An image processing apparatus that processes a tomographic image generated by using tomographic signals acquired by subjecting a subject to optical coherence tomographic imaging, includes an acquiring unit configured to acquire the tomographic signals, and a generation unit configured to generate a tomographic image based on a representative value in each pixel position of the tomographic image, generated by using the tomographic signals, the generation unit includes a region determination unit configured to determine a target region where contrast is reduced in the tomographic image, by using tomographic signals, and an estimation unit configured to estimate an estimation value, by ...

A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly

A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation ...

Various embodiments of the present disclosure describe an ultra-wide field of view (FOV) optical coherence tomography (OCT) imaging system. The ultra-wide FOV OCT imaging system can include an imaging probe, a console and a cable. The imaging probe can include an optical widow, a first imaging module and a second imaging module. The first imaging module is configured to form a first image of the eye. The second imaging module is configured to form a second image of the eye. The second imaging module can include a scanning mirror configured to receive a sample arm portion of a second light ...

The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The embodiments disclosed herein can use linear registration, affine registration and/or elastic registration to align a plurality of optical coherence tomography angiography images or videos at corresponding superficial vascular layers having ...

An apparatus includes first and second light sources, an optical interferometer, one or more light detectors, and an electronic processor. The second light source is configured to output light of a different wavelength than the first source. The optical interferometer has optical reference and sample arms. The optical sample arm has a first optical path to transmit light received from the first and second light sources to an area of a target and has a second optical path to transmit light collected from the area of the target to one or more interference regions. The optical reference arm is configured ...

Data processing method and computer equipment for the characterization of a parametric indicator for central nervous system health status based on data collected from non-invasive retina imaging by optical coherence tomography, OCT, said method comprising: processing data from the collected OCT data to compute a texture parameter or parameters from collected fundus imaging data; classifying the computed texture parameter or parameters into a central nervous system health status for characterizing said parametric indicator. The method is able to analysed optical coherence tomography data of one or more tissues of the human and animal central nervous system. The presented method overcomes ...

<p id="p-0001" num="0000">In part, the disclosure relates to a lens assembly. The lens assembly can be used to direct light for sensing and imaging. In one embodiment, the lens assembly is a component of an intravascular data collection probe such as an optical coherence tomography probe. The lens assembly can include an optical fiber having a first diameter and a gradient index lens that includes a rod having a length L. The rod can include a substantial planar end and a polished end.

Embodiments provide systems and methods associated with a reflectance-based projection-resolved (rbPR) optical coherence tomography angiography (OCTA) algorithm which uses optical coherence tomography (OCT) reflectance to enhance the flow signal and suppress the projection artifacts in 3-dimensional OCTA. rbPR improves the vascular connectivity and improved the discrimination of the deeper plexus angiograms in healthy eyes, compared to prior PR-OCTA method. Additionally, rbPR removes flow projection artifacts more completely from the outer retinal slab in the eyes with age-related macular degeneration, and preserves vascular integrity of the intermediate and deep capillary plexuses in the eyes with diabetic retinopathy. Additionally, the rbPR method ...

Exemplary imaging apparatuses are described. Various imaging apparatuses may implement optical coherence tomography (OCT) and/or optical frequency domain imaging (OFDI) gastrointestinal tissue imaging methods and technologies. Furthermore, the imaging apparatuses may include a rotatable imaging element to scan a bodily lumen, such as the esophagus. The imaging element may be housed within an inflatable balloon. Still further, the imaging apparatuses may include a shaped tip. The shaped tip may aid in guiding an imaging apparatus through the esophagus, or other bodily lumen.

Various embodiments of the present disclosure describe an ultra-wide field of view (FOV) optical coherence tomography (OCT) imaging system. The ultra-wide FOV OCT imaging system can include an imaging probe, a console and a cable. The imaging probe can include an optical widow, a first imaging module and a second imaging module. The first imaging module is configured to form a first image of the eye. The second imaging module is configured to form a second image of the eye. The second imaging module can include a scanning mirror configured to receive a sample arm portion of a second light ...

Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliab

A system and method for performing Optical Coherence Tomography on a sample utilizes collimated, phase modulated beams of light in an interferometer. At least one of the beams of light utilized exists as an Airy beam for at least a portion of the procedure, obviating any deleterious impact caused by the Gaussian beam diffraction. The system may incorporate a light source, polarization beam splitter, delay line, non-polarization beam splitters, lenses, phase masks, waveplates, and mirrors, any or all of which may be controlled by a computing element.

Optical coherent receiver arrays are described. The optical coherent receiver arrays include an integrated array of photodetectors separated by integrated mirrors which may cause interference of received free space optical and local oscillator signals. The mirrors may serve as splitters, helping to align the received signal and local oscillator to cause interference. The photodetectors of the optical coherent receiver array may be electrically coupled in various manners to read out the signals. The optical coherent receiver array may be implemented in an optical coherence tomography (OCT) imaging system in some embodiments.

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time.

Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT) imager is configured to capture a B-scan frame of the tissue. An image processing component is configured to determine a frequency of the shear wave in the tissue from the B-scan frame of the tissue at each of a plurality of locations within the B-scan.

The present invention provides a light emitting device which emit light having a high-order level without increasing a current injection density to an active layer. A light emitting device according to the present invention includes an upper electrode layer, a lower electrode layer, and an active layer provided between them. In this case, light is emitted by injection of electric current to the active layer through the upper electrode layer and the lower electrode layer, the active layer has a plurality of quantum-confined structures, and a first quantum-confined structure has a ground level having an energy level E₀ and ...

A motion-compensated cutting system includes a hand-held tool body, and an actuator connected to the tool body. A shaft of the actuator is movable relative to the tool body so that a distal end of a cutting implement attached to the shaft is axially movable relative to the tool body. An optical coherence tomography system includes an optical fiber with a distal end fixed relative to the distal end of the cutting implement. The system includes a control unit that can determine a position of the distal end of the cutting implement relative to a reference surface based on input ...

A system and method for resampling interference datasets of samples in segments, in a swept- source based Optical Coherence Tomography (OCT) system. The resampling is preferably performed within a Field Programmable Gate Array (FPGA) of the OCT system, the FPGA preferably having Fourier-transform based signal processing capabilities such as Fast Fourier Transform (FFT) cores. Resampling the interference datasets in segments provides a flexible approach to resampling that makes efficient use of system resources such as FFT cores. By resampling the interference datasets in segments, the system adjusts to an increased number of resampling points as the imaging depth upon the ...

An autofocus apparatus is capable of detecting the position of a sample on a microscope. The sample may consist of a specimen mounted between a microscope slide and coverslip or specimens within a well plate. The device tracks the position of a sample by identifying refractive index boundaries through Fresnel reflections. A change in refractive index can correspond to the top and bottom of a coverslip, the top of a slide, the bottom of a well plate or the bottom of a well within a well plate. Using optical coherence tomography (OCT) these reflections are used to form a depth ...

Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach, a retinal vessel relief height relative to a retinal plane may be calculated from OCT image data and the presence or absence of a glaucoma condition may be determined based on the retinal vessel relief height.

Disclosed is an apparatus (1) for inspecting containers (2) in a container treatment machine, comprising an optical probe (6, 6a-6e) which is designed as an optical coherence tomography probe providing in-plane resolution and/or volume resolution for detecting surface irregularities (5a, 5b, 17a, 17b, 20a, 20b).

This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This disclosure also particularly relates to methods and systems for OCT angiography. This disclosure further relates to systems for health characterization of an eye by OCT angiography.

Unlike most MEMS device configurations which simply switch between two positions in many optical devices the state of a MEMS mirror is important in all transition positions. It may determine the characteristics of an optical delay line system and by that an optical coherence tomography system in one application and in another the number of wavelength channels and the dynamic wavelength switching capabilities in the other.