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    1. Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data

      Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data

      Importance Early diagnosis of plus disease is critical in the management of retinopathy of prematurity (ROP). However, there is substantial interexpert disagreement in the diagnosis of plus disease based on vascular changes alone. Information derived from optical coherence tomography (OCT) may help characterize the severity of vascular and structural abnormalities in ROP. Objective To describe integrated visualization of 3-dimensional (3-D) data from investigational swept-source OCT optimized to delineate retinal vascular and microanatomical features in eyes with and without ROP. Design, Setting, and Participants This cross-sectional, observational report of OCT was captured in the prospective Study of Eye Imaging in Preterm ...

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      Mentions: Duke University
    2. Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology

      Correlation of Optical Coherence Tomography Angiography of Type 3 Macular Neovascularization With Corresponding Histology

      Importance By validating optical coherence tomography angiography (OCTA) in the analysis of type 3 macular neovascularization secondary to age-related macular degeneration, the overall value of clinical OCTA for disease observation, diagnosis, and staging is increased. Objective To assess the association of in vivo OCTA of type 3 macular neovascularization secondary to age-related macular degeneration with corresponding ex vivo histology. Design, Setting, and Participants This study included clinical imaging, laboratory microscopy, and eye-tracked clinicopathologic correlation of a single case from a community-based practice evaluated at a university-based research laboratory from 2014 to 2019. Exposures Infrared reflectance and eye-tracked spectral-domain OCTA clinical ...

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    3. Association of Rates of Optical Coherence Tomography Angiography Vessel Density Loss on Initial Visits With Future Visual Field Progression

      Association of Rates of Optical Coherence Tomography Angiography Vessel Density Loss on Initial Visits With Future Visual Field Progression

      We, as clinicians, appreciate on a daily basis that the diagnosis of glaucoma can be challenging because of the inherent differences in optic nerve head appearances among individuals. Even more challenging during the initial visits is to make the determination a priori about which patients are at the greatest risk of progression in the long term, thus adding uncertainty about potential for undertreatment vs overtreatment. Objective measurements of circumpapillary retinal nerve fiber layer (RNFL) measurements and macular ganglion cell complex (GCC) thickness using optical coherence tomography (OCT) have proven effective in glaucoma evaluation and progression, especially in cases of mild ...

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      Mentions: UCLA
    4. Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Association of Initial Optical Coherence Tomography Angiography Vessel Density Loss With Faster Visual Field Loss in Glaucoma

      Importance: Rapid vessel density loss during an initial follow-up period may be associated with the rates of visual field loss over time. Objectives: To evaluate the association between the rate of vessel density loss during initial follow-up and the rate of visual field loss during an extended follow-up period in patients suspected of having glaucoma and patients with primary open-angle glaucoma. Design, setting, and participants: This retrospective cohort study assessed 124 eyes (86 with primary open-angle glaucoma and 38 suspected of having glaucoma) of 82 patients who were followed up at a tertiary glaucoma center for a mean of 4 ...

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      Mentions: UCSD
    5. Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood

      Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood

      Importance The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) have been proposed as potential biomarkers for Alzheimer disease (AD). Although a number of studies have shown that knowing the thickness of RNFL and GCL can help differentiate between patients with AD and healthy controls, it is unclear whether these associations are observable earlier in life. Objective To examine whether RNFL and GCL thickness was associated with global cognitive performance in middle age and in childhood and with a decline in cognitive performance from childhood to adulthood and whether RNFL and GCL thickness was associated with decline in ...

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    6. Optical Coherence Tomography of Retinal Artery Occlusion Associated With Mucormycosis and COVID-19

      Optical Coherence Tomography of Retinal Artery Occlusion Associated With Mucormycosis and COVID-19

      41-year-old woman presented with mucormycosis-induced orbital apex syndrome following SARS-CoV-2 infection. Magnetic resonance imaging showed pansinusitis with thickening and enhancement of the extraocular muscles. A histopathological examination disclosed broad-based, filamentous, aseptate hyphae, suggestive of mucormycosis. A fundus examination showed signs of central retinal artery occlusion, including loss of transparency, presumably from ischemia to the ganglion cell layer and boxcarring of the retinal arterioles. Macular folds on fundus photography with separation of the neurosensory retina from the retinal pigment epithelium on optical coherence tomography were noted ( Figure ). Prompt treatment with systemic amphotericin B (10 mg/kg/d) and debridement of the ...

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    7. Widefield Swept-Source Optical Coherence Tomography Angiography of a "Polypoidal-Like" Retinal Arteriovenous Anastomosis in Proliferative Diabetic Retinopathy

      Widefield Swept-Source Optical Coherence Tomography Angiography of a "Polypoidal-Like" Retinal Arteriovenous Anastomosis in Proliferative Diabetic Retinopathy

      A 69-year-old man with a history of proliferative diabetic retinopathy in both eyes presented with retinal hemorrhages and a whitish boundary demarcating the arterioles ( Figure , A, yellow arrowheads, right eye shown). His visual acuity was 20/400 OU. The right eye received several anti–vascular endothelial growth factor injections. En face widefield swept-source optical coherence tomography angiography (SS-OCTA; 15 × 15 mm) of the total retina showed extensive retinal capillary and arteriolar nonperfusion ( Figure , B, yellow segmentation lines). The en face OCTA image revealed a tangled-vessel structure surrounded by retinal capillary and arteriolar nonperfusion ( Figure , B, blue box). The “polypoidal-like” lesion ...

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    8. Deep Learning–Based Automated Optical Coherence Tomography Segmentation in Clinical Routine: Getting Closer

      Deep Learning–Based Automated Optical Coherence Tomography Segmentation in Clinical Routine: Getting Closer

      Recently, many ophthalmologists have heard the keywords artificial intelligence , machine learning , deep learning , and automatization at every conference and keynote lecture and seen them in every ophthalmology journal. 1 Many studies 1 have evaluated the use of such algorithms on large retrospective data sets—primarily on color fundus photographs at first, then on optical coherence tomography (OCT) images as well. Most of these have been study data sets with standardized and well-structured imaging protocols and reading center image collections with a predefined protocol, and therefore of good quality. However, how functional will algorithms be in a busy clinical routine? Can ...

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    9. Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

      Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

      Importance: Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual grading. Expert-level deep learning systems for automatic OCT segmentation have recently been developed. However, the potential clinical applicability of these systems is largely unknown. Objective: To evaluate a deep learning model for whole-volume segmentation of 4 clinically important pathological features and assess clinical applicability. Design, setting, participants: This diagnostic study used OCT data from 173 patients with a total of 15 558 B-scans, treated at Moorfields Eye Hospital. The data set included 2 common OCT devices ...

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    10. Comparison of Central Macular Fluid Volume With Central Subfield Thickness in Patients With Diabetic Macular Edema Using Optical Coherence Tomography Angiography

      Comparison of Central Macular Fluid Volume With Central Subfield Thickness in Patients With Diabetic Macular Edema Using Optical Coherence Tomography Angiography

      Importance: Diabetic macular edema (DME) is the predominant cause of visual impairment in patients with type 1 or 2 diabetes. Automated fluid volume measurements using optical coherence tomography (OCT) may improve the diagnostic accuracy of DME screening. Objective: To assess the diagnostic accuracy of an automated central macular fluid volume (CMFV) quantification using OCT for DME. Design, setting, and participants: A cross-sectional observational study was conducted at a tertiary academic center among 215 patients with diabetes (1 eye each) enrolled from January 26, 2015, to December 23, 2019. All participants underwent comprehensive examinations, 6 × 6-mm macular structural OCT horizontal raster ...

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    11. Understanding Visual Acuity Outcomes After Retinal Detachment Repair by Assessing Photoreceptor Integrity on Spectral-Domain Optical Coherence Tomography

      Understanding Visual Acuity Outcomes After Retinal Detachment Repair by Assessing Photoreceptor Integrity on Spectral-Domain Optical Coherence Tomography

      The annual incidence of rhegmatogenous retinal detachment is approximately 18 to 22 per 100 000 population1,2 and reported techniques for reattaching the retina include pneumatic retinopexy (PnR), scleral buckle, and pars plana vitrectomy (PPV). Recently, it has become increasingly common to repair a retinal detachment using vitrectomy and gas, given the higher anatomical success rate of this procedure. However, the Pneumatic Retinopexy Versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT) showed that even though the anatomical success of PnR is lower than that of PPV, visual acuity outcomes were better and rates ...

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    12. Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity

      Preterm Infant Stress During Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity

      Importance: Binocular indirect ophthalmoscopy (BIO) examination for retinopathy of prematurity (ROP) is a well-known cause of repeated preterm infant stress. Objective: To compare stress during investigational optical coherence tomography (OCT) imaging to that during BIO for ROP. Design, setting, and participants: This cross-sectional study examined infants at the bedside in the intensive care nursery. Consecutive preterm infants enrolled in Study of Eye Imaging in Preterm Infants (BabySTEPS) who had any research OCT imaging as part of the study. Patients were recruited from June to November 2019, and analysis began April 2020. Main outcomes and measures: Infant stress was measured using ...

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    13. Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

      Importance: Determination of retinal thinning rates may help to identify patients who are at risk of progression of sickle cell retinopathy. Objective: To assess the rates of macular thinning in adults with and without sickle cell retinopathy using spectral-domain optical coherence tomography (OCT) and to identify ocular and systemic risk factors associated with retinal thinning. Design, setting, and participants: This longitudinal prospective case-control study enrolled adult participants from a university-based retina subspecialty clinic between February 11, 2009, and July 3, 2019. The study was designed in autumn 2008 and conducted from February 2, 2009, to July 3, 2020. Participants with ...

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    14. Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury

      Association of Optical Coherence Tomography With Longitudinal Neurodegeneration in Veterans With Chronic Mild Traumatic Brain Injury

      Importance: Mild traumatic brain injury (TBI) may predispose individuals to progressive neurodegeneration. Objective: To identify evidence of neurodegeneration through longitudinal evaluation of changes in retinal layer thickness using optical coherence tomography in veterans with a history of mild TBI. Design, setting, and participants: This longitudinal cohort study evaluated veterans who were receiving services at the Minneapolis Veterans Affairs Health Care System. Symptomatic or mild TBI was diagnosed according to the Mayo TBI Severity Classification System. Participants in the age-matched control group had no history of TBI. Participants with any history or evidence of retinal or optic nerve disease that could ...

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    15. Interaction Between the Distribution of Diabetic Retinopathy Lesions and the Association of Optical Coherence Tomography Angiography Scans With Diabetic Retinopathy Severity

      Interaction Between the Distribution of Diabetic Retinopathy Lesions and the Association of Optical Coherence Tomography Angiography Scans With Diabetic Retinopathy Severity

      Importance Studies have not yet determined whether the distribution of lesions in the retinal periphery alters the association between the severity of diabetic retinopathy (DR) and macular vessel density. Objective To evaluate the association of DR lesion distribution with optical coherence tomography angiography (OCTA) metrics and DR severity. Design, Setting, and Participants This cross-sectional observational study was conducted at a tertiary care center for diabetic eye disease among 225 patients with type 1 or 2 diabetes who had undergone imaging between February 15, 2016, and December 31, 2019. Exposures Optical coherence tomography angiography 3 × 3-mm macular scans and ultra-widefield color ...

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    16. Using Optical Coherence Tomography as a Surrogate of Measurements of Intracranial Pressure in Idiopathic Intracranial Hypertension

      Using Optical Coherence Tomography as a Surrogate of Measurements of Intracranial Pressure in Idiopathic Intracranial Hypertension

      Importance There is an unmet need for noninvasive biomarkers of intracranial pressure (ICP), which manifests as papilledema that can be quantified by optical coherence tomography (OCT) imaging. Objective To determine whether OCT of the optic nerve head in papilledema could act as a surrogate measure of ICP. Design, Setting, and Participants This longitudinal cohort study used data collected from 3 randomized clinical trials that were conducted between April 1, 2014, and August 1, 2019. Participants who were female and had active idiopathic intracranial hypertension were enrolled from 5 National Health Service hospitals in the UK. Automated perimetry and OCT imaging ...

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    17. Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale

      Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale

      Objectives To compare and contrast 2 methods of quantitating papilledema, namely, optical coherence tomography (OCT) and Modified Frisén Scale (MFS). Methods Digital optic disc photographs and OCT fast retinal nerve fiber layer (RNFL) thickness, fast RNFL map, total retinal thickness, and fast disc images were obtained in 36 patients with papilledema. Digital optic disc photographs were randomized and graded by 4 masked expert reviewers using the MFS. We performed Spearman rank correlations of OCT RNFL thickness, OCT total retinal thickness, and MFS grade from photographs. Results OCT RNFL thickness and MFS grade from photographs correlated well ( R = 0.85 ...

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    18. Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

      Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

      Importance Sensitive outcome measures for disease progression are needed for treatment trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Objective To quantify photoreceptor degeneration outside regions of GA in eyes with nonexudative AMD, to evaluate its association with future GA progression, and to characterize its spatio-temporal progression. Design, Setting, and Participants Monocenter cohort study (Directional Spread in Geographic Atrophy [ NCT02051998 ]) and analysis of data from a normative data study at a tertiary referral center. One hundred fifty-eight eyes of 89 patients with a mean (SD) age of 77.7 (7.1) years, median area of GA of ...

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    19. Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Model-to-Data Approach for Deep Learning in Optical Coherence Tomography Intraretinal Fluid Segmentation

      Importance Amid an explosion of interest in deep learning in medicine, including within ophthalmology, concerns regarding data privacy, security, and sharing are of increasing importance. A model-to-data approach, in which the model itself is transferred rather than data, can circumvent many of these challenges but has not been previously demonstrated in ophthalmology. Objective To determine whether a model-to-data deep learning approach (ie, validation of the algorithm without any data transfer) can be applied in ophthalmology. Design, Setting, and Participants This single-center cross-sectional study included patients with active exudative age-related macular degeneration undergoing optical coherence tomography (OCT) at the New England ...

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      Mentions: Tufts University
    20. Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes

      Association of Optical Coherence Tomography Angiography Metrics With Detection of Impaired Macular Microvasculature and Decreased Vision in Amblyopic Eyes

      Importance Microvascular abnormalities in amblyopia are becoming evident with high-resolution imaging, such as optical coherence tomography angiography (OCT-A); however, to our knowledge, the clinical significance and use of these findings are unknown. Objective To assess changes in quantitative OCT-A metrics in amblyopic eyes and explore their association with visual acuity in children. Design, Setting, and Participants This population-based nested case-control study included children aged 6 to 8 years who were consecutively recruited between January 2016 and July 2017 from the population-based Hong Kong Children Eye Study (HKCES) at the Chinese University of Hong Kong Eye Centre. All participants underwent OCT-A ...

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    21. Optical Coherence Tomography Angiography as an Important Diagnostic Tool for Amblyopia

      Optical Coherence Tomography Angiography as an Important Diagnostic Tool for Amblyopia

      Amblyopia has been a diagnosis of exclusion. Besides best-corrected visual acuity, there are presently no standardized metrics that are used for the diagnosis and evaluation of amblyopia. For more than a decade, studies using structural optical coherence tomography (OCT) had identified several differences between amblyopic and control eyes. 1 Qualitatively, the increase in height of the ellipsoid zone at the central fovea was noted to be attenuated or absent in 60% of amblyopic eyes compared with 29% of normal eyes. 2 Several studies had reported that the foveal minimum thickness was greater in amblyopic eyes compared with normal controls, but ...

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    1-24 of 113 1 2 3 4 5 »
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