Articles from index

1. Correlation between Disc Damage Likelihood Scale and Optical Coherence Tomography in the Diagnosis of Glaucoma

   Explore Article index (Feb 25 2010) Ophthalmology

   Purpose: To investigate the relationship between the Disc Damage Likelihood Scale (DDLS), visual field and various optical coherence tomography (OCT) parameters for glaucoma diagnosis. Methods: The study comprised 149 eyes from 149 patients. The patients were categorized as normal, glaucoma suspect or with glaucoma. They were clinically examined and graded according to the DDLS system. OCT was performed to acquire both a retinal nerve fibre layer analysis and an optic nerve head analysis. The relationships between DDLS score, visual field and OCT parameters were analysed using multiple correlation analysis. Results: The normal, glaucoma suspect and glaucoma groups had average DDLS ... (Read Full Article)
   

   Comment on Article Mentions:   University of Oxford

2. Bleb Needling in Encapsulated Filtering Blebs: Evaluation by Optical Coherence Tomography

   Explore Article index (Nov 23 2009) Ophthalmology

   Purpose: To evaluate the role of anterior segment optical coherence tomography (OCT) in describing the morphology and outcome of encapsulated filtering blebs after bleb needling. Procedures: Prospective assessment of 9 patients - before, 2 days and 6 months after filtering bleb needling with 5-FU - using slit-lamp examination, Goldmann tonometry and OCT. Results: Before the needling, the average internal height of the cyst was 1.3 ± 0.8 mm. Two days after the needling procedure, the cyst collapsed in 5 patients. After 6 months, the average internal cyst height was 0.7 ± 0.4 mm. All patients with a collapsed cyst at ... (Read Full Article)
   

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3. Relation between Axial Length and Ocular Parameters

   Explore Article index (Oct 31 2009) Ophthalmology

   Purpose: To investigate the relation between axial length (AL) and ocular parameters. Methods: Measurements of ocular biometric parameters were performed with an optical biometer, pachymeter, optical coherence tomography, and an automatic refractometer. AL, refractive error (RE), central corneal thickness, anterior chamber depth (ACD), corneal curvature (CC), white-to-white distance (WWD), and retinal nerve fiber layer (RNFL) thickness were measured. AL was evaluated in relation to ocular parameters. The Pearson correlation coefficient (r) was used to statistically evaluate each scattergram. Results: With elongation of the AL, the mean RE (r = -0.790, p < 0.001), CC (r = -0.444, p < 0.001), ... (Read Full Article)
   

   Comment on Article Mentions:   Seoul National University   Sungkyunkwan University

4. Combined Three-Dimensional Spectral OCT/SLO Topography and Microperimetry: Steps toward Achieving Functional Spectral OCT/SLO

   Explore Article index (Oct 16 2009) Ophthalmology

   Aims: To investigate the combination of 3D optical coherence tomography (OCT) retinal thickness measurements and superimposed scanning laser ophthalmoscopy (SLO) microperimetry obtained using a Spectral OCT/SLO and to test the correlation between retinal thickness and retinal sensitivity in retinal diseases grouped according to anatomic locations. Methods: Patients with various retinal diseases and subjects with normal fundi underwent microperimetry testing and imaging with the Spectral OCT/SLO. Based on the Spectral OCT/SLO findings, the participants were divided into 4 groups: patients with retinal thickening due to the outer retina pathology (group I); patients with retinal thickening due to the cystic changes observed ... (Read Full Article)
   

   Comment on Article Mentions:   New York Eye and Ear Infirmary   Richard B. Rosen

5. Spontaneous Reattachment of the Margins of a Macular Retinal Pigment Epithelium Tear: Optical Coherence Tomography Documentation of a Case

   Explore Article index (Sep 11 2009) Ophthalmology

   Purpose: To document by optical coherence tomography (OCT) the reattachment of the margins of a retinal pigment epithelium (RPE) tear. Methods: Single case report, documented by OCT scans, autofluorescence and fluorescein angiography. Results: A 67-year-old male presented with a spontaneous RPE tear due to age-related macular degeneration in his right eye. Three months later we observed that the focal RPE tear had healed and there was a new intraretinal fluid, well documented by OCT imaging. Conclusions: OCT scans show the reattachment of the margins of an RPE tear healed by tissue remodelling, and illustrate how the disease can recur. (Read Full Article)
   

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6. Evaluation of Retinal Nerve Fiber Layer with Optic Nerve Tracking Optical Coherence Tomography in Thyroid-Associated Orbitopathy

   Explore Article index (Sep 1 2009) Ophthalmology

   Aims: To evaluate retinal nerve fiber layer (RNFL) thickness in eyes with Graves' orbitopathy (GO), in eyes with ocular hypertension (OHT) and in a control group of healthy eyes. Methods: Observational, controlled cross-sectional study. We evaluated all patients with primary open-angle glaucoma (POAG) and all patients with GO and intraocular pressure >23 mm Hg in primary position examined from March 2006 to June 2007. Forty apparently healthy patients (80 eyes) were enrolled as a control group. Complete ophthalmic evaluation, visual field (VF) examination with the Humphrey Visual Field Analyzer and RNFL thickness measurement with optic nerve tracking optical coherence tomography ... (Read Full Article)
   

   Comment on Article Mentions:   OTI Ophthalmic Technologies Inc.   Ophthalmic Technologies Spectral OCT/SLO   University Federico II

7. Complete Regression of Choroidal Metastasis Secondary to Non-Small-Cell Lung Cancer with Intravitreal Bevacizumab and Oral Erlotinib Combination Therapy

   Explore Article index (Jul 26 2009) Oncology

   Purpose: To report a case of a complete regression of choroidal metastasis secondary to non-small-cell lung cancer (NSCLC). Methods: Retrospective case review of a female patient treated with intravitreal bevacizumab and oral erlotinib combination therapy for choroidal metastases secondary to NSCLC. Best corrected visual acuity (BCVA), fluorescein angiography (FA), optical coherence tomography (OCT), and B-scan ultrasonography were compared during the 4-month treatment period. Results: Four weeks after the third injection of bevacizumab (2.5 mg), the BCVA had improved to 20/40 from 20/200 and the 2 subretinal masses had completely disappeared. FA demonstrated only a retinal pigment epithelial (RPE) window defect ... (Read Full Article)
   

   Comment on Article Mentions:   Korea University

8. Comparison of Three Different Optical Coherence Tomography Models for Total Macular Thickness Measurements in Healthy Controls

   Explore Article index (Jul 1 2009) Ophthalmology

   Background/Aims: Conventional time domain optical coherence tomography (OCT) has become an important diagnostic tool to measure retinal thickness in clinical routine. Recently, different models of high-speed, high-resolution frequency domain OCTs have been introduced by various manufacturers. The purpose of this study was to compare 3 commercially available OCT models for retinal thickness measurements in healthy controls. Methods: OCT scans were performed on 28 healthy eyes with the RTVue-100 FD-OCT (Optovue Inc., USA), the Cirrus HD-OCT (Carl Zeiss Meditec Inc., USA) and the Stratus OCT 3000 (Carl Zeiss Meditec Inc.). Retinal thickness values were calculated and compared between OCT models. Results: ... (Read Full Article)
   

   Comment on Article Mentions:   Optovue   Zeiss Stratus OCT   Optovue RTVue-100

9. The Influence of Eccentric Scanning of Optical Coherence Tomography on Retinal Nerve Fiber Layer Analysis in Normal Subjects

   Explore Article index (May 28 2009) Ophthalmology

   Aim: To investigate the influence of eccentric scanning on retinal nerve fiber layer (RNFL) analysis using Stratus optical coherence tomography (OCT) in normal Koreans when the eccentricity of scanning occurs in 4 different directions. Methods: Thirty-one eyes of 31 persons underwent 1 concentric disk-centered and 4 superiorly, inferiorly, nasally and temporally eccentric RNFL OCT scans. Results: The average RNFL thickness measured by temporally eccentric scanning (115.1 µm) was significantly greater when compared with that found by concentric scanning (107.1 µm; p < 0.0001). The proportions of eyes outside normal limits on the RNFL analysis map using the criterion of 1 ... (Read Full Article)
   

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10. Evaluation of Posterior Pole with Echography and Optical Coherence Tomography in Patients with Behçet's Disease

    Explore Article index (Mar 19 2009) Ophthalmology

    Background: In Behçet's disease posterior segment involvement is very frequent (about 80%). Macular edema is the most commonly observed complication and is related to reduction of visual acuity. The purpose of the study was to evaluate choroidal involvement during posterior vasculitis due to Behçet's disease. Methods: Thirty eyes (15 patients) presenting with posterior vasculitis due to Behçet's disease were studied. All patients had been evaluated with optical coherence tomography (Stratus OCT, Zeiss) to evaluate the retinal thickness (RT) and with standardized 8-MHz A scan echography to determine the retinochoroidal thickness (RCT). Echographic evaluation with 10- and 20-MHz probes was performed ... (Read Full Article)
    

    Comment on Article Mentions:   University Federico II

11. Correlation between Retina Blood Flow Velocity Assessed by Retinal Function Imager and Retina Thickness Estimated by Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

    Explore Article index (Jan 12 2009) Ophthalmology , Doppler

    Purpose: The purpose of this study was to evaluate the correlation between the retinal blood flow (RBF) assessed by the retinal functional imager (RFI) and central macular thickness/volume assessed by a spectral scanning laser ophthalmoscopy/optical coherence tomography (SLO-OCT) system. Methods: Seventeen eyes of 14 consecutive patients with various ocular diseases were examined. Retinal blood circulation characteristics were measured using the RFI. Retinal thickness/volume parameters were obtained by SLO-OCT. Analysis of correlation between RBF velocity and SLO-OCT findings was performed. Results: The analysis of the correlation between RBF and central retinal thickness/volume (5 × 5 mm grid pattern) showed a strong ... (Read Full Article)
    

    Comment on Article Mentions:   New York Eye and Ear Infirmary   Richard B. Rosen

12. Foveal Thickness Can Predict Visual Outcome in Patients with Persistent Central Serous Chorioretinopathy

    Explore Article index (Oct 10 2008) Ophthalmology

    Aims: To evaluate relationships between visual prognosis and foveal thickness measured by optical coherence tomography in patients with unilateral persistent central serous chorioretinopathy. Methods: Fifteen eyes of fifteen patients with symptoms for more than 6 months were evaluated on visual acuity and foveal thickness before and after foveal reattachment. Results: Mean age was 49.7 years (range 34-69), symptoms prolonged for 21.8 months (7-36), logarithm of the minimum angle of resolution (LogMAR) was 0.27 (decimal visual acuity 0.53). After foveal reattachment, LogMAR was 0.16 (0.69). Final foveal thickness (mean 109 µm) was thinner than that of initial presentation (151 µm) and ... (Read Full Article)
    

    Comment on Article Mentions:   Gunma University

13. Retinal Nerve Fiber Layer Evaluation in Open-Angle Glaucoma: Optimum Criteria for Optical Coherence Tomography

    Explore Article index (Oct 10 2008) Ophthalmology

    Purpose: To determine the optimum criteria for optical coherence tomography (OCT) to discriminate best between healthy and glaucomatous eyes. Design: A prospective cross-sectional study. Methods: In total, 164 eyes selected from clinical practice were included in this study. These were classified into 98 healthy and 66 glaucomatous eyes, depending on the intraocular pressure, appearance of the optic disc and standard automated perimetry results. Only 1 eye per subject was randomly included. The retinal nerve fiber layer (RNFL) was evaluated by means of OCT (Stratus OCT 3000). The sensitivity and specificity values of different diagnostic criteria (4 abnormal quadrants and 1-5 ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

14. Optical Coherent Tomography for in vivo Determination of Changes in Hair Cross Section and Diameter during Treatment with Glucocorticosteroids - A Simple Method to Screen for Doping Substances?

    Explore Article index (Sep 18 2008)

    Eighty percent of hair follicles are in the growing phase. They grow approximately 0.3 mm/day. The hair follicles are surrounded by a close network of capillaries, which supplies them with nutrients. It is well known that substances which influence the metabolic processes of humans also influence hair growth. Steroids, which are used for doping in sport, are among these substances. In the present paper, optical coherent tomography is used for the analysis of changes in the hair structure during the application of steroids for the treatment of patients suffering from auto-immune diseases. Significant differences in the hair cross section could ... (Read Full Article)
    

    Comment on Article Mentions:   Russian Academy of Sciences   Valentin M. Gelikonov

15. Foveolitis Associated with Dengue Fever: A Case Series

    Explore Article index (Jul 15 2008) Ophthalmology

    Background: Dengue fever (DF), a viral infection caused by dengue virus, is characterized by fever, headache, muscle and joint pains. Approximately 50-100 million people are infected annually. Ocular manifestations during DF are uncommon and include intraretinal hemorrhages and cotton wool spots; manifestations predominantly characterized by foveal involvement have not been described before in DF or any other retinopathies. We describe the clinical features of a series of patients with DF-associated foveolitis. Methods: A retrospective review of patients with maculopathy associated with DF was conducted. Patients found to have a yellow-orange lesion at the fovea, supported by a typical optical coherence ... (Read Full Article)
    

    Comment on Article Mentions:   National University of Singapore

16. Evaluation of the Effect of Aging on Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography

    Explore Article index (Jul 14 2008) Ophthalmology

    Purpose: To evaluate the relationship between age and retinal nerve fiber layer (RNFL) thickness in normal subjects, as measured by optical coherence tomography (OCT). Methods: One hundred and forty-four normal subjects (144 eyes), ranging from 16 to 84 years of age, were enrolled in this cross-sectional study. The RNFL thickness was determined using OCT with three circle scans 3.4 mm in diameter. Results: The average RNFL thickness was inversely correlated with age (r = -0.348, p (Read Full Article)
    

    Comment on Article Mentions:   Makoto Nakamura   Akiyasu Kanamori   Kobe University Graduate School of Medicine

17. Fundus Autofluorescence, Optical Coherence Tomography and Visual Acuity in Adult-Onset Foveomacular Dystrophy

    Explore Article index (May 15 2008) Ophthalmology

    Original Paper Claudio Furino, Francesco Boscia, Nicola Cardascia, Luigi Sborgia, Carlo Sborgia Department of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy Address of Corresponding Author Ophthalmologica 2008;222:240-244 (DOI: 10.1159/000130427) Key Words Abstract Aim: We investigated fundus autofluorescence (FA) patterns and tomographic retinal changes by means of op (Read Full Article)
    

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18. The Anterior Visual System and Circadian Function with Reference to Alzheimer's Disease (Book Chapter)

    Explore Article index (Jun 1 2004) Textbooks

    Alzheimer’s disease (AD) impacts visual function early in the course of the disease, and functional losses correlate with cognitive losses. Several functional vision losses are frequently identified in AD. There is evidence for deficits in contrast sensitivity [1], motion perception [2, 3], performance on backward masking tests [1] and color discrimination of blue, short-wavelength hues [4]. Damage secondary to AD occurs in the visual association cortex and other higher cortical areas, as well as the primary visual cortex [5, 6]. Additional studies have reported def icits in the retinocalcarine pathway [7–10]. This path- way extends from the photoreceptors of the ... (Read Full Article)
    

    Comment on Article Mentions:   Boston University   Denise A. Valenti

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