Local anatomic precursors to new onset geographic atrophy in age-related macular degeneration as defined on optical coherence tomography

Purpose In macula-wide analyses, spectral domain optical coherence tomography (SDOCT) features such as drusen volume, hyperreflective foci and OCT-reflective drusen substructures independently predict onset of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). We sought to identify SDOCT features in the location of new GA prior to its onset. Design Retrospective study Subjects Age-Related Eye Disease Study 2 Ancillary SDOCT Study Participants Methods We analyzed longitudinally-captured SDOCT and color photographs from 488 eyes (of 488 participants) with intermediate AMD at baseline. Sixty-two eyes with sufficient image quality demonstrated new onset GA on color photographs during study years two through ...