1. 25-48 of 100 « 1 2 3 4 5 »
    1. Spectral-Domain Optical Coherence Tomography–Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population

      Spectral-Domain Optical Coherence Tomography–Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population

      Purpose To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population. Design Cross-sectional study and reliability analysis. Methods The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables. Results Mean BMO ...

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    2. Optic Nerve Head Drusen Prevalence and Associated Factors in Clinically Normal Subjects Measured Using Optical Coherence Tomography

      Optic Nerve Head Drusen Prevalence and Associated Factors in Clinically Normal Subjects Measured Using Optical Coherence Tomography

      Aim: The purpose of this study is to establish a normative database of subfoveal choroidal thickness (CT) in healthy young Indians using spectral domain optical coherence tomography (SD OCT). Evaluation and comparison of CT of central serous chorioretinopathy (CSC) and fellow eyes were also performed. Materials and Methods: This was a prospective, cross-sectional, and observational study. It included 112 normal eyes of 112 healthy volunteers who had no evidence of ocular or systemic disease, 84 CSC eyes with acute, treatment-naïve CSC, and 69 fellow eyes with no evidence of neurosensory detachment or pigment epithelium detachment on SD OCT. Complete ...

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    3. Estimating OCT Structural Measurement Floors to Improve Detection of Progression In Advanced Glaucoma

      Estimating OCT Structural Measurement Floors to Improve Detection of Progression In Advanced Glaucoma

      Purpose “Floor effects” in retinal imaging are defined as the points at which no further structural loss can be detected. We estimated the measurement floors for spectral-domain optical coherence tomography (SD-OCT) measurements and compared global change over time in advanced glaucoma eyes. Design Validity study to investigate measurement floors. Methods A longitudinal “Variability Group” of 41 eyes with moderate to advanced glaucoma (SAP MD ≤ -8 dB) was used to estimate measurement floors. Minimum rim width (MRW), ganglion cell-inner plexiform layer thickness (GC-IPLT) and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) were determined. Floors were defined as the average image area ...

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    4. Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity

      Quantification of Diabetic Macular Ischemia Using Optical Coherence Tomography Angiography and Its Relationship with Visual Acuity

      Purpose To quantify foveal avascular zone (FAZ) area and macular vascular density objectively using optical coherence tomography angiography (OCTA) and to examine correlations with visual acuity in eyes with diabetic retinopathy (DR) in the absence of diabetic macular edema. Design Retrospective observational case series. Participants Eighty-four eyes from 55 patients with DR and 34 control eyes from 27 age-matched healthy participants. Methods All eyes underwent OCTA (RTVue-XR Avanti; Optovue, Inc, Fremont, CA). Integrated automated algorithms were used to quantify FAZ area and macular vascular density. Main Outcome Measures FAZ area, vessel area density (VAD), vessel length density (VLD), and visual ...

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    5. Choroidal neovascularization secondary to Best vitelliform macular dystrophy detected by optical coherence tomography angiography

      Choroidal neovascularization secondary to Best vitelliform macular dystrophy detected by optical coherence tomography angiography

      Best vitelliform macular dystrophy (VMD) is a hereditary condition that causes childhood-onset macular dystrophy. In rare cases, VMD is accompanied by formation of a choroidal neovascular membrane (CNVM). We report a case of CNVM secondary to Best VMD in a 10-year-old boy that was detected using optical coherence tomography angiography, a new noninvasive diagnostic modality that detects motion contrast in repeated B-scans to identify blood flow within vessels.

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    6. En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy

      En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy

      Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument. If available, additional en face OCT images and B-scans were analyzed at follow-up times beyond the 52-week period. Results A total of 37 eyes (27 patients) were ...

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    7. Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Purpose The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in eyes with nonexudative age-related macular degeneration (AMD). Design Cross-sectional study. Participants Patients with nonexudative AMD were prospectively enrolled in an SS-OCT imaging study at the Bascom Palmer Eye Institute. Methods On the same day, all participants underwent color, FAF, and IR fundus imaging, as well as imaging with a prototype Zeiss 100 kHz SS-OCT instrument (Carl Zeiss Meditec Inc, Dublin ...

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    8. Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Purpose To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. Design Cross-sectional observational clinical study. Participants Patients with iris lesions and healthy volunteers. Methods Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months. Main Outcome Measures OCT and OCTA images, qualitative evaluation of iris and tumor vasculature, and quantitative vessel density. Results One eye each of 8 normal volunteers and 9 patients with iris ...

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    9. Safety of optical coherence tomography in pediatric heart transplant patients

      Safety of optical coherence tomography in pediatric heart transplant patients

      Background Cardiac allograft vasculopathy (CAV) is a crucial problem after heart transplantation, in adults as well as in children. CAV is the main risk factor for a reduced long-term graft survival. The early diagnosis and treatment of CAV is essential for a successful long-term preservation of the donor heart. However, asymptomatic progression of CAV and concentric hyperplasia of the coronary arteries may complicate the early diagnosis by conventional measures. Intravascular imaging, such as are intravascular ultrasound and optical coherence tomography (OCT), enables the diagnosis of early stage CAV. To date, there is little known about OCT in children. We present ...

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    10. Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation

      Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation

      Optical coherence tomogra Background/Objectives Optical coherence tomography (OCT) is widely used for evaluation of healing response to stent implantation. We sought to test the agreement between the 1-mm and 0.6-mm sampling intervals for assessment of the percentage of uncovered and malapposed struts by OCT. Methods Thirty­eight patients presenting with acute coronary syndrome were randomized to receive either a titanium­nitride­oxide­coated stent (n = 19) or an everolimus­eluting stent (n = 19). Neointimal strut coverage and strut apposition were evaluated by OCT at 2­month follow­up. Two independent investigators performed offline OCT image analysis at 1 ...

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    11. Mechanical abnormalities associated with first and second-generation drug eluting stent thrombosis analyzed by optical coherence tomography in the national PESTO French registry

      Mechanical abnormalities associated with first and second-generation drug eluting stent thrombosis analyzed by optical coherence tomography in the national PESTO French registry

      Background and objectives DES thrombosis may be triggered by different mechanisms that are difficult to identify by angiography alone. This work aimed to investigate and compare the characteristics of stent thrombosis (ST) between 1 st and 2 nd generation drug eluting stents (DES) among a large cohort of patients explored by optical coherence tomography (OCT). Methods and results The PESTO study was a prospective national registry involving 29 French catheterization facilities. Patients with acute coronary syndromes were prospectively screened for presence of definite ST and analyzed by OCT after culprit lesion deocclusion The analysis involved 71 subjects including 34 patients ...

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    12. Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography

      Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography

      Purpose To validate the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with spectral domain optical coherence tomography (SD-OCT). Method Design: Comparison of diagnostic algorithms Setting: multiple institutional practice Study participants Training dataset included 94 eyes of 94 open angle glaucoma (OAG) patients and 84 eyes of 84 normal subjects and testing dataset included 114 eyes of 114 OAG patients and 82 eyes of 82 normal subjects. In both groups, OAG eyes with mean deviation (MD) values better than -5.0 dB were included. Observation Procedure Using the training dataset, classifiers were built to discriminate between glaucoma and ...

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    13. Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen

      Purpose Enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD OCT) has been recognized as the most sensitive tool to diagnose optic nerve head drusen (ONHD). The relationship between OCT characteristics and visual loss has not been well documented. This study compares EDI SD OCT–determined morphologic characteristics of drusen in eyes with or without visual field (VF) defects. Design Descriptive study of patients attending the neuro-ophthalmology service of Moorfields Eye Hospital between January 2013 and October 2014. Subjects Patients with diagnosed ONHD and EDI SD OCT imaging of the optic nerve head. Methods Eyes with and without VF defects ...

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    14. Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma

      Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma

      Purpose To characterize the error of optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) thickness when using automated retinal layer segmentation algorithms without manual refinement. Design: cross-sectional study Methods Setting: glaucoma clinical practice. Study Population: 3490 scans from 412 eyes of 213 individuals with a diagnosis of glaucoma or glaucoma suspect. Observational Procedures: We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness in a 6-degree peripapillary circle, and exported the native 'automated segmentation only' results. In addition, we exported the results after 'manual refinement' to correct errors in the automated segmentation of ...

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    15. Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration

      Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration

      Purpose Structural and compositional heterogeneity within drusen comprising lipids, carbohydrates, and proteins have been previously described. We sought to detect and define phenotypic patterns of drusen heterogeneity in the form of optical coherence tomography–reflective drusen substructures (ODS) and examine their associations with age-related macular degeneration (AMD)–related features and AMD progression. Design Retrospective analysis in a prospective study. Participants Patients with intermediate AMD (n = 349) enrolled in the multicenter Age-Related Eye Disease Study 2 (AREDS2) ancillary spectral-domain optical coherence tomography (SD OCT) study. Methods Baseline SD OCT scans of 1 eye per patient were analyzed for the presence of ...

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    16. Prediction of Postoperative Intraocular Lens Position with Angle-to-Angle Depth Using Anterior Segment Optical Coherence Tomography

      Prediction of Postoperative Intraocular Lens Position with Angle-to-Angle Depth Using Anterior Segment Optical Coherence Tomography

      Purpose To evaluate the accuracy of a new formula for predicting postoperative anterior chamber depth (ACD) with preoperative angle-to-angle (ATA) depth using anterior segment (AS) optical coherence tomography (OCT) and to compare it with established methods. Design Retrospective consecutive case series. Participants Three hundred four eyes (276 patients) implanted with acrylic intraocular lenses (IOLs) were divided randomly into a training set (152 eyes) and a validation set (152 eyes). Methods Based on the training set data, the postoperative ACD measured 1 month after surgery was analyzed via multiple linear regression analysis with 5 preoperatively measured variables: ATA depth, ATA width ...

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    17. Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma

      Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma

      Purpose To investigate factors associated with dropout of the parapapillary deep retinal layer microvasculature assessed by optical coherence tomography angiography (OCTA) in glaucomatous eyes. Design Cross-sectional study. Participants Seventy-one eyes from 71 primary open-angle glaucoma (POAG) patients with β-zone parapapillary atrophy (βPPA) enrolled in the Diagnostic Innovations in Glaucoma Study. Methods Parapapillary deep-layer microvasculature dropout was defined as a complete loss of the microvasculature located within the deep retinal layer of the βPPA from OCTA-derived optic nerve head vessel density maps by standardized qualitative assessment. Circumpapillary vessel density (cpVD) within the retinal nerve fiber layer (RNFL) also was calculated using ...

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    18. Optical coherence tomography: The next ACE in CTO interventions?

      Optical coherence tomography: The next ACE in CTO interventions?

      When used to guide percutaneous coronary interventions (PCI), intracoronary imaging is associated with improved clinical outcomes [1–4]. Intracoronary imaging guidance during PCI reduces in-stent restenosis and repeat revascularization after bare-metal stent placement [1] and has been shown to reduce major adverse cardiac events (MACE), stent thrombosis, target vessel myocardial infarction, and target lesion revascularization after drug-eluting stent (DES) placement [2–4]. These benefits have been attributed to the use of larger diameter stents and more aggressive post-dilation when intracoronary imaging is used to guide PCI, thus achieving larger lumen areas within the stent than are achieved with angiographic guidance ...

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    19. Neoatherosclerosis causing occlusive in-stent restenosis: Impact of intracoronary imaging in the intensity of lipid-lowering therapy

      Neoatherosclerosis causing occlusive in-stent restenosis: Impact of intracoronary imaging in the intensity of lipid-lowering therapy

      The unique physical properties of optical coherence tomography (OCT) make it a useful technique in the study of restenosis mechanisms. In fact, OCT is able to differentiate between neointimal proliferation and neoatherosclerosis within the stent. We report a rare case of occlusive neoatherosclerosis presenting beyond one year after a successful drug-eluting stent implantation. The impact of OCT findings in the clinical decision making process is emphasized.

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      Mentions: Fernando Alfonso
    20. Detection of retrobulbar blood vessels in optical coherence tomography angiographic images in eyes with pathologic myopia

      Detection of retrobulbar blood vessels in optical coherence tomography angiographic images in eyes with pathologic myopia

      Purpose To report the detection of retrobulbar blood vessel in the optical coherence tomography angiographic (OCTA) images of two eyes with pathologic myopia. Observations Two eyes of 2 cases with pathologic myopia were examined by OCTA (RTVue XR Avanti, Optovue, and Cirrus 5000, Zeiss). Case 1 was a 64-year-old man, and Case 2 was a 65-year-old woman. In Case 1, the thickness of the subfoveal choroid was 38 μm and the sclera was 274 μm, and they were 17 μm and 214 μm, respectively, in Case 2. The axial length was 35.8 mm in Case 1 and 29.5 ...

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    21. Limbus-insertion distance of superior rectus in primary angle closure glaucoma: an anterior segment OCT study

      Limbus-insertion distance of superior rectus in primary angle closure glaucoma: an anterior segment OCT study

      Objective To compare the distance from the corneoscleral limbus to the insertion site of the superior rectus of primary angle-closure glaucoma (PACG) patients with normal controls and to identify potential characteristics associated with limbus-insertion distance. Design Cross-sectional study. Participants A total of 92 subjects (eyes) were enrolled in the study: 35 were nonglaucoma controls and 57 were PACG patients. Methods The limbus-insertion distance of the superior rectus was measured by anterior segment optical coherence tomography (AS-OCT) and intraoperative surgical caliper. The anterior chamber parameters were also measured using AS-OCT to identify potential characteristics associated with limbus-insertion distance. Results The limbus-insertion ...

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    22. Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma

      Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma

      Purpose To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. Design Observational, cross-sectional study. Participants A total of 153 eyes from 31 healthy participants, 48 glaucoma suspects, and 74 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. Methods All eyes underwent imaging using OCT-A (Angiovue; Optovue, Fremont, CA), spectral-domain OCT (Avanti; Optovue), and standard automated perimetry (SAP). Retinal vasculature information was summarized as vessel density, the percentage of area occupied by flowing blood vessels in the selected region. Two measurements from the retinal ...

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    23. Primary posterior capsulotomy in femtosecond laser–assisted cataract surgery: In vivo spectral-domain optical coherence tomography study

      Primary posterior capsulotomy in femtosecond laser–assisted cataract surgery: In vivo spectral-domain optical coherence tomography study

      Purpose To evaluate whether the size of Berger space is safely predictable in patients having cataract surgery using 3-dimensional spectral-domain optical coherence tomographic (3-D SD-OCT) image analysis. Setting Ruhr University Eye Hospital, Bochum, Germany. Design Prospective interventional case series. Methods Eyes having routine femtosecond laser–assisted cataract surgery were included. After wound closure, the anterior eye segment was visualized using the incorporated 3-D SD-OCT. Visualization of Berger space was performed in the axial and sagittal planes. Results The study comprised 165 consecutive eyes. In 155 eyes, 3-D SD-OCT visualized Berger space and its dimensions were analyzed. In 72% of the ...

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    24. Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Macular disease detection with a swept-source optical coherence tomography-based biometry device in patients scheduled for cataract surgery

      Purpose To assess the sensitivity and specificity for detecting macular disease with a new optical biometry device with swept-source optical coherence tomography (SS-OCT) used before cataract surgery. Setting Hanusch Hospital, Vienna, Austria. Design Consecutive case series. Methods This study included patients with or without macular disease. All patients were scanned using the new biometry device (IOLMaster 700), which allows a 1.0 mm central retinal scan using SS-OCT technology. Also, all eyes were assessed using a dedicated retinal OCT device (RTVue) on the same day. Two experienced examiners and 1 ophthalmology resident graded all scans individually. Sensitivity and specificity for ...

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