Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

Objective To report a novel finding of EpiRetinal Neovascularization (ERN) in cases of macular telangiectasia type 2 (MacTel) and describe its clinical and multimodal imaging features. Design Retrospective chart review Subjects/ participants- Patients attending the retina clinic from January 2017 to April 2018. Those diagnosed as MacTel by clinical and imaging findings were included. Methods Best corrected visual acuity (BCVA) in the logarithm of minimal angle of resolution (log Mar), anterior segment examination, slit lamp biomicroscopy, fundus photography, spectral domain- optical coherence tomography (SD-OCT), autofluorescence (AF) imaging, fundus fluorescein angiography (FFA) and optical coherence tomography angiography (OCTA) were done in ...

Objective To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs), before and after surgery, to normal controls. Design A retrospective study Subjects Patients with ERMs before and after surgery and normal controls. Methods Spectral domain optical coherence tomography (SD-OCT) of eyes with ERMs, before and after surgery, and normal eyes were analyzed for morphologic appearance and using a customized algorithm to measure retinal layer reflectance and thickness. Findings were correlated with visual acuity outcomes. Main Outcome Measure Retinal layer thickness and reflectance Results Thirty-four ERM and 12 normal eyes were identified. Mean preoperative ...

ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 (mean: 2.1) OCTs were performed. On OCT, nevi were classified into 5 subtypes: 3.2% were “not visible,” 37.2% had “hyperreflectivity confined within normal choroidal thickness,” 16.0 ...

Retinoblastoma (RB) is the most common primary intraocular malignancy of children. 1 Improvements in screening tactics and treatment methods have dramatically increased both patient and globe survival. 1,2 Imaging modalities such as fluorescein angiography (FA) have demonstrated retinal vascular abnormalities in both large and small caliber retinal vessels in eyes with retinoblastoma, 1 and optical coherence tomography (OCT) can reveal or confirm otherwise subclinical lesions. 2 OCT angiography (OCT-A) is a non-invasive imaging modality allowing for in vivo visualization of retinal and choroidal vasculature.

Purpose To report OCTA findings in 3 cases, 2 active and 1 inactive, of serpiginous choroidopathy (SC) and describe OCTA changes in response to treatment. Design Retrospective case series. Participants We studied 6 eyes of 3 patients with SC. Methods Retrospective case series of 3 patients with SC undergoing multimodal imaging, including OCTA. In 1 treated eye, both pre- and posttreatment images were compared. Main Outcome Measures Description of OCTA findings in patients with SC. Results In the active phase, OCTA images show an apparent absence of the choriocapillaris with variable outer retinal and retinal pigment epithelial thickening. After treatment ...

Purpose Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design Prospective cohort study. Participants Nine eyes from 9 healthy participants. Methods One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm 2 ) were acquired at baseline and during oxygen breathing. The split-spectrum amplitude-decorrelation algorithm was used to detect blood flow. The projection-resolved algorithm was used to suppress projection artifacts and resolve blood flow in 3 distinct parafoveal plexuses. The Wilcoxon signed-rank test was used to compare baseline and hyperoxic parameters. The ...