1. Articles from reviewofoptometry.com

  2. 1-15 of 15
    1. Diurnal Choroidal Variations Detected by OCT-A

      Diurnal Choroidal Variations Detected by OCT-A

      Upon investigating the diurnal changes of choroidal sublayer perfusion in normal eyes and identifying influencing factors using optical coherence tomography angiography (OCT-A), German researchers found that OCTA-based analysis demonstrated significant diurnal variations in choroidal sublayer perfusion. The prospective study evaluated 22 healthy volunteers who underwent repeated measurements of subfoveal choroidal thickness with enhanced-depth-imaging OCT as well as perfusion of choroidal vascular sublayers using OCT-A at 7am, 12pm, 4pm and 8pm. The team looked into possible interactions between diurnal variations and other factors, such as mean arterial pressure, gender and age. The study authors observed a significant pattern of diurnal variation ...

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    2. OCT Signs Associated With Fellow Eye AMD Progression

      OCT Signs Associated With Fellow Eye AMD Progression

      Researchers confirmed that four previously reported optical coherence tomography (OCT) risk factors were associated with progression to late age-related macular degeneration (AMD) in the fellow eyes of participants newly diagnosed with macular neovascularization. This multicenter, prospective, randomized, double-masked, active treatment-controlled phase 3 clinical trial evaluated 501 eyes of 501 patients with macular neovascularization secondary to neovascular AMD and early or intermediate AMD in the fellow eye. The team reviewed OCT scans and assessed baseline features, including intraretinal hypereflective foci (IHRF), hyporeflective foci (hRF) within drusenoid lesions (DLs), subretinal drusenoid deposits (SDDs) and drusen volume (DV) ≥ 0.03 mm 3 . Masked ...

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    3. Structure, Function Changes Correlate in Myopic Eyes

      Structure, Function Changes Correlate in Myopic Eyes

      A new study looked at the structure-function relationship in high myopia using spectral‐domain optical coherence tomography (SD-OCT) and visual fields and found ganglion cell layer thickness changes may result in visual field defects in highly myopic eyes. The study included 58 highly myopic patients who had no posterior abnormalities (mean spherical equivalent refraction ≤-6.00D and axial length ≥ 26.0mm). The study calculated the average macular layer thicknesses in each quadrant in a 6mmx6mm area centered on the fovea, and visual fields were assessed from 17 central locations (10°), approximately the equivalent of the area tested by SD-OCT in ...

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    4. OCT-A Can Distinguish Papilledema from Its Mimickers

      OCT-A Can Distinguish Papilledema from Its Mimickers

      True swelling of the optic nerve head (papilledema) is an urgent, life-threatening condition. Pseudopapilledema, on the other hand, is a mostly benign buildup of optic nerve drusen. Telling them apart can be tricky, and doctors rarely have the luxury of time to do so. Papilledema can indicate an underlying brain tumor, obstructive hydrocephalus or meningitis. Over the years, doctors have hunted for small distinctions—such as the presence of Paton’s Lines, flame-shaped hemorrhages or cotton wool spots, but while these aren’t present in pseudopapilledema, they’re not 100% guaranteed to be present in papilledema either. 1 According to ...

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    5. Detect Diabetic Retinopathy Earlier with OCT-A

      Detect Diabetic Retinopathy Earlier with OCT-A

      Routine screening could change the standard of care. A new study found screening diabetes patients with optical coherence tomography angiography (OCT-A) could uncover early microvascular changes that may help clinicians intervene sooner to avoid the development of diabetic retinopathy (DR). 1 Researchers at the Vanderbilt Eye Institute studied 37 eyes of 20 patients with diabetes, none of whom showed signs of DR upon clinical and dilated exam by a retina specialist. Subjects had a mean glycated hemoglobin A1c of 7.2%. After assessing vessel density, flow area and foveal avascular zone size with OCT-A, the researchers discovered 15 eyes had ...

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    6. SD-OCT Detects Elusive Epiretinal Membrane

      SD-OCT Detects Elusive Epiretinal Membrane

      Researchers from Spain recommend practitioners perform spectral-domain optical coherence tomography (SD-OCT) before cataract surgery because fundus examination might not detect an epiretinal membrane. In their study, the membrane’s presence in the macular area with no foveal alterations was the only risk factor for pseudophakic cystoid macular edema (CME) and may implicate a previous subclinical damage or increased predisposition to both conditions. In a prospective cohort study, 112 patients underwent SD-OCT within one week pre-op and three months post-op. CME incidence in the cohort was 11.6% (13 eyes), all of which were diagnosed at one month, and seven eyes ...

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    7. Head Tilt Significantly Affects OCT Image Orientation

      Head Tilt Significantly Affects OCT Image Orientation

      Head tilt can impact the orientation of posterior pole images. Knowing this, a team of Canadian researchers conducted a study of 56 healthy patients to determine the effect of head tilt on image orientation measured by the fovea-Bruch’s membrane opening (FoBMO) angle with optical coherence tomography (OCT) imaging. The researchers measured head tilt by affixing a smartphone with a built-in gyroscope to each patient's head. They then performed OCT imaging in both eyes at 0°, 5° and 10° of head tilt in the direction of the imaged eye (ipsilateral head tilt) and in the opposite direction (contralateral head ...

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    8. OCT Matches or Beats FA

      OCT Matches or Beats FA

      A team of researchers discovered that spectral-domain optical coherence tomography (OCT) as an initial diagnostic test has a sensitivity and a specificity similar to fluorescein angiography (FA) in diagnosing choroidal neovascularization (CNV) in age-related macular degeneration. Both tests were combined color fundus photography. The study evaluated 148 eyes of 148 patients at least 50 years of age who were referred for suspicious recent-onset CNV. The team found that the sensitivities of OCT and FA were 90.9%. Type 2 CNV was diagnosed in 98% to 100% of cases using both modalities, while Type 1 CNV was diagnosed in 82.9 ...

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    9. OCT-A Proposed as Alternative to Iris Angiography

      OCT-A Proposed as Alternative to Iris Angiography

      A recent prospective study tested whether optical coherence tomography angiography (OCT-A) was useful in appraising anterior segment ischemia (ASI), a rare but potentially vision-threatening complication of strabismus surgery. 1 Researchers believe the invasive and time-consuming nature and potential adverse effects limit the utility of indocyanine green angiography and fluorescein angiography, the current standard for assessing anterior segment circulation. The study prospectively recruited nine adults undergoing strabismus surgery on at least one vertical muscle and evaluated images of 10 eyes. Indocyanine green angiography and OCT-A of the iris were taken preoperatively and one day post-op. The researchers found a 2% reduction ...

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    10. DME Microaneurysms Detected More on FA than OCT-A

      DME Microaneurysms Detected More on FA than OCT-A

      In diabetic macular edema (DME) patients, optical coherence tomography angiography (OCT-A) may detect fewer microaneurysms than fundus fluorescein angiography (FA), likely due to leakage and retinal thickening, new research reports. Investigators examined OCT-A and FA images of 31 eyes of 24 participants and graded them for microaneurysms. They found just 58% of microaneurysms detected on FA were also visible on OCT-A. Additionally, microaneurysms with focal leakage in a thickened retinal area were detected more frequently on OCT-A than non-leaking microaneurysms in non-thickened retinal areas. Most microaneurysms on OCT-A were seen in the intermediate (23%) and deep capillary plexus (22%). Of ...

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    11. Think OCT for Measuring Strabismus

      Think OCT for Measuring Strabismus

      In an effort to better automate strabismus evaluations, which are prone to error when done manually, researchers in the United Kingdom used binocular optical coherence tomography (OCT) to measure the size of strabismus, with positive results. The study included 15 patients with strabismus and 15 controls, and evaluated the findings of both automated anterior segment imaging and alternating prism cover test (APCT). The researchers found OCT imaging “correctly revealed the type and direction of the deviation in all 15 participants with strabismus, including horizontal and vertical deviations,” and the imaging was strongly correlated with the APCT measurement. APCT results also ...

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    12. SS-OCT Better Than Scheimpflug for Corneal Thickness

      SS-OCT Better Than Scheimpflug for Corneal Thickness

      Swept-source Fourier-domain optical coherence tomography (SS-OCT) yields better corneal thickness measurements than the Scheimpflug camera for patients with Fuch's endothelial corneal dystrophy (FECD) or an endothelial transplant, a recent study found. Researchers from Spain compared repeatability and reproducibility coefficients of the two imaging modalities between 36 control eyes, 35 FECD eyes, 30 FECD eyes with corneal edema, 25 eyes after Descemet stripping automated endothelial keratoplasty and 29 eyes that had Descemet’s membrane endothelial keratoplasty. While both systems showed high corneal thickness reproducibility and repeatability, SS-OCT results were higher and more precise across patient groups—often significantly so. “The ...

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    13. OCT-A Pinpoints Irregularities in Best Disease

      OCT-A Pinpoints Irregularities in Best Disease

      A team of researchers found optical coherence tomography angiography (OCT-A) is a useful diagnostic tool in assessing eyes with Best disease and associated choroidal neovascularization (CNV). In a study published in the British Journal of Ophthalmology , investigators used OCT-A to find eyes with Best disease had abnormal foveal avascular zones (FAZ), patchy vascularity loss in the superficial and deep layers of the retina and capillary dropout with a hyporeflective center in the choriocapillary layer. Additionally, the investigators found OCT-A is superior to fluorescein angiography (FA) in measuring CNV. The prospective observational study included 19 eyes of 10 patients with Best ...

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    14. OCT Reveals Ocular Changes in Astronauts

      OCT Reveals Ocular Changes in Astronauts

      Researchers recently found that astronauts have disc edema-like changes in eye structure after returning to Earth from the International Space Station (ISS). The study looked at morphological changes in the optic nerve head and surrounding tissues in 15 astronauts after they completed a roughly six-month mission aboard the ISS. The results were compared with 43 healthy control patients with no history of exposure to microgravity in space. After analyzing optical coherence tomography (OCT) data for the astronauts collected before and after the mission, the researchers found three major changes in eye structure. Before the flight, the astronauts presented with recessed ...

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    15. Understanding Today's State of the Art OCT Technology

      Understanding Today's State of the Art OCT Technology

      Goal Statement: With optical coherence tomography techniques expanding, optometrists need to know when to apply which modalities to which patients. This article explains how OCT—with an emphasis on enhanced depth imaging, swept source technology and OCT angiography—can be applied clinically to diagnose and monitor macular disease, diabetic retinopathy and glaucoma, among others.

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    1-15 of 15
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