1. 1-3 of 3
    1. A flow cytometric and optical coherence analysis of the role of microparticles as determinants of plaque instability in acute coronary syndrome (FOAM study) (Thesis)

      A flow cytometric and optical coherence analysis of the role of microparticles as determinants of plaque instability in acute coronary syndrome (FOAM study) (Thesis)

      Introduction: Microparticles (MPs) are implicated in the pathogenesis of coronary artery disease (CAD). / Aims: To determine whether circulating MPs correlate with high-risk coronary atherosclerotic plaque phenotype. / Methods: 25 patients with CAD undergoing percutaneous coronary intervention (PCI) were recruited; 13 were diagnosed to have acute coronary syndrome (ACS) & 12 with stable angina (SA). We characterized and compared coronary atherosclerotic plaque burden and vulnerable plaque phenotype by three-vessel optical coherence tomography (OCT) between ACS and SA groups. Endothelial (EMPs), platelet (PMPs), Neutrophil (NMPs), tissue factor (TFMPs) and smooth muscle (SMMPs) were quantified by flow cytometry, compared between groups pre PCI, post PCI ...

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    2. The Clinical Application of Optical Coherence Tomography for Head and Neck Premalignant/Malignant Lesions (Thesis)

      The Clinical Application of Optical Coherence Tomography for Head and Neck Premalignant/Malignant Lesions (Thesis)

      Abstract The principle of Optical Coherence Tomography (OCT) is based on the property of light coherence. OCT generates cross-sectional images of two-dimensional objects to obtain in-vitro and in-vivo images of tissues. Non–commercially available OCT systems, which have a higher resolution and scanning rate, have been previously reported. However, some clinical research has already been conducted using the first commercially available OCT device (Niris system) to image the larynx; but applications on oral and skin tissue have not been tested yet. This thesis aims to explore, compare and validate three specific types of commercially available OCT equipment for imaging head ...

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    3. Retrograde trans-synaptic retinal ganglion cell loss following retrogeniculate lesions of human visual pathway identified using optical coherence tomography (Thesis)

      Retrograde trans-synaptic retinal ganglion cell loss following retrogeniculate lesions of human visual pathway identified using optical coherence tomography (Thesis)
      Retrograde trans-synaptic degeneration (RTSD) in the human visual pathway has not been well clarified. Aims 1. To confirm the RTSD in human visual pathway. 2. To study the rate of RTSD. 3. To study the pupil function in the RTSD. Methods: 1. The peripapillary retinal nerve fibre layer (RNFL) thickness measured with optical coherence tomography was compared among patients with acquired and congenital retrogeniculate lesions and normal subjects. Humphrey perimetry and brain imaging were performed. 2. A relationship between the duration of the disease and the RNFL thickness measured at a single time point was evaluated. Additionally the RNFL thickness ...
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    1-3 of 3
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