Purpose To describe clinical, anterior segment optical coherence tomography (AS-OCT), in vivo confocal microscopy (IVCM), histopathologic, and immunohistochemical findings in a patient with multiple endocrine neoplasia type 2b (MEN 2b) syndrome Materials and methods Retrospective case report of a patient with MEN 2b. Results A 31-year-old male diagnosed with MEN 2b presented with eye redness, burning, and visible conjunctival mass in both eyes. The patient’s past medical history revealed that he underwent bilateral adrenalectomy and total thyroidectomy. Genetic testing revealed M918T heterozygous mutation in the RET proto-oncogene. Corrected visual acuity was 20/20 in both eyes. Anterior segment examination ...

Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. The population included patients with stable angina pectoris (SA) and non-ST-elevation myocardial infarction (NSTEMI). It was found that the prevalence of HCPR was greater in subjects with higher DNA ligase activity (correlation ...

We have developed a highly phase stable optical coherence tomography and vibrometry system that attaches directly to the accessory area of a surgical microscope common to both the otology clinic and operating room. Careful attention to minimizing sources of phase noise has enabled a system capable of measuring vibrations of the middle ear with a sensitivity of < 5 pm in an awake human patient. The system is shown to be capable of collecting a wide range of information on the morphology and function of the ear in live subjects, including frequency tuning curves below the hearing threshold, maps of tympanic ...

Dear Editor, Retinal cavernous hemangioma (RCH) is a rare, benign, congenital vascular anomaly, incidentally diagnosed in asymptomatic patients. Its characteristics were first reported by Gass [ 1 ] in 1971, as multiple saccular intraretinal aneurysms with dark red color. In most cases, RCH presents with no symptoms, but sometimes it causes visual deterioration when the lesion involves macular and/or vitreous hemorrhage. Several reports have demonstrated that RCH may accompany cutaneous and central nervous system angiomatous lesions, so that RCH could be classified as part of a neuro-oculocutaneous syndrome [ 2 , 3 ]. The lesions are mostly located in the inner retinal layer or ...

A 79-year-old male with history of coronary artery disease with percutaneous revascularization of medium left anterior descending artery with a bare metal stent 2.5 × 23 mm presented with unstable angina. A significant in-stent restenosis (ISR) was observed ( Panel A ), and treated by means of an in-stent bioresorbable vascular scaffold (BVS) (absorb 2.5 × 28 mm) with excellent angiographic result. Six months later, the patient presented again with unstable angina and significant restenosis intra-scaffold was observed. Optical coherence tomography (OCT) of the BVS was performed showing significant neointimal proliferation ( Panel B ). Firstly, an angioplasty with a cutting balloon 2.75 ...