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    1. Cholesterol crystal-induced coronary inflammation: Insights from optical coherence tomography and pericoronary adipose tissue computed tomography attenuation

      Cholesterol crystal-induced coronary inflammation: Insights from optical coherence tomography and pericoronary adipose tissue computed tomography attenuation

      Vascular inflammation is a key driver of atherogenesis and atherothrombosis. 1 Free cholesterol accumulation within the arterial wall formulates cholesterol crystals, which incite a local inflammatory response. 1 Intracoronary optical coherence tomography (OCT) enables in vivo visualization of cholesterol crystals, shown to associate with features of plaque vulnerability. 2 Recent evidence demonstrates that coronary inflammation propagates “inside-out” to pericoronary adipose tissue (PCAT), with proinflammatory cytokines inhibiting adipocyte lipid accumulation.

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    2. In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

      In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

      Background In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity. Objective We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference. Methods Multimodality imaging was prospectively performed in 30 NSTEMI patients. Plaque characteristics were assessed in 1083 cross-sections of 30 culprit lesions, co-registered among modalities. Absence of plaque, fibrous and fibrocalcific plaque on OCT were defined as early plaque, whereas ...

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