1. 1-24 of 77 1 2 3 4 »
    1. Diagnosis of lacrimal punctum lesions using optical coherence tomography: a preliminary study

      Diagnosis of lacrimal punctum lesions using optical coherence tomography: a preliminary study

      AIM : To study the imaging characteristics of lacrimal punctum lesion with optical coherence tomography (OCT), and provide imaging basis for the diagnosis and treatment of lacrimal punctum diseases. METHODS : A total of 25 patients (28 eyes) with epiphora and lacrimal puncta lesions were enrolled. Lacrimal puncta lesions included: punctum membrane obstruction in 7 cases (9 eyes), punctum agenesis in 1 case (1 eye), a mass protruded from the punctum in 1 case (1 eye), slit puncta in 1 case (1 eye), peri-puncta mass in 2 cases (2 eyes), chronic dacryocystitis in 4 cases (4 eyes), and primary puncta stenosis in ...

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    2. Comparison of choroidal thickness in high myopic eyes after FS-LASIK versus implantable collamer lens implantation with swept-source optical coherence tomography

      Comparison of choroidal thickness in high myopic eyes after FS-LASIK versus implantable collamer lens implantation with swept-source optical coherence tomography

      AIM : To investigate the changes in choroidal thickness (CT) in high myopic eyes after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) surgery or central hole implantable collamer lens (ICL V4c) implantation using swept-source optical coherence tomography (SS-OCT). METHODS : We examined the right eyes of 116 patients with high myopia who were candidates for FS-LASIK surgery and ICL implantation. Sixty eyes underwent ICL V4c implantation and 56 eyes were subjected to FS-LASIK surgery. The CT was measured with SS-OCT. All data were recorded preoperatively and 2h, 1wk, 1 and 3mo postoperatively. Other demographic information was collected, including age, sex, uncorrected visual acuity ...

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    3. Comment on “Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography”

      Comment on “Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography”

      Dear Editor, We enjoy reading the retrospectively study by Deng et al[1] which investigated microvascular changes in eyes with macular edema resulting from central retinal vein occlusion (CRVO) before and after intravitreal conbercept (Lumintin; Chengdu Kanghong Biotech Co, Ltd., China) injection and evaluated correlations between these changes, best-corrected visual acuity (BCVA), and retinal thickness. The authors concluded that optical coherence tomography angiography (OCTA) enables the non-invasive, layer-specific and quantitative assessment of microvasacular changes, and can be used to obtain quantitative data and more detailed information regarding the vascular network of the superficial capillary plexus (SCP) and deep retinal capillary ...

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    4. Intraoperative optical coherence tomography findings during surgery for optic disc pit-associated maculopathy

      Intraoperative optical coherence tomography findings during surgery for optic disc pit-associated maculopathy

      , We report our experience using a continuous intraoperative optical coherence tomography (OCT)-enabled microscope system for real-time anatomical evaluation of the optic pit during surgery in an 8-year-old girl who presented with symptomatic optic disc pit (ODP) maculopathy. ODP is an extremely rare congenital anomaly secondary to colobomatous malformation of the optic nerve head, with a reported incidence of 0.00009%[1]. Although patients are frequently asymptomatic, approximately 40%-50% of patients experience visual symptoms because of subretinal fluid (SRF) accumulation beneath the macula, manifesting as serous macular detachment or retinoschisis[1]. The pathogenesis, nature, and source of the fluid ...

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    5. Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography

      Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography

      AIM : To elucidate the changes of different ganglion cell layer (GCL) thinning patterns between the optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS : A prospective, observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography. RESULTS : Thinning on optical coherence tomography in the NAION group occurs as early as 11d after symptomatic onset of vision loss and follows an altitudinal pattern. The mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7 μm in the NAION cohort compared to controls of 0 ...

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    6. Effects of intravitreal conbercept before panretinal photocoagulation on lipid exudates in diabetic macular documented by optical coherence tomography

      Effects of intravitreal conbercept before panretinal photocoagulation on lipid exudates in diabetic macular documented by optical coherence tomography

      Aims: To evaluate the effects of intravitreal Conbercept (IVC) as adjunctive treatments before PRP to decrease hyperreflective dots (HRDs) in Chinese PDR patients. Methods: Fifty-nine enrolled patients were categorized into 2 groups: single dose IVC (0.5 mg/0.05 mL) 1wk before PRP (Plus group) or PRP only (PRP group). Six months later, we measured the best corrected visual acuity (BCVA), central macula thickness (CMT) by OCT and counted the number of HRDs in different retina layers. Results: The average CMT significantly decreased in Plus group but increased in PRP group. The average BCVA in the Plus group was ...

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    7. Widefield optical coherence tomography of foveal dragging in retinopathy of prematurity

      Widefield optical coherence tomography of foveal dragging in retinopathy of prematurity

      Dear Editor, Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge[1]. Visual acuity loss in patients with ROP has been associated with structural retinal abnormalities (including retinal detachment, retinal folds, and pigmentary retinopathy), cataract, glaucoma, and amblyopia due to refractive error or strabismus[2]. A subset of patients with ROP, either treated or untreated may develop temporal dragging of the fovea. The reported incidence of foveal dragging varies widely, but can be affected by retinal photocoagulation and the prematurity level of the infant. For example, a recent study reported an incidence ...

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    8. Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

      Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

      AIM : To investigate microvascular changes in eyes with central retinal vein occlusion (CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity (BCVA) and retinal thickness. METHODS : Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography (OCTA) automatic measurements of the vessel density in the superficial (SCP) and deep retinal capillary plexus (DCP), the foveal avascular zone (FAZ) area, the ...

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    9. Effects of chronic elevated intraocular pressure on parameters of optical coherence tomography in rhesus monkeys

      Effects of chronic elevated intraocular pressure on parameters of optical coherence tomography in rhesus monkeys

      AIM : To determine the progression of parameters from optical coherence tomography (OCT) in chronic elevated intraocular pressure (IOP) monkeys. METHODS : A chronic elevated IOP model of rhesus monkeys was induced by laser photocoagulation. Representative OCT parameters, including the average and four-quadrant retinal nerve fiber layer (RNFL) thickness, and parameters from optic nerve head (ONH) analysis were collected before and after laser treatments biweekly for up to 28wk. The performance of each parameter for early progression detection was analyzed. The progressive trends toward elevated IOP were analyzed using a linear mixed-effects model. RESULTS : There were 10 successfully maintained high IOP eyes ...

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    10. Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

      Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia

      AIM : To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness obtained by spectral-domain optical coherence tomography (SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma (PPG) from highly myopic healthy eyes. METHODS : A total of 254 eyes, including 76 normal controls (NC), 116 eyes with high myopia (HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic (AUROC) curve in two distinguishing groups: PPG eyes with non-glaucomatous eyes including NC and HM (Group 1), and PPG eyes with HM eyes ...

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    11. A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

      A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

      AIM : To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVueTM, AngioPlexTM, Spectralis® OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT AngioTM. METHODS : Twenty-seven undilated right eyes of 27 participants underwent OCTA examination using five different systems respectively for both 3×3 and 6×6 mm2 scan pattern (Spectralis OCTA for 3×3 mm2 scan only). Image quality, including vessel valid visibility and the number of motion artifacts, and acquisition time were evaluated. Repeated measures analysis of variance (ANOVA) with Bonferroni's post-test and Friedman test with Dunn's post-test were used to ...

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    12. Bimodal imaging of proliferative diabetic retinopathy vascular features using swept source optical coherence tomography angiography

      Bimodal imaging of proliferative diabetic retinopathy vascular features using swept source optical coherence tomography angiography

      AIM : To categorize neovessels morphology and to detect response to anti-angiogenic therapy by using structural and angiographic modes of swept source optical coherence tomography (SS-OCT). METHODS : Thirty-two eyes with neovessels at disc (NVD) and neovessels elsewhere (NVE) - as diagnosed by fluorescein angiography- were included. Cross sectional OCT images of disc and macular regions were registered to enface OCT angiography (OCTA), B-scan blood flow over lay and density maps. Three eyes received anti-angiogenic treatment. RESULTS : Pin point registration of cross-sectional OCT and OCTA images differentiated active NVD with vascular elements from fibrous or equivalent fibrovascular elements. En face images delineated NVE ...

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    13. Comparison of anterior segment optical coherence tomography findings in acanthamoeba keratitis and herpetic epithelial keratitis

      Comparison of anterior segment optical coherence tomography findings in acanthamoeba keratitis and herpetic epithelial keratitis

      This study is to investigate the characteristic features of Acanthamoeba keratitis (AK) that differentiating it from herpetic epithelial keratitis (HEK) using anterior segment optical coherence tomography (AS-OCT). Medical records of three eyes of each AK and herpetic keratitis who had AS-OCT examination were reviewed in this study. Slit-lamp biomicroscopy and AS-OCT was performed on the initial visit and on every follow-up visits in all patients. In all three AK cases, reflective bands in the corneal stroma that correspond to the area of radial keratoneuritis were observed. The depth of the reflective bands varied in each case. After AK treatment, slit-lamp ...

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    14. Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma

      Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma

      AIM : To analyze the diagnostic capabilities of peripapillary retinal nerve fiber layer (pRNFL) thickness and segmented inner macular layer (IML) thickness measured by spectral-domain optical coherence tomography for detection of early glaucoma. METHODS : Fifty-three patients with primary open angle glaucoma (POAG), 60 patients with normal tension glaucoma (NTG) and 32 normal control subjects were enrolled. Thicknesses of pRNFL, total macular layers (TML), and the IML, including macular RNFL (mRNFL) and macular ganglion cell layer (mGCL) were assessed. The areas under the receiver operating characteristic curves (AROC) were calculated to compare the diagnostic power of different parameters. RESULTS : There were no ...

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    15. Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology

      Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology

      AIM : To investigate choroidal thickness changes in the horizontal meridian after orthokeratology. METHODS : This is a prospective cross-sectional observed study. Subjects (n=30; 11.3±1.7y) with low-to-moderate myopia (-1.0 to -6.0 diopters), wore orthokeratology (Ortho-K) lenses for 3mo. Before and after Ortho-K, OCT scans were made through the fovea in the horizontal meridian. Choroid thickness around the fovea was acquired by custom software. The analyzed regions along the horizontal meridian were divided into 7 equal zones. Ocular parameters were measured by Lenstar LS 900 non-contact biometry. RESULTS : Only the right eye ocular parameters were analyzed in ...

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    16. Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography

      Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography

      AIM : To evaluate the ability of macular ganglion cell complex (GCC) thickness using Fourier domain optical coherence tomography (FD-OCT) to detect glaucoma in highly myopic eyes. METHODS : Cross-sectional study. A total of 114 participants, consecutively were enrolled. Macular GCC thickness and peripapillary retinal nerve fiber layer (RNFL) thickness were obtained with RTVue FD-OCT. Receiver operating characteristics curves were constructed for each measurement parameter, and areas under the curves (AUCs) were compared. RESULTS : Both the average GCC and average RNFL thickness showed negative correlations with axial length (rGCC=-0.404, P=0.001; rRNFL=-0.561, P<0.001). The largest ...

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    17. Comparison of choroidal vessel thickness in children and adult eyes by enhanced-depth imaging optical coherence tomography imaging

      Comparison of choroidal vessel thickness in children and adult eyes by enhanced-depth imaging optical coherence tomography imaging

      AIM : To evaluate choroidal thickness, medium choroidal vessel thickness (MCVT) and large choroidal vessel thickness (LCVT) in normal children and adult subjects. METHODS : Manual measurements of subfoveal choroidal thickness (SFCT), MCVT and LCVT at subfoveal and 750 μm nasal and temporal to fovea locations were completed on enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of normal children and adult subjects. RESULTS : Fifty adult and fifty-seven child subjects were included in the study (including 80 adult and 103 child eyes). Mean (±SD) SFCT of adult and children eyes in the study was 309.3±95.7 μm and 279.3±50 ...

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    18. The optic nerve head perfusion and its correlation with the macular blood perfusion in unilateral idiopathic macular hole: an optical coherence tomography angiography study

      The optic nerve head perfusion and its correlation with the macular blood perfusion in unilateral idiopathic macular hole: an optical coherence tomography angiography study

      AIM : To compare the optic nerve head (ONH) perfusion in both eyes of unilateral idiopathic macular hole (IMH) with normal control group by using optical coherence tomography angiography (OCTA) and investigate its correlationship with the macular blood perfusion. METHODS : We performed a prospective and cross-sectional study that included 19 patients with full-thickness unilateral IMH and 24 age- and sex-matched controls. All participants received OCTA test. The ONH perfusion was evaluated by the regions of peripapillary and whole en face (the sum of peripapillary and optic disc). The potential correlationship between ONH and parafovea were implied. All the data were performed ...

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    19. Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls

      Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls

      AIM : To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls. METHODS : This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3.0 D, up to -6.0 D) and high myopia (HM; SE greater than -6.0 D). The control group consisted of emmetropic (EM) patients ...

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    20. Optical coherence tomography angiography in retinal cavernous hemangioma

      Optical coherence tomography angiography in retinal cavernous hemangioma

      Cavernous hemangiomas of the retina are rare benign vascular tumors, commonly diagnosed in children and young adults. They are characterized by dilated blood vessels that form cavities or caverns through which the blood flow is very low or virtually absent [1] . Retinal lesions may be associated with cerebral hemangiomas [1] , which conversely, do not harbor any tissue within the malformation, the smooth muscle is impaired and there is no capsule surrounding the caverns. Cavernous hemangioma has also been associated with choroidal hemangioma [2] and ocular melanocytosis [3] . Retinal lesions vary in size and location, and generally follow the course of ...

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    21. Optical coherence tomography changes following vitrectomy for long standing premacular hemorrhage in Valsalva retinopathy

      Optical coherence tomography changes following vitrectomy for long standing premacular hemorrhage in Valsalva retinopathy

      Dear Editor, Premacular hemorrhage is a common cause of sudden profound visual loss in otherwise healthy eye. One of the commonest causes of premacular hemorrhage in clinical practice is Valsalva retinopathy, which was first described by Thomas Duane in 1972 [1] . In the setting of Valsalva retinopathy these hemorrhages are a result of ruptured perifoveal capillaries because of raised intravenous pressure of the eye. This happens when the raised intra-thoracic pressure due to Valsalva maneuver is transmitted to the ocular venous system because of valve-less nature of the later. While the exact location of these hemorrhages has been disputed, they ...

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    22. Optical coherence tomography with or without enhanced depth imaging for peripapillary retinal nerve fiber layer and choroidal thickness

      Optical coherence tomography with or without enhanced depth imaging for peripapillary retinal nerve fiber layer and choroidal thickness

      AIM : To assess peripapillary retinal nerve fiber layer (RNFL) and choroidal thickness obtained with enhanced depth imaging (EDI) mode compared with those obtained without EDI mode using Heidelberg Spectralis optical coherence tomography (OCT). METHODS : Fifty eyes of 25 normal healthy subjects and 32 eyes of 20 patients with different eye diseases were included in the study. All subjects underwent 3.4 mm diameter peripapillary circular OCT scan centered on the optic disc using both the conventional and the EDI OCT protocols. The visualization of RNFL and choroidoscleral junction was assessed using an ordinal scoring scale. The paired t-test, intraclass correlation ...

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    23. Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

      Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

      AIM : To investigate foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and to assess the reproducibility of FAZ and PRVD measurements. METHODS : Sixty diabetic patients (60 eyes) with different stage of DR (graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners. FAZ area in all patients was also assessed using fluorescein angiography (FA). RESULTS : In subject with proliferative DR and with moderate-severe non proliferative DR ...

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    24. Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

      Evaluation of the iridocorneal angle with accommodation using optical coherence tomography

      The changes in the iridocorneal angle structure during accommodation are assessed by means of anterior segment optical coherence tomography. Thirteen right eyes were included in the study. The device used for the measurement was the Visante® omni system. The stimuli were set up at different vergences (0.0 D, -1.5 D, and -3.0 D). The angle opening distance 500 and 750, the trabecular iris space area 500 and 750, and the scleral spur angle parameters were assessed at the nasal and temporal regions. The results in the iridotrabecular angle comparing the three accommodative states of the eye did ...

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