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    1. Potential of OCT to identify genetic risk in AMD

      Potential of OCT to identify genetic risk in AMD

      T he genetic component for progression of age-related macular degeneration to advanced disease, including geographic atrophy and neovascular disease, has been well documented. 1-4 Early and intermediate disease stages, primarily characterized by the formation of drusen, precede each advanced subtype. To lower the rate of disease progression and preserve vision, we need to identify therapeutic targets for earlier, high-risk disease stages. With advances in in vivo imaging, spectral-domain optical coherence tomography can noninvasively visualize and discriminate the retinal and choroidal layers. OCT can also directly visualize and measure retinal pigment epithelium irregularities, including area and volume where drusen develop. Our ...

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    2. How SD-OCT is enhancing our management of DR

      How SD-OCT is enhancing our management of DR

      Laser therapy was a major breakthrough in diabetic retinopathy treatment, with its efficacy validated by a number of clinical studies in the last three decades of the 20th century. However, it relied on fundus photography and fluorescein angiography to diagnose clinically significant macular edema. Since then, optical coherence tomography has revolutionized the clinical management of diabetic macular edema because of its widespread availability, ease of use, and ability to quantify DME noninvasively. This tool has become even more powerful coupled with the emergence of pharmacotherapies to treat the disease. Here, we review how OCT has changed the way retina specialists ...

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    3. How OCT angiography is improving our view of diabetic retinopathy

      How OCT angiography is improving our view of diabetic retinopathy

      The Early Treatment Diabetic Retinopathy Study (ETDRS) established and refined the current clinical grading of diabetic r etinopathy that retina specialists use as an adaptation of the Modified Airlie House Classification. The parameters of the grading system rely primarily on identifying somewhat indirect signs of microvascular ischemic disease that include retinal hemorrhages, venous beading, intraretinal microvascular abnormalities or preretinal neovascularization. However, identifying indirect signs of microvascular disease is fraught with challenges in ensuring reproducibility among different observers and operators, which may introduce error into research or clinical settings. ETDRS made attempts to measure and minimize this variability and found that ...

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    1-3 of 3
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