1. Articles from asa.scitation.org

  2. 1-6 of 6
    1. Dynamic optical coherence elastography: Emerging tool for noninvasive quantification of mechanical properties of ocular tissues

      Dynamic optical coherence elastography: Emerging tool for noninvasive quantification of mechanical properties of ocular tissues

      Optical coherence elastography (OCE) is an emerging method for noninvasive quantification of tissue viscoelastic properties. The underlying technology is based on Optical Coherence Tomography (OCT) imaging and analysis of external (or internal) force-induced mechanical waves propagating through the tissue. In this presentation, I will overview recent progress made in my lab on quantification of mechanical properties of ocular tissues (such as cornea and the lens of the eye) using OCE and their alternations during diseases progression. In particular, I will demonstrate that it is possible to quantify mechanical properties of the cornea and lens as a function of Intra-Ocular Pressure ...

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    2. HIFU tissue lesion quantification by optical coherence tomography

      HIFU tissue lesion quantification by optical coherence tomography

      Heating of tissue by high-intensity focused ultrasound (HIFU) can result in sufficient temperature elevation to cause irreversible changes in the tissue structure. The contiguous volume occupied by these changes, a lesion, and the extent of the tissue changes may be quantified histologically or estimated through techniques such as ultrasonic elastography. We have shown that changes in tissue optical scattering could be used as a proxy to improve sensing and imaging of HIFU lesion formation as an alternative to thermometry. Optical coherence tomography (OCT) is a light-based method appropriate for optically accessible tissues, which we have used to quantify lesion volume ...

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    3. Optical coherence tomography reveals complex motion between the basilar membrane and organ of corti in the gerbil cochlea

      Optical coherence tomography reveals complex motion between the basilar membrane and organ of corti in the gerbil cochlea

      The mechanical basis of auditory transduction within the mammalian cochlea is not fully understood but relies on complex mechanical interactions between different structures within the Organ of Corti (OoC). We used spectral domain phase microscopy, a functional extension of optical coherence tomography (OCT), to measure the sound-evoked motion in response to “Zwuis” frequency complexes, in vivo, in the basal region of the gerbil cochlea. Because OCT allows for measurements from multiple axial positions along the optical path, we are able to simultaneously record vibration at different points within the OoC between the basilar membrane (BM) and tectorial membrane. Imaging through ...

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    4. Motion of intracochlear structures measured with a commercial optical coherence tomography (OCT) system

      Motion of intracochlear structures measured with a commercial optical coherence tomography (OCT) system

      Most knowledge of the motion of cochlear structures has been limited to measurements through the round window at the extreme base of the cochlea or through a hole made in the cochlear capsule, which can modify cochlear mechanics. Optical coherence tomography (OCT) provides the ability to measure shape or motion of structures through a thin layer of tissue or bone. The motion of cochlear structures has been measured in the mouse cochlear apex without making an opening into the cochlea, using a custom OCT system. Here we describe intracochlear vibrometry using a commercial OCT system. Specimens were prepared by opening ...

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      Mentions: Thorlabs
    5. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy

      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be presented that integrates optical coherence tomography that is spatially and temporally co-registered with laryngeal videoendoscopic technology through a common path probe. Optical coherence tomography is a non-contact, micron-resolution imaging technology ...

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    6. Signal competition in optical coherence tomography and its relevance for cochlear vibrometry

      Signal competition in optical coherence tomography and its relevance for cochlear vibrometry

      The usual technique for measuring vibration within the cochlear partition is heterodyne interferometry. Recently, spectral domain phase microscopy (SDPM) was introduced and offers improvements over standard heterodyneinterferometry. In particular, it has a penetration depth of several mm due to working in the infrared range, has narrow and steep optical sectioning due to using a wideband light source, and is able to measure from several cochlear layers simultaneously. However, SDPM is susceptible to systematic error due to “phase leakage,” in which the signal from one layer competes with the signal from other layers. Here, phase leakage is explored in vibration measurements ...

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    1-6 of 6
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