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    1. A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions

      A modified frequency domain optical coherence tomography procedure for imaging severely stenotic coronary artery lesions

      Aims: This proof-of-concept study aimed to investigate the clinical feasibility of a modified frequency domain optical coherence tomography (FD-OCT) procedure for imaging severely stenotic coronary artery lesions. Methods and results: In total, 46 patients in whom clear images were unobtainable using conventional FD-OCT examination were consecutively enrolled in this study. Then, they were randomly divided into two groups: group A (FD-OCT examination using the new modified procedure, n=23), and group B (FD-OCT examination using a previously described procedure, the Yamaguchi method, n=23). The procedure success was 100% in group A and 86.96% in group B. Clear images ...

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    2. Differences in optical coherence tomography findings between an endothelial progenitor cell-capture sirolimuseluting stent and a paclitaxel-eluting stent: insights from the OCT substudy of the REMEDEE first-in-man trial

      Differences in optical coherence tomography findings between an endothelial progenitor cell-capture sirolimuseluting stent and a paclitaxel-eluting stent: insights from the OCT substudy of the REMEDEE first-in-man trial

      Aims: First-generation DES are associated with delayed endothelial coverage and poor stent healing, increasing the risk of late stent thrombosis, late catch-up and neoatherosclerosis. This observational REMEDEE substudy aimed to examine differences in vascular healing by OCT between the EPC-capture sirolimus-eluting COMBO stent and a paclitaxel-eluting stent (TAXUS). Methods and results: A subset of 33 patients (COMBO=23, TAXUS=10) with de novo coronary artery lesions in the REMEDEE study had OCT examination at the nine-month angiographic follow-up. Betweenstent differences of OCT strut coverage, apposition, and neointimal morphology were compared by a core laboratory. Four thousand eight hundred and seventy-five ...

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    3. Serial observation of a calcified nodule by optical coherence tomography

      Serial observation of a calcified nodule by optical coherence tomography

      The three most common underlying mechanisms of acute coronary syndrome (ACS) are believed to be plaque rupture, plaque erosion and, least common, a calcified nodule. Although treatment of ACS mainly consists of catheter-based reperfusion using a coronary stent, it remains under discussion whether deployment of a coronary stent is necessary for a culprit calcified nodule, particularly when coronary flow is preserved. A 75-year-old man with ST-elevation myocardial infarction (STEMI) was referred to our hospital. He had a history of hypertension and dyslipidaemia. Emergency coronary angiography revealed a moderately stenotic lesion in the mid left anterior descending coronary artery (LAD) with ...

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      Mentions: Koji Kato
    4. Distribution characteristics of coronary calcification and its substantial impact on stent expansion: an optical coherence tomography study

      Distribution characteristics of coronary calcification and its substantial impact on stent expansion: an optical coherence tomography study

      According to previous studies, the presence of coronary calcification was associated with worse clinical outcomes due to plaque fracture after angioplasty and stent underexpansion. It remained the biggest issue even after the emergence of drug-eluting stents (DES). Intravascular ultrasound (IVUS) played an important role in the evaluation of coronary calcification during percutaneous coronary intervention (PCI). However, due to limited resolution and inevitable artefacts such as acoustic shadowing and side lobes, only the arc or the “approximate” degree of superficiality of coronary calcifications could be assessed. Currently, optical coherence tomography (OCT), another intravascular imaging technique with a higher spatial resolution, has ...

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    1-4 of 4
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