1. 73-96 of 100 « 1 2 3 4 5 »
    1. Anterior segment optical coherence tomography findings in epithelial ingrowth after neodymium:YAG laser treatment

      Anterior segment optical coherence tomography findings in epithelial ingrowth after neodymium:YAG laser treatment

      We describe the case of a patient with recurrent epithelial ingrowth treated with the neodymium:YAG (Nd:YAG) laser after flap relifting and removal of the ingrowth. Spectral domain anterior segment optical coherence tomography (AS-OCT) was performed preoperatively and several times during the first postoperative year. Clinical biomicroscopy showed recurrent Machat grade 3 epithelial ingrowth associated with the flap border. The AS-OCT showed ingrowth as a highly reflective stromal band and laser craters with endothelial band disruption recorded immediately after laser impacts. After 1 year, the visual acuity improved, corneal topography was more regular, and corneal transparency with residual scarring ...

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    2. Macular segmentation via optical coherence tomography in pediatric optic nerve head drusen and mild papilledema

      Macular segmentation via optical coherence tomography in pediatric optic nerve head drusen and mild papilledema

      Optic nerve head drusen (ONHD) and papilledema in children can lead to partial optic atrophy, and frequently children with idiopathic intracranial hypertension may have both. The purpose of this study is to use SD-OCT to identify possible subclinical atrophy of the inner macula in eyes of children with pseudopapilledema due to ONHD and mild papilledema.

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    3. Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Purpose To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR). Setting Private practice, Castrop-Rouxelle, Germany. Design Prospective evaluation of diagnostic test. Methods Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients. Analyses used a paired t test, Pearson correlation coefficient ( r ), and Bland-Altman plots. Intraocular lens (IOL) power calculations were compared using the Hoffer Q, Holladay 1, and SRK/T formulas. Results The difference in ...

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      Mentions: Giacomo Savini UCLA
    4. Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      New Spectralis (Heidelberg, Germany) segmentation software allows automatic quantitation of the thickness of each macular layer. We evaluated the role of Spectralis spectral domain optical coherence tomography (SD-OCT) segmentation in children during acute papilledema to predict the subsequent development of optic atrophy.

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    5. Spectral domain optical coherence tomography (SD-OCT) Imaging of the Vascular-Avascular junction in the nursery in infants with retinopathy of prematurity

      Spectral domain optical coherence tomography (SD-OCT) Imaging of the Vascular-Avascular junction in the nursery in infants with retinopathy of prematurity

      Since the publication of Foos, there has been little additional microanatomic data on the vascular-avascular junction in retinopathy of prematurity (ROP) in infants. We hypothesize that one could view retinal development across the vascular-avascular (V-AV) junction in infants with ROP using portable bedside SDOCT imaging and novel image analysis.

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    6. Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optical coherence tomography imaging of optic disc cavernous haemangioma

      Optic disc cavernous haemangiomas are either found incidentally or after presentation with vitreous haemorrhage. They are characterised by a cluster of grapes appearance to the multiple vascular saccules that make up the tumour. They are more often found in the retinal periphery but rarely occur at the optic disc. Optical coherence tomography (OCT) imaging may be a useful non-invasive imaging modality to follow-up these lesions. We present the case of an asymptomatic 60-year-old lady referred from her optometrist with a lesion overlying the optic disc and the ensuing diagnosis of cavernous haemangioma using fundus fluorescein angiography and OCT.

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    7. Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy

      Optical Coherence Tomography as a Tool for in Vivo Staging and Grading of Upper Urinary Tract Urothelial Carcinoma: A Study for Diagnostic Accuracy

      Purposes Biopsies and cytology are cornerstones in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). However, a high rate of non-diagnostic biopsies, tumor upgrading and -staging after nephroureterectomy is observed. In this prospective in vivo study we aimed to evaluate the diagnostic accuracy of OCT for grading and staging of UTUC Material & Methods Twenty-six patients underwent diagnostic URS including biopsies and OCT imaging, followed by nephroureterectomy or segmental ureter resection. Sensitivity, specificity, negative predictive value and positive predictive value of UTUC grading and staging by OCT were evaluated according to the STARD initiative and second stage (2a and 2b ...

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    8. The Difference between the optical coherence tomography (OCT) findings of newly progressed coronary lesions in symptomatic and asymptomatic patients

      The Difference between the optical coherence tomography (OCT) findings of newly progressed coronary lesions in symptomatic and asymptomatic patients

      Background Generally, newly progressed coronary lesions (NPCLs) are considered to be composed of lipid-rich plaques. In case of vulnerable plaque rupture, they may quickly become culprit lesions responsible for acute coronary syndromes. Methods Between September 2011 and September 2015, 2034 patients underwent scheduled follow-up coronary angiography (CAG) after percutaneous coronary intervention (PCI) in Tsuchiya General Hospital. Patients with NPCLs found by CAG during the follow-up period were evaluated by optical coherence tomography (OCT). NPCLs were defined as the lesions with less than 50% diameter stenosis, which progressed to more than 75% diameter stenosis within 3 years after the previous CAG ...

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    9. Quantitative Optical Coherence Tomography Angiography of Radial Peripapillary Capillaries in Glaucoma, Glaucoma Suspect and Normal Eyes

      Quantitative Optical Coherence Tomography Angiography of Radial Peripapillary Capillaries in Glaucoma, Glaucoma Suspect and Normal Eyes

      Purpose To evaluate the quantitative characteristics of the radial peripapillary capillary (RPC) network in glaucoma, glaucoma suspect and normal eyes using speckle variance optical coherence tomography angiography (OCT-A). To determine correlations between RPC density, nerve fibre layer (NFL) thickness and visual field indices. Design Cross sectional study. Methods OCT-A images of RPCs were acquired at a single institution using a custom-built 1060nm system from three groups: unilateral glaucoma (10 eyes from 5 subjects); glaucoma suspects (6 eyes from 3 subjects); and normal control eyes (16 eyes from 9 normal subjects). Peripapillary NFL thickness measurements were determined using spectral-domain OCT. Glaucoma ...

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    10. Dark Atrophy: An Optical Coherence Tomography Angiography Study

      Dark Atrophy: An Optical Coherence Tomography Angiography Study

      Purpose To assess the status of choriocapillaris in eyes with macular atrophy secondary to age-related macular degeneration (AMD) (geographic atrophy [GA]) and Stargardt disease (STGD) using optical coherence tomography angiography (OCTA). Design Prospective, observational case series. Participants A total of 14 patients (20 eyes) affected by GA and 10 patients (20 eyes) affected by STGD. Methods Each patient underwent a complete ophthalmological examination including fundus autofluorescence (FAF), dynamic simultaneous fluorescein angiography (FA) and indocyanine green angiography (ICGA), enhanced-depth imaging optical coherence tomography (EDI-OCT) (HRA+OCT Spectralis, Heidelberg Engineering, Heidelberg, Germany), and OCTA using AngioVue technologies (Optovue Inc, Freemont, CA). Main ...

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    11. Assessment of bacterial demineralization around composite restorations using swept-source optical coherence tomography (SS-OCT)

      Assessment of bacterial demineralization around composite restorations using swept-source optical coherence tomography (SS-OCT)

      Objective To observe the bacterial demineralization of the enamel and dentin around composite restorations bonded with one-step and two-step self-etch adhesive systems using swept-source optical coherence tomography (SS-OCT). Methods Forty class V cavities (2.5-mm surface diameter, 2.0-mm maximum depth) were prepared on cervical areas of 20 human molars. The specimens were either treated with one-step adhesive (Clearfil Tri-S Bond ND Quick; TS) or two-step adhesive (Clearfil SE Bond; SE), restored with a flowable resin composite (Estelite Flow Quick). Specimens in the demineralized group were incubated for 2 weeks after Streptococcus mutans biofilm formation, while specimens in the control ...

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    12. Quantitative Analysis of Retinal OCT

      Quantitative Analysis of Retinal OCT

      Clinical acceptance of 3-D OCT retinal imaging brought rapid development of quantitative 3-D analysis of retinal layers, vascu-lature, retinal lesions as well as facilitated new research in retinal diseases. One of the cornerstones of many such analyses is segmentation and thickness quantification of retinal layers and the choroid, with an inherently 3-D simultaneous multi-layer LO-GISMOS (Layered Optimal Graph Image Segmentation for Multiple Objects and Surfaces) segmentation approach being extremely well suited for the task. Once retinal layers are segmented, regional thickness, brightness, or texture-based indices of individual layers can be easily determined and thus contribute to our understanding of retinal ...

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    13. Factors affecting choroidal vascular density in normal eyes: Quantification using en face swept-source optical coherence tomography

      Factors affecting choroidal vascular density in normal eyes: Quantification using en face swept-source optical coherence tomography

      Purpose To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS-OCT). Design A prospective cross-sectional study. Methods One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS-OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length ...

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    14. Monitoring of cariogenic demineralization at the enamel–composite interface using swept-source optical coherence tomography

      Monitoring of cariogenic demineralization at the enamel–composite interface using swept-source optical coherence tomography

      Objectives The aim of this study was to evaluate enamel demineralization at composite restoration margins caused by cariogenic biofilm using swept-source optical coherence tomography (SS-OCT). Methods Sixty round-shaped cavities were prepared on the mid-buccal enamel surface of extracted human molars. The cavities were restored with Estelite Flow Quick flowable composite using either Clearfil SE Bond or Clearfil Tri-S Bond ND bonding agents. Streptococcus mutans suspension was applied to form a cariogenic biofilm on the surface. After 1, 2, or 3 weeks of incubation ( n = 10), the biofilm was removed to observe the carious demineralization at the cavosurface margins using SS-OCT ...

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    15. Central Corneal Thickness After Cross-linking Using High-Definition Optical Coherence Tomography, Ultrasound, and Dual Scheimpflug Tomography: A Comparative Study Over One Year

      Central Corneal Thickness After Cross-linking Using High-Definition Optical Coherence Tomography, Ultrasound, and Dual Scheimpflug Tomography: A Comparative Study Over One Year

      Purpose To assess central corneal thickness (CCT) and corneal haze in keratoconus eyes following corneal cross-linking (CXL). Design Prospective noncomparative case series. Methods Forty patients (44 eyes) with keratoconus that had serial evaluation for CCT, following CXL, using high-definition optical coherence tomography (HD-OCT), ultrasound pachymetry (USP), and dual Scheimpflug tomography. CCT was measured at baseline, then at 2 weeks and 1, 3, 6, and 12 months postoperatively. Results The mean baseline CCT measurements were 470.02 μm, 469.79 μm, and 466.66 μm using the HD-OCT, the USP, and dual Scheimpflug tomography, respectively ( P = .91). Following CXL, the mean ...

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    16. Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography

      Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the choroidal vascular structural changes in eyes with central serous chorioretinopathy (CSC) by using swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods We prospectively examined 40 eyes of 34 consecutive patients with CSC. Three-dimensional choroidal images of the macular area, covering 3 × 3 mm and 6 × 6 mm, were obtained with SS-OCT. En face images of the microvasculature of the inner choroid and large choroidal vessel layers were converted to binary images. Choroidal vascular areas were analyzed quantitatively using the binary images. Results The choroidal vascular area was larger in eyes with CSC (the microvasculature ...

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    17. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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    18. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization

      Purpose To describe the optical coherence tomography angiography (OCT-A) features of treatment-naïve quiescent choroidal neovascularization (CNV) secondary to age-related macular degeneration, and to estimate the detection rate for neovascularization by means of OCT-A. Design Diagnostic tool validity assessment. Methods Treatment-naïve quiescent CNV were identified from a pool of patients at 2 retina referral centers. Patients underwent a complete ophthalmologic examination including fluorescein angiography, indocyanine green angiography, spectral-domain OCT and OCT-A. Detection rates of CNV by means of OCT-A were estimated with a second cohort of patients without CNV (negative controls) Results Twenty-two eyes of 20 consecutive patients with ...

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    19. Swept Source optical coherence tomography of choroidal nevi

      Swept Source optical coherence tomography of choroidal nevi

      Objective The aim of this article is to report on retinal and choroidal morphology in choroidal nevi documented with Swept Source optical coherence tomography (SS-OCT). Design This is a retrospective, observational study. Participants We included 27 consecutive patients with choroidal nevi. Mean age was 66.3 years (21–95 years). Methods The SS-OCT scanning protocol consisted of a single line scan through the centre of the nevi with a resolution of 3 µm, built from 1024 A-scans, with a length of 12 mm. We attempted to visualize the outer choroidoscleral boundary and suprachoroidal layer (SCL) below the choroidal nevus and ...

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    20. Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      A 52-year old gentleman was admitted to our department to undergo catheterization due to recent onset stable angina in minimal effort. He had a history of myocardial infarction 10 years ago, with coronary artery bypass graft surgery 8 years ago. A left internal mammary artery (LIMA) graft had been anastomosed in the mid left anterior descending (LAD) artery and two saphenous vein grafts (SVGs) in the left circumflex (LCx) and the right coronary artery (RCA), respectively. Six years ago, he underwent percutaneous coronary intervention (PCI) of the native LCx, with implantation of two overlapping second generation drug-eluting stents (DES), due ...

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    21. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography automatic segmentation

      Background Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography (SD-OCT) research software can automatically quantify the thickness of each individual retinal layer. The macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The aim of this study was to characterize and compare the volume of each macular layer in the eyes of children with glaucoma versus those of normal controls. Methods The medical records of children with primary glaucoma and physiologic cupping who had undergone Spectralis SD-OCT imaging of the macula and pRNFL were ...

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    22. Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model

      Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model

      Background This purpose of this study is to evaluate, concomitantly with quantitative coronary angiography (QCA), the potential discrepancy between frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) measurements in a phantom coronary model and in human coronary arteries within and outside stented segments. Methods FD-OCT and IVUS images sequentially obtained from a phantom coronary model and 57 stented human coronary arteries were compared between each other and with QCA. Results Lumen area (LA) by IVUS was 10.1% larger (6.43 ± 0.09 mm 2 ) while by FD-OCT was similar (5.78 ± 0.09 mm 2 ) to actual ...

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    73-96 of 100 « 1 2 3 4 5 »
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