1. 49-72 of 78 « 1 2 3 4 »
    1. Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

      Importance Spectral-domain optical coherence tomography (SD-OCT) has an integral role in the diagnosis and treatment of glaucoma. Understanding the types of artifacts commonly seen in the imaging of patients being evaluated for glaucoma will help physicians better implement these data in the care of patients. Objectives To determine the frequency and distribution of SD-OCT imaging artifacts in patients being evaluated for glaucoma and to provide examples of common artifacts. Design, Setting, and Participants A retrospective cross-sectional study design was used to examine SD-OCT images (using Spectralis SD-OCT) of 277 consecutive patients who had a diagnosis of glaucoma of any stage ...

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    2. Spectral-Domain Optical Coherence Tomography Staging and Autofluorescence Imaging in Achromatopsia

      Spectral-Domain Optical Coherence Tomography Staging and Autofluorescence Imaging in Achromatopsia

      Importance Evidence is mounting that achromatopsia is a progressive retinal degeneration, and treatments for this condition are on the horizon. Objectives To categorize achromatopsia into clinically identifiable stages using spectral-domain optical coherence tomography and to describe fundus autofluorescence imaging in this condition. Design, Setting, and Participants A prospective observational study was performed between 2010 and 2012 at the Edward S. Harkness Eye Institute, New York-Presbyterian Hospital. Participants included 17 patients (aged 10-62 years) with full-field electroretinography-confirmed achromatopsia. Main Outcomes and Measures Spectral-domain optical coherence tomography features and staging system, fundus autofluorescence and near-infrared reflectance features and their correlation to optical ...

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    3. Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Handheld Optical Coherence Tomography During Sedation in Young Children With Optic Pathway Gliomas

      Importance Monitoring young children with optic pathway gliomas (OPGs) for visual deterioration can be difficult owing to age-related noncompliance. Optical coherence tomography (OCT) measures of retinal nerve fiber layer (RNFL) thickness have been proposed as a surrogate marker of vision but this technique is also limited by patient cooperation. Objective To determine whether measures of circumpapillary RNFL thickness, acquired with handheld OCT (HH-OCT) during sedation, can differentiate between young children with and without vision loss from OPGs. Design, Setting, and Participants This cross-sectional analysis of a prospective observational study was conducted at a tertiary-care children’s hospital. Children with an ...

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    4. Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography

      Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography

      Importance Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to the suprachoroidal layer (SCL). Objective To identify factors associated with the presence and thickness of the SCL in healthy participants and determine how different CSJ boundary definitions impact CT measurements. Design, Setting, and Participants Secondary analysis of EDI-OCT images obtained prospectively from 74 eyes of 74 controls (mean age, 68.6 years) from the Age-Related Eye Disease Study 2 Ancillary SDOCT Study. Main Outcomes and Measures The CSJ ...

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    5. Multimodal Imaging in Persistent Placoid Maculopathy

      Multimodal Imaging in Persistent Placoid Maculopathy

      Importance Persistent placoid maculopathy (PPM) is a rare clinical entity with features that superficially resemble acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and macular serpiginous choroidopathy. It is important to differentiate PPM from APMPPE because both conditions may appear similar at presentation. Objective To investigate the short-term and long-term retinal changes in patients with PPM using spectral domain optical coherence tomography (SD-OCT), indocyanine green angiography (ICG-A), fluorescein angiography (FA), and fundus autofluorescence (FAF). Design, Setting, and Participants We performed a retrospective medical record review in 5 patients diagnosed as having PPM at tertiary retinal practices. Main Outcomes and Measures Findings ...

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    6. Inner Macular Hyperreflectivity Demonstrated by Optical Coherence Tomography in Niemann-Pick Disease

      Inner Macular Hyperreflectivity Demonstrated by Optical Coherence Tomography in Niemann-Pick Disease

      We describe spectral-domain optical coherence tomography (OCT; Heidelberg Spectralis) imaging of 3 patients with Niemann-Pick disease type B. This expands the range of previously reported anatomical correlates of the ophthalmoscopic macular halo surrounding the “cherry-red spot.”

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    7. Sclerochoroidal Calcification Is Primarily a Scleral Condition Based on Enhanced Depth Imaging Optical Coherence Tomography

      Sclerochoroidal Calcification Is Primarily a Scleral Condition Based on Enhanced Depth Imaging Optical Coherence Tomography

      Sclerochoroidal calcification (SC) is found in elderly white individuals with calcium pyrophosphate deposition in the sclera and/or choroid, appearing as a typical yellow subretinal mass usually along the retinal vascular arcades. 1 - 4 Most cases are idiopathic, but some have a systemic relationship. 1 - 2 We review multimodal imaging findings of SC.

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    8. Analysis of Morphological Features and Vascular Layers of Choroid in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Analysis of Morphological Features and Vascular Layers of Choroid in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Importance Diabetic retinopathy (DR) is characterized by microaneurysms, capillary nonperfusion, and ischemia within the retina, ultimately leading to neovascularization and/or macular edema. Evidence suggests that choroidal angiopathy may coexist with retinal vascular damage. Recent advances in spectral-domain optical coherence tomography (SD-OCT) permit an efficient visualization of the choroid. Objective To analyze the morphological features and vascular layers of the choroid in patients with DR using SD-OCT. Design A cross-sectional retrospective review identified patients with DR and healthy (control) subjects who underwent 1-line raster scanning from February 1, 2010, through June 30, 2012. Patients were classified into the following 3 ...

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    9. Spectral-Domain Optical Coherence Tomography Measures of Outer Segment Layer Progression in Patients With X-Linked Retinitis Pigmentosa

      Spectral-Domain Optical Coherence Tomography Measures of Outer Segment Layer Progression in Patients With X-Linked Retinitis Pigmentosa

      Importance Determining the annual rate of change in the width of the inner segment ellipsoid zone (EZ; ie, inner/outer segment border) in the context of short-term variability should allow us to better understand the value of this measure for future treatment trials in X-linked retinitis pigmentosa (XLRP). Objectives To identify the width of the central region showing an EZ and to determine the short-term repeat variability and the annual rate of change in the width of the EZ from spectral-domain optical coherence tomography (SD-OCT) measures in RP. Design Patients with recessive or simplex RP (age range, 8-65 years; mean ...

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    10. Optimizing Descemet Membrane Endothelial Keratoplasty Using Intraoperative Optical Coherence Tomography

      Optimizing Descemet Membrane Endothelial Keratoplasty Using Intraoperative Optical Coherence Tomography

      Importance Descemet membrane endothelial keratoplasty (DMEK) is a challenging procedure for the surgeon, particularly because of deficient visibility of the delicate tissue due to the natural en face view through the operating microscope. A cross-sectional view would greatly enhance intraoperative overview and enable the surgeon to better control the procedure. Objective To retrospectively analyze the use of intraoperative optical coherence tomography (iOCT) for improving the safety of DMEK. Design Intraoperative OCT during DMEK was performed in 26 eyes of 26 patients. We retrospectively analyzed imaging and video data. Setting Department of Ophthalmology, University of Cologne. Participants Seven men and 19 ...

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    11. Interval Spectral-Domain Optical Coherence Tomography and Electrophysiology Findings in Neonatal Adrenoleukodystrophy

      Interval Spectral-Domain Optical Coherence Tomography and Electrophysiology Findings in Neonatal Adrenoleukodystrophy

      A 20-month-old boy was referred for examination following a diagnosis of neonatal adrenoleukodystrophy (NALD). He initially presented with delayed developmental milestones, hypotonia, and macrocephaly with a large anterior fontanelle. Pregnancy was uncomplicated; there was no related family history. Laboratory studies showed elevated very long-chain fatty acid and phytanic acid levels, and cultured skin fibroblast complementation analysis confirmed the diagnosis of NALD.

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    12. Characteristics of myelinated retinal nerve fiber layer in ophthalmic imaging: findings on autofluorescence, fluorescein angiographic, infrared, optical coherence tomographic, and red-free images

      Characteristics of myelinated retinal nerve fiber layer in ophthalmic imaging: findings on autofluorescence, fluorescein angiographic, infrared, optical coherence tomographic, and red-free images

      Myelinated retinal nerve fiber layers (RNFLs) are relatively common and generally benign. They appear as white, sharply demarcated patches on the surface of the retina that obscure the underlying retinal vessels. They have frayed or feathered borders that correspond in shape and distribution to ganglion cell axons. Myelination of the RNFL is often congenital but can be acquired or even progress in childhood or adolescence.1 Also, partial or total regression of the myelinated RNFL has been observed after injury to the optic nerve

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    13. Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography

      Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography

      A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses low-coherence interferometry of light to examine the retina in vivo on a micrometer scale. 1 Recent advances in spectral-domain OCT make visualization of the choroid feasible. Using image averaging and enhanced depth imaging, successful examination and measurement of choroidal thickness in normal and pathologic states have been reported

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    14. Characterization of Birdshot Chorioretinopathy Using Extramacular Enhanced Depth Optical Coherence Tomography

      Characterization of Birdshot Chorioretinopathy Using Extramacular Enhanced Depth Optical Coherence Tomography

      Objective To combine “extramacular” and “enhanced depth” optical coherence tomographic (OCT) scanning protocols to facilitate enhanced characterization of patients with birdshot chorioretinopathy. Methods Spectral-domain OCT images were prospectively collected from 24 eyes of 12 patients with birdshot chorioretinopathy. The images were acquired both from the macula and from 4 peripheral locations: superior and inferior to the temporal vascular arcades, nasal to the optic disc, and temporal to the macula. All images were obtained using enhanced depth scanning protocols. Qualitative and quantitative assessments were performed and compared with those from healthy, age-matched controls. Results Generalized loss of the photoreceptor inner segment ...

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    15. Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy

      Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy

      Objective To evaluate changes in the speed of pupil constriction and in anterior segment parameters after laser peripheral iridotomy (LPI) in patients with angle closure using anterior segment optical coherence tomography. Methods In this prospective observational study, videos of pupil and anterior segment changes in response to illumination were captured with real-time video recording using anterior segment optical coherence tomography and were analyzed frame by frame before and after LPI. Customized software was used to measure the speed of pupil constriction and changes in anterior chamber depth and anterior chamber area, as well as iris thickness at 750 μm from ...

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    16. Long-term Follow-up of Outer Retinal Tubulation Documented by Eye-Tracked and En Face Spectral-Domain Optical Coherence Tomography

      Long-term Follow-up of Outer Retinal Tubulation Documented by Eye-Tracked and En Face Spectral-Domain Optical Coherence Tomography

      Outer retinal tubulation (ORT) is a rearrangement of the photoreceptor layer in response to retinal injury. 1 - 2 Seen clinically with spectral-domain optical coherence tomography (SD-OCT) and confirmed on histopathologic sections, these rosette-like structures occur in a variety of retinal disorders characterized by photoreceptor disruption. 2 - 5 On SD-OCT, ORT appears as round or ovoid hyporeflective structures with hyperreflective margins. The margins are believed to represent the inner segment–outer segment junction of the photoreceptor cells or the ellipsoid portion of the photoreceptor inner segment. 6 These tubules often contain hyperreflective material thought to represent deranged photoreceptor outer segments. 1 ...

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    17. Spectral-Domain Optical Coherence Tomography of White Dot Fovea

      Spectral-Domain Optical Coherence Tomography of White Dot Fovea

      White dot fovea is thought to be a benign condition and was originally recognized in 1997 by Yokotsuka and associates. 1 It is characterized by the appearance of multiple tiny, white dots on the surface of the foveola that typically are arranged in a ringlike pattern at the foveal margin; the appearance can simulate a macular hole. In that early report, nearly all (28 of 30) cases described were bilateral, and all patients were Japanese. Fekrat and Humayun 2 also identified the same condition in an African American patient with an asymptomatic, single, ringlike, white macular lesion in the right ...

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    18. Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy

      Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy

      Optical coherence tomography (OCT) has been developed to objectively evaluate structural damage in vivo. The tool can be used to evaluate damage to the circumpapillary retinal nerve fiber layer (cpRNFL). Measurements of the cpRNFL play an important role in the diagnosis and management of patients with glaucoma. The recent introduction of spectral-domain OCT has enhanced the scan resolution and provides more reproducibility for image acquisition compared with time-domain OCT, a previous version of OCT. Furthermore, the RTVue (Optovue Inc), one of the spectral-domain OCT instruments, allows us to evaluate inner retinal layer thickness. Reference to the ganglion cell complex (GCC ...

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    19. Spectral-Domain Optical Coherence Tomographic Characteristics of Autosomal Recessive Isolated Foveal Hypoplasia

      Spectral-Domain Optical Coherence Tomographic Characteristics of Autosomal Recessive Isolated Foveal Hypoplasia

      Foveal hypoplasia, also referred to as foveal planum, is a congential condition that can be associated with other ocular abnormalities such as aniridia, albinism, microphthalmos, and achromatopsia. 1 Isolated foveal hypoplasia (IFH) is an even rarer disorder, with similar clinical findings in the fovea. The characteristic findings of patients with IFH are nystagmus, poor visual acuity, absent or abnormal maculofoveal reflexes on ophthalmoscopy, and variable and incomplete filtering of the choroidal fluorescence in the macular area on fluorescein angiography. No single hereditary pattern has been established for patients with IFH. Reported cases include patients with autosomal dominant and autosomal recessive ...

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    20. Evaluation of Normal Human Foveal Development Using Optical Coherence Tomography and Histologic Examination

      Evaluation of Normal Human Foveal Development Using Optical Coherence Tomography and Histologic Examination

      Objective To assess outer retinal layer maturation during late gestation and early postnatal life using optical coherence tomography and histologic examination. Methods Thirty-nine participants 30 weeks' postmenstrual age or older were imaged using a handheld optical coherence tomography system, for a total of 102 imaging sessions. Foveal images from 16 participants (21 imaging sessions) were normal and evaluated for inner retinal excavation and the presence of outer retinal reflective bands. Reflectivity profiles of central, parafoveal, and parafoveal retina were extracted and were compared with age-matched histologic sections. Results The foveal pit morphologic structure in infants was generally distinguishable from that ...

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    21. Progression of an acquired vitelliform lesion to a full-thickness macular hole documented by eye-tracked spectral-domain optical coherence tomography

      Progression of an acquired vitelliform lesion to a full-thickness macular hole documented by eye-tracked spectral-domain optical coherence tomography

      Vitelliform lesions (VLs), classically seen in young patients in autosomal dominant Best disease, are also seen as acquired lesions in entities such as adult-onset foveomacular vitelliform dystrophy, cuticular drusen, and central serous chorioretinopathy. These lesions appear as round yellowish deposits of material exhibiting hyperautofluorescence with fundus autofluorescence imaging. Spectral-domain optical coherence tomography (SD-OCT) shows hyperreflective material in the subretinal space, often with focal thickening at the level of the retinal pigment epithelium.1 The natural course of these lesions is often a gradual reduction in lesion size with fragmentation and resorption of the vitelliform material and eventual photoreceptor disruption and ...

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    22. Optical Coherence Tomographic Imaging of Sub-Retinal Pigment Epithelium Lipid

      Optical Coherence Tomographic Imaging of Sub-Retinal Pigment Epithelium Lipid

      Objective To describe an optical coherence tomographic finding of layered hyperreflective bands beneath the retinal pigment epithelium (RPE), the so-called onion sign believed to represent lipid within a vascularized pigment epithelial detachment. Methods This retrospective observational case series involved reviewing clinical histories of patients with the onion sign. Imaging studies analyzed included spectral-domain optical coherence tomography, color and red-free photographs, near infrared reflectance, fundus autofluorescence, and blue-light fundus autofluorescence. Results A total of 22 eyes of 20 patients with sub-RPE hyperreflective bands were identified. There were 15 women and 5 men with a mean patient age of 76 years (range ...

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    23. Anterior segment spectral-domain optical coherence tomography findings in cystinosis

      Anterior segment spectral-domain optical coherence tomography findings in cystinosis

      A 45-year-old woman was referred for a 10-year history of blurry vision and photophobia. Slitlamp examination showed bilateral corneal deposits (Figure, A and B). Best-corrected visual acuity was 20/25 in both eyes. Spectral-domain optical coherence tomography with an anterior segment module revealed hyperreflective deposits disseminated in the corneal stroma and endothelium that might correspond to cystine crystals (Figure, C). Systemic workup findings (kidney, thyroid, and liver) were negative. To our knowledge, this is the first report of spectral-domain optical coherence tomography performed in cystinosis

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    24. Effect of Peripapillary Vitreous Opacity on Retinal Nerve Fiber Layer Thickness Measurement Using Optical Coherence Tomography

      Effect of Peripapillary Vitreous Opacity on Retinal Nerve Fiber Layer Thickness Measurement Using Optical Coherence Tomography

      Optical coherence tomography (OCT) is a widely used technique for the measurement of retinal nerve fiber layer (RNFL) thickness. It emits a light from the light source to the retina or reference mirror and measures RNFL thickness by detecting the different reflectivities of retinal structures.1 Therefore, any media opacity in the cornea, lens, or vitreous body can affect OCT measurement. However, little is known about the effect of vitreous opacity on RNFL thickness measurement. Vitreous opacity associated with age-related posterior vitreous detachment is a commonly found abnormality.2 - 3 In aged eyes with posterior vitreous detachment, a vitreous opacity ...

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    49-72 of 78 « 1 2 3 4 »
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