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    1. Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

      Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

      Objective Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired ...

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    2. Subclinical Foveal Vasculopathy in Patients With Systemic Lupus Erythematosus Using Optical Coherence Tomography Angiography

      Subclinical Foveal Vasculopathy in Patients With Systemic Lupus Erythematosus Using Optical Coherence Tomography Angiography

      Purpose: This article identifies subclinical microvascular changes in systemic lupus erythematosus (SLE) patients using vascular perfusion densities derived from optical coherence tomography angiography (OCTA). Methods: A retrospective review was performed on individuals with SLE (10 eyes of 5 patients) and age-matched controls imaged with a spectral-domain OCT system (XR Avanti, Optovue, Inc). A split-spectrum amplitude-decorrelation algorithm (SSADA) generated OCTA of the superficial retinal capillaries, deep retinal capillaries, and foveal avascular zone (FAZ). Skeletonized OCTAs were used to create capillary vessel density (VD) values for each image. VD values were compared with clinical staging, and groups were compared using Kruskal–Wallis ...

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      Mentions: UC Irvine
    3. Optical Coherence Tomography Angiography Detects Choriocapillaris Loss in Decalcification of Choroidal Osteoma

      Optical Coherence Tomography Angiography Detects Choriocapillaris Loss in Decalcification of Choroidal Osteoma

      Purpose: Choroidal osteoma, which typically affects young women, is a benign intraocular tumor composed of mature bone within the choroid. Tumor decalcification and subfoveal choroidal neovascularization often lead to poor visual acuity although the etiology is unknown. Choriocapillaris characteristics in choroidal osteoma also are unknown. Methods: We report 4 cases of choroidal osteoma with decalcification in which the choriocapillaris could be imaged by optical coherence tomography angiography (OCTA). Results: OCTA showed that the choriocapillaris structure was maintained in the calcified portion, whereas a loss occurred in parts of the decalcified portion in all cases. Conclusions: OCTA may be useful for ...

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    4. Acute angle-closure glaucoma with choroidal effusion revealing a hantavirus infection: Description of ultrasound biomicroscopy imagery and optical coherence tomography Visante

      Acute angle-closure glaucoma with choroidal effusion revealing a hantavirus infection: Description of ultrasound biomicroscopy imagery and optical coherence tomography Visante

      Purpose: To report a case of bilateral angle-closure associated with systemic hantavirus infection. Materials and methods: A 32-year-old Caucasian man was referred with blurred vision, fever, cough, dyspnea and thrombocytopenia. Ophthalmologic examination revealed myopic shift, elevated intraocular pressure (30 mmHg right eye and 24 mmHg left eye), corneal edema, iridocorneal angle closure and shallow anterior chamber. Ciliochoroidal effusion was detected on anterior segment optical coherence tomography and ultrasound biomicroscopy. Serologic test and polymerase chain reaction confirmed the diagnosis of hantavirus infection and the serotype Puumala. On the sixth day after he started topical anti-glaucoma and cycloplegic medications, the anterior chamber ...

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    5. Identification of separated lenticular planes using optical coherence tomography

      Identification of separated lenticular planes using optical coherence tomography

      Purpose: To discuss how optical coherence tomography can be used to identify separated lenticular planes during small incision lenticule extraction (SMILE). Methods: SMILE procedures were performed on 26 eyes of 13 patients. An anterior segment optical coherence tomography examination was performed after laser scan. Anterior segment optical coherence tomography examinations were conducted again both after separation of the anterior lenticular plane in the right eye and after separation of the posterior lenticular plane in the left eye. Lenticule extraction was then completed, followed by another anterior segment optical coherence tomography examination. Anterior segment optical coherence tomography was also conducted on ...

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      Mentions: Fudan University
    6. Is optical coherence tomography angiography helpful in the differential diagnosis of choroidal nevus versus melanoma?

      Is optical coherence tomography angiography helpful in the differential diagnosis of choroidal nevus versus melanoma?

      Purpose: To describe the imaging features of choroidal nevus and melanoma using optical coherence tomography angiography, and evaluate the ability of this technique to establish the differential diagnosis based on the display of the tumor’s intrinsic vasculature. Methods: Comparative analysis of optical coherence tomography angiography findings in consecutive patients diagnosed with choroidal nevus or choroidal melanoma following a complete ophthalmic evaluation, including best-corrected visual acuity and several imaging studies: color fundus photography, B-scan ultrasound, spectral-domain optical coherence tomography, and optical coherence tomography angiography. Optical coherence tomography angiography was used to investigate qualitative differences in the tumor vasculature. Results: Thirty-six ...

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    7. Angiographic features of polypoidal choroidal vasculopathy using indocyanine green angiography and optical coherence tomography angiography: A comparative study

      Angiographic features of polypoidal choroidal vasculopathy using indocyanine green angiography and optical coherence tomography angiography: A comparative study

      Background: To compare the vascular lesion size using optical coherence tomography angiography and indocyanine green angiography in eyes with polypoidal choroidal vasculopathy. Methods: Treatment-naïve cases (46 eyes of 44 patients) with polypoidal choroidal vasculopathy were retrospectively analyzed. The comparison of mean area of branching vascular network and polyp detection rate was done between indocyanine green angiography and optical coherence tomography angiography and correlated with various optical coherence tomography features. Results: The mean age of the study patients was 62.33 ± 10.74 years. The mean branching vascular network size was 7.47 ± 5.74 and 7.51 ± 5.69 ...

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    8. Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that ...

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      Mentions: Xincheng Yao
    9. Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

      Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

      Purpose: To report the presence of a new structural optical coherence tomography finding, namely, subretinal pseudocysts, in a patient affected by age-related macular degeneration. Methods: Case report including multimodal imaging discussion. Case Report: We report a case of a 77-year-old woman affected by age-related macular degeneration from 7 years. Best corrected visual acuity was counting fingers and 20/40 in the right and left eye, respectively. The left eye was affected by type 1 macular neovascularization treated by 34 intravitreal injections of anti-vascular endothelial growth factor (22 ranibizumab and 12 aflibercept injections). Interestingly, structural optical coherence tomography showed the persistence ...

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    10. Best Clinical Practice for Age-Related Macular Degeneration Imaging

      Best Clinical Practice for Age-Related Macular Degeneration Imaging

      Purpose: To identify best clinical practices for macular degeneration imaging. Methods: We reviewed best clinical practices for imaging patients with age-related macular degeneration. These recommendations are based on different levels of evidence (I-III). Results: The type of imaging needed depends to some degree on the clinical scenario: first visit vs follow-up visit vs poorly responsive patient. Conclusions: Imaging technologies that may be useful include optical coherence tomography, fundus photography, fundus autofluorescence imaging, fluorescein angiography, indocyanine green angiography, and optical coherence tomography angiography.

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    11. Evaluation of amalgam-related retinal neurotoxicity with optical coherence tomography findings

      Evaluation of amalgam-related retinal neurotoxicity with optical coherence tomography findings

      Purpose: To evaluate the neurotoxic effect of amalgam dental fillings on plasma mercury (Hg) levels and retino-choroidal layers measured by spectral domain optical coherence tomography (SD-OCT). Materials/Methods: Study participants included 56 cases with amalgam dental fillings and 44 healthy controls. All participants were examined in terms of detailed ophthalmic examination, oral examination, and body mass index (BMI). The measurement of retinal layers and choroid was performed using SD-OCT. Venous blood samples were collected and blood Hg levels were measured using cold vapor atomic absorption spectrometric analysis. Correlations between SD-OCT measurement results and blood Hg levels were analyzed. Results: There ...

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    12. First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

      First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

      The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients ( n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a ...

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      Mentions: Haag-Streit OPMedt
    13. Optical Coherence Tomography Angiography: Practical Usefulness

      Optical Coherence Tomography Angiography: Practical Usefulness

      Purpose: The purpose of this article is to highlight the practical usefulness of optical coherence tomography angiography (OCTA) in the management of a spectrum of retinal diseases and support it as a reimbursable diagnostic tool by third-party payers. Methods: Case presentations are discussed. Results: Noninvasive OCTA provides information to guide clinical decision making, prognosis, and treatment response across a wide variety of retinal disorders. Conclusions: OCTA is able to detect ischemic and neovascular processes in numerous retinal diseases and is valuable for diagnosis and treatment. OCTA is able to meet all the criteria required for reimbursement of a new diagnostic ...

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    14. Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      The aim is to present the changes in ultra-widefield and widefield multimodal imaging, including optical coherence tomography angiography of a 33-year-old woman diagnosed with Susac syndrome, over 1 year of follow-up. Fundus examination and multimodal imaging revealed bilateral arterial occlusion of multiple vascular branches with retinal ischemia. Over 1 year follow-up, best-corrected visual acuity improved while retinal ischemia gradually resolved. Widefield optical coherence tomography angiography showed reperfusion of macular large vessels, but not of the small capillaries. Despite anatomical improvement, functional defects of the visual field persisted. In conclusion, widefield and ultra-widefield imaging provided high-resolution details of the central and ...

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    15. An overview of optical coherence tomography angiography and the posterior pole

      An overview of optical coherence tomography angiography and the posterior pole

      Optical coherence tomography angiography is a relatively new, noninvasive technology that has revolutionized imaging of the retinal and choroidal microvasculature. This technology is based on the detection of movement or changes that represent moving red cells in sequential optical coherence tomography scans. As with other established imaging technologies, it has unique benefits as well as certain disadvantages, which include a limited field of view and vulnerability to imaging artifacts. However, software and hardware improvements are continually evolving to mitigate these limitations. Optical coherence tomography angiography has been used to gain a better understanding of microvascular changes across a spectrum of ...

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    16. Serial optical coherence tomography and angioscopic assessments of 10-year in-stent restenosis of Cypher sirolimus-eluting stent treated with drug-coated balloon angioplasty

      Serial optical coherence tomography and angioscopic assessments of 10-year in-stent restenosis of Cypher sirolimus-eluting stent treated with drug-coated balloon angioplasty

      The drug-coated balloon (DCB) angioplasty is considered a standard therapeutic option for in-stent restenosis. In the present case, we observed high-intensity spots on optical coherence tomography (OCT) and bright spots on coronary angioplasty (CAS) immediately after DCB angioplasty. The superficial high-intensity area on OCT presumably corresponded with the bright spots on CAS. The high-intensity superficial regions were thought to represent an iopromide/paclitaxel mixture. The present serial observation demonstrated that the eluted drugs remained for at least 2 months but disappeared within 6 months. At the site where we observed the drugs, neointimal growth was successfully inhibited and stabilized at ...

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      Mentions: Osaka University
    17. Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Purpose: The aim of the study is to evaluate the relationship between functional defects shown by cluster analysis of computerized visual field and anatomic defects from optical coherence tomography–ganglion cell complex examination in ocular hypertension or eyes affected by glaucoma. Methods: 205 eyes affected by ocular hypertension (intraocular pressure > 22 mmHg) or early stage glaucoma were enrolled. The age of the patients ranged from 26 to 87 years (average: 61.83 ± 1.54 years). Computerized 30° visual field (Octopus G1x Dynamic strategy) and optical coherence tomography–ganglion cell complex (I-Vue Optovue) analyses were performed for each eye selected; 68 ...

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    18. Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

      Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

      Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult— euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle ...

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    19. The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

      The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

      Optical coherence tomography is designed to evaluate in vivo qualitative and quantitative changes of the anterior segment, optic nerve and the retina. Initial applications of this technology were confined mainly to ophthalmic diseases. However recently, numerous studies have evaluated its use in systemic conditions and in therapeutics where, optic nerve and retinal architecture can be assessed to monitor progression of systemic conditions and its response to treatment. This is a narrative review aimed at evaluating the debate surrounding the role of spectral domain optical coherence tomography, in systemic conditions where optic nerve affection can be measured and be used in ...

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    20. Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them ...

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    21. Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in ...

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    22. Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Purpose: To report a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome and the changes seen in the optical coherence tomography angiography before and after treatment with eculizumab. Case description: A 22-year-old man with an unremarkable medical history presented with acute, bilateral blurred vision and headache of 1-week duration. Best corrected visual acuity of 20/50 and 20/40, respectively, in the patient’s right eye and left eye. Funduscopy revealed multiple cotton-wool spots associated with intrarretinal fluid. Swept source optical coherence tomography revealed multifocal retinal detachments with increased choroidal thickness. Optical coherence tomography angiography showed areas of ...

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    23. Correlation analysis of fundus autofluorescence, spectral domain optical coherence tomography, and visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept

      Correlation analysis of fundus autofluorescence, spectral domain optical coherence tomography, and visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept

      Purpose: The aim of this study was to evaluate the correlations between fundus autofluorescence and morphologic parameters as well as visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept. Methods: A total of 34 eyes of 20 patients with untreated diabetic macular oedema received an intravitreal injection of ziv-aflibercept at baseline, and 1 and 2 months later. The baseline, 1-month, and two-month best corrected visual acuity determination, contrast sensitivity, spectral domain optical coherence tomography, mean central macular thickness, mean macular cube volume, mean macular cube average thickness, and fundus autofluorescence (decreased, normal, or increased; and single or ...

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    24. Evaluation of choroidal thickness in amblyopia using optical coherence tomography

      Evaluation of choroidal thickness in amblyopia using optical coherence tomography

      Objective: To investigate the choroidal thickness in children with amblyopia through spectral-domain optical coherence tomography. Methods: A total of 31 children with unilateral amblyopia and 31 right eyes of controls with normal vision were enrolled in the study. The choroidal thickness was measured directly below the fovea and at 12 other locations: 1, 2 and 3 mm superior, temporal, inferior, and nasal to the fovea. All the parameters were compared between amblyopic eyes, fellow eyes, and control eyes. Results: The mean subfoveal choroidal thickness was 398.03 ± 74.60, 354.13 ± 81.78, and 328.12 ± 65.93 μm in ...

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