1. 1-11 of 11
    1. Outcome After Crossing Femoropopliteal Chronic Total Occlusions Based on Optical Coherence Tomography Guidance

      Outcome After Crossing Femoropopliteal Chronic Total Occlusions Based on Optical Coherence Tomography Guidance

      Aims: The crossing of chronic total occlusions (CTOs) is the key step for an endovascular treatment. The Ocelot system is a novel device that combines a steerable drilling tip with optical coherence tomography (OCT) technology. It provides intraluminal imaging to help the crossing of CTOs in the femoropopliteal segment. Aim of the study was to determine early and midterm results after recanalization with this device. Methods and Results: During a period of 16 months, 84 CTOs were treated using the Ocelot system and prospectively registered. The primary end points were technical success and the primary and secondary patency of the ...

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      Mentions: Arne G. Schwindt
    2. Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

      Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

      The influence of both severe chronic carotid stenosis and carotid endarterectomy (CEA) on ocular tissue has been poorly evaluated. The goal of this study was to measure subfoveal choroidal thickness (SFCT), before and after CEA, in patients with severe carotid stenosis. Consecutive patients (n = 36) with severe carotid stenosis were prospectively included. Patients (n = 19) were followed up at 1 and 3 months after CEA. The SFCT was measured bilaterally using enhanced depth imaging optical coherence tomography (EDI-OCT). Preoperatively, the median SFCT of the ipsilateral eye did not differ significantly from the contralateral eye (223 vs 236 µm; P = .75 ...

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    3. Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis: Results from a clinical trial cohort

      Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis: Results from a clinical trial cohort

      Background: Limited prospective information exists regarding spectral-domain optical coherence tomography (SD-OCT) in secondary progressive multiple sclerosis (SPMS). Objective: Document cross-sectional and longitudinal retinal nerve fiber layer (RNFL) and macular ganglion cell plus inner plexiform layer (GCIPL) features of an SPMS clinical trial cohort. Methods: Prospective, observational study using a 2-year randomized placebo-controlled SPMS trial cohort with yearly SD-OCT testing. Post hoc analysis determined influences of optic neuritis (ON), disease duration, and baseline SD-OCT on annualized atrophy rates and on correlations between OCT and brain atrophy. Results: Mean RNFL and GCIPL values of patients ( n = 47, mean age = 59 years, mean ...

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    4. Peripapillary retinal nerve fibre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability progression in multiple sclerosis

      Peripapillary retinal nerve fibre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability progression in multiple sclerosis

      Background: Peripapillary retinal nerve fibre layer (pRNFL) thickness is emerging as a marker of axonal degeneration in multiple sclerosis (MS). Objective: We aimed to prospectively assess the predictive value of pRNFL for progression of physical and cognitive disability in relapsing-remitting MS (RRMS). Methods: In this 3-year longitudinal study on 151 RRMS patients, pRNFL was measured by spectral-domain optical coherence tomography (OCT). We used proportional hazard models, correcting for age, sex, disease duration, Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT) at baseline, to test a pRNFL thickness ≤88 µm at baseline for prediction of EDSS progression and ...

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    5. Ultrawide Field Imaging and OCT Angiography in Late-Onset Chloroquine Retinopathy

      Ultrawide Field Imaging and OCT Angiography in Late-Onset Chloroquine Retinopathy

      Purpose: To describe the clinical features of a 57-year-old female with palindromic rheumatism and a 15-year history of chloroquine use and bilateral vision loss. Methods: Ophthalmological examination, including ultrawide field (UWF) fundus images (Optomap-200TX) and cross-sectional retinal scans obtained with Zeiss spectral domain optical coherence tomography angiography (SD-OCTA, HD-5000, Angioplex), was performed. Results: Best-corrected visual acuity was 20/60 in both eyes. Ultrawide field fundus images revealed a ring-shaped area of pericentral and paracentral mottling of the retinal pigment epithelium (RPE), vascular attenuation, and loss of foveal reflex bilaterally. The SD-OCT showed obvious thinning in the outer retina, loss of ...

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    6. Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis

      Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis

      Background: Optical coherence tomography (OCT) angiography is a new method to assess the density of the vascular networks. Vascular abnormalities are considered involved in multiple sclerosis (MS) pathology. Objective: To assess the presence of vascular abnormalities in MS and to evaluate their correlation to disease features. Methods: A total of 50 MS patients with and without history of optic neuritis (ON) and 46 healthy subjects were included. All underwent spectral domain (SD)-OCT and OCT angiography. Clinical history, Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS) and disease duration were collected. Results: Angio-OCT showed a vessel density reduction ...

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    7. Persistent Placoid Maculopathy Treatment Response Imaged With OCT Angiography

      Persistent Placoid Maculopathy Treatment Response Imaged With OCT Angiography

      A 70-year-old Caucasian gentleman presented with decreased vision in the left eye and a subtle whitish macular plaque in the left eye and pigment mottling bilaterally. Indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) revealed left macular hypoperfusion. Systemic evaluation was negative for infectious or inflammatory disorder. A diagnosis of persistent placoid maculopathy was made and systemic immunosuppression was initiated. A marked improvement in macular perfusion was noted on ICGA and OCTA following 1 week of immunosuppression, providing additional evidence of an inflammatory rather than ischemic etiology.

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    8. Evaluation of the Radiation Dose–Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma

      Evaluation of the Radiation Dose–Volume Effects of Optic Nerves and Chiasm by Psychophysical, Electrophysiologic Tests, and Optical Coherence Tomography in Nasopharyngeal Carcinoma

      Purpose: To evaluate the radiation dose–volume effects of optic nerves and chiasm by visual psychophysical, electrophysiologic tests, and optical coherence tomography in patients with locally advanced nasopharyngeal carcinoma. Materials and Methods: A series of visual tests including visual acuity, visual field, contrast sensitivity, visual evoked potential, and optical coherence tomography were administered to 20 patients with locally advanced (T3-T4) nasopharyngeal carcinoma who were treated with definitive chemoradiotherapy. Volume that received 55 Gy (V 55 ), mean dose ( D mean ), highest dose to 5% of the volume (D 5 ), and maximum dose (D max ) for optic nerves and chiasm were evaluated ...

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    9. Lower Extremity Revascularization Using Optical Coherence Tomography–Guided Directional Atherectomy: Final Results of the EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for Use in the Peripheral Vasculature (VISION) St

      Lower Extremity Revascularization Using Optical Coherence Tomography–Guided Directional Atherectomy: Final Results of the EValuatIon of the PantheriS OptIcal COherence Tomography ImagiNg Atherectomy System for Use in the Peripheral Vasculature (VISION) St

      Purpose: To evaluate the safety and efficacy of a novel optical coherence tomography (OCT)–guided atherectomy catheter in treating patients with symptomatic femoropopliteal disease. Methods: The VISION trial ( ClinicalTrials.gov identifier NCT01937351) was a single-arm, multicenter, global investigational device exemption study enrolling 158 subjects (mean age 67.2±10.5 years; 87 men) across 20 participating sites. In this cohort, 198 lesions were treated with an average length of 53±40 mm using the Pantheris catheter alone or Pantheris + adjunctive therapy. The primary safety endpoint was the composite of major adverse events (MAEs) through 6 months (objective performance goal 43 ...

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    10. West Nile Virus Chorioretinitis With Foveal Involvement Evolution of Lesions on Optical Coherence Tomography

      West Nile Virus Chorioretinitis With Foveal Involvement Evolution of Lesions on Optical Coherence Tomography

      Purpose: To describe the clinical course of foveal West Nile virus (WNV) chorioretinitis with longitudinal spectral domain optical coherence tomography (SD-OCT) imaging. Methods: Case report. Results: A 41-year-old man with diabetes mellitus presented with flashes and floaters of both eyes (OU) and decreased vision of the right eye (OD) 2 weeks after being discharged from a local hospital. He had been treated for WNV meningoencephalitis, and he recovered systemically with supportive therapy. Ophthalmic examination revealed WNV chorioretinitis bilaterally, with predominantly foveal involvement OD. His best-corrected visual acuity (BCVA) was 8/200 OD and 20/20 of the left eye (OS ...

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    11. Prevalence of Different Optical Coherence Tomography Findings in a Spanish Cohort With High Myopia

      Prevalence of Different Optical Coherence Tomography Findings in a Spanish Cohort With High Myopia

      Purpose: To evaluate the prevalence of different optical coherence tomography (OCT) findings in European patients with high myopia. Methods: Cross-sectional study conducted in the Macula Unit of the University and Polytechnic Hospital La Fe (Valencia, Spain). A total of 134 myopic eyes of 69 patients (16 males and 53 females) were included. All patients underwent a spectral domain OCT examination at least once. The presence of tractional and atrophic myopic maculopathy and choroidal neovascularization (CNV) was evaluated through OCT scans. Results: The prevalence of tractional myopic maculopathy was found in 53.7% of the eyes. Within this group, 9.7 ...

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    1-11 of 11
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