1. 1-4 of 4
    1. Visual fields and optical coherence tomography (OCT) in neuro-ophthalmology: Structure-function correlation

      Visual fields and optical coherence tomography (OCT) in neuro-ophthalmology: Structure-function correlation

      Visual field (VF) testing is an essential component of the neurological examination. The differential diagnosis of VF defects depends on relating this measure of afferent visual function to the structure of the visual pathway and optical coherence tomography (OCT) is an invaluable tool for detailed structural evaluation of the optic nerve and retina. This review describes the ways in which interpretation of VF and OCT can be used together to increase the accuracy of the localization of lesions along the visual pathway. Lesions of the anterior visual pathway (originating in ganglion cells or nerve fibre layer of the retina or ...

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    2. OCT parameters of the optic nerve head and the retina as surrogate markers of brain volume in a normal population, a pilot study

      OCT parameters of the optic nerve head and the retina as surrogate markers of brain volume in a normal population, a pilot study

      The relationship between optical coherence tomography (OCT) measurements of the retinal structures has been described for various neurological diseases including Multiple Sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Brain volume changes, both globally and by area, are associated with some of these same diseases, yet the correlation of OCT and disease is not fully elucidated. Our study looked at normal subjects, at the correlation of OCT measurements and brain volumes, both globally and for specific regions including the pericalcarine grey matter, entorhinal grey matter, and cerebellar volume using a retrospective, cross-sectional cohort study design. Thickness of ...

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    3. The role of Optical Coherence Tomography in Parkinsonism: A critical review

      The role of Optical Coherence Tomography in Parkinsonism: A critical review

      Optical coherence tomography (OCT) has been evaluated as a tool to assess retinal changes in various neurodegenerative disorders. Parkinson's disease (PD), is a neurodegenerative disorder wherein dopaminergic deficiency results in some of the symptoms. As retina also has high concentration of dopamine, it would be of interest for both the clinician as well as the basic scientist to know if there is a correlation between the clinical features and the retinal changes. The objective of this review is to critically evaluate the literature and study the utility of OCT as a tool to evaluate retinal changes in PD .

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    4. Software updates of OCT segmentation algorithms influence longitudinal assessment of retinal atrophy

      Software updates of OCT segmentation algorithms influence longitudinal assessment of retinal atrophy

      Objective To investigate whether there is a systematic difference in peripapillary retinal nerve fiber layer (pRNFL) thickness measurements between subsequent updates of pRNFL segmentation software provided by Heidelberg Spectralis optical coherence tomography (OCT). Methods In total, 838 pRNFL scans from 213 multiple sclerosis (MS) patients and 61 healthy controls were analyzed. All scans were performed on the same OCT device followed by automated segmentation (HRA 5.6.4.0) and data extraction. Subsequently, all scans were re-segmented with an updated software version (HRA 6.0.7.0). To assess level of agreement between the two algorithms, Bland-Altman Plots were constructed ...

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    1-4 of 4
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