1. 1-24 of 33 1 2 »
    1. Acute Solar Retinopathy Imaged With Adaptive Optics, Optical Coherence Tomography Angiography, and En Face Optical Coherence Tomography

      Acute Solar Retinopathy Imaged With Adaptive Optics, Optical Coherence Tomography Angiography, and En Face Optical Coherence Tomography

      Importance Solar retinopathy is a rare form of retinal injury that occurs after direct sungazing. Objective To enhance understanding of the structural changes that occur in solar retinopathy by obtaining high-resolution in vivo en face images. Design, Setting, and Participant Case report of a young adult woman who presented to the New York Eye and Ear Infirmary with symptoms of acute solar retinopathy after viewing the solar eclipse on August 21, 2017. Main Outcomes and Measures Results of comprehensive ophthalmic examination and images obtained by fundus photography, microperimetry, spectral-domain optical coherence tomography (OCT), adaptive optics scanning light ophthalmoscopy, OCT angiography ...

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    2. Optical Coherence Tomography Features of Dermatophytoma

      Optical Coherence Tomography Features of Dermatophytoma

      Dermatophytoma was first described in 1998 to complicate toenail infections and is characterized by fungal elements compacted into a fungal ball. 1 Clinically, it appears as a dense white or yellow linear or round white patch within the nail plate. Cutting back the overlying nail plate reveals a hyperkeratotic mass that can be easily removed because it is not adherent to the nail plate or nail bed, and histologic analysis reveals a dense mass of abnormal-appearing, densely walled, dermatophyte hyphae. 1 , 2 The standard diagnostic test for onychomycosis involves clinical suspicion and at least 1 positive finding on a laboratory ...

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    3. En Face Optical Coherence Tomography of Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      En Face Optical Coherence Tomography of Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      A woman in her 60s presented with 2 months of blurred vision in the left eye, with visual acuity of 20/40. Examination of the left ocular fundus revealed spokelike foveal cysts. Fluorescein angiography showed no foveal leakage. En face optical coherence tomography (Optovue Inc) in the left eye revealed stellate hyporeflectivity ( Figure , A). A retinal cross-section scan revealed foveomacular retinoschisis involving the outer plexiform layer ( Figure , B). The fellow eye was normal. Without evidence of X-linked retinoschisis, niacin or taxane use, enhanced S-cone syndrome, glaucoma, traction, optic pit, or pathologic myopia, the patient was diagnosed as having stellate nonhereditary ...

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    4. Intraoperative Optical Coherence Tomography for Anterior Chamber and Sulcus Positioning

      Intraoperative Optical Coherence Tomography for Anterior Chamber and Sulcus Positioning

      Presence in the anterior chamber can be confirmed by observation of the reflective needle tip. The silicone tube and its lumen can be appreciated when subsequently inserted into the anterior chamber. The presence of the needle in the sulcus can be confirmed by the lack of a signal from the needle and anterior displacement of the iris.

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    5. Use of Intraoperative OCT for Tube Positioning in Glaucoma Surgery

      Use of Intraoperative OCT for Tube Positioning in Glaucoma Surgery

      Intraoperative optical coherence tomography (iOCT) has become a valuable adjunct to ophthalmic surgery in the past decade. Although iOCT has been used extensively in retinal surgery for epiretinal membrane peel and in corneal surgery for lamellar keratoplasty, 1 - 4 its use in surgical procedures for glaucoma remains limited. Dada et al 5 describe the use of iOCT in guiding needling of a trabeculectomy bleb, whereas Siebelmann et al 6 introduced the use of iOCT in canaloplasty. To our knowledge, the utility of iOCT has not been assessed in implantation of glaucoma drainage devices. We herein propose the use of iOCT ...

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    6. Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy

      Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy

      Importance Investigating the quantitative 3-dimensional (3-D) anatomy of polypoidal complex is important for a better understanding of the pathogenesis of polypoidal choroidal vasculopathy (PCV). Objective To quantitatively evaluate the 3-D characteristics of polypoidal structures, branching vascular networks (BVNs), and origin of PCV using optical coherence tomography angiography (OCTA) and multiple image systems. Design, Setting, and Participants A prospective, observational study was conducted in 47 consecutive Taiwanese patients (47 eyes) from May 21, 2015, to April 30, 2017. All participants were scanned with the Optovue-RTVue-XR-Avanti OCTA system. Patients in whom PCV was identified on OCTA were examined to define characteristics and ...

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    7. The Role of Optical Coherence Tomography Angiography in Polypoidal Choroidal Vasculopathy

      The Role of Optical Coherence Tomography Angiography in Polypoidal Choroidal Vasculopathy

      Retinal imaging technology has progressed rapidly in recent years and plays increasingly vital roles in guiding the clinical management of retinal diseases, as well as facilitating greater understanding of the disease process. Polypoidal choroidal vasculopathy (PCV) is an important variant of neovascular age-related macular degeneration with distinct phenotypic features that can be seen both on clinical examination and using indocyanine green angiography (ICGA). In this issue of JAMA Ophthalmology, the optical coherence tomography angiography (OCTA) features of PCV are described and evaluated by Chi et al.1

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    8. Imaging Congenital Optic Disc Pits and Associated Maculopathy Using Optical Coherence Tomography

      Imaging Congenital Optic Disc Pits and Associated Maculopathy Using Optical Coherence Tomography

      Objective: To elucidate the anatomy of congenital optic disc pits with and without maculopathy using optical coherence tomography. Setting: All patients were examined, photographed, and scanned at the New York Eye and Ear Infirmary. Patients: Ten eyes of eight consecutive patients with congenital optic disc pits were studied. Three eyes had associated serous macular detachment (group 1), four had evidence of resolved detachment (group 2), and three had no clinical macular pathologic lesion (group 3). Methods: Optical coherence tomography, a new, noninvasive, noncontact, imaging technology capable of producing cross-sectional images of the retina in vivo with high resolution (<17 μm ...

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    9. Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography

      Image Averaging, a Powerful Tool in Optical Coherence Tomography and OCT Angiography

      In an elegantly conducted study, Uji et al 1 describe the association of averaging multiple en face images with the quality of the optical coherence tomography angiography (OCTA) images of the choroidal microvasculature. They demonstrate that the resulting vascular images approximate much more closely the structure of the choriocapillaris as visualized histopathologically. This is an interesting and potentially important advance in the ability of OCTA to image the choriocapillaris in vivo.

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    10. Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases

      Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases

      Importance Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study. Main Outcomes and Measures Features of iris racemose hemangioma on OCTA. Results Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study. Mean patient age was 50 years, all patients were white, and ...

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    11. Repeatability and Reproducibility of Superficial Macular Retinal Vessel Density Measurements Using Optical Coherence Tomography Angiography En Face Images

      Repeatability and Reproducibility of Superficial Macular Retinal Vessel Density Measurements Using Optical Coherence Tomography Angiography En Face Images

      Importance The repeatability and reproducibility of quantitative metrics from optical coherence tomographic angiography (OCTA) must be assessed before these data can be confidently interpreted in clinical research and practice. Objective To evaluate the repeatability and reproducibility of OCTA-derived retinal vascular quantitative metrics. Design, Setting and Participants In this cross-sectional study, 21 healthy volunteers (42 eyes) and 22 patients with retinal disease (22 eyes), including 14 with age-related macular degeneration, 3 with epiretinal membrane, 2 with diabetic retinopathy, 2 with myopic macular degeneration, and 1 with retinal vein occlusion, were enrolled. Participants were recruited from September 1 through November 31, 2016 ...

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    12. Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases

      Optical Coherence Tomography Angiography Features of Iris Racemose Hemangioma in 4 Cases

      Importance Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study. Main Outcomes and Measures Features of iris racemose hemangioma on OCTA. Results Four eyes of 4 patients with unilateral iris racemose hemangioma were included in the study. Mean patient age was 50 years, all patients were white, and ...

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    13. Spectral-Domain Optical Coherence Tomographic Angiography in Children With Amblyopia

      Spectral-Domain Optical Coherence Tomographic Angiography in Children With Amblyopia

      Importance Amblyopia is the most common cause of visual impairment in childhood, with a prevalence of 1% to 4% in children in the United States. To date, no studies using noninvasive optical coherence tomographic angiography (OCTA) have measured blood flow in the retinal capillary layers in children with amblyopia. Objective To evaluate the retinal and microvascular features using OCTA in children (<18 years) with amblyopia. Design, Setting, and Participants This observational case-control study enrolled patients from September 1, 2016, through May 31, 2017, and was conducted from September 1, 2016, through June 30, 2017, at the Stein Eye Institute at ...

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      Mentions: UCLA
    14. Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Importance Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra–wide-field OCT or OCTA images in neonates. Objective To obtain ultra–wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device. Design, Setting, and Participants This observational case series was conducted ...

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    15. Space Flight–Associated Neuro-ocular Syndrome

      Space Flight–Associated Neuro-ocular Syndrome

      New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight–associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts ...

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    16. Association of Electrochemical Therapy With Optical, Mechanical, and Acoustic Impedance Properties of Porcine Skin

      Association of Electrochemical Therapy With Optical, Mechanical, and Acoustic Impedance Properties of Porcine Skin

      Importance The classic management of burn scars and other injuries to the skin has largely relied on soft-tissue transfer to resurface damaged tissue with local tissue transfer or skin graft placement. In situ generation of electrochemical reactions using needle electrodes and an application of current may be a new approach to treat scars and skin. Objective To examine the changes in optical, mechanical, and acoustic impedance properties in porcine skin after electrochemical therapy. Design, Setting, and Participants This preclinical pilot study, performed from August 1, 2015, to November 1, 2016, investigated the effects of localized pH-driven electrochemical therapy of ex ...

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    17. Association of Glaucoma-Related, Optical Coherence Tomography–Measured Macular Damage With Vision-Related Quality of Life

      Association of Glaucoma-Related, Optical Coherence Tomography–Measured Macular Damage With Vision-Related Quality of Life

      Question What is the association of structural macular retinal ganglion cell plus inner plexiform layer (RGC+IPL) loss measured by spectral-domain optical coherence tomography (SD-OCT) with vision-related quality of life among individuals with primary open-angle glaucoma? Finding In this cross-sectional study of 214 eyes of 107 patients with glaucoma, diffuse macular RGC+IPL loss, as measured by SD-OCT, was associated with diminished vision-related quality of life.

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    18. Exclusion of Traumatic Anterior Capsule Laceration Using Anterior Segment Optical Coherence Tomography

      Exclusion of Traumatic Anterior Capsule Laceration Using Anterior Segment Optical Coherence Tomography

      A woman in her 60s presented with a penetrating injury to the right cornea sustained on a plant. An examination revealed a small corneal laceration and a formed anterior chamber with minimal wound leakage. A possible defect of the anterior capsule was observed ( Figure , A). Anterior segment optical coherence tomography imaging was performed (SPECTRALIS; Heidelberg Engineering) that confirmed that the anterior capsule was intact ( Figure , B). She was treated with a bandage contact lens and observed. She remained asymptomatic with a logarithm of the minimum angle of resolution visual acuity of 0.14 log units (Snellen equivalent, 20/30 OD).

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    19. Optical Coherence Tomography Angiography Artifacts and Potential for False Negative—Reply

      Optical Coherence Tomography Angiography Artifacts and Potential for False Negative—Reply

      In Reply We thank Ashraf and colleagues for their attention to our article. We agree that other interpretations of the clinical findings among our patients are possible, but in our opinion, these interpretations are not very likely for the following reasons. First, it is known that ischemic insults in watershed areas of the brain can be located far away from the actual blood stream blockage site. 1 Thus, the single observation that the earliest finding in acute macular neuroretinopathy occurs at the level of the outer plexiform layer–the watershed zone of the retina—does not prove a cause and ...

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    20. Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease

      Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease

      Importance Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease. Design, Setting, and Participants In this case report analysis, OCT imaging in pediatric patients, MIOCTA images were obtained during examination under anesthesia from a young boy with a history of idiopathic vitreous hemorrhage ...

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    21. Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children

      Evaluation of Optical Coherence Tomography to Detect Elevated Intracranial Pressure in Children

      Importance Detecting elevated intracranial pressure in children with subacute conditions, such as craniosynostosis or tumor, may enable timely intervention and prevent neurocognitive impairment, but conventional techniques are invasive and often equivocal. Elevated intracranial pressure leads to structural changes in the peripapillary retina. Spectral-domain (SD) optical coherence tomography (OCT) can noninvasively quantify retinal layers to a micron-level resolution. Objective To evaluate whether retinal measurements from OCT can serve as an effective surrogate for invasive intracranial pressure measurement. Design, Setting, and Participants This cross-sectional study included patients undergoing procedures at the Children’s Hospital of Philadelphia from September 2014 to June 2015 ...

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    22. Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography

      Retinal nerve fiber layer (RNFL) defects are a defining feature of optic neuropathies and have been implicated in a few neurodegenerative disorders, including multiple sclerosis, 1 Alzheimer disease, 2 and Parkinson disease. 3 Ashina et al 4 conducted a prospective study observing 1406 children recruited from the Cophenhagen Child Cohort over 10 years. They showed that children of mothers with a history of smoking during pregnancy had a mean reduction in average circumpapillary RNFL thickness of 5.7 μm, adjusting for axial length, birth weight, and other covariates, compared with children without such history. Smoking during pregnancy has a detrimental ...

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    23. Optical Coherence Tomography for the Noninvasive Detection of Elevated Intracranial Pressure A New Role for the Ophthalmologist?

      Optical Coherence Tomography for the Noninvasive Detection of Elevated Intracranial Pressure A New Role for the Ophthalmologist?

      Lumbar puncture is the usual confirmatory procedure for the diagnosis of idiopathic intracranial hypertension. However, the lumbar cerebrospinal fluid pressure does not always reflect the intracranial pressure (ICP), especially in children. 1 Therefore, direct ICP monitoring is the gold standard for ascertainment of ICP. However, this procedure is more invasive, requiring general anesthesia and hospital admission to monitor ICP over a period of days. It also carries low risk for central nervous system infection or injury. Consequently, newer techniques are being devised to noninvasively monitor ICP. 2

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    1-24 of 33 1 2 »
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