Purpose In macula-wide analyses, spectral domain optical coherence tomography (SDOCT) features such as drusen volume, hyperreflective foci and OCT-reflective drusen substructures independently predict onset of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). We sought to identify SDOCT features in the location of new GA prior to its onset. Design Retrospective study Subjects Age-Related Eye Disease Study 2 Ancillary SDOCT Study Participants Methods We analyzed longitudinally-captured SDOCT and color photographs from 488 eyes (of 488 participants) with intermediate AMD at baseline. Sixty-two eyes with sufficient image quality demonstrated new onset GA on color photographs during study years two through ...

Purpose To assess the accuracy of macular spectral domain optical coherence tomography (OCT) in detecting complete posterior vitreous detachment (PVD). Design Evaluation of diagnostic test or technology using a retrospective comparative study. Subjects 175 eyes in 175 patients (111 female, 64 male; mean age = 65 years) with pre-operative OCT within 90 days of vitrectomy. Methods PVD status on preoperative macular OCT was compared to PVD determination during vitrectomy. Attached vitreous was identified on OCT by visualizing the posterior vitreous cortex or the premacular bursa. Complete PVD was identified by the absence of these findings, and was considered a positive outcome ...

Aim We describe a novel spectral domain optical coherence tomography (SD-OCT) finding of double layer sign at the site of activity in tubercular serpiginous-like choroiditis (SLC) and how this sign can be used to assess treatment response in these eyes. Materials Methods Retrospective observational case series. We retrospectively reviewed simultaneous fundus photographs, SD-OCT and fundus autofluorescence (FAF) images of eyes affected with tubercular SLC from acute stage until resolution of lesions using Heidelberg Spectralis HRA and OCT system (Heidelberg Engineering, Heidelberg, Germany). Results Five eyes of five patients were studied in detail. SD-OCT findings included choroidal elevation, and a double ...

Purpose To determine whether presence of macular hemorrhage on dilated fundus exam (DFE) or fundus photography influences vision outcomes with optical coherence tomography (OCT)-guided pro re nata (PRN) ranibizumab (RBZ) re-treatment in patients with neovascular age-related macular degeneration (nAMD), we investigated whether hemorrhage without OCT-detectable fluid impacted vision outcomes. Design Post hoc analysis of prospectively collected data from the 24-month phase III HARBOR trial (NCT00891735). Participants This post hoc analysis examined 1097 patients from the intention-to-treat population of HARBOR. Methods DFE and fundus photography were evaluated for hemorrhage, and spectral domain (SD)-OCT images from HARBOR participants were analyzed ...

Purpose To report the spectrum of posterior segment findings in tubulointerstitial nephritis and uveitis syndrome (TINU) and discuss the abnormalities that can be seen on imaging. Design Retrospective, consecutive case series. Participants Patients with TINU and posterior segment manifestations on exam or imaging. Methods Patients with elevated urine beta-2 microglobulin (Uβ2M) and a diagnosis of TINU were included if they were evaluated at the Cole Eye Institute and did not have alternative etiologies for uveitis. Electronic medical records were reviewed for abnormal findings on ultra-widefield fluorescein angiography (UWFFA) and optical coherence tomography (OCT). Main Outcome Measures Presence of peripheral ...

Purpose To determine the significance of the correlation between the intraoperative optical coherence tomographic (OCT) findings and the postoperative retinal morphology and physiology in eyes with an idiopathic macular hole (MH). Design Retrospective interventional case control study. Subjects Pars plana vitrectomy with internal limiting membrane (ILM) peeling and air tamponade was performed on 33 eyes with idiopathic MHs. All of the eyes were followed for at least 6 months. Methods The intraoperative OCT (Rescan, Carl Zeiss Meditec) images were used to detect the presence of residual fragments at the edge of the MH, and the eyes were divided into those ...

Objective To elucidate the relationship between vessel density (VD) measurements and signal strength in optical coherence tomography angiography (OCTA). Design Cross-sectional study. Subjects: Healthy volunteers. Methods OCTA images obtained from healthy volunteers were analyzed to demonstrate the relationship between signal strength index (SSI) and VD. Experiments were performed to determine the effects of signal strength reduction on VD measurements on the Optovue/AngioVue and Cirrus/AngioPlex OCTA systems. Signal strength reduction was generated by either neutral density filters (NDF) or defocus. Main Outcome Measures Regression analysis of signal strength effects on VD. Results VD decreased linearly with signal strength with ...

Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

Objective To report a novel finding of EpiRetinal Neovascularization (ERN) in cases of macular telangiectasia type 2 (MacTel) and describe its clinical and multimodal imaging features. Design Retrospective chart review Subjects/ participants- Patients attending the retina clinic from January 2017 to April 2018. Those diagnosed as MacTel by clinical and imaging findings were included. Methods Best corrected visual acuity (BCVA) in the logarithm of minimal angle of resolution (log Mar), anterior segment examination, slit lamp biomicroscopy, fundus photography, spectral domain- optical coherence tomography (SD-OCT), autofluorescence (AF) imaging, fundus fluorescein angiography (FFA) and optical coherence tomography angiography (OCTA) were done in ...

Objective To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs), before and after surgery, to normal controls. Design A retrospective study Subjects Patients with ERMs before and after surgery and normal controls. Methods Spectral domain optical coherence tomography (SD-OCT) of eyes with ERMs, before and after surgery, and normal eyes were analyzed for morphologic appearance and using a customized algorithm to measure retinal layer reflectance and thickness. Findings were correlated with visual acuity outcomes. Main Outcome Measure Retinal layer thickness and reflectance Results Thirty-four ERM and 12 normal eyes were identified. Mean preoperative ...

ABSTRACT Purpose To characterize the enhanced-depth imaging optical coherence tomography (EDI-OCT) features of ultrasonographically flat choroidal nevi. Design Retrospective observational study Participants Patients with ultrasonographically flat choroidal nevi identified over 3-year period. Methods Comprehensive eye examinations and multimodal imaging were performed every 6 -12 months. Main Outcome Measures Lesion thickness and features, EDI-OCT findings Results 102 nevi (98 patients) were included. Median follow-up was 9 (range: 0-144) months and 1-8 (mean: 2.1) OCTs were performed. On OCT, nevi were classified into 5 subtypes: 3.2% were “not visible,” 37.2% had “hyperreflectivity confined within normal choroidal thickness,” 16.0 ...

Retinoblastoma (RB) is the most common primary intraocular malignancy of children. 1 Improvements in screening tactics and treatment methods have dramatically increased both patient and globe survival. 1,2 Imaging modalities such as fluorescein angiography (FA) have demonstrated retinal vascular abnormalities in both large and small caliber retinal vessels in eyes with retinoblastoma, 1 and optical coherence tomography (OCT) can reveal or confirm otherwise subclinical lesions. 2 OCT angiography (OCT-A) is a non-invasive imaging modality allowing for in vivo visualization of retinal and choroidal vasculature.

Purpose To report OCTA findings in 3 cases, 2 active and 1 inactive, of serpiginous choroidopathy (SC) and describe OCTA changes in response to treatment. Design Retrospective case series. Participants We studied 6 eyes of 3 patients with SC. Methods Retrospective case series of 3 patients with SC undergoing multimodal imaging, including OCTA. In 1 treated eye, both pre- and posttreatment images were compared. Main Outcome Measures Description of OCTA findings in patients with SC. Results In the active phase, OCTA images show an apparent absence of the choriocapillaris with variable outer retinal and retinal pigment epithelial thickening. After treatment ...

Purpose Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design Prospective cohort study. Participants Nine eyes from 9 healthy participants. Methods One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm 2 ) were acquired at baseline and during oxygen breathing. The split-spectrum amplitude-decorrelation algorithm was used to detect blood flow. The projection-resolved algorithm was used to suppress projection artifacts and resolve blood flow in 3 distinct parafoveal plexuses. The Wilcoxon signed-rank test was used to compare baseline and hyperoxic parameters. The ...