1. 1-24 of 76 1 2 3 4 »
    1. Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that ...

      Read Full Article
      Mentions: Xincheng Yao
    2. Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

      Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration

      Purpose: To report the presence of a new structural optical coherence tomography finding, namely, subretinal pseudocysts, in a patient affected by age-related macular degeneration. Methods: Case report including multimodal imaging discussion. Case Report: We report a case of a 77-year-old woman affected by age-related macular degeneration from 7 years. Best corrected visual acuity was counting fingers and 20/40 in the right and left eye, respectively. The left eye was affected by type 1 macular neovascularization treated by 34 intravitreal injections of anti-vascular endothelial growth factor (22 ranibizumab and 12 aflibercept injections). Interestingly, structural optical coherence tomography showed the persistence ...

      Read Full Article
    3. Best Clinical Practice for Age-Related Macular Degeneration Imaging

      Best Clinical Practice for Age-Related Macular Degeneration Imaging

      Purpose: To identify best clinical practices for macular degeneration imaging. Methods: We reviewed best clinical practices for imaging patients with age-related macular degeneration. These recommendations are based on different levels of evidence (I-III). Results: The type of imaging needed depends to some degree on the clinical scenario: first visit vs follow-up visit vs poorly responsive patient. Conclusions: Imaging technologies that may be useful include optical coherence tomography, fundus photography, fundus autofluorescence imaging, fluorescein angiography, indocyanine green angiography, and optical coherence tomography angiography.

      Read Full Article
    4. Evaluation of amalgam-related retinal neurotoxicity with optical coherence tomography findings

      Evaluation of amalgam-related retinal neurotoxicity with optical coherence tomography findings

      Purpose: To evaluate the neurotoxic effect of amalgam dental fillings on plasma mercury (Hg) levels and retino-choroidal layers measured by spectral domain optical coherence tomography (SD-OCT). Materials/Methods: Study participants included 56 cases with amalgam dental fillings and 44 healthy controls. All participants were examined in terms of detailed ophthalmic examination, oral examination, and body mass index (BMI). The measurement of retinal layers and choroid was performed using SD-OCT. Venous blood samples were collected and blood Hg levels were measured using cold vapor atomic absorption spectrometric analysis. Correlations between SD-OCT measurement results and blood Hg levels were analyzed. Results: There ...

      Read Full Article
    5. First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

      First in vivo visualization of the human subarachnoid space and brain cortex via optical coherence tomography

      The present work explores optical coherence tomography (OCT) as a suitable in vivo neuroimaging modality of the subarachnoid space (SAS). Patients ( n = 26) with frontolateral craniotomy were recruited. The temporal and frontal arachnoid mater and adjacent anatomical structures were scanned using microscope-integrated three-dimensional OCT, (iOCT). Analysis revealed a detailed depiction of the SAS (76.9%) with delineation of the internal microanatomical structures such as the arachnoid barrier cell membrane (ABCM; 96.2%), trabecular system (50.2%), internal blood vessels (96.2%), pia mater (26.9%) and the brain cortex (96.2%). Orthogonal distance measuring was possible. The SAS showed a ...

      Read Full Article
      Mentions: Haag-Streit OPMedt
    6. Optical Coherence Tomography Angiography: Practical Usefulness

      Optical Coherence Tomography Angiography: Practical Usefulness

      Purpose: The purpose of this article is to highlight the practical usefulness of optical coherence tomography angiography (OCTA) in the management of a spectrum of retinal diseases and support it as a reimbursable diagnostic tool by third-party payers. Methods: Case presentations are discussed. Results: Noninvasive OCTA provides information to guide clinical decision making, prognosis, and treatment response across a wide variety of retinal disorders. Conclusions: OCTA is able to detect ischemic and neovascular processes in numerous retinal diseases and is valuable for diagnosis and treatment. OCTA is able to meet all the criteria required for reimbursement of a new diagnostic ...

      Read Full Article
    7. Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      Widefield OCT angiography and ultra-widefield multimodal imaging of Susac syndrome

      The aim is to present the changes in ultra-widefield and widefield multimodal imaging, including optical coherence tomography angiography of a 33-year-old woman diagnosed with Susac syndrome, over 1 year of follow-up. Fundus examination and multimodal imaging revealed bilateral arterial occlusion of multiple vascular branches with retinal ischemia. Over 1 year follow-up, best-corrected visual acuity improved while retinal ischemia gradually resolved. Widefield optical coherence tomography angiography showed reperfusion of macular large vessels, but not of the small capillaries. Despite anatomical improvement, functional defects of the visual field persisted. In conclusion, widefield and ultra-widefield imaging provided high-resolution details of the central and ...

      Read Full Article
    8. An overview of optical coherence tomography angiography and the posterior pole

      An overview of optical coherence tomography angiography and the posterior pole

      Optical coherence tomography angiography is a relatively new, noninvasive technology that has revolutionized imaging of the retinal and choroidal microvasculature. This technology is based on the detection of movement or changes that represent moving red cells in sequential optical coherence tomography scans. As with other established imaging technologies, it has unique benefits as well as certain disadvantages, which include a limited field of view and vulnerability to imaging artifacts. However, software and hardware improvements are continually evolving to mitigate these limitations. Optical coherence tomography angiography has been used to gain a better understanding of microvascular changes across a spectrum of ...

      Read Full Article
    9. Serial optical coherence tomography and angioscopic assessments of 10-year in-stent restenosis of Cypher sirolimus-eluting stent treated with drug-coated balloon angioplasty

      Serial optical coherence tomography and angioscopic assessments of 10-year in-stent restenosis of Cypher sirolimus-eluting stent treated with drug-coated balloon angioplasty

      The drug-coated balloon (DCB) angioplasty is considered a standard therapeutic option for in-stent restenosis. In the present case, we observed high-intensity spots on optical coherence tomography (OCT) and bright spots on coronary angioplasty (CAS) immediately after DCB angioplasty. The superficial high-intensity area on OCT presumably corresponded with the bright spots on CAS. The high-intensity superficial regions were thought to represent an iopromide/paclitaxel mixture. The present serial observation demonstrated that the eluted drugs remained for at least 2 months but disappeared within 6 months. At the site where we observed the drugs, neointimal growth was successfully inhibited and stabilized at ...

      Read Full Article
      Mentions: Osaka University
    10. Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Cluster analysis of computerized visual field and optical coherence tomography–ganglion cell complex defects in high intraocular pressure patients or early stage glaucoma

      Purpose: The aim of the study is to evaluate the relationship between functional defects shown by cluster analysis of computerized visual field and anatomic defects from optical coherence tomography–ganglion cell complex examination in ocular hypertension or eyes affected by glaucoma. Methods: 205 eyes affected by ocular hypertension (intraocular pressure > 22 mmHg) or early stage glaucoma were enrolled. The age of the patients ranged from 26 to 87 years (average: 61.83 ± 1.54 years). Computerized 30° visual field (Octopus G1x Dynamic strategy) and optical coherence tomography–ganglion cell complex (I-Vue Optovue) analyses were performed for each eye selected; 68 ...

      Read Full Article
    11. Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

      Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model

      Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult— euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle ...

      Read Full Article
    12. The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

      The role of optical coherence tomography in therapeutics and conditions, which primarily have systemic manifestations: a narrative review

      Optical coherence tomography is designed to evaluate in vivo qualitative and quantitative changes of the anterior segment, optic nerve and the retina. Initial applications of this technology were confined mainly to ophthalmic diseases. However recently, numerous studies have evaluated its use in systemic conditions and in therapeutics where, optic nerve and retinal architecture can be assessed to monitor progression of systemic conditions and its response to treatment. This is a narrative review aimed at evaluating the debate surrounding the role of spectral domain optical coherence tomography, in systemic conditions where optic nerve affection can be measured and be used in ...

      Read Full Article
    13. Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Central perpendicular line in macular spectral-domain optical coherence tomography in five eyes

      Purpose: The aim of this study is to report a rare spectral-domain optical coherence tomography finding in the macula. Methods: This is a descriptive consecutive case series. Patients diagnosed with hyperreflective central perpendicular line in the macular spectral-domain optical coherence tomography were included. Best-corrected visual acuity assessment, standard Amsler grid test, biomicroscopic examination and macular spectral-domain optical coherence tomography were performed. Results: We examined three men and one woman, aged 56 to 91 years (average age: 75.25 years). Spectral-domain optical coherence tomography showed a hyperreflective central perpendicular line in five eyes accompanied by vitreofoveal adhesion in all of them ...

      Read Full Article
    14. Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

      Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in ...

      Read Full Article
    15. Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome

      Purpose: To report a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome and the changes seen in the optical coherence tomography angiography before and after treatment with eculizumab. Case description: A 22-year-old man with an unremarkable medical history presented with acute, bilateral blurred vision and headache of 1-week duration. Best corrected visual acuity of 20/50 and 20/40, respectively, in the patient’s right eye and left eye. Funduscopy revealed multiple cotton-wool spots associated with intrarretinal fluid. Swept source optical coherence tomography revealed multifocal retinal detachments with increased choroidal thickness. Optical coherence tomography angiography showed areas of ...

      Read Full Article
    16. Correlation analysis of fundus autofluorescence, spectral domain optical coherence tomography, and visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept

      Correlation analysis of fundus autofluorescence, spectral domain optical coherence tomography, and visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept

      Purpose: The aim of this study was to evaluate the correlations between fundus autofluorescence and morphologic parameters as well as visual function in patients with diabetic macular oedema treated with intravitreal ziv-aflibercept. Methods: A total of 34 eyes of 20 patients with untreated diabetic macular oedema received an intravitreal injection of ziv-aflibercept at baseline, and 1 and 2 months later. The baseline, 1-month, and two-month best corrected visual acuity determination, contrast sensitivity, spectral domain optical coherence tomography, mean central macular thickness, mean macular cube volume, mean macular cube average thickness, and fundus autofluorescence (decreased, normal, or increased; and single or ...

      Read Full Article
    17. Evaluation of choroidal thickness in amblyopia using optical coherence tomography

      Evaluation of choroidal thickness in amblyopia using optical coherence tomography

      Objective: To investigate the choroidal thickness in children with amblyopia through spectral-domain optical coherence tomography. Methods: A total of 31 children with unilateral amblyopia and 31 right eyes of controls with normal vision were enrolled in the study. The choroidal thickness was measured directly below the fovea and at 12 other locations: 1, 2 and 3 mm superior, temporal, inferior, and nasal to the fovea. All the parameters were compared between amblyopic eyes, fellow eyes, and control eyes. Results: The mean subfoveal choroidal thickness was 398.03 ± 74.60, 354.13 ± 81.78, and 328.12 ± 65.93 μm in ...

      Read Full Article
    18. Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Utility of optical coherence tomography angiography in detecting vascular retinal damage caused by arterial hypertension

      Objective: To evaluate the potential utility of perfusion density measurements to discriminate patients with arterial hypertension by cardiovascular risk category. Methods: In this cross-sectional study, one eye per subject was evaluated (N = 73). The study cohort was divided into three groups according to the clinical criteria established by the European Guidelines for Arterial Hypertension: 26 controls, 24 patients with low cardiovascular risk, and 23 patients with very high cardiovascular risk. All patients were examined using RS-3000 Advance optical coherence tomography angiography to analyze macular and peripapillary perfusion density. Results: There were no differences among the three risk groups by sex ...

      Read Full Article
    19. Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus

      Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus

      Objective The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ). Methods SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. We compared data from 2012 (first) and 2017 (second) SD-OCT. Results We studied 110 patients and 195 eyes. No cases of HCQ toxicity were detected. At the time of the second SD-OCT, 99% patients ...

      Read Full Article
    20. Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

      Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds

      Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology. OCT and its recent variant, dynamic OCT, permit rapid noninvasive depth-resolved imaging of the capillaries in the superficial dermis via a handheld probe ...

      Read Full Article
    21. Optical Coherence Tomography and Retinal Thickness Analyzer Features of Spontaneous Resolution of Vitreomacular Traction Syndrome: A Case Report

      Optical Coherence Tomography and Retinal Thickness Analyzer Features of Spontaneous Resolution of Vitreomacular Traction Syndrome: A Case Report

      Purpose To report optical coherence tomography (OCT) and retinal thickness analyzer (RIA) findings in a case of spontaneous resolution of vitreomacular traction syndrome. METHODS Qualitative and quantitative analysis of the macular region was performed with OCT and RTA. Results In the left eye of a 34-year-old woman with blurred vision, OCT and RTA examination showed a discrete linear signal anterior to the retina with attachment at the macula and secondary cystoid macular changes. OCT and RTA examination showed an increase in macular thickness (350 μm). Six months later the patient showed a spontaneous complete recovery of visual acuity. Vitreomacular traction ...

      Read Full Article
    22. Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia

      Spectral-domain optical coherence tomography foveal morphology as a prognostic factor for vision performance in congenital aniridia

      Background: Patients with congenital aniridia usually have some degree of foveal hypoplasia, thus representing a limiting factor in the final visual acuity achieved by these patients. The purpose of this study was to analyze whether the foveal morphology assessed by spectral-domain optical coherence tomography may serve as a prognostic indicator for best-corrected visual acuity in congenital aniridia patients. Methods: Observational two-center study performed between January 2012 and March 2017 in the pediatric ophthalmology department at Vissum Alicante and Vissum Madrid, Spain. A total of 31 eyes from 19 patients with congenital aniridia were included. After a complete ophthalmological examination, a ...

      Read Full Article
    23. Spinal cord and infratentorial lesions in radiologically isolated syndrome are associated with decreased retinal ganglion cell/inner plexiform layer thickness

      Spinal cord and infratentorial lesions in radiologically isolated syndrome are associated with decreased retinal ganglion cell/inner plexiform layer thickness

      Background: The role of retinal imaging with optical coherence tomography (OCT) in assessing individuals with radiologically isolated syndrome (RIS) remains largely unexplored. Objective: To assess retinal layer thicknesses in RIS and examine their associations with clinical features suggestive of increased risk for conversion to multiple sclerosis (MS). Methods: A total of 30 RIS subjects and 60 age- and sex-matched healthy controls (HC) underwent retinal imaging with spectral-domain OCT, followed by automated segmentation of retinal layers. Results: Overall, retinal layer thicknesses did not differ between RIS and HC. However, RIS subjects with spinal cord (SC) lesions had lower ganglion cell + inner ...

      Read Full Article
    24. Inter-relationship between retinal and choroidal vasculatures using optical coherence tomography angiography in normal eyes

      Inter-relationship between retinal and choroidal vasculatures using optical coherence tomography angiography in normal eyes

      Purpose: To quantify vascular and structural macular variables in healthy eyes and to investigate correlations between these variables and age using optical coherence tomography angiography. Materials and methods: A total of 261 eyes of 261 subjects with normal fundus were included. Central macular thickness, ganglion cell layer to inner plexiform layer thickness, outer retina layer thickness, subfoveal choroidal thickness, and choroidal vascularity index were measured using optical coherence tomography. Foveal avascular zone area, vascular density, and flow void area were measured using optical coherence tomography angiography. Results: Vascular density in the superficial capillary plexus was correlated with central macular thickness ...

      Read Full Article
      Mentions: Korea University
    1-24 of 76 1 2 3 4 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks