1. 25-48 of 78 « 1 2 3 4 »
    1. Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

      Importance New methods are needed to compare peripapillary retinal nerve fiber layer thickness (pRNFLT) measurements taken from time-domain optical coherence tomography (TD-OCT) and spectral-domain OCT (SD-OCT). Objective To compare the agreement of measured and predicted pRNFLT using different equations based on pRNFLT measurements obtained by TD-OCT and SD-OCT. Design, Setting, and Participants Cross-sectional single-center study that took place at the Department of Ophthalmology, University of Erlangen–Nuremberg from November 16, 2005, to June 3, 2015, and included 138 eyes of control participants, 126 eyes of patients with ocular hypertension, 128 eyes of patients with preperimetric glaucoma, and 160 eyes of ...

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    2. Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Determination of Feasibility and Utility of Microscope-Integrated Optical Coherence Tomography During Ophthalmic Surgery The DISCOVER Study RESCAN Results

      Importance Optical coherence tomography (OCT) has transformed the clinical management of a myriad of ophthalmic conditions. Applying OCT to ophthalmic surgery may have implications for surgical decision making and patient outcomes. Objective To assess the feasibility and effect on surgical decision making of a microscope-integrated intraoperative OCT (iOCT) system. Design, Setting, and Participants Report highlighting the 1-year results (March 2014–February 2015) of the RESCAN 700 portion of the DISCOVER (Determination of Feasibility of Intraoperative Spectral Domain Microscope Combined/Integrated OCT Visualization During En Face Retinal and Ophthalmic Surgery) study, a single-site, multisurgeon, prospective consecutive case series regarding this investigational ...

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    3. Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      Intraoperative Optical Coherence Tomography Ocular Surgery on a Higher Level or Just Nice Pictures?

      In recent years, optical coherence tomography (OCT) has developed into one of the most important imaging techniques in ophthalmology. Nonetheless, this technology is still evolving rapidly as recent developments in multimodal swept-source OCT devices and 4-dimensional real-time OCT demonstrate. Another currently developing sector in OCT application is the intraoperative use of OCT technology. Several approaches have been used to transfer OCT into an intraoperative setting, beginning with OCT-compatible positioning of the anesthetized patient 1 and handheld OCT devices. 2

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    4. Association of Diabetic Macular Nonperfusion With Outer Retinal Disruption on Optical Coherence Tomography

      Association of Diabetic Macular Nonperfusion With Outer Retinal Disruption on Optical Coherence Tomography

      Importance Diabetic macular nonperfusion leads to decreased perifoveal capillary blood flow, which in turn causes chronic ischemia of the retinal tissue. Using point-to-point correlation between spectral-domain optical coherence tomography (SD-OCT) and nonperfusion on fluorescein angiography, we observed that retinal capillary nonperfusion is associated with photoreceptor compromise on OCT. This study highlights a new concept of a possible contribution of the retinal deep capillary plexus to photoreceptor compromise in diabetic retinopathy in the absence of diabetic macular edema. Objective To report outer retinal structural changes associated with enlargement of the foveal avascular zone and/or capillary nonperfusion in the macular area ...

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    5. Silicone Oil Confined Within a Lamellar Macular Hole as Demonstrated by En Face Swept Source Optical Coherence Tomography

      Silicone Oil Confined Within a Lamellar Macular Hole as Demonstrated by En Face Swept Source Optical Coherence Tomography

      A man in his early 60s with pathologic myopia had undergone multiple procedures, including vitrectomy and cataract surgery, on the left eye for a rhegmatogenous retinal detachment 2 years previously. He subsequently had received multiple intravitreous ranibizumab injections to the left eye for myopic choroidal neovascularization. Best-corrected visual acuities were 20/40 OD and 20/200 OS. Multimodal imaging revealed emulsified silicone oil forming a meniscus in the fovea of the left eye ( Figure , A). En face imaging with swept source optical coherence tomography demonstrated the confinement of the hyperoleon within a lamellar macular hole ( Figure , B).

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    6. Sequential Optical Coherence Tomographic Angiography for Diagnosis and Treatment of Choroidal Neovascularization in Multifocal Choroiditis

      Sequential Optical Coherence Tomographic Angiography for Diagnosis and Treatment of Choroidal Neovascularization in Multifocal Choroiditis

      This case report describes choroidal neovascularization in multifocal choroiditis diagnosed using optical coherence tomographic angiography. Accurate diagnosis of choroidal neovascularization (CNV) is critical to ensure timely anti–vascular endothelial growth factor therapy and preclude loss of visual acuity. Dye-based angiography is the gold standard for CNV diagnosis; however, it is invasive, is associated with risk of allergy, and may be limited by availability. Optical coherence tomography (OCT) angiography (OCTA) is a noninvasive, non–dye-based modality that generates en face images (OCT angiograms) of retinal and choroidal vascular layers. 1 - 4 This is one of the first reports, to our knowledge ...

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    7. En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema

      En Face Optical Coherence Tomography of Outer Retinal Discontinuity and Fan-Shaped Serous Macular Detachment in Diabetic Macular Edema

      This case report describes en face optical coherence tomographic imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. We report en face optical coherence tomographic (OCT) imaging of serous macular detachment secondary to retinal microangiopathy in a patient with diabetic retinopathy and macular edema. The en face OCT clearly delineated a fan shape of the detachment. Our findings implicate an outer retinal discontinuity as the site through which fluid may have entered the subretinal space.

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    8. JAMA Ophthalmology | A Promising Future for Optical Coherence Tomography Angiography

      JAMA Ophthalmology | A Promising Future for Optical Coherence Tomography Angiography

      This Viewpoint reports on optical coherence tomography angiography and how its use could greatly enrich our understanding of the ischemic processes affecting different layers of the retinal vasculature. Fluorescein angiography has been the gold standard imaging modality for the retinal vasculature since its groundbreaking introduction in 1961 by Alvis and Novotny and has revolutionized our ability to diagnose diseases of the retinal vasculature and to identify retinal and choroidal neovascularization. 1 Its greatest advantage may lie in its ability to detect dynamic patterns of dye transit and leakage. Various innovations have broadened the use of angiography, including the application of ...

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    9. Association of Choroidal Neovascularization and Central Serous Chorioretinopathy With Optical Coherence Tomography Angiography

      Association of Choroidal Neovascularization and Central Serous Chorioretinopathy With Optical Coherence Tomography Angiography

      Importance Choroidal neovascularization (CNV) is a major cause of vision loss in chronic central serous chorioretinopathy (CSCR). Detecting CNV using fluorescein angiography (FA) may be challenging owing to the coexistence of features related to the primary diagnosis of CSCR. Optical coherence tomography angiography (OCTA) allows noninvasive visualization of retinal and choroidal vasculature via motion contrast and may contribute to the unequivocal diagnosis of CNV in this population. Objective To evaluate the sensitivity of spectral-domain OCTA in detecting CNV associated with chronic CSCR. Design, Setting, and Participants Observational cross-sectional study including 23 patients (27 eyes) who presented at the New England ...

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    10. A Promising Future for Optical Coherence Tomography Angiography

      A Promising Future for Optical Coherence Tomography Angiography

      This Viewpoint reports on optical coherence tomography angiography and how its use could greatly enrich our understanding of the ischemic processes affecting different layers of the retinal vasculature. Fluorescein angiography has been the gold standard imaging modality for the retinal vasculature since its groundbreaking introduction in 1961 by Alvis and Novotny and has revolutionized our ability to diagnose diseases of the retinal vasculature and to identify retinal and choroidal neovascularization. 1 Its greatest advantage may lie in its ability to detect dynamic patterns of dye transit and leakage. Various innovations have broadened the use of angiography, including the application of ...

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    11. Enhanced Depth Imaging–Optical Coherence Tomography of Choroidal Osteom

      Enhanced Depth Imaging–Optical Coherence Tomography of Choroidal Osteom

      Color photograph (A) and near-infrared image (B) of the left macula of a 46-year-old asymptomatic emmetropic woman demonstrates an orange calcified choroidal osteoma (best-corrected visual acuity, 6/4.8 OU; the green arrow indicates the raster line that the optical coherence tomographic scan was taken from, with the arrowhead indicating that the right side of the scan is temporal). C, Enhanced depth imaging–optical coherence tomography shows a spongelike choroidal tumor with focal choroidal excavation.

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    12. Sequential En Face Spectral-Domain Optical Coherence Tomographic Analysis of Macular Hole Formation

      Sequential En Face Spectral-Domain Optical Coherence Tomographic Analysis of Macular Hole Formation

      Idiopathic macular hole is a condition widely believed to result from disruption of retinal tissue due to anteroposterior vitreofoveal traction. 1 Previous reports have used spectral-domain optical coherence tomography (SD-OCT) to demonstrate cross-sectional images of macular hole formation in the setting of vitreomacular traction. 1 - 3 Herein, we present sequential en face SD-OCT analysis of an evolving macular hole to attempt to elucidate its pathogenesis.

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      Mentions: Brandon J. Lujan
    13. Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

      Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

      Importance Differences in ocular anatomy may contribute to ethnic differences in glaucoma risk. Because the trabecular meshwork (TM) plays an important role in aqueous outflow, its anatomy in relation to at-risk populations may provide insight into a potential contributor to elevated intraocular pressure and thus to probability of glaucoma development. Objective To investigate whether differences exist in TM height between ethnic groups. Design, Setting, and Participants This prospective study took place from January 1, 2012, to December 31, 2013. Adult patients who self-reported as being of white, Asian, Hispanic, or African American ethnicity were recruited from ophthalmology clinics at the ...

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    14. Choroidal Hyperreflective Foci in Stargardt Disease Shown by Spectral-Domain Optical Coherence Tomography Imaging Correlation With Disease Severity

      Choroidal Hyperreflective Foci in Stargardt Disease Shown by Spectral-Domain Optical Coherence Tomography Imaging Correlation With Disease Severity

      Importance The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process. Objectives To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomography (SD-OCT) images from eyes with Stargardt disease and investigate the relationship between the number of hyperreflective foci and disease severity. Design, Setting, and Participants Twenty-six eyes of 13 patients with a clinical diagnosis of Stargardt disease were evaluated in a retrospective case series. Patient data were collected between January 1, 2009, and August 31, 2014 ...

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    15. Filtering Blebs Using 3-Dimensional Anterior-Segment Optical Coherence Tomography: A Prospective Investigation

      Filtering Blebs Using 3-Dimensional Anterior-Segment Optical Coherence Tomography: A Prospective Investigation

      Importance Posttrabeculectomy changes in bleb parameters measured using 3-dimensional (3-D) anterior-segment optical coherence tomography (OCT) remain uncharacterized and might be related to postsurgical intraocular-pressure (IOP) control. Objective To evaluate time-dependent posttrabeculectomy changes in filtering bleb parameters using 3-D anterior-segment OCT. Design, Setting, and Participants This prospective observational study was conducted at Kumamoto University Hospital, Kumamoto, Japan. Patients with open-angle glaucoma who underwent uncombined fornix-based trabeculectomy at Kumamoto University Hospital between January 1, 2012, and October 31, 2012, were included. Twenty-nine eyes were enrolled, 23 of which were followed up for 1 year without additional glaucoma surgical procedures; 3 required additional ...

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    16. Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography

      Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography

      Importance The retinal vasculature is involved in many ocular diseases that cause visual loss. Although fluorescein angiography is the criterion standard for evaluating the retina vasculature, it has risks of adverse effects and known defects in imaging all the layers of the retinal vasculature. Optical coherence tomography (OCT) angiography can image vessels based on flow characteristics and may provide improved information. Objective To investigate the ability of OCT angiography to image the vascular layers within the retina compared with conventional fluorescein angiography. Design, Setting, and Participants In this study, performed from March 14, 2014, through June 24, 2014, a total ...

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    17. Retinal Vascular Layers in Macular Telangiectasia Type 2 Imaged by Optical Coherence Tomographic Angiography

      Retinal Vascular Layers in Macular Telangiectasia Type 2 Imaged by Optical Coherence Tomographic Angiography

      Importance Macular telangiectasia type 2 (MacTel 2) is a rare disease in which abnormalities of the retinal vasculature play a key role. The vascular abnormalities are typically evaluated using fluorescein angiography, a modality with known defects in imaging the deeper layers of the retinal vasculature. Angiography based on optical coherence tomography can image vessels based on flow characteristics without dye injection and may provide improved information concerning the pathophysiology of MacTel 2. Objective To investigate MacTel 2 using optical coherence tomographic angiography. Design, Setting, and Participants Fourteen eyes of 7 patients with MacTel 2 were analyzed in a community-based retina ...

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    18. Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography

      Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography

      Importance The retinal vasculature is involved in many ocular diseases that cause visual loss. Although fluorescein angiography is the criterion standard for evaluating the retina vasculature, it has risks of adverse effects and known defects in imaging all the layers of the retinal vasculature. Optical coherence tomography (OCT) angiography can image vessels based on flow characteristics and may provide improved information. Objective To investigate the ability of OCT angiography to image the vascular layers within the retina compared with conventional fluorescein angiography. Design, Setting, and Participants In this study, performed from March 14, 2014, through June 24, 2014, a total ...

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    19. Optical Coherence Tomography of a Cystic Retinal Tuft

      Optical Coherence Tomography of a Cystic Retinal Tuft

      Cystic retinal tuft (CRT) is a developmental vitreoretinal abnormality found in 5% of autopsy eyes. Clinical examination reveals a focal, elevated gliotic lesion in the peripheral retina associated with vitreous traction (Figure, A and B). Histopathological analysis demonstrates a dome-shaped area with internal microcysts, glial cell proliferation, outer retinal degeneration, and photoreceptor loss.

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    20. Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

      Importance Understanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings. Objective To evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert retinal thickness measurements from SD-OCT to equivalent values on TD-OCT. Design, Setting, and Participants A cross-sectional observational study was conducted in private and institutional practices. Persons with diabetes mellitus who had at least 1 eye with central-involved diabetic macular ...

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    21. Enhanced Vitreous Imaging Technique With Spectral-Domain Optical Coherence Tomography for Evaluation of Posterior Vitreous Detachment

      Enhanced Vitreous Imaging Technique With Spectral-Domain Optical Coherence Tomography for Evaluation of Posterior Vitreous Detachment

      Vitreous degeneration, gradual separation of the posterior vitreous cortex (PVC), and eventual development of posterior vitreous detachment (PVD) are important in vitreoretinal interface diseases. However, determination of the stages of PVD with biomicroscopy or ultrasonography is not sufficiently sensitive and specific. 1 , 2 Since the advent of spectral-domain (SD) optical coherence tomography (OCT), PVD detection has improved and new concepts regarding the evolution of PVD have emerged. 2 , 3 However, SD-OCT remains underused, possibly owing to general low awareness of its potential to image the vitreoretinal interface and the vitreous itself. 4 , 5 We aim to demonstrate the usefulness of ...

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    22. Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy

      Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy

      Importance Birdshot chorioretinopathy (BCR) is a bilateral posterior uveitis that typically requires aggressive therapy to prevent loss of vision. Clinical signs of disease activity may be subtle and visual acuity is often preserved despite significant loss of visual function. Optical coherence tomography with enhanced depth imaging (OCT-EDI), a new technology that allows visualization of structures posterior to the retinal pigment epithelium, may be a useful tool to monitor disease activity in these patients. Objective To determine the correlation between symptoms and signs of disease activity in BCR and specific findings on OCT-EDI. Design, Setting, and Participants Retrospective medical record review ...

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    23. Vision Loss After Intravitreal Ocriplasmin Correlation of Spectral-Domain Optical Coherence Tomography and Electroretinography

      Vision Loss After Intravitreal Ocriplasmin Correlation of Spectral-Domain Optical Coherence Tomography and Electroretinography

      Importance Clinical trials indicate that visual impairment is significantly greater in patients receiving ocriplasmin than placebo. The mechanism of this symptom has not been explained. We report a patient with persistent darkening of her vision after intravitreal ocriplasmin and describe ancillary testing findings that may yield insights into the effects of ocriplasmin and the cause of this symptom. Observations We describe a 71-year-old woman with symptomatic vitreomacular traction who received intravitreal ocriplasmin and experienced darkening of vision in dim illumination for 4 months, despite improvement in visual acuity and release of symptomatic vitreomacular traction. We demonstrate that disruption of photoreceptor ...

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    25-48 of 78 « 1 2 3 4 »
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