84%±6.18%) was increased, when ...

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    12. Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome

      Spectral-domain optical coherence tomography dynamic changes and steroid response in multiple evanescent white dot syndrome

      Dear Editor, Multiple evanescent white dot syndrome (MEWDS) was first described in 1984 as a rare, acute, unilateral, multifocal retinochoroidal disorder, typically affecting young myopic women[1]. Previous studies with fluorescein angiography (FA) and electrophysiology suggested that MEWDS to be a disease in the retinal pigment epithelium (RPE) or outer retina[2], while recent studies with spectraldomain optical coherence tomography (SD-OCT) suggested it may be an outer retinal disease due to observation of hyperreflective material in outer retina and subtle disruptions of the ellipsoid zone without RPE disruption[3]. However, some studies with indocyanine green angiography (ICGA) and choroidal thickness ...

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    13. Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia

      Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia

      AIM : To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS : This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the optic disc using Stratus and Spectralis OCT. Areas under the receiver operating characteristic curve (AUROC) and the sensitivity at specificity of >80% and >95% for p-RNFL parameters obtained using the ...

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    14. Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease

      Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease

      Dear Editor, Vogt-Koyanagi-Harada (VKH) disease is a cell-mediated autoimmune syndrome directed against melanocytes. It is considered a multisystem disorder characterized by granulomatous panuveitis often associated with neurologic and cutaneous manifestations. The choroid is the main site of autoimmune inflammation in ocular tissues[1]. Here we report the case of a 48-year-old woman with diminished vision that began about 15d earlier. The patient has consented to the submission of this Letter for submission to the journal. Her visual acuity was 0.8 in both eyes. She also suffered from headache and hearing loss, and reported a bout of influenza some days ...

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    15. Retinal ganglion cell complex changes using spectral domain optical coherence tomography in diabetic patients without retinopathy

      Retinal ganglion cell complex changes using spectral domain optical coherence tomography in diabetic patients without retinopathy

      AIM : To assess the ganglion cell complex (GCC) thickness in diabetic eyes without retinopathy. METHODS : Two groups included 45 diabetic eyes without retinopathy and 21 non diabetic eyes. All subjects underwent full medical and ophthalmological history, full ophthalmological examination, measuring GCC thickness and central foveal thickness (CFT) using the RTVue? spectral domain-optical coherence tomography (SD-OCT), and HbA1C level. RESULTS : GCC focal loss volume (FLV%) was significantly more in diabetic eyes (22.2% below normal) than normal eyes (P=0.024). No statistically significant difference was found between the diabetic group and the control group regarding GCC global loss volume (GLV ...

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    16. Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia

      Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia

      AIM : To investigate the effect of posterior scleral reinforcement (PSR) on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography (OCTA). METHODS : The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR (PSR group) for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary (RPC) flow density were measured by OCTA, and the measurements were compared between groups. RESULTS : OCTA found no significant differences in macular flow density between PSR and control groups. For the superficial flow, whole enface ...

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    17. Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography

      Macular changes of neuromyelitis optica through spectral-domain optical coherence tomography

      AIM : To evaluate the thickness of the retinal layers in the macula using spectral-domain optical coherence tomography (SD-OCT) in patients with neuromyelitis optica (NMO). METHODS : Spectralis SD-OCT, utilizing automated macular layer segmentation, was performed in 26 NMO patients and 26 healthy controls. Visual function including visual field tests and pattern visual evoked potential were recorded in study subjects. RESULTS : Forty-one eyes from 26 NMO patients and 52 eyes from 26 age- and sex-matched healthy controls were included. Besides total macular volume, peri-paipillary retinal nerve fiber layer (RNFL) thickness, the thickness of macular RNFL, ganglion cell layer (GCL) and inner plexiform ...

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    18. Peripapillary choroidal thickness in Chinese children using enhanced depth imaging optical coherence tomography

      Peripapillary choroidal thickness in Chinese children using enhanced depth imaging optical coherence tomography

      AIM : To evaluate the peripapillary choroidal thickness (PPCT) in Chinese children, and to analyze the influencing factors. METHODS : PPCT was measured with enhanced depth imaging optical coherence tomography (EDI-OCT) in 70 children (53 myopes and 17 non-myopes) aged 7 to 18y, with spherical equivalent refractive errors between 0.50 and -5.87 diopters (D). Peripapillary choroidal imaging was performed using circular scans of a diameter of 3.4 mm around the optic disc. PPCT was measured by EDI-OCT in six sectors: nasal (N), superonasal (SN), superotemporal (ST), temporal (T), inferotemporal (IT) and inferonasal (IN), as well as global RNFL thickness ...

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    19. Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy

      This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy (NAION) and time delay before therapy. Total 24 patients received the same treatment within or after 2wk (early and late groups). There were significantly lower level of destruction of nerve fibers (P=0.0014) and significantly better visual field sensitivity (P=0.039) in early group. The results indicate that therapy should be started within 2wk. The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity.

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      Mentions: András Berta
    20. Effect of head tilt on repeatability of optic nerve head parameters using cirrus spectral-domain optical coherence tomography

      Effect of head tilt on repeatability of optic nerve head parameters using cirrus spectral-domain optical coherence tomography

      AIM : To assess the repeatability of measuring optic nerve head (ONH) parameters using the Cirrus optical coherence tomography (OCT), as well as to assess the effect of head tilt on these measurements. METHODS : Thirty healthy participants with no evidence of glaucoma were recruited for the study. Visual acuity, intraocular pressure, standard automated perimetry and ocular examination were performed for each participant. One eye was then randomly selected and scanned undilated with the Cirrus OCT in 3 positions (neutral, 30° right tilt and 30° left tilt). RESULTS : Data collected from 29 eyes were used for analysis. One patient was omitted due ...

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    21. Anterior segment optical coherence tomography for identifying muscle status in strabismus surgery

      Anterior segment optical coherence tomography for identifying muscle status in strabismus surgery

      Dear Sir, Anterior segment optical coherence tomography (AS-OCT) finds very few indications in the domain of strabismus surgery. Current applications remain restricted to determining limbus-muscle insertion distance and anterior segment changes after strabismus surgery. We discuss two cases of operated strabismus surgery where AS-OCT imaging helped in identifying the operated eye and/or extra ocular muscles (EOM) and thus proved instrumental in planning and management. Case 1 A 45 years old orthotropic male presented with post traumatic left eye rhegmatogenous retinal detachment. He had history of strabismus surgery in the left eye in childhood for exotropia. He was planned for ...

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    22. Infrared autofluorescence, short-wave autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytomas

      Infrared autofluorescence, short-wave autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytomas

      AIM : To investigate the findings of infrared fundus autofluorescence (IR-AF) and spectral-domain optical coherence tomography (SD-OCT) in eyes with optic disc melanocytoma (ODM). METHODS : IR-AF findings and those of other ophthalmologic imaging examinations, including short-wave autofluorescence (SW-AF), fluorescein angiography (FA), fundus color photography, and SD-OCT of 8 eyes of 8 consecutive cases with ODM were assessed. RESULTS : The ODMs in all cases (100%) presented similar IR-AF, SW-AF, and FA findings. On IR-AF images, ODMs showed outstanding hyper-AF with well-defined outline. On SW-AF images, the area of ODMs presented as hypo-AF. FA images revealed the leaking retinal telangiectasia on the surface ...

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    23. Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion

      Choroidal thickness measurements with optical coherence tomography in branch retinal vein occlusion

      AIM : To evaluate central macular thickness (CMT) and mean choroidal thickness (MCT) in eyes with branch retinal vein occlusion (BRVO), before and after ranibizumab treatment using spectral domain-optical coherence tomography (SD-OCT). METHODS : Forty-two patients with unilateral BRVO and macular edema were included in this study. There were 25 men and 17 women. Using SD-OCT, choroidal thickness was measured at 500 ?m intervals up to 1500 ?m temporal and nasal to the fovea. MCT was calculated based on the average of the 7 locations. All the eyes with BRVO were treated with intravitreal ranibizumab (0.5 mg/0.05 mL). Comparisons ...

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    1-24 of 62 1 2 3 »
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