1. 1-24 of 49 1 2 »
    1. Optical coherence tomography: Translation from 3D-printed vascular models of the anterior cerebral circulation to the first human images of implanted surface modified flow diverters

      Optical coherence tomography: Translation from 3D-printed vascular models of the anterior cerebral circulation to the first human images of implanted surface modified flow diverters

      Background The new generation of flow diverters includes a surface modification with a synthetic biocompatible polymer, which makes the device more biocompatible and less thrombogenic. Optical coherence tomography (OCT) can be used to visualize perforators, stent wall apposition, and intra-stent thrombus. Unfortunately real world application of this technology has been limited because of the limited navigability of these devices in the intracranial vessels. In this report, we share our experience of using 3D-printed neurovascular anatomy models to simulate and test the navigability of a commercially available OCT system and to show the application of this device in a patient treated ...

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    2. Association Between Insulin Resistance and Coronary Plaque Vulnerability in Patients With Acute Coronary Syndromes: Insights From Optical Coherence Tomography

      Association Between Insulin Resistance and Coronary Plaque Vulnerability in Patients With Acute Coronary Syndromes: Insights From Optical Coherence Tomography

      We investigated the correlation between insulin resistance (IR) and optical coherence tomography and identified culprit plaque characteristics in patients with acute coronary syndrome (ACS). Patients with ACS who underwent selective coronary intervention were prospectively enrolled. A total of 159 culprit lesions were identified in 145 patients. Culprit plaque characteristics, including thin-cap fibroatheroma (TCFA) and spotty calcification, were analyzed. The IR was assessed using the homeostasis model assessment of IR (HOMA-IR). Patients were divided into 4 interquartile ranges (IQRs) according to HOMA-IR values. The prevalence rates of TCFA were significantly different among the 4 groups (17.5% [IQR1 group] vs 17 ...

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    3. A comparison of two optical coherence tomography–angiography devices in pseudoexfoliation glaucoma versus primary open-angle glaucoma and healthy subjects

      A comparison of two optical coherence tomography–angiography devices in pseudoexfoliation glaucoma versus primary open-angle glaucoma and healthy subjects

      Purpose: To compare peripapillary vascular parameters derived from two optical coherence tomography angiography devices in pseudoexfoliation glaucoma, primary open-angle glaucoma, and healthy controls and to evaluate their diagnostic accuracy. Methods: Observational, cross-sectional study. In total, 20 eyes with pseudoexfoliation glaucoma, 20 primary open-angle glaucoma eyes matched by peripapillary retinal nerve fiber layer thickness, and 20 control eyes were recruited. Participants underwent standard automated perimetry and peripapillary retinal nerve fiber layer analysis by Optovue and Cirrus optical coherence tomography. Vascular parameters provided by Angiovue and Angioplex optical coherence tomography angiography were compared. Their diagnostic accuracy and correlation with structural and functional ...

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    4. The effect of tunnel length and position on postoperative corneal astigmatism: An optical coherence tomographic study

      The effect of tunnel length and position on postoperative corneal astigmatism: An optical coherence tomographic study

      Purpose: The purpose of this study is to evaluate the effects of variation in tunnel length of same-sized clear corneal phacoemulsification incisions on the generation of surgically induced astigmatism and corneal astigmatism. Methods: A total of 126 cataract patients treated in four study groups based on location and tunnel length of the clear corneal incisions (superior long, superior short, temporal long, temporal short) were reviewed. In the short tunnel groups, a 2.8 mm keratome was used with a motion parallel to the iris surface, while in the long tunnel groups, the same keratome was advanced in the corneal stroma ...

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    5. Intraoperative Optical Coherence Tomographic Imaging During Internal Limiting Membrane Retracting-Door Technique for Macular Hole

      Intraoperative Optical Coherence Tomographic Imaging During Internal Limiting Membrane Retracting-Door Technique for Macular Hole

      A 44-year-old man noticed a reduction in his vision that our examination showed was due to a myopic macular hole. The internal limiting membrane (ILM) retracting-door technique was used to successfully close the macular hole. A large flap of the ILM was created on the nasal side of the macular hole with the ILM forceps, and it was carried temporally over the macular hole. Unfortunately, the ILM flap shrank and wadded due to contraction of an epiretinal membrane (ERM). Viscoelastic material was injected onto the ILM flap to stabilize it and draped back to cover the macular hole, which was ...

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    6. Comparison of two biometers: A swept-source optical coherence tomography and an optical low-coherence reflectometry biometer

      Comparison of two biometers: A swept-source optical coherence tomography and an optical low-coherence reflectometry biometer

      Purpose: The technological improvements in optical biometers have made cataract surgery evolve to the level of refractive surgery. This study assessed the correlation and agreement between a biometer using swept-source optical coherence tomography technology (IOLMaster 700; Carl Zeiss Meditec, Jena, Germany) and a biometer using optical low-coherence reflectometry (Lenstar; Haag Streit, Koeniz, Switzerland). Procedures: Optical biometric measurements were taken with the IOLMaster 700 and the Lenstar on 129 eyes of 129 patients referred for cataract surgery. We compared biometric data (axial length, mean keratometry, central pachymetry, anterior chamber depth, lens thickness, and horizontal white-to-white measurement) and the emmetropic intraocular lens ...

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    7. Optical coherence tomography angiography findings in a case with acute posterior multifocal placoid pigment epitheliopathy

      Optical coherence tomography angiography findings in a case with acute posterior multifocal placoid pigment epitheliopathy

      Twenty-six-year-old male patient admitted to the outpatient clinic with a complaint of decreased vision in both eyes. Visual acuity was 2/10 in the right and 7/10 in the left eye. Fundus examination revealed bilateral yellow-white subretinal lesions involving the macula. Fluorescein angiography showed hypofluorescent lesions in early and hyperflourescent lesions in the late phase. Optical coherence tomography angiography performed in the acute phase showed bilateral hypofluorescency at the choriocapillary level. A diagnosis of acute posterior multifocal placoid pigment epitheliopathy was given. After steroid treatment, visual acuity was improved to 10/10 and earlier lesions in optical coherence tomography ...

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    8. Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment

      Purpose . Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Methods . Mastectomy and breast-conserving surgery specimens from 26 women were imaged with a handheld OCT probe. During standard pathology specimen dissection, representative 1-cm × 1-cm tissue regions were grossly identified, assessed with OCT, inked for orientation and ...

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    9. The optical coherence tomography angiography findings of rheumatoid arthritis patients taking hydroxychloroquine

      The optical coherence tomography angiography findings of rheumatoid arthritis patients taking hydroxychloroquine

      Purpose: The aim of this study is to measure retinal vessel density and thickness of the macula by optical coherence tomography angiography in patients with rheumatoid arthritis taking hydroxychloroquine. Methods: The study included 40 patients with rheumatoid arthritis taking hydroxychloroquine and 20 age-, gender-, and axial length-matched control subjects. Patients were divided into two groups according to the duration of hydroxychloroquine use. Twenty four of the patients were taking hydroxychloroquine for more than 5 years (Group 1), and the rest of 16 were taking hydroxychloroquine for less than 5 years (Group 2). A total of 20 age- and gender-matched volunteers ...

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    10. Swept-Source Optical Coherence Tomography Angiography in Central Serous Chorioretinopathy

      Swept-Source Optical Coherence Tomography Angiography in Central Serous Chorioretinopathy

      Purpose: This article aims to evaluate the appearance of central serous chorioretinopathy (CSC) with swept-source optical coherence tomography angiography (SS-OCTA), to discuss whether localization of the leakage spot seen on fluorescein angiography (FA) corresponds to any recognizable spot on SS-OCTA, and to provide subsequent diagnosis of choroidal neovascularization (CNV) in the course of CSC. Methods: A prospective interventional case series was conducted in a private outpatient office on 30 eyes of 27 patients. In addition to ophthalmic examination, FA, spectral-domain OCT, SS-OCT and SS-OCTA were performed at least once. If laser photocoagulation or anti-vascular endothelial growth factor (anti-VEGF) injection was ...

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    11. Optical coherence tomography findings predictive of response to treatment in diabetic macular edema

      Optical coherence tomography findings predictive of response to treatment in diabetic macular edema

      Objective To evaluate the short-term efficacy of intravitreal bevacizumab (IVB) and posterior sub-tenon triamcinolone injections (PSTI) on the basis of spectral-domain optical coherence tomography (SD-OCT) patterns in diabetic macular edema (DME). Methods We retrospectively reviewed 73 eyes of 73 patients with DME. Based on the presence of serous retinal detachment (SRD), eyes were categorized into two groups, and either IVB or PSTI treatment was performed. Central macular thickness (CMT) and the degree of SRD were assessed preoperatively and 1 month postoperatively. The severity of intraretinal edema was approximated based on the distance from the external limiting membrane to the internal ...

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    12. Association of Foveal Avascular Zone Enlargement and Diabetic Retinopathy Progression Using Optical Coherence Tomography Angiography

      Association of Foveal Avascular Zone Enlargement and Diabetic Retinopathy Progression Using Optical Coherence Tomography Angiography

      Purpose: The purpose of this article is to evaluate long-term change of the foveal avascular zone (FAZ) area in diabetic eyes using optical coherence tomography angiography (OCTA) (AngioVue, Avanti OCT, Optovue). Methods: A retrospective chart review was conducted of patients who had undergone OCTA fundus examinations with at least 12 months of follow-up. Eyes with previous laser photocoagulation and antivascular endothelial growth factor treatments were excluded. ImageJ software was used to evaluate the FAZ area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). Results: Forty eyes were analyzed in this study and divided into 3 groups: healthy ...

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    13. Choroidal neovascularization due to choroidal osteoma treated with anti–vascular endothelial growth factor therapy: An optical coherence tomography angiography study

      Choroidal neovascularization due to choroidal osteoma treated with anti–vascular endothelial growth factor therapy: An optical coherence tomography angiography study

      Purpose: To evaluate the response to anti–vascular endothelial growth factor therapy for choroidal neovascularization secondary to choroidal osteoma using optical coherence tomography angiography. Methods: This retrospective study included four eyes of four females with choroidal osteoma complicated by choroidal neovascularization, treated with ranibizumab. All patients underwent full ophthalmologic examination, including ocular ultrasound, retinography, fluorescein angiography, spectral-domain or swept-source optical coherence tomography, and optical coherence tomography angiography. These images were analyzed to measure choroidal osteoma and to study choroidal neovascularization changes after intravitreal anti–vascular endothelial growth factor. Results: In all cases, fluorescein angiography revealed the presence the choroidal neovascularization ...

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    14. Posterior keratoconus—clinical aspects and anterior segment optical coherence tomography findings: A case report

      Posterior keratoconus—clinical aspects and anterior segment optical coherence tomography findings: A case report

      Purpose: To describe a case of Posterior Keratoconus (keratoconus posticus); its clinical condition, corneal, refractive response to intracorneal ring implantation (MyoRing), anterior segment optical coherence tomography findings; and micro incisional cataract surgery outcome. Methods: Case report. Results: The case was studied with high resolution anterior segment optical coherence tomography (OCT), epithelium OCT, corneal topography, and aberrometry. A MyoRing was implanted and after the development of cataract, microincisional cataract surgery was performed. A large hyperopic shift was observed following the ring implantation. Calculation of the intraocular lens showed poor predictability. Conclusions: Posterior keratoconus is a rare corneal congenital disorder characterized by ...

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    15. Macular Changes on Optical Coherence Tomography Before, During, and After Silicone Oil Tamponade for Macula-On Retinal Detachment: A Case Series

      Macular Changes on Optical Coherence Tomography Before, During, and After Silicone Oil Tamponade for Macula-On Retinal Detachment: A Case Series

      Purpose: Assess changes on spectral domain optical coherence tomography (OCT) before, during, and after removal of silicone oil (SO). Methods: Retrospective series of patients who underwent SO tamponade for macula-on rhegmatogenous retinal detachment. OCT scans of the affected eye were taken before, during, and 3 months after SO tamponade. Qualitative assessment of foveal contour and quantitative comparison of OCT parameters (central macular, cube, ganglion cell layer [GCL], and outer retinal thicknesses) were done between 3 time points. Results: Ten eyes of 9 patients were included. Flattening of the foveal contour during SO tamponade was completely reversed after SO removal. Average ...

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    16. Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine

      Bioabsorbable Drug-Eluting Stent Versus Bare Metal Stent in Iliac Artery Evaluated by Optical Coherence Tomography: An In Vivo Study in Porcine

      Objective: This study aimed to compare, using optical coherence tomography (OCT), the outcomes of bioabsorbable drug-eluting stent with those of bare metal stent (BMS) following implantation in porcine iliac artery. Methods: After the placement of BMS and bioabsorbable drug-eluting stents, we used OCT and digital subtraction angiography to investigate stent appositions, arterial neointima, evagination, and restenosis at 1 and 3 months. Results: At 1 and 3 months after stent implantation, OCT study was performed to investigate 32 stents and 21 788 struts. Thirty-three malapposed struts were found in the bioabsorbable drug-eluting stent groups and 2 were found in BMS groups ...

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    17. Optic coherence tomography appearances of retinal astrocytic hamartoma and systemic features in tuberous sclerosis of Japanese patients

      Optic coherence tomography appearances of retinal astrocytic hamartoma and systemic features in tuberous sclerosis of Japanese patients

      Purpose: To describe the optical coherence tomography findings of retinal astrocytic hamartoma of tuberous sclerosis and to confirm the association between the type of retinal astrocytic hamartoma and systemic manifestations in Japanese patients. Study Design: A retrospective observational case series. Methods: The medical records of 35 patients with tuberous sclerosis who underwent ophthalmological examination were reviewed. The retinal astrocytic hamartomas were classified into four types based on the optical coherence tomography findings, and their association with systemic disease was evaluated. Results: A total of 40 retinal astrocytic hamartomas in 13 eyes of eight patients aged 4–28 years were identified ...

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    18. Optical coherence tomography angiography in myopic choroidal neovascularization after intravitreal ranibizumab

      Optical coherence tomography angiography in myopic choroidal neovascularization after intravitreal ranibizumab

      Purpose: To describe the optical coherence tomography angiography characteristics of myopic patients with choroidal neovascularization secondary to pathologic myopia during ranibizumab therapy. Methods: Nineteen patients were enrolled in this prospective study (13 females, 6 males, mean age 55.25 ± 9.63 years) for a total of 20 eyes examined (14 right eyes, 6 left eyes). Images were analyzed independently by two examiners. Results: Mean follow-up was 5.75 ± 1.88 months, with a mean intravitreal injections of 1.90 ± 0.44. Mean best-corrected visual acuity at baseline was 0.39 ± 0.18 logMAR versus 0.26 ± 0.16 logMAR 6 ...

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    19. Measurement of Normative Foveal Avascular Zone Parameters in Healthy Adults Using Optical Coherence Tomography Angiography

      Measurement of Normative Foveal Avascular Zone Parameters in Healthy Adults Using Optical Coherence Tomography Angiography

      Background and Objective: The purpose of this study was to quantify the geometric dimension of the foveal avascular zone (FAZ) area and its index measurement of morphology as a circle (acircularity index) in healthy participants according to age and sex, using optical coherence tomography angiography (OCTA). Study Design/Materials and Method: This is a cross-sectional descriptive study conducted at LV Prasad Eye Institute, India. Written informed consent was obtained from all participants before the study. Deep range imaging-optical coherence tomography (DRI-OCT; Topcon) was performed on right eyes of all participants in this study. The OCTA scans were analyzed and processed ...

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    20. Evaluation of the lamina cribrosa in patients with diabetes mellitus using enhanced depth imaging spectral-domain optical coherence tomography

      Evaluation of the lamina cribrosa in patients with diabetes mellitus using enhanced depth imaging spectral-domain optical coherence tomography

      Purpose: To compare the lamina cribrosa thickness and anterior lamina cribrosa depth between patients with and without diabetes mellitus and to investigate the effect of metabolic control and duration of diabetes mellitus on lamina cribrosa thickness and anterior lamina cribrosa depth using enhanced depth imaging spectral-domain optical coherence tomography. Methods: A total of 70 patients were enrolled in this cross-sectional study and were divided into the diabetes and control groups. Intraocular pressure, circumpapillary retinal nerve fibre layer thickness, anterior lamina cribrosa depth and lamina cribrosa thickness were compared between the groups. Results: In the control group, the mean intraocular pressure ...

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    21. Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review

      Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review

      Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the keywords “tympanic membrane or middle ear,”“optical coherence tomography,” and “imaging.” Conclusion Conventional imaging techniques cannot adequately resolve the microscale features of TM and ME, sometimes necessitating diagnostic exploratory surgery ...

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    22. Optical coherence tomography angiography characterization of acute and late stage Purtscher retinopathy

      Optical coherence tomography angiography characterization of acute and late stage Purtscher retinopathy

      Purpose: To report a case of Purtscher retinopathy imaged with optical coherence tomography angiography. Methods: Case-report. Left eye fundoscopic examination in a 21-year old male after a road traffic accident with chest compression revealed multiple peri-papillary cotton-wool spots and intra- and pre-retinal hemorrhages. A diagnosis of Purtscher retinopathy was assumed. Results: In both the superficial and deep retinal plexuses, acute stage optical coherence tomography angiography identified multiple irregular areas of capillary non-perfusion that extended beyond the clinically visible peri-papillary cotton-wool spots. At 5-month follow-up, despite the clearing of visible cotton-wool spots, there were still permanent areas of irregular capillary non-perfusion ...

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    23. Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography

      Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography

      Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed. Choroidal blood flow was deemed present if deeper choroidal vessels appeared bright after appropriate segmentation. Results: Structural visualization of choroidal vessels was feasible in all eyes by en face imaging ...

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    24. Optical coherence tomography angiography in age-related macular degeneration: The game changer

      Optical coherence tomography angiography in age-related macular degeneration: The game changer

      Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch’s membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions. Optical coherence tomography angiograms, due to the longer wavelength used by optical ...

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