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    1. Optical Coherence Tomographic Angiography in Acute Macular Neuroretinopathy

      Optical Coherence Tomographic Angiography in Acute Macular Neuroretinopathy

      Importance Acute macular neuroretinopathy (AMN) is a rare, yet increasingly recognized, entity identified predominantly in young healthy females with acute onset of paracentral scotomas. The exact pathophysiology is unknown but an underlying vascular process is suspected. This study used optical coherence tomographic angiography (OCTA) to assess for any evidence of vascular flow abnormality in the retina or choroid in this elusive disease. Observations Three eyes from 2 young female patients with classic features of AMN are presented. Multimodal imaging testing, including near-infrared reflectance, spectral-domain OCT, and OCTA (Carl Zeiss Meditec), were performed. Near-infrared reflectance identified typical hyporeflective tear-drop parafoveal lesions ...

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    2. Demonstration of Choroidal Neovascularization Associated With an Intraretinal Lesion on Indocyanine Green Angiography Independent of Choroidal New Vessel on Optical Coherence Tomography

      Demonstration of Choroidal Neovascularization Associated With an Intraretinal Lesion on Indocyanine Green Angiography Independent of Choroidal New Vessel on Optical Coherence Tomography

      This case report describes woman in her late 70s with decreased visual acuity in the right eye, which on imaging showed leakage at the level of the inner retina due to an intraretinal vascular complex and, separately, choroidal neovascularization under the retinal pigment epithelium. A woman in her late 70s presented with decreased visual acuity in her right eye. Imaging showed leakage at the level of the inner retina ( Figure , A) due to an intraretinal vascular complex and, separately, choroidal neovascularization under the retinal pigment epithelium. The choroidal new vessel was visualized on optical coherence tomography ( Figure , B) and was ...

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    3. Optical Coherence Tomography in High Myopia

      Optical Coherence Tomography in High Myopia

      Optical coherence tomography (OCT) is a precise technology that can be used for interrogating tissue structure and function noninvasively, painlessly, and quickly using near-infrared light. At its inception, OCT was typically a tool for assessing tissue thickness. Time-domain OCT is fast enough to scan a circle centered on the optic nerve head (circumpapillary) to assess retinal nerve fiber layer (RNFL) thickness. With the development of spectral-domain OCT, volumetric (3-dimensional) scanning becomes feasible.

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    4. Estimating Retinal Blood Flow Velocities by Optical Coherence Tomography

      Estimating Retinal Blood Flow Velocities by Optical Coherence Tomography

      Importance While optical coherence tomography (OCT) angiography has been considered to evaluate retinal capillary blood flow instead of fluorescein angiography, the reflectance pattern of blood vessels on structural OCT might also provide retinal capillary flow data in the absence of fluorescein angiography. This potential has been insufficiently explored, despite promising data concerning a possible relationship between the reflectance pattern of blood vessels and their perfusion velocity in a laboratory setting. Objective To evaluate the potential of retinal blood flow velocity estimation by structural OCT. Design, Setting, and Participants Cross-sectional observational study conducted from June to November 2015 at a tertiary ...

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    5. Optical Coherence Tomography in High Myopia

      Optical Coherence Tomography in High Myopia

      Optical coherence tomography (OCT) is a precise technology that can be used for interrogating tissue structure and function noninvasively, painlessly, and quickly using near-infrared light. At its inception, OCT was typically a tool for assessing tissue thickness. Time-domain OCT is fast enough to scan a circle centered on the optic nerve head (circumpapillary) to assess retinal nerve fiber layer (RNFL) thickness. With the development of spectral-domain OCT, volumetric (3-dimensional) scanning becomes feasible.

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    6. Phase-Variance Optical Coherence Tomographic Angiography Imaging of Choroidal Perfusion Changes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      Phase-Variance Optical Coherence Tomographic Angiography Imaging of Choroidal Perfusion Changes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      This case report uses phase-variance optical coherence tomographic angiography to demonstrate transient inner choroidal flow changes associated with acute posterior multifocal placoid pigment epitheliopathy. Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is characterized by bilateral multiple placoid white-gray lesions of the posterior pole at the level of the retinal pigment epithelium (RPE) and/or choriocapillaris, which self-resolve with recovery of vision. 1 , 2 The etiology is unknown, but APMPPE has been associated with viral prodromes and vasculitis. The placoid lesions are thought to represent focal RPE inflammation or choriocapillaris ischemia based on fluorescein angiogram findings of early hypofluorescence and late ...

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    7. Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography

      Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography

      Importance Progressive geographic atrophy (GA) of the retinal pigment epithelium leads to loss of central vision. To identify GA in age-related macular degeneration and assess treatment, correlation of function observed on microperimetry with structure observed on optical coherence tomographic (OCT) images may be of value. Objective To characterize the microperimetric function of GA as identified from en face OCT imaging. Design, Setting, and Participants In a case-series study, 20 patients (22 eyes) entered the study at the University of Padova according to preplanned conditions. From March 1 to July 30, 2014, en face OCT images were obtained at the outer ...

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    8. Optical Coherence Tomography of Cavitary Retinoblastoma

      Optical Coherence Tomography of Cavitary Retinoblastoma

      This case report describes a young boy with regressed retinoblastoma following intra-arterial chemotherapy. Cavitary retinoblastoma is a unique form of retinoblastoma that demonstrates characteristic intralesional translucent cavities that are often more pronounced following tumor regression. 1 - 4 There can be a single or multiple cavities, which are usually gray and spherical in configuration. Histopathologically, there is no endothelial or epithelial lining. The cavities are typically hypofluorescent on fluorescein angiography and echolucent on B-scan ultrasonography. 2

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    9. Optical Coherence Tomography Angiography in Choroideremia: Correlating Choriocapillaris Loss With Overlying Degeneration

      Optical Coherence Tomography Angiography in Choroideremia: Correlating Choriocapillaris Loss With Overlying Degeneration

      Importance Novel therapies for choroideremia, an X-linked recessive chorioretinal degeneration, demand a better understanding of the primary site(s) of cellular degeneration. Optical coherence tomography angiography allows for choriocapillaris (CC) imaging. We compared the extent of structural alterations of the CC, retinal pigment epithelium, and photoreceptors with multimodal imaging. Observations In a clinical case series conducted from September 15, 2014, through February 5, 2015, 14 eyes of 7 male patients with choroideremia (median age, 34 years [interquartile range, 15-46 years]; age range, 13-48 years), 4 eyes of 2 women with choroideremia carrier state (both in mid-50s), and 6 eyes of ...

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    10. Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Select Features of Diabetic Retinopathy on Swept-Source Optical Coherence Tomographic Angiography Compared With Fluorescein Angiography and Normal Eyes

      Importance Optical coherence tomographic angiography (OCTA) is a recently developed noninvasive imaging technique that can visualize the retinal and choroidal microvasculature without the injection of exogenous dyes. Objective To evaluate the potential clinical utility of OCTA using a prototype swept-source OCT (SS-OCT) device and compare it with fluorescein angiography (FA) for analysis of the retinal microvasculature in diabetic retinopathy. Design, Setting, and Participants Prospective, observational cross-sectional study conducted at a tertiary care academic retina practice from November 2013 through November 2014. A cohort of diabetic and normal control eyes were imaged with a prototype SS-OCT system. The stage of diabetic ...

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    11. Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

      Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain–Optical Coherence Tomography

      Importance New methods are needed to quantify the change in the outer retinal structures in retinitis pigmentosa (RP). Objective To implement an alternate method for tracking ellipsoid zone (EZ) changes in RP by quantifying the EZ area on en face spectral domain–optical coherence tomographic (SD-OCT) images. Design, Setting, and Participants Data for this observational case study were collected at the Department of Ophthalmology, University of California, Los Angeles, from May 1 to July 30, 2015, and included SD-OCT images of a subset of patients from the Trial of Oral Valproic Acid for Retinitis Pigmentosa. To be eligible for the ...

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    12. Direct Visualization of a New Choroidal Vessel on Spectral-Domain Optical Coherence Tomography

      Direct Visualization of a New Choroidal Vessel on Spectral-Domain Optical Coherence Tomography

      This Ophthalmic Image shows a new choroidal vessel on spectral-domain optical coherence tomography in a man in his 60s. Spectral-domain optical coherence tomography detects choroidal neovascularization by its indirect effects on the retina. 1 However, actual subretinal pigment epithelium (RPE) (type 1) or subretinal (type 2) 2 new vessels often are not noted.

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    13. Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      Glaucoma Tube Changes After Suture Lysis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography

      This Ophthalmic Image shows swept-source optical coherence tomography of glaucoma tube changes after Baerveldt glaucoma implant into the ciliary sulcus. A woman developed Takayasu disease and neovascular glaucoma in her early 20s. She underwent cardiovascular bypass surgery, but lost vision in her left eye. When another cardiovascular bypass was planned in her mid-40s, 95% of her right eye angle was closed, but her intraocular pressure (IOP) did not exceed the high teens while receiving glaucoma medications, probably because of reduced ocular circulation. 1 In preparation for the IOP increase with circulation improvement, we performed a Baerveldt glaucoma implant into the ...

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    14. Transient Ciliochoroidal Detachment After Ab Interno Trabeculotomy for Open-Angle Glaucoma A Prospective Anterior-Segment Optical Coherence Tomography Study

      Transient Ciliochoroidal Detachment After Ab Interno Trabeculotomy for Open-Angle Glaucoma A Prospective Anterior-Segment Optical Coherence Tomography Study

      Importance Although trabeculotomy is a glaucoma surgical procedure for modest intraocular pressure (IOP) reduction, some eyes exhibit very low IOP during the early postoperative period. To our knowledge, the reason and its effect have not been investigated. Objectives To investigate ciliochoroidal detachment (CCD) immediately after ab interno trabeculotomy and evaluate its effect on IOP immediately after surgery. Design, Setting, and Participants This prospective, observational, case series was conducted at Kyoto University Hospital, Kyoto, Japan. Patients with open-angle glaucoma who underwent ab interno trabeculotomy using a microsurgical device by a single surgeon between July 1, 2014, and May 31, 2015, were ...

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    15. Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Importance Macular ischemia is a key feature of diabetic retinopathy (DR). Quantification of macular ischemia has potential as a biomarker for DR. Objective To assess the feasibility of automated quantification of capillary nonperfusion as a potential sign of macular ischemia using optical coherence tomography (OCT) angiography. Design, Setting, and Participants An observational study conducted in a tertiary, subspecialty, academic practice evaluated macular nonperfusion with 6 × 6-mm OCT angiography obtained with commercially available 70-kHz OCT and fluorescein angiography (FA). The study was conducted from January 22 to September 18, 2014. Data analysis was performed from October 1, 2014, to April 7 ...

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    16. Comparison of Prevalence of Diabetic Macular Edema Based on Monocular Fundus Photography vs Optical Coherence Tomography

      Comparison of Prevalence of Diabetic Macular Edema Based on Monocular Fundus Photography vs Optical Coherence Tomography

      Importance Diagnosing diabetic macular edema (DME) from monocular fundus photography vs optical coherence tomography (OCT) central subfield thickness (CST) can yield different prevalence rates for DME. Epidemiologic studies and telemedicine screening typically use monocular fundus photography, while treatment of DME uses OCT CST. Objective To compare DME prevalence from monocular fundus photography and OCT. Design, Setting, and Participants Retrospective cross-sectional study of DME grading based on monocular fundus photographs and OCT images obtained from patients with diabetic retinopathy at a single visit between July 1, 2011, and June 30, 2014, at a university-based practice and analyzed between July 30, 2014 ...

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    17. Polypoidal Choroidal Vasculopathy Imaging by Indocyanine Green Angiography and En Face Optical Coherence Tomography

      Polypoidal Choroidal Vasculopathy Imaging by Indocyanine Green Angiography and En Face Optical Coherence Tomography

      This case report describes polypoidal choroidal vasculopathy imaged by indocyanine green angiography and en face optical coherence tomography. Polypoidal choroidal vasculopathy is a variant of subretinal neovascularization. It causes subretinal exudation, subretinal hemorrhage, and retinal pigment epithelial (RPE) detachments. Indocyanine green angiography can visualize well the characteristic branching vascular network and polypoidal dilations lying beneath the RPE. En face optical coherence tomography using data from noninvasive spectral-domain optical coherence tomographic imaging may localize polypoidal choroidal vasculopathy vessels beneath the RPE by using en face imaging software, creating a 20- to 30-μm slice beneath the RPE.

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    18. Myopic Cleavage of Retinal Nerve Fiber Layer Assessed by Split-Spectrum Amplitude-Decorrelation Angiography Optical Coherence Tomography

      Myopic Cleavage of Retinal Nerve Fiber Layer Assessed by Split-Spectrum Amplitude-Decorrelation Angiography Optical Coherence Tomography

      This case report describes a man in his 50s with primary open-angle glaucoma and myopic cleavage of the retinal nerve fiber layer. Myopic cleavage of the retinal nerve fiber layer, characterized by cuneiformic dark areas near the major retinal vessels, was first reported in 1992 1 and later confirmed. 2 - 4 The cleavage occurs at the superficial retina in eyes with high myopia or epiretinal membrane and may be associated with visual field defects. 4 Stress, such as myopic cleavage of the retinal nerve fiber layer, deformation of the lamina cribrosa, and stretching and compression of the retinal nerve fiber ...

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    19. Enhanced Depth Imaging Optical Coherence Tomography of Endogenous Fungal Chorioretinitis

      Enhanced Depth Imaging Optical Coherence Tomography of Endogenous Fungal Chorioretinitis

      This case report describes findings in a patient with endogenous fungal chorioretinitis. A man in his mid-30s with a history of chronic alcohol-related pancreatitis complicated by pseudocyst formation presented with a 2-week history of fever and floaters in both eyes. The patient was receiving total parenteral nutrition via a percutaneous intravenous central catheter during the previous 3 months. Blood cultures obtained at admission grew Candida albicans and intravenous treatment was initiated with micafungin sodium and fluconazole. Echocardiography revealed a large right atrial vegetation and computed tomography of the chest demonstrated multiple septic emboli. The patient’s percutaneous intravenous central catheter ...

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    20. Optical Coherence Tomography Angiography of Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy

      Optical Coherence Tomography Angiography of Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy

      This case report describes acute macular neuroretinopathy/paracentral acute middle maculopathy in a pregnant woman. Acute macular neuroretinopathy (AMN) has been characterized as wedge-shaped superficial retinal defects in the macula, resulting in paracentral scotomas. It has been associated with vasoconstrictors and sympathomimetics. 1 In 2013, paracentral acute middle maculopathy (PAMM) was described as an AMN variant, seen as a hyperreflective band involving the middle retinal layers on spectral-domain optical coherence tomography (SD-OCT). 1 Type 1 PAMM lesions involve layers above the outer plexiform layer (OPL), reflecting superficial or intermediate capillary plexus occlusion; type 2 lesions involve layers below the OPL ...

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    21. A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

      A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

      Objective To test the feasibility of using frequency-domain optical coherence tomography (FD-OCT) and a region-of-interest (ROI) approach to measure progressive changes in glaucomatous damage. Design, Setting, and Participants Among a group of patients in an institutional glaucoma practice who were likely to show glaucoma progression, eyes with a history of an optic disc hemorrhage (DH) confirmed by stereophotography were followed up with FD-OCT cube scans of the optic disc. All patients underwent FD-OCT scans on at least 2 occasions separated by at least 1 year (mean, 3.45 years; range, 1.42-6.39 years). Because we were not studying the ...

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    22. Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

      Macular Vascular Abnormalities Identified by Optical Coherence Tomographic Angiography in Patients With Sickle Cell Disease

      Importance Patients with sickle cell disease may develop various macular vascular abnormalities that have not been described previously and can be seen using optical coherence tomographic angiography. Observations Ten eyes from 5 consecutive patients (3 men and 2 women) with sickle cell disease (4 patients with hemoglobin SS disease and 1 patient with hemoglobin SC disease) were included. The mean age was 37.6 years. Five of 10 eyes (50%) had retinal thinning that was identified using spectral-domain optical coherence tomography. Each of these eyes had corresponding loss of vascular density in the superficial or deep retinal plexus (or both ...

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    23. Posterior Scleral Bowing With Choroidal Nevus on Enhanced-Depth Imaging Optical Coherence Tomography

      Posterior Scleral Bowing With Choroidal Nevus on Enhanced-Depth Imaging Optical Coherence Tomography

      Importance Recognition of posterior scleral bowing with choroidal nevus is essential to avoid an underestimation of tumor thickness. Objective To describe a particular observation of posterior scleral bowing associated with choroidal nevus on enhanced-depth imaging (EDI) optical coherence tomography (OCT). Design, Setting, and Participants Retrospective observational case series at a referral center involving 17 eyes of 17 patients. Patients were seen from June 2013 to July 2014, with all data collected and analyzed from June 2014 to July 2014. Interventions Retrospective medical record review and multimodal imaging including fundus photography, autofluorescence, infrared reflectance, ultrasonography, and EDI-OCT. Main Outcomes and Measures ...

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    24. Epiretinal Membrane Demonstrated by Optical Coherence Tomography in a Patient With Retinal Cavernous Hemangioma

      Epiretinal Membrane Demonstrated by Optical Coherence Tomography in a Patient With Retinal Cavernous Hemangioma

      This case report describes the use of optical coherence tomography to identify retinal cavernous hemangioma in an asymptomatic child. A cluster of dilated saccular aneurysms of varying sizes occurred in an asymptomatic young girl. Fluorescein angiography demonstrated late-phase hyperfluorescence with fluid levels at the blood-fluorescein interface ( Figure , A). Optical coherence tomography demonstrated an elevated intraretinal mass with superimposed saccular clusters and an overlying epiretinal membrane spanning the exterior of the lesion ( Figure , B).

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    1-24 of 78 1 2 3 4 »
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