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    1. OCT angiography offers dual advantage of imaging structure, blood flow

      OCT angiography offers dual advantage of imaging structure, blood flow

      tate-of-the-art of optical coherence tomography angiography in 2017 is for diagnosis and management of neovascularization, according to a speaker here. “It’s a single device, two modalities,” Jay S. Duker, MD , said at Retina 2017. “And once you get over the initial cost of buying OCTA, there’s really not a lot of added cost. It’s a few seconds of chair time per eye.” Jay S. Duker OCT angiography allows clinicians to view both the structure and blood flow of the retinal and choroidal tissue simultaneously via three-dimensional angiograms, providing a tool for diagnosing neovascularization and other abnormalities. It ...

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    2. Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      Agreement Between Three Optical Coherence Tomography Devices to Assess the Insertion Distance and Thickness of Horizontal Rectus Muscles

      PURPOSE: To assess the agreement between two different spectral domain (SD-OCT) and one swept source (SS-OCT) optical coherence tomography device to measure the insertion distance and the thickness of the horizontal rectus muscles. . METHODS: Seventy eyes from 35 healthy patients were studied. Three OCT instruments—Spectralis (Heidelberg Engineering Inc., Heidelberg, Germany), Cirrus 5000 (Carl Zeiss Meditec, Dublin, CA), and Triton (Topcon, Inc., Tokyo, Japan)—were used to measure the limbus insertion distance and the thickness of the lateral rectus and medial rectus muscles. The intraclass correlation coefficient (ICC) was calculated to determine the reproducibility and the agreement between the three ...

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    3. Waheed gives four steps for detecting CNV with OCT angiography

      Waheed gives four steps for detecting CNV with OCT angiography

      Even though fluorescein angiography plus high-resolution optical coherence tomography is the gold standard for detecting neovascularization, OCT angiography does a better job than FA in some situations, Nadia K. Waheed , MD, said at Retina 2017. However, interpreting the OCT angiography findings can be time consuming, with the reader needing sometimes to scroll through entire data sets. In cases of suspected choroidal neovascularization, Waheed offered guidance to help OCT angiography users interpret the data. First, she said, make sure to look at the right spot using the 3 by 3 scan to provide the highest resolution. “The second step that I ...

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    4. OCT Study of the Femtosecond Laser Opaque Bubble Layer

      OCT Study of the Femtosecond Laser Opaque Bubble Layer

      PURPOSE: To characterize the location and regularity of the opaque bubble layer (OBL) in the corneal stroma after femtosecond laser-assisted LASIK (FS-LASIK) flap generation. METHODS: In this prospective study, 30 eyes of 15 patients who had FS-LASIK surgery for myopia, astigmatism, and/or hyperopia were included. Screen captures were obtained at the end of the flap creation and the eyes with hard type OBL were immediately imaged with anterior segment optical coherence tomography. RESULTS: The mean age of the 9 men and 6 women was 40 ± 11.3 years (range: 22 to 60 years). Seven eyes (23.3%) developed hard ...

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      Mentions: Cleveland Clinic
    5. Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      BACKGROUND AND OBJECTIVE: To compare the features of cystoid cavities associated with full-thickness macular hole (FTMH) imaged with optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Prospective, observational, cross-sectional study. Clinical practice and observation. Thirteen patients (13 eyes) with FTMH were evaluated before vitrectomy. All eyes underwent OCTA or en face OCT imaging. RESULTS: There was a statistically significant positive correlation between groups for the total cavity area in both inner nuclear layer ( P < .001; r 2 = 0.82) and outer plexiform and Henle fiber layer complex ( P < .001; r 2 = 0.84). CONCLUSIONS: OCTA and ...

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    6. Choroidal Osteoma Deossification Visualized by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Choroidal Osteoma Deossification Visualized by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Choroidal osteoma (CO) is a rare, benign ossifying lesion of the choroid found in otherwise healthy patients. Although associated with good visual prognosis, tumor deossification in choroidal osteoma has been linked with vision loss, presumably due to overlying photoreceptor degeneration. Here the authors present a case of CO in an elderly male demonstrating tumor deossification and photoreceptor atrophy during a 3-year follow-up using enhanced depth imaging optical coherence tomography (EDI-OCT). Visual acuity was maintained due to the tumor's noncentral location. Patients with CO should undergo regular imaging with EDI-OCT to screen for tumor deossification and impending vision loss.

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    7. OCTA useful for early detection in diabetic retinopathy

      OCTA useful for early detection in diabetic retinopathy

      Optical coherence tomography angiography detected microaneurysms that were not seen in fundus photography, according to Jessica Steen, OD, FAAO. Steen presented her study results here at a press conference sponsored by the American Academy of Optometry . Jessica Steen She presented a case series of three female patients between the ages of 62 and 68 years who had diabetes mellitus type 2 for a duration of 16 to 32 years. Their clinical level of diabetic retinopathy ranged from none to proliferative. “Microaneurysms are the earliest marker for diabetic retinopathy,” Steen said. In these three patients, Steen “qualitatively identified microaneurysms on OCT ...

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    8. Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity

      Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity

      BACKGROUND AND OBJECTIVE: To characterize the in vivo microstructural features of patients with history of retinopathy of prematurity (ROP). PATIENTS AND METHODS: A single-center, retrospective imaging case series during which a chart review was performed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpretable SD-OCT images were excluded. Main outcome measures included best-corrected visual acuity (BCVA) and exploratory SD-OCT findings. RESULTS: A total of 186 eyes of 112 patients (mean age: 31.5 years; range: 8 years to 70 years ...

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    9. Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA. In this report, a 38-year-old woman with PIC and idiopathic CNV presented with blurred vision despite 18/20 visual acuity. FA revealed positive staining and possible leakage, but did not provide clear ...

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    10. Optical Coherence Tomography Angiography in Foveal Hypoplasia

      Optical Coherence Tomography Angiography in Foveal Hypoplasia

      BACKGROUND AND OBJECTIVE: A retrospective case series reporting optical coherence tomography angiography (OCTA) findings in foveal hypoplasia. PATIENTS AND METHODS: Patients with foveal hypoplasia who presented to the authors' tertiary eye center. Cases of foveal hypoplasia that underwent OCTA were reviewed, and the clinical histories as well as imaging findings were summarized. RESULTS: Three patients presented to the authors' eye center for evaluation of foveal hypoplasia and underwent OCTA: a 5-year-old girl, a 40-year-old woman, and a 22-year-old man. OCTA images were taken for both eyes of all patients. Four of five eyes with foveal hypoplasia had a small but ...

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    11. Ultra-wide Field Imaging and Swept Source Optical Coherence Tomography of Ocular Electrical Injury in a Child

      Ultra-wide Field Imaging and Swept Source Optical Coherence Tomography of Ocular Electrical Injury in a Child

      History of trauma in children may be obscured and physicians often rely on signs for diagnosis. The authors discuss a case of electrical injury where ocular signs led to diagnosis of the cause of macular atrophy. A high index of suspicion must always be maintained in such atypical cases, and the setting of electrical injury to the body requires meticulous ocular examination.

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    12. Comparison of Optical Coherence Tomography Angiography and Fluorescein Angiography for the Identification of Retinal Vascular Changes in Eyes With Diabetic Macular Edema

      Comparison of Optical Coherence Tomography Angiography and Fluorescein Angiography for the Identification of Retinal Vascular Changes in Eyes With Diabetic Macular Edema

      BACKGROUND AND OBJECTIVE: To compare the visualization of microaneurysms (MA) and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) versus fluorescein angiography (FA) in patients with diabetic macular edema (DME). PATIENTS AND METHODS: Patients were prospectively recruited for same-day imaging on spectral-domain OCTA and FA. OCTA images were automatically segmented into superficial (sOCTA) and deep (dOCTA) capillary plexuses. The number of visible MAs and the FAZ area were compared between the two imaging modalities. RESULTS: Nineteen eyes of 10 patients were included. There was a statistically significant difference between MA counts for FA, sOCTA, and dOCTA ...

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    13. Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      Optical Coherence Tomography Angiography Findings in Dengue-Related Maculopathy: A Case Report

      The ophthalmic manifestations of dengue fever include a visually impairing maculopathy, where patients are left with a central or paracentral relative scotoma. The authors present a case of a 26-year-old female patient returning from Thailand with unilateral reduction in visual acuity and a central scotoma associated with dengue fever. The authors report the use of the optical coherence tomography angiography (OCTA) as a noninvasive imaging platform to demonstrate its value in showing the persistent changes corresponding to the functional central scotoma in dengue-related maculopathy, which often cannot be visualized clinically or by standard OCT and fundus fluorescein angiography.

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    14. Optical Coherence Tomography Angiography Characteristics of Fovea in Residual Subfoveal Perfluorocarbon Liquid Eye

      Optical Coherence Tomography Angiography Characteristics of Fovea in Residual Subfoveal Perfluorocarbon Liquid Eye

      The authors report a case of optical coherence tomography angiography (OCTA) features of retina and choriocapillaris before and after the surgical removal of a subfoveal perfluorocarbon liquid (PFCL) bubble. Before the surgery, the fovea avascular zone (FAZ) of both superficial and deep inner retinal layers (SRL/DRL) dramatically enlarged. However, after the removal, the FAZ continually decreased in both layers, even becoming close to normal in size. The abnormal choriocapillaris dark areas were also undetectable. Before and after surgery, the angle of the maximum FAZ diameter constantly remained horizontal and within normal limit in the SRL, forming an oval-shaped FAZ.

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    15. OCT-guided PCI noninferior to IVUS-guided PCI

      OCT-guided PCI noninferior to IVUS-guided PCI

      Optical coherence tomography-guided PCI was noninferior to IVUS-guided PCI in achieving minimum stent area and in procedural MACE, according to new data from the ILUMIEN III (OPTIMIZE PCI) trial presented at TCT 2016. The trial included 450 patients aged 18 years and older from 29 hospitals in eight countries who had one or more target lesions in a native coronary artery with a visually estimated reference vessel diameter of 2.25 mm to 3.50 mm and length 40 mm. Its purpose was to determine whether an OCT-based stent sizing strategy would result in a minimum stent area better than ...

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    16. Value of Optical Coherence Tomography Angiography Imaging in Diagnosis and Treatment of Hemangioblastomas in von Hippel-Lindau Disease

      Value of Optical Coherence Tomography Angiography Imaging in Diagnosis and Treatment of Hemangioblastomas in von Hippel-Lindau Disease

      BACKGROUND AND OBJECTIVE: The introduction of optical coherence tomography angiography (OCTA) provides new insights into the retinal vasculature. The aim of this study was to explore the value of OCTA in imaging retinal hemangioblastomas and monitoring laser treatment in patients with von Hippel-Lindau (VHL) disease. PATIENTS AND METHODS: Ten eyes of 10 patients with VHL disease were included in this retrospective case series. All patients underwent complete ophthalmological work-up including OCTA for retinal and optic nerve head hemangioblastoma. RESULTS: Two patients showed retinal scars and no recurrence of hemangioblastoma in OCTA. Three patients revealed recurrent hemangioblastomas. Two patients demonstrated a ...

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    17. Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response

      Optical Coherence Tomography Features in Diabetic Macular Edema and the Impact on Anti-VEGF Response

      BACKGROUND AND OBJECTIVE: To assess the relationship between spectral-domain optical coherence tomography (SD-OCT) features and functional outcomes for diabetic macular edema (DME) undergoing treatment with intravitreal bevacizumab (Avastin; Genentech, South San Francisco, CA). PATIENTS AND METHODS: Institutional review board-approved, retrospective, consecutive case series of eyes receiving intravitreal bevacizumab (1.25 mg) for DME. SD-OCT features were evaluated and correlated with functional response to anti-vascular endothelial growth factor (VEGF) therapy. RESULTS: One hundred fifty-nine eyes of 159 subjects were included in this study. Mean visual acuity improved from 20/76 to 20/58. The proportion of eyes with 20/40 or ...

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    18. Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye, previously treated with anti-vascular endothelial growth factor, and was imaged on both SD-OCT and SS-OCT. The neovascular complex could be visualized on both devices. Structural en face SS-OCT images demonstrated ...

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    19. Portable Optical Coherence Tomography Detection or Confirmation of Ophthalmoscopically Invisible or Indeterminate Active Retinoblastoma

      Portable Optical Coherence Tomography Detection or Confirmation of Ophthalmoscopically Invisible or Indeterminate Active Retinoblastoma

      Portable, hand-held optical coherence tomography (OCT) revealed three clinically relevant yet not ophthalmoscopically detected or confirmed manifestations of retinoblastoma in a single patient with familial bilateral disease. Specifically, OCT showed new retinal tumors, new vitreous seeds, and tumor recurrence before they could be detected or confirmed by ophthalmoscopy.

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    20. Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Associated With Focal Choroidal Excavation

      Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Associated With Focal Choroidal Excavation

      The authors report the use of optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) to localize, characterize, and confirm the presence of a choroidal neovascular membrane in a patient of focal choroidal excavation (FCE) with recent-onset metamorphopsia and visual blurring. En face OCTA images just above the level of the retinal pigment epithelium-Bruch's membrane complex typically showed the presence of a glomerulus-like neovascular network with an adjacent dark area suggestive of a Type 2 choroidal neovascularization (CNV). OCTA was found to be a very useful, noninvasive, and quick imaging modality to detect secondary CNV formation in ...

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    21. Optical Coherence Tomography Angiography Imaging of Congenital Retinal Macrovessel

      Optical Coherence Tomography Angiography Imaging of Congenital Retinal Macrovessel

      Congenital retinal macrovessels (CRM) are rarely reported, aberrant, large branches of retinal vessels that can be both arteries and veins; however, they are more commonly veins that cross the horizontal raphe to either supply or drain the macula. In this brief report, the authors discuss optical coherence tomography angiography features of CRM in a 12-year-old male patient presenting with low visual acuity in the right eye since childhood. To the authors' knowledge, this is the first such report published in the literature.

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    22. Optovue launches OCTA in optometry

      Optovue launches OCTA in optometry

      Optovue introduced AngioVue, a noninvasive 3-D visualization of retinal blood flow, as an addition to its conventional OCT, here at Vision Expo West . Optovue’s senior director of U.S. sales, Joe Garibaldi, told Primary Care Optometry News that this conference represented the product’s launch in optometry. With AngioVue, “You’re getting fluorescein angiography-like results and indocyanine green results,” Garibaldi said, in 5 seconds, with no injections. He noted that the technology is a software upgrade to the Avanti OCT. The company also announced the launch of Vault Mapping software, an addition to its iVue/iFusion and iScan OCT ...

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      Mentions: Optovue
    23. Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg receives FDA clearance to market Spectralis OCT glaucoma module

      Heidelberg Engineering received 510(k) clearance from the FDA to market the Spectralis OCT Glaucoma Module Premium Edition, which creates an anatomic map unique to each patient’s eye. The module provides clinicians with objective and automatic measurement parameters for increased diagnostic accuracy, according to a company press release. It utilizes a new technology called Anatomic Positioning System, which uses the center of the fovea and the center of Bruch’s membrane opening to create an anatomic map of the eye. Each scan thereafter is automatically oriented according to each patient’s unique anatomic eye map. In addition, the module ...

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    24. Optical Coherence Tomography Angiography of Chorioretinal Diseases

      Optical Coherence Tomography Angiography of Chorioretinal Diseases

      Fluorescein angiography (FA) and indocyanine green angiography (ICGA) have been the gold standard for the evaluation of retinal and choroidal vasculature in the last three decades and have revolutionized the diagnosis of retinal and choroidal vascular diseases. The advantage of these imaging modalities lies in their ability to document retinal and choroidal vasculature through the dynamic assessment of contrast transit over time in the intravascular and extravascular spaces. However, disadvantages include the absence of depth resolution, blurring of details by contrast leakage, and the inability to selectively evaluate different levels of the retinal and choroidal microvasculature. In addition, these angiographic ...

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