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    1. Optical Coherence Tomography–Guided Robotic System for Automated Retinal Microsurgery (Thesis)

      Optical Coherence Tomography–Guided Robotic System for Automated Retinal Microsurgery (Thesis)

      Retinal vein occlusion is one of the most common disease-related causes of vision loss. It occurs when a blood clot or other obstruction occludes a retinal vein inside the eye. While treatment options exist, there is no cure. One potential remedy is retinal vein cannulation, a surgical procedure where the occluded vein is cannulated and infused with an anticoagulant to dissolve the obstruction. However, due to the physiological limitations of human surgeons—including hand tremor and limited resolution of depth perception—retinal vein cannulation remains only a theoretical practice. This work presents a robotic system capable of performing automated retinal ...

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      Mentions: UCLA
    2. Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Techniques in Optical Coherence and Resonance for Sensing (Thesis)

      Optical sensors are ubiquitous for their precision and non-contact acquisition, and have enjoyed widespread use in applications such as biosensing, environmental monitoring, and security. Despite their sensitivity, many of these sensors rely on costly laboratory instrumentation, and are not adaptable to the ever-growing volume of consumer detectors and optics that are readily available, making their application limited to benchtop analytics. This work leverages plasmonic resonances and optical coherence phenomena to make modifications upon traditional sensing formats that improve their sensitivity when deployed in off-the-shelf optical systems. In particular, we demonstrate that label-free plasmonic sensors can be combined with electrochemical impedance ...

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    3. Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns

      Speckle-variance optical coherence tomography: a novel approach to skin cancer characterization using vascular patterns

      Non-invasive imaging devices are currently being utilized in research and clinical settings to help visualize, characterize, anddiagnose cancers of the skin. Speckle-variance optical coherence tomography (svOCT) is one such technology that offers considerable promise for non-invasive, real time detection of skin cancers given its added ability to show changes in microvasculature. We present four early lesions of the face namely sebaceous hyperplasia, basal cell skin cancer, pigmented actinic keratosis, and malignant melanoma in situ that each display different important identification markers on svOCT. Up until now, svOCT has mainly been evaluated for lesion diagnosis using transversal (vertical) sections. Our preliminary ...

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    1-3 of 3
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