Objective: To investigate multiple sclerosis (MS) optical coherence tomography (OCT) cross-sectional correlations with central nervous system (CNS) magnetic resonance imaging (MRI). Material and methods: Peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner (INL) and outer nuclear layer (ONL) of 54 relapsing remitting (RRMS) and 38 progressive (PMS, 9 primary and 29 secondary) patients were measured. With less than 3 months brain parenchymal fraction (BPF), spinal cord (SC), total gray matter (GM) and white matter volumes were calculated. Demographical and clinical data was compared according to the history of optic neuritis (HON). Relationships between ...

Pre-eclampsia is a multisystem progressive disorder characterized by the new onset of hypertension and proteinuria or end-organ dysfunction in the last half of pregnancy. The prevalence of retinal involvement may vary according to the severity of pre-eclampsia. The correlation between systemic features and retinal morbidity in pre-eclamptic women is still controversial. To the best of our knowledge, there is lack of data regarding the correlation between other systemic features and retinal morbidity.

Background Third-generation drug-eluting-stents (3rd DES) may improve coronary arterial healing and reduce neoatherosclerosis formation. We evaluated post-stent findings and subsequent vascular healing of 3rd DES by comparing to second-generation drug-eluting-stents (2nd DES) at intermediate-term follow-up using optical coherence tomography (OCT). Method We evaluated 170 patients with 170 lesions who underwent DES implantation (2nd DES, n = 98; 3rd DES, n = 72) and OCT-guided follow-up examination. After propensity score (PS) matching for baseline clinical characteristics, OCT findings from 56 pairs of patients with 2nd DES and 3rd DES implants were compared. Post-stent irregular protrusion (IP) was defined as the protrusion of material ...

Very late stent recoil is a rare albeit recognized phenomenon leading to subsequent in-stent restenosis. Angiography alone may not be adequate in making the diagnosis, and intravascular imaging with optical coherence tomography (OCT) is far superior in confirming the diagnosis and guiding subsequent management. We describe a case with interesting coronary angiogram and OCT images demonstrating very rare diagnosis of the late stent collapse. These images provide a valuable insight into a novel mechanism responsible for late target lesion failure. These images highlight the importance of modern intra-coronary imaging techniques in understanding the mechanisms underlying target-lesion failure, and guiding appropriate ...

A 49-year-old Caucasian woman with prior history of hypertension, diabetes and smoking presented with an inferior ST-elevation myocardial infarction in Killip class I. Ischemia time was four hours. Primary percutaneous coronary intervention (PCI) was performed with thrombus aspiration and direct stenting with a drug-eluting stent (DES). She subsequently underwent PCI with bioresorbable vascular scaffolds (BVS) in the circumflex artery (Cx). After deployment of the BVS a coronary perforation was seen at the distal edge of the device. A stent graft was implanted overlapping the edge of the BVS. The perforation was resolved, nevertheless the distal lesion on the CX artery ...

Objective To assess the agreement between intraoperative measurements of the limbus-insertion distance of the extraocular muscles with those measured by spectral domain optical coherence tomography. Methods An analysis was made of a total of 67 muscles of 21 patients with strabismus. The limbus-insertion distance of the horizontal rectus muscles were measured using pre-operative SD-OCT and intra-operatively in 2 ways: 1) direct, after a conjunctival dissection in patients who underwent surgery, or 2) transconjunctival in patients who were treated with botulinum toxin, or in those who were not going to be operated. The intraclass correlation coefficient and Bland-Altman plots were calculated ...

Images in Intervention

Images in Intervention

Images in Intervention

Coronary artery disease is the most important cause of late morbidity and mortality after heart transplantation. It is usually an immunologic phenomenon termed cardiac allograft vasculopathy, but can also be the result of donor-transmitted atherosclerosis. Routine surveillance by coronary angiography should be complemented by intracoronary imaging, in order to determine the nature of the coronary lesions, and also by assessment of their functional significance to guide the decision whether to perform percutaneous coronary intervention. We report a case of coronary angiography at five-year follow-up after transplantation, using optical coherence tomography and fractional flow reserve to assess and optimize treatment of ...

There are numerous treatments options for patients with peripherial artery disease (PAD)....

Images in intervention.

No abstract provided.

OBJECTIVES: The aim of this study was to evaluate sex differences in plaque morphology in stable coronary artery disease (CAD) patients using a multimodality intravascular imaging approach. BACKGROUND: Differences in atherosclerotic burden and plaque morphology between men and women is a focus of treatment and preventative measures. METHODS: We retrospectively analyzed data from 383 patients with stable CAD who were referred for angiography and underwent optical coherence tomography. Among them, 128 also underwent intravascular ultrasound (IVUS)/near infrared spectroscopy. RESULTS: Of the 383 patients included in the study, 268 were men and 115 were women. Women tended to be older ...

No abstract provided.

Objectives This study sought to report the late multimodality imaging and clinical outcomes of the novel poly- l -lactic-acid–based DESolve novolimus-eluting bioresorbable coronary scaffold for the treatment of de novo coronary lesions. Background Bioresorbable scaffolds are an alternative to drug-eluting metallic stents and provide temporary vascular scaffolding, which potentially may allow vessel restoration and reduce the risk of future adverse events. Methods Overall, 126 patients were enrolled at 13 international sites between November 2011 and June 2012. The primary endpoint was in-scaffold late lumen loss at 6 months. Major adverse cardiac events, the main safety endpoint, were defined as ...

A 56-year-old man with a medical history of hypertension and diabetes was referred by his primary care physician to out hospital for an electrocardiographic abnormality.

No abstract provided

Purpose To compare subfoveal choroidal thickness (GCSF) in patients with diabetic macular oedema (DMO) and healthy subjects using swept source optical coherence tomography (SS-OCT). Method Cross-sectional study including 50 eyes of 36 patients with DMO, and 47 eyes of 34 patients as a control group. GCSF was measured in both groups, analysing between the eyes with DMO according to the type of oedema (predominantly cystic or diffuse). Results The study groups were homogeneous in terms of mean age (63.4 years for DMO and 62.65 years for controls; P =.36) and the mean axial length (23.21 mm for ...

No abstract provided.

A 33-year-old man presented with chest pain and dynamic ST-segment elevation in the anterior leads...

Objective To study the structures of the iridocorneal angle using anterior segment optical coherence tomography (OCT) defining their tomographic characteristics and quantifying their identification frequency. Material and methods A cross-sectional study was performed on 267 right eyes of 267 consecutive healthy patients. Fourier domain OCT RTVue (Optovue Inc, CA, EE. UU.) was used to examine the iridocorneal angle in the nasal and temporal sectors. The structures evaluated were: Sclerocorneal limbus, sclerocorneal transition, Schwalbe's line, trabecular meshwork, Schlemm's canal, scleral spur, and angular recess. Within and between agreements to identify structures were calculated using Cohen's kappa coefficient. Results ...

Given the marked increase in the number of patients with atrial fibrillation more than 80% of acute limb ischemia cases are now due to cardiac embolism associated with atrial fibrillation.

Abstract Cardiovascular death is the most frequently reported cause of adult natural death in autopsy reports in the UK. However, the approach used for diagnosing coronary artery disease at autopsy is largely based on visual assessment of coronary artery cross sections to determine the severity of stenosis. This is subject to criticism and heterogeneity. Objective We investigated the potential role of a novel intravascular imaging technique, Optical Coherence Tomography (OCT), in post-mortem diagnosis of coronary artery disease and what effect re-pressurisation has on vessel dimensions, as measured by OCT. Our long term aim is to investigate the role of OCT ...