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    1. Role of Disorganization of Retinal Inner Layers as an Optical Coherence Tomography Biomarker in Diabetic and Uveitic Macular Edema

      Role of Disorganization of Retinal Inner Layers as an Optical Coherence Tomography Biomarker in Diabetic and Uveitic Macular Edema

      The role of optical coherence tomography (OCT) in characterizing normal and pathologic retinal architecture is still evolving. Numerous groups have tried to use OCT findings of retinal features as a surrogate for visual acuity in macular edema, but no traditional measure consistently accounts for visual outcomes. Retina specialists are still trying to process the data in the literature regarding this topic, as no good review currently exists. Dilraj S. Grewal, MD, and Glenn J. Jaffe, MD, provide us with an overview of the literature and focus on the role of disorganization of the retinal inner layers (DRIL) as an OCT ...

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      Mentions: Duke University
    2. Optical Coherence Tomography Angiography Features in Melanocytoma of the Optic Nerve

      Optical Coherence Tomography Angiography Features in Melanocytoma of the Optic Nerve

      Optic disc melanocytoma (ODM) is a pigmented tumor with malignant potential characterized clinically as a dark brown to black lesion with feathery margins. The authors report a case of ODM and describe the utility of optical coherence tomography angiography (OCTA) in detecting superficial tumor vascularization. This case report demonstrated the ability of OCTA to reveal the fine abnormal retinal vasculature on the surface of the lesion, a characteristic of ODM, which has been previously correlated with tumor growth.

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    3. Choriocapillaris Changes Imaged by OCT Angiography After Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      Choriocapillaris Changes Imaged by OCT Angiography After Half-Dose Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

      BACKGROUND AND OBJECTIVE: To evaluate the choriocapillaris using optical coherence tomographic angiography (OCTA) after half-dose verteporfin photodynamic therapy (hd-PDT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: We studied six eyes (six patients) with chronic CSC treated by hd-PDT. OCTA was performed before, 1 week after, and 1 month after hd-PDT. The area of flow abnormality at the choriocapillaris level within the PDT spot after hd-PDT was compared with that before hd-PDT. RESULTS: Serous retinal detachment was diminished in all eyes, with three achieving complete resolution at 1 month. On OCTA, all eyes showed irregular choriocapillaris flow before hd-PDT ...

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    4. Intraoperative Optical Coherence Tomography Vault Measurement in Posterior Chamber Phakic Intraocular Lens Implantation

      Intraoperative Optical Coherence Tomography Vault Measurement in Posterior Chamber Phakic Intraocular Lens Implantation

      PURPOSE: To describe the use of intraoperative optical coherence tomography (OCT) vault measurement in 5 cases of posterior chamber phakic intraocular lens (IOL) implantation. METHODS: This case series included 5 eyes in 3 consecutive patients undergoing phakic IOL implantation. RTVue OCT (Optovue, Inc., Fremont, CA) was used to obtain intraoperative vault measurements after pupil constriction. Visante OCT (Carl Zeiss Meditec, Jena, Germany) was used to obtain postoperative vault measurements. RESULTS: Intraoperative vault measurements ranged from 228 to 1,060 µ m. There were no postoperative complications. Postoperative OCT vault measurements ranged from 230 to 670 µ m. CONCLUSIONS: Intraoperative OCT can be ...

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    5. Ultra-Wide-Field Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Findings in Syphilitic Outer Retinitis

      Ultra-Wide-Field Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Findings in Syphilitic Outer Retinitis

      BACKGROUND AND OBJECTIVE: To determine the ultra-wide-field fundus autofluorescence (UWFFAF) and optical coherence tomography (OCT) features of syphilitic outer retinopathy (SOR). PATIENTS AND METHODS: Retrospective chart review. RESULTS: Three patients with SOR were investigated. Treatment with parenteral penicillin led to improvement of outer retinopathy, visual acuity, and symptoms. UWFFAF showed speckled hyperautofluorescence, hypoautofluorescence, and normal autofluorescence, similar to what has been described as a trizonal pattern in acute zonal occult outer retinopathy (AZOOR) in the chronic case of SOR, but with hyperautofluorescent areas in the two acute cases. OCT showed disruption of the photoreceptor outer segment ellipsoid zone and external ...

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    6. Fluorescein Angiography Versus Optical Coherence Tomography Angiography in Macular Telangiectasia Type I Treated With Bevacizumab Therapy

      Fluorescein Angiography Versus Optical Coherence Tomography Angiography in Macular Telangiectasia Type I Treated With Bevacizumab Therapy

      This is a report of microvascular changes seen on fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) in a 47-year-old man with macular telangiectasia Type 1 (MacTel1) after a 7-year bevacizumab (Avastin; Genentech, South San Francisco, CA) treatment course. OCTA allowed for clear visualization of most telangiectasias and aneurysms in the deep capillary plexus, with only few microvascular dilatations in the superficial plexus. In addition, areas of capillary dropout in the superficial and deep vascular plexa located near telangiectasias were documented on OCTA. Serial FA demonstrated reduced number of aneurysms and telangiectasias at the 7-year mark compared to baseline.

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    7. Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study

      Microscope-Integrated OCT Feasibility and Utility With the EnFocus System in the DISCOVER Study

      BACKGROUND AND OBJECTIVE: To evaluate the feasibility and utility of a novel microscope-integrated intraoperative optical coherence tomography (OCT) system. PATIENTS AND METHODS: The DISCOVER study is an investigational device study evaluating microscope-integrated intraoperative OCT systems for ophthalmic surgery. This report focuses on subjects imaged with the EnFocus prototype system (Leica Microsystems/Bioptigen, Morrisville, NC). OCT was performed at surgeon-directed milestones. Surgeons completed a questionnaire after each case to evaluate the impact of OCT on intraoperative management. RESULTS: Fifty eyes underwent imaging with the EnFocus system. Successful imaging was obtained in 46 of 50 eyes (92%). In eight cases (16%), surgical ...

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    8. Subfoveal Choroidal Vascularity in Myopia: Evidence From Spectral-Domain Optical Coherence Tomography

      Subfoveal Choroidal Vascularity in Myopia: Evidence From Spectral-Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: To evaluate subfoveal choroidal vascularity in eyes with myopia in comparison to age-matched healthy subjects. PATIENTS AND METHODS: Retrospective analysis of single foveal enhanced depth imaging optical coherence tomography (EDI-OCT) scans of 30 eyes with myopia (axial length greater than 25 mm). Subfoveal choroidal vascularity was evaluated by calculating vessel-area-to-stromal-area ratio using a previously validated automated algorithm. RESULTS: The subfoveal stromal area was significantly smaller in myopes (0.95 mm 3 ± 0.22 mm 3 ) compared to controls (1.33 mm 3 ± 0.23 mm 3 ; P < .0001). However, there was no significant difference in vascular area ...

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    9. OCT imaging of retina useful in detecting glaucoma ‘masqueraders’

      OCT imaging of retina useful in detecting glaucoma ‘masqueraders’

      Optic nerve and macular optical coherence tomography can be helpful in distinguishing between glaucoma and glaucoma masqueraders, according to researchers. Researchers reported a case series of 4 patients and their spectral-domain OCT findings with retinal disease or nonglaucomatous optic neuropathy, who presented with suspected or previously diagnosed normal-tension glaucoma. The first patient was found to have marked diffuse retinal nerve fiber layer (RNFL) and macular thinning on OCT due to cancer-associated retinopathy, researchers wrote. The 76-year-old woman was referred after cataract surgery failed to relieve her symptoms of progressive vision loss. The second patient showed deep focal inferotemporal RNFL loss ...

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    10. Omega Sign: A Distinct Optical Coherence Tomography Finding in Macular Combined Hamartoma of Retina and Retinal Pigment Epithelium

      Omega Sign: A Distinct Optical Coherence Tomography Finding in Macular Combined Hamartoma of Retina and Retinal Pigment Epithelium

      BACKGROUND AND OBJECTIVE: To report a distinct optical coherence tomography (OCT) appearance of macular combined hamartoma of retina and retinal pigment epithelium (CHRRPE). \ PATIENTS AND METHODS: This is a retrospective case series of four eyes of four patients with macular CHRRPE who were assessed with the help of color fundus photographs, swept-source OCT (SS-OCT), and fundus fluorescein angiography wherever required. RESULTS: All four patients presented with decreased visual acuity. SS-OCT in all patients showed adherent epiretinal membrane (ERM) and localized thickening of underlying retina. An omega-shaped disorganization of inner retinal layers was seen bounded posteriorly by the outer plexiform layer ...

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    11. Optical Coherence Tomography Angiography of Paracentral Acute Middle Maculopathy Associated With Primary Antiphospholipid Syndrome

      Optical Coherence Tomography Angiography of Paracentral Acute Middle Maculopathy Associated With Primary Antiphospholipid Syndrome

      The authors present the first case of paracentral acute middle maculopathy as a manifestation of primary antiphospholipid syndrome (APS) with multimodal imaging, including optical coherence tomography angiography (OCTA). The association between APS and ophthalmic sequela is well-known. Recent advances in multimodal imaging, specifically OCTA, allow for better characterization of the mechanism and extent by which retinal arterial thrombosis can cause vision loss. Using advanced imaging modalities, the authors provide a comprehensive assessment of retinal ischemia, which showed not only localized capillary occlusion, but also ischemia of the deep retinal capillary plexus.

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    12. Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery

      Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery

      The authors report the use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT), capable of live four-dimensional (three-dimensional across time) intraoperative imaging, to directly visualize suture depth during lateral rectus resection. Key surgical steps visualized in this report included needle depth during partial and full-thickness muscle passes along with scleral passes.

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    13. Detection of Minimally Visible Recurrent Retinoblastoma by Hand-held Spectral-Domain Optical Coherence Tomography

      Detection of Minimally Visible Recurrent Retinoblastoma by Hand-held Spectral-Domain Optical Coherence Tomography

      A 2-month-old male infant with bilateral familial retinoblastoma was treated with intravenous chemotherapy and focal adjuvant therapy. At 5 months of follow-up, fundus examination and ultrasonography disclosed no recurrence; however, hand-held spectral-domain optical coherence tomography (SD-OCT) demonstrated subclinical recurrence within a previous regression scar. Subsequent treatment led to flat scar. Hand-held SD-OCT can be a useful tool for detection of subclinical recurrent retinoblastoma.

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    14. OCT angiography offers dual advantage of imaging structure, blood flow

      OCT angiography offers dual advantage of imaging structure, blood flow

      tate-of-the-art of optical coherence tomography angiography in 2017 is for diagnosis and management of neovascularization, according to a speaker here. “It’s a single device, two modalities,” Jay S. Duker, MD , said at Retina 2017. “And once you get over the initial cost of buying OCTA, there’s really not a lot of added cost. It’s a few seconds of chair time per eye.” Jay S. Duker OCT angiography allows clinicians to view both the structure and blood flow of the retinal and choroidal tissue simultaneously via three-dimensional angiograms, providing a tool for diagnosing neovascularization and other abnormalities. It ...

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    15. Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      PURPOSE: To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles. . METHODS: Seventy eyes from 35 healthy patients were studied. Three OCT instruments—Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)—were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles. The intraclass correlation coefficient (ICC) was calculated to determine the reproducibility and the agreement between the three ...

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    16. Waheed gives four steps for detecting CNV with OCT angiography

      Waheed gives four steps for detecting CNV with OCT angiography

      Even though fluorescein angiography plus high-resolution optical coherence tomography is the gold standard for detecting neovascularization, OCT angiography does a better job than FA in some situations, Nadia K. Waheed , MD, said at Retina 2017. However, interpreting the OCT angiography findings can be time consuming, with the reader needing sometimes to scroll through entire data sets. In cases of suspected choroidal neovascularization, Waheed offered guidance to help OCT angiography users interpret the data. First, she said, make sure to look at the right spot using the 3 by 3 scan to provide the highest resolution. “The second step that I ...

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    17. OCT Study of the Femtosecond Laser Opaque Bubble Layer

      OCT Study of the Femtosecond Laser Opaque Bubble Layer

      PURPOSE: To characterize the location and regularity of the opaque bubble layer (OBL) in the corneal stroma after femtosecond laser-assisted LASIK (FS-LASIK) flap generation. METHODS: In this prospective study, 30 eyes of 15 patients who had FS-LASIK surgery for myopia, astigmatism, and/or hyperopia were included. Screen captures were obtained at the end of the flap creation and the eyes with hard type OBL were immediately imaged with anterior segment optical coherence tomography. RESULTS: The mean age of the 9 men and 6 women was 40 ± 11.3 years (range: 22 to 60 years). Seven eyes (23.3%) developed hard ...

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      Mentions: Cleveland Clinic
    18. Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      BACKGROUND AND OBJECTIVE: To compare the features of cystoid cavities associated with full-thickness macular hole (FTMH) imaged with optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Prospective, observational, cross-sectional study. Clinical practice and observation. Thirteen patients (13 eyes) with FTMH were evaluated before vitrectomy. All eyes underwent OCTA or en face OCT imaging. RESULTS: There was a statistically significant positive correlation between groups for the total cavity area in both inner nuclear layer ( P < .001; r 2 = 0.82) and outer plexiform and Henle fiber layer complex ( P < .001; r 2 = 0.84). CONCLUSIONS: OCTA and ...

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    19. Choroidal Osteoma Deossification Visualized by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Choroidal Osteoma Deossification Visualized by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Choroidal osteoma (CO) is a rare, benign ossifying lesion of the choroid found in otherwise healthy patients. Although associated with good visual prognosis, tumor deossification in choroidal osteoma has been linked with vision loss, presumably due to overlying photoreceptor degeneration. Here the authors present a case of CO in an elderly male demonstrating tumor deossification and photoreceptor atrophy during a 3-year follow-up using enhanced depth imaging optical coherence tomography (EDI-OCT). Visual acuity was maintained due to the tumor's noncentral location. Patients with CO should undergo regular imaging with EDI-OCT to screen for tumor deossification and impending vision loss.

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    20. OCTA useful for early detection in diabetic retinopathy

      OCTA useful for early detection in diabetic retinopathy

      Optical coherence tomography angiography detected microaneurysms that were not seen in fundus photography, according to Jessica Steen, OD, FAAO. Steen presented her study results here at a press conference sponsored by the American Academy of Optometry . Jessica Steen She presented a case series of three female patients between the ages of 62 and 68 years who had diabetes mellitus type 2 for a duration of 16 to 32 years. Their clinical level of diabetic retinopathy ranged from none to proliferative. “Microaneurysms are the earliest marker for diabetic retinopathy,” Steen said. In these three patients, Steen “qualitatively identified microaneurysms on OCT ...

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    21. Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity

      Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity

      BACKGROUND AND OBJECTIVE: To characterize the in vivo microstructural features of patients with history of retinopathy of prematurity (ROP). PATIENTS AND METHODS: A single-center, retrospective imaging case series during which a chart review was performed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpretable SD-OCT images were excluded. Main outcome measures included best-corrected visual acuity (BCVA) and exploratory SD-OCT findings. RESULTS: A total of 186 eyes of 112 patients (mean age: 31.5 years; range: 8 years to 70 years ...

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    22. Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA. In this report, a 38-year-old woman with PIC and idiopathic CNV presented with blurred vision despite 18/20 visual acuity. FA revealed positive staining and possible leakage, but did not provide clear ...

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    23. Optical Coherence Tomography Angiography in Foveal Hypoplasia

      Optical Coherence Tomography Angiography in Foveal Hypoplasia

      BACKGROUND AND OBJECTIVE: A retrospective case series reporting optical coherence tomography angiography (OCTA) findings in foveal hypoplasia. PATIENTS AND METHODS: Patients with foveal hypoplasia who presented to the authors' tertiary eye center. Cases of foveal hypoplasia that underwent OCTA were reviewed, and the clinical histories as well as imaging findings were summarized. RESULTS: Three patients presented to the authors' eye center for evaluation of foveal hypoplasia and underwent OCTA: a 5-year-old girl, a 40-year-old woman, and a 22-year-old man. OCTA images were taken for both eyes of all patients. Four of five eyes with foveal hypoplasia had a small but ...

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    1-24 of 223 1 2 3 4 5 6 7 8 9 10 »
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