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    1. Comparison of post-stent irregular protrusion and subsequent neointimal characteristics between second- and third-generation drug-eluting stent implantation

      Comparison of post-stent irregular protrusion and subsequent neointimal characteristics between second- and third-generation drug-eluting stent implantation

      Background Third-generation drug-eluting-stents (3rd DES) may improve coronary arterial healing and reduce neoatherosclerosis formation. We evaluated post-stent findings and subsequent vascular healing of 3rd DES by comparing to second-generation drug-eluting-stents (2nd DES) at intermediate-term follow-up using optical coherence tomography (OCT). Method We evaluated 170 patients with 170 lesions who underwent DES implantation (2nd DES, n = 98; 3rd DES, n = 72) and OCT-guided follow-up examination. After propensity score (PS) matching for baseline clinical characteristics, OCT findings from 56 pairs of patients with 2nd DES and 3rd DES implants were compared. Post-stent irregular protrusion (IP) was defined as the protrusion of material ...

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    2. Late stent collapse identified with OCT – An underdiagnosed mechanism of restenosis?

      Late stent collapse identified with OCT – An underdiagnosed mechanism of restenosis?

      Very late stent recoil is a rare albeit recognized phenomenon leading to subsequent in-stent restenosis. Angiography alone may not be adequate in making the diagnosis, and intravascular imaging with optical coherence tomography (OCT) is far superior in confirming the diagnosis and guiding subsequent management. We describe a case with interesting coronary angiogram and OCT images demonstrating very rare diagnosis of the late stent collapse. These images provide a valuable insight into a novel mechanism responsible for late target lesion failure. These images highlight the importance of modern intra-coronary imaging techniques in understanding the mechanisms underlying target-lesion failure, and guiding appropriate ...

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    3. Optical coherence tomography images of three different overlapping stents

      Optical coherence tomography images of three different overlapping stents

      A 49-year-old Caucasian woman with prior history of hypertension, diabetes and smoking presented with an inferior ST-elevation myocardial infarction in Killip class I. Ischemia time was four hours. Primary percutaneous coronary intervention (PCI) was performed with thrombus aspiration and direct stenting with a drug-eluting stent (DES). She subsequently underwent PCI with bioresorbable vascular scaffolds (BVS) in the circumflex artery (Cx). After deployment of the BVS a coronary perforation was seen at the distal edge of the device. A stent graft was implanted overlapping the edge of the BVS. The perforation was resolved, nevertheless the distal lesion on the CX artery ...

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    4. Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Agreement between intraoperative measurements and optical coherence tomography of the limbus-insertion distance of the extraocular muscles

      Objective To assess the agreement between intraoperative measurements of the limbus-insertion distance of the extraocular muscles with those measured by spectral domain optical coherence tomography. Methods An analysis was made of a total of 67 muscles of 21 patients with strabismus. The limbus-insertion distance of the horizontal rectus muscles were measured using pre-operative SD-OCT and intra-operatively in 2 ways: 1) direct, after a conjunctival dissection in patients who underwent surgery, or 2) transconjunctival in patients who were treated with botulinum toxin, or in those who were not going to be operated. The intraclass correlation coefficient and Bland-Altman plots were calculated ...

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    5. Heart transplant coronary artery disease: Multimodality approach in percutaneous intervention

      Heart transplant coronary artery disease: Multimodality approach in percutaneous intervention

      Coronary artery disease is the most important cause of late morbidity and mortality after heart transplantation. It is usually an immunologic phenomenon termed cardiac allograft vasculopathy, but can also be the result of donor-transmitted atherosclerosis. Routine surveillance by coronary angiography should be complemented by intracoronary imaging, in order to determine the nature of the coronary lesions, and also by assessment of their functional significance to guide the decision whether to perform percutaneous coronary intervention. We report a case of coronary angiography at five-year follow-up after transplantation, using optical coherence tomography and fractional flow reserve to assess and optimize treatment of ...

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    6. Multimodality Intravascular Imaging to Evaluate Sex Differences in Plaque Morphology in Stable CAD

      Multimodality Intravascular Imaging to Evaluate Sex Differences in Plaque Morphology in Stable CAD

      OBJECTIVES: The aim of this study was to evaluate sex differences in plaque morphology in stable coronary artery disease (CAD) patients using a multimodality intravascular imaging approach. BACKGROUND: Differences in atherosclerotic burden and plaque morphology between men and women is a focus of treatment and preventative measures. METHODS: We retrospectively analyzed data from 383 patients with stable CAD who were referred for angiography and underwent optical coherence tomography. Among them, 128 also underwent intravascular ultrasound (IVUS)/near infrared spectroscopy. RESULTS: Of the 383 patients included in the study, 268 were men and 115 were women. Women tended to be older ...

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    7. Serial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions

      Serial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions

      Objectives This study sought to report the late multimodality imaging and clinical outcomes of the novel poly- l -lactic-acid–based DESolve novolimus-eluting bioresorbable coronary scaffold for the treatment of de novo coronary lesions. Background Bioresorbable scaffolds are an alternative to drug-eluting metallic stents and provide temporary vascular scaffolding, which potentially may allow vessel restoration and reduce the risk of future adverse events. Methods Overall, 126 patients were enrolled at 13 international sites between November 2011 and June 2012. The primary endpoint was in-scaffold late lumen loss at 6 months. Major adverse cardiac events, the main safety endpoint, were defined as ...

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    8. Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Subfoveal choroidal thickness in eyes with diabetic macular oedema using swept source optical coherence tomography

      Purpose To compare subfoveal choroidal thickness (GCSF) in patients with diabetic macular oedema (DMO) and healthy subjects using swept source optical coherence tomography (SS-OCT). Method Cross-sectional study including 50 eyes of 36 patients with DMO, and 47 eyes of 34 patients as a control group. GCSF was measured in both groups, analysing between the eyes with DMO according to the type of oedema (predominantly cystic or diffuse). Results The study groups were homogeneous in terms of mean age (63.4 years for DMO and 62.65 years for controls; P =.36) and the mean axial length (23.21 mm for ...

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    9. Identification of iridocorneal angle structures assessed by Fourier domain optical coherence tomography

      Identification of iridocorneal angle structures assessed by Fourier domain optical coherence tomography

      Objective To study the structures of the iridocorneal angle using anterior segment optical coherence tomography (OCT) defining their tomographic characteristics and quantifying their identification frequency. Material and methods A cross-sectional study was performed on 267 right eyes of 267 consecutive healthy patients. Fourier domain OCT RTVue (Optovue Inc, CA, EE. UU.) was used to examine the iridocorneal angle in the nasal and temporal sectors. The structures evaluated were: Sclerocorneal limbus, sclerocorneal transition, Schwalbe's line, trabecular meshwork, Schlemm's canal, scleral spur, and angular recess. Within and between agreements to identify structures were calculated using Cohen's kappa coefficient. Results ...

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      Mentions: Optovue
    10. Optical coherence tomography of re-pressurized porcine coronary arteries: A systematic study

      Optical coherence tomography of re-pressurized porcine coronary arteries: A systematic study

      Abstract Cardiovascular death is the most frequently reported cause of adult natural death in autopsy reports in the UK. However, the approach used for diagnosing coronary artery disease at autopsy is largely based on visual assessment of coronary artery cross sections to determine the severity of stenosis. This is subject to criticism and heterogeneity. Objective We investigated the potential role of a novel intravascular imaging technique, Optical Coherence Tomography (OCT), in post-mortem diagnosis of coronary artery disease and what effect re-pressurisation has on vessel dimensions, as measured by OCT. Our long term aim is to investigate the role of OCT ...

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