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    1. Optical coherence tomography findings in unilateral peripheral cone dysfunction syndrome: a case report

      Optical coherence tomography findings in unilateral peripheral cone dysfunction syndrome: a case report

      Introduction To report a case of unilateral peripheral cone dysfunction syndrome and evaluate the associated clinicopathological changes using swept-source optical coherence tomography (SS-OCT). Case presentation A 39-year-old Japanese woman reported a visual field defect of 2-years duration in the right eye. The patient underwent visual field testing, full-field electroretinography (ff-ERG), SS-OCT, and a routine ophthalmologic examination. The best-corrected visual acuity was 20/20 bilaterally. The funduscopy examination was normal bilaterally. Visual field testing showed a relative paracentral scotoma in the right eye. SS-OCT scans showed an unclear interdigitation zone (IZ) throughout the posterior pole except for the foveal zone in ...

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    2. Assessment of the deformation of the outer nuclear layer in the Epiretinal membrane using spectral-domain optical coherence tomography

      Assessment of the deformation of the outer nuclear layer in the Epiretinal membrane using spectral-domain optical coherence tomography

      Background: We aimed to investigate the deformation of the outer nuclear layer using optical coherence tomography in patients with epiretinal membrane (ERM) and its relationship with metamorphopsia. Methods: Thirty-nine eyes from 39 patients with ERM were included in the study. Patients with the subtypes of pseudo macula hole and lamellar hole were excluded. Twenty-one fellow eyes without macular disease were included as normal controls. Forty-nine B-scan images were obtained in the range of 20 degrees around the macula using SD-OCT. The outer nuclear layer (ONL) was evaluated as a three-dimensional image (3D-ONL) reconstructed using the distance between the ONL and ...

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      Mentions: Masahiro Akiba
    3. Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study

      Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study

      Background To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters. Methods We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24–2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co., Heidelberg, Germany). The following optic nerve head parameters were measured on serial vertical EDI OCT B-scans by two experienced examiners masked to patients clinical data: lamina cribrosa (LC) thickness and area, prelaminar neural tissue thickness and area, anterior ...

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    4. Accuracy of swept-source optical coherence tomography based biometry for intraocular lens power calculation: a retrospective cross–sectional study

      Accuracy of swept-source optical coherence tomography based biometry for intraocular lens power calculation: a retrospective cross–sectional study

      Background To evaluate the accuracy of biometric measurements by a swept-source optical coherence tomography (SS–OCT) based biometry for intraocular lens (IOL) power calculation. Methods This retrospective observational study enrolled 431 patients undergoing cataract surgery. The charts were reviewed to investigate the failure rate of axial length (AL) measurement of the SS–OCT biometer, partial coherence interferometry (PCI), and A–scan ultrasonography (US) according to cataract type and severity. AL and keratometry in 164 eyes with the same IOL inserted were measured using the SS–OCT biometer, PCI, and A–scan US. The SRK/T formula was used to calculate ...

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    5. Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects

      Background Despite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements. Methods Cross sectional observational cohort study. Subjects with normal eyes were recruited. Two sets of optical coherence tomography angiography images of macula and optic nerve head were acquired during one visit. Novel in-house developed software was used to count the pixels in each images and to ...

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    6. Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

      Repeatability, reproducibility and interocular difference in the assessments of optic nerve OCT in children– a Swedish population-based study

      Background The aim was, first, to collect normative data of the optic nerve head and the peripapillary retinal nerve fibre layer (RNFL) thickness assessed with Cirrus SD-OCT, in healthy children in a population-based study; second, using these data, to examine repeatability, reproducibility and the interocular difference. Methods One-hundred and ten eyes from 57 children aged 6–15 born at term, were examined. Best-corrected visual acuity and refraction were assessed. Both eyes were examined and the interocular difference was calculated. Repeatability was calculated by one examiner performing three assessments. Thereafter, a second examiner repeated the assessments to calculate reproducibility. Results Mean ...

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    7. Comparison of a new swept-source optical biometer with a partial coherence interferometry

      Comparison of a new swept-source optical biometer with a partial coherence interferometry

      Background The purpose of this study is to compare the biometric parameters and intraocular lens (IOL) power calculation by a new swept-source optical coherence tomography (SS-OCT) biometer with those by a partial coherence interferometry (PCI) biometer. Methods Medical records of 175 eyes from 175 patients were retrospectively reviewed. One of two monofocal IOLs (Tecnis ZCB00 or Acrysof SA60AT) were implanted in the eyes. Axial length (AL), mean keratometry (Km), J0, J45 and anterior chamber depth (ACD) were compared between PCI and SS-OCT biometers. The refractive mean error (ME) and refractive mean absolute error (MAE) were also compared. Examination failure rates ...

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    8. Development of a full thickness macular hole after vitrectomy for rhegmatogenous retinal detachment: a sequential study via optical coherence tomography

      Development of a full thickness macular hole after vitrectomy for rhegmatogenous retinal detachment: a sequential study via optical coherence tomography

      Background To demonstrate a full thickness macular hole (MH) development after vitrectomy (VT) for rhegmatogenous retinal detachment (RRD) and to investigate the possible disease mechanism with optical coherence tomography (OCT). Case presentation A 47-year-old female underwent 23G vitrectomy surgery to repair the macula-detached RRD successfully. However, intraretinal cysts initially developed two months after surgery. Cysts gradually increased in number and size, and cystoid macular edema was noted at the 5th month. Thereafter, inner retina dehiscence and a lamellar macular hole developed. The lamellar hole further dehisced and progressed into a full-thickness MH at the 10th month. The patient then received ...

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    9. A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis

      A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis

      Background Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. Methods This prospective case-control study involved 152 eyes from 143 optic neuritis (ON) patients. All the patients were divided into either the NMOSD-ON group or the IDON group based on the AQP4-Ab test. The retinal nerve fiber layer thickness (RNFLT), retinal thickness (RT), and choroidal ...

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    10. Suprachoroidal hemorrhage followed by swept-source optical coherence tomography: a case report

      Suprachoroidal hemorrhage followed by swept-source optical coherence tomography: a case report

      Background To report a case of Suprachoroidal Hemorrhage followed by Swept-Source Optical Coherence Tomography. Case presentation A 66-year-old woman with a rhegmatogenous retinal detachment in her left eye underwent pars plana vitrectomy. During the intraocular photocoagulation for a retinal tear after fluid-air exchange, a vitreous hemorrhage and suprachoroidal hemorrhage (SCH) developed. The surgical incisions were closed after filling the vitreous cavity with silicone oil. Two weeks later, the hemolyzed hemorrhage was removed, and new silicone oil was injected. After the surgery, a low reflective region was detected near the macula in the swept-source optical coherence tomographic (SS-OCT) images. The low ...

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    11. Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment

      Optical coherence tomography patterns and outcomes of contusion maculopathy caused by impact of sporting equipment

      Background To describe the patterns and outcomes of contusion maculopathy after ocular contusions resulting from accidental impact with sporting equipment. Methods We conducted a retrospective study of interventional case series. Patient Population: Twenty-one eyes of 21 patients who sustained blunt ocular trauma while playing a sport. Intervention/Observation Procedure(s): Surgery or observation by optical coherence tomography (OCT). Main Outcome Measure(s): The morphologic changes within the macula in the early stages after injury and changes in visual function in the early and recovery stages after injury. Results In the early stage, OCT visualized four injury patterns: type Ι, commotio retinae ...

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      Mentions: Gunma University
    12. Assessment of the effect of age on macular layer thickness in a healthy Chinese cohort using spectral-domain optical coherence tomography

      Assessment of the effect of age on macular layer thickness in a healthy Chinese cohort using spectral-domain optical coherence tomography

      Background To determine the effect of age on the thickness of individual retinal and choroidal vascular layers in the macula in an ophthalmologically healthy Chinese cohort by using spectral-domain optical coherence tomography (SD-OCT). Methods In all, 525 health eyes of 525 subjects were examined with SD-OCT. The instrument automatically obtained the regional retinal thickness of 8 layers. Subfoveal choroidal vascular layers’ thickness was measured using enhanced depth imaging mode. The correlation of age with layer thickness measurements was determined. Results No age-associated variation was found on retinal thickness (RT) in the fovea; however, the foveal thickness of outer nuclear layer ...

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    13. Evaluation of peripapillary choroidal distribution in children by enhanced depth imaging optical coherence tomography

      Evaluation of peripapillary choroidal distribution in children by enhanced depth imaging optical coherence tomography

      Background To evaluate the peripapillary choroidal thickness (PPCT) in Chinese children aged 6 to 12 years old and to analyze correlative factors. Methods PPCT was measured with enhanced depth imaging optical coherence tomography (EDI-OCT) in 154 children (76 myopes and 78 emmetropia) aged 6 to 12 years, with spherical equivalent refractive errors between + 0.50 and − 5.50 diopters(D). Peripapillary choroidal imaging was performed using circular scans of a diameter of 3.4 mm around the optic disc. PPCT and the corresponding peripapillary retinal thickness (PPRT) were measured by EDI-OCT at nine positions: I, inferior; IN, inferonasal; IT, inferotemporal ...

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    14. Influence of pterygium size on corneal higher-order aberration evaluated using anterior-segment optical coherence tomography

      Influence of pterygium size on corneal higher-order aberration evaluated using anterior-segment optical coherence tomography

      Background The prospective observation study aimed to evaluate changes in corneal higher-order aberrations induced by advancement of pterygium using an anterior-segment optical coherence tomography (AS-OCT) and Zernike aberration analysis. Methods The corneal topography of 284 eyes with primary pterygia originating from the nasal region was measured using an AS-OCT (SS-1000, Tomey). With anterior corneal elevation data, Zernike polynomial coefficients were calculated in diameters of 1.0, 3.0, and 5.0 mm, and the coma, spherical, coma-like, spherical-like, and total higher-order aberrations were obtained. Pterygium size was also measured as a ratio of positions of the pterygium end with respect ...

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    15. Evaluating inner retinal dimples after inner limiting membrane removal using multimodal imaging of optical coherence tomography

      Evaluating inner retinal dimples after inner limiting membrane removal using multimodal imaging of optical coherence tomography

      Background To evaluate inner retinal dimples after peeling of the inner limiting membrane (ILM) for macular holes (lamellar macular hole [LMH] and full-thickness macular hole [FTMH]) via multiple imaging modes of spectral-domain optical coherence tomography (OCT) and to assess their relationship with preoperative vitreoretinal interface conditions. Methods The data of 38 eyes in 35 patients who underwent surgery for LMH, and FTMH were retrospectively studied. The presence of postoperative inner retinal dimples was judged by a combination of en face OCT layer images and cross-sectional images. The demographic and clinical characteristics of eyes with and without inner retinal defects were ...

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    16. Quantification of macular perfusion using optical coherence tomography angiography: repeatability and impact of an eye-tracking system

      Quantification of macular perfusion using optical coherence tomography angiography: repeatability and impact of an eye-tracking system

      Background The aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography. Methods 20 healthy subjects were included in this study. OCT-angiography was performed using RTVue XR Avanti (Optovue Inc., Fremont, California, USA). The macula was imaged using a 3 × 3 mm scan twice with and twice without activation of the ET. Flow density data of the macular in the superficial and deep OCT angiograms were extracted and analyzed. Results The difference between the flow density (whole en face) in the ...

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    17. Assessment of capillary dropout in the superficial retinal capillary plexus by optical coherence tomography angiography in the early stage of diabetic retinopathy

      Assessment of capillary dropout in the superficial retinal capillary plexus by optical coherence tomography angiography in the early stage of diabetic retinopathy

      Background To assess capillary dropout in the superficial retinal capillary plexus (SCP) by optical coherence tomography angiography (OCTA) in the early stage of diabetic retinopathy (DR). Methods This study was a cross-sectional observational study. Patients that underwent OCTA examinations in our hospital between November 2015 and May 2016 were included in the study. The subjects were divided into two groups: A) normal controls (41 eyes of 41 subjects) and B) the DR patients (49 eyes of 49 patients with mild non-proliferative DR (NPDR)). The retinal thickness and SCP vessel density were analyzed using built-in software in nine sections of the ...

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    18. Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report

      Acute hydrops with a 180-degree massive edematous cavern demonstrated by three dimensional view of anterior segment optical coherence tomography in a patient with pellucid marginal corneal degeneration, a case report

      Background Pellucid marginal corneal degeneration is a non-inflammatory disorder complicated by severe inferior corneal thinning. The central portion of the cornea, consequently, appears to protrude outwards, decreasing vision by means of an irregular stigmatism. Additionally, acute hydrops can occur in case of Descemet’s membrane rupture. Case presentation A 41-year-old Japanese woman presenting with severe visual loss in the left eye was examined and observed to have had full thickness corneal perforation as well as a Descemet membrane rupture with massive edema in the corneal stroma. Anterior segment optical coherence tomography-based corneal topography revealed a distorted crab claw sign indicating ...

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      Mentions: Osaka University
    19. Choroidal perfusion abnormalities associated with Acute Posterior Multifocal Placoid Pigment Epitheliopathy: a case report

      Choroidal perfusion abnormalities associated with Acute Posterior Multifocal Placoid Pigment Epitheliopathy: a case report

      Background Indocyanine Green Angiography (ICG-A) and Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI-OCT) are essential imaging techniques for diagnosis, management and understanding of the pathophysiology of many chorioretinal diseases. Herein, we report the ICG-A and EDI-OCT findings from a case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE), in which these imaging techniques enable the visualization of more diagnostic details than those observable with other widely used diagnostic tools. Case presentation A 60-year-old white female presented with bilateral blurred vision for few days. Fundus examination showed multiple, yellow-white placoid lesions at the posterior pole of both eyes. The placoid ...

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    20. Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

      Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

      Background Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. Methods Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. The internal limiting membrane and RNFL thickness of the most severely affected eye was examined for SegE and re-segmented. Using ...

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    21. Incidental branch retinal artery occlusion on optical coherence tomography angiography presenting as segmental optic atrophy in a child: a case report

      Incidental branch retinal artery occlusion on optical coherence tomography angiography presenting as segmental optic atrophy in a child: a case report

      Background Retinal artery occlusion is extremely rare in the pediatric population and most patients have risk factors. We report a case of a healthy child with segmental optic atrophy, complicated by incidental branch retinal artery occlusion (BRAO). Case presentation A 10-year-old boy who had a history of his mother’s gestational diabetes presented with an inferonasal visual field defect in the left eye. His best-corrected visual acuities were 20/20 in both eyes (OU). Fundoscopic examination revealed segmental pallor of the left optic disc, thinning of the superotemporal rim, a relative superior entrance of the central retinal artery and superior ...

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    22. Ten years follow-up after surgery for a foveal detachment due to optic disc pit: a case report of outer retinal layer healing

      Ten years follow-up after surgery for a foveal detachment due to optic disc pit: a case report of outer retinal layer healing

      Background To report a case of complete progressive visual recovery and healing of outer retinal layers after vitrectomy for foveal detachment associated with optic disc pit. Case presentation Optical coherence tomography (OCT) follow-up was performed on a 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10 years after vitrectomy with gas. The foveal detachment was successfully reattached with complete reapplication of the retina. OCT scans showed a progressive long-term retinal healing with reappearance of the ellipsoid line and visual acuity improved from 20/100 before surgery to 20/25, 10 years after surgery. Conclusions Photoreceptor ...

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    23. Foveal microvasculature features of surgically closed macular hole using optical coherence tomography angiography

      Foveal microvasculature features of surgically closed macular hole using optical coherence tomography angiography

      Background To describe the features of foveal microvasculature using optical coherence tomography angiography (OCTA) and to determine the related clinical factors in eyes with surgically closed macular hole (MH). Methods A retrospective case series of 18 patients with unilateral MH was reviewed. The patients maintained complete hole closure after vitrectomy with inner limiting membrane (ILM) peeling for at least 12 months. The healthy fellow eyes were studied as controls. The foveal microvasculature of both eyes was examined by OCTA. The area of the foveal avascular zone (FAZ) and the vascular density (VD) ratio in the superficial and deep capillary plexuses ...

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    24. Assessment of macular function in patients with idiopathic Epiretinal membrane by multifocal Electroretinography: correlation with visual acuity and optical coherence tomography

      Assessment of macular function in patients with idiopathic Epiretinal membrane by multifocal Electroretinography: correlation with visual acuity and optical coherence tomography

      Background This study evaluates the macular function changes in patients with idiopathic macular epiretinal membrane (ERM) by multifocal electroretinography (mfERG) and their correlations with visual acuity and central macular thickness (CMT) by optical coherence tomography (OCT). Methods Twenty eyes of 20 patients with ERM underwent OCT and mfERG examinations. The response amplitude densities and implicit times of mfERG were compared to the control fellow eyes. Correlation analyses among visual acuity, central macular thickness and mfERG values in the central two concentric rings were performed. Results The mfERG P1 response amplitude densities in ring 1–2 and P1 implicit time in ...

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    1-24 of 43 1 2 »
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