1. 361-384 of 390 « 1 2 ... 13 14 15 16 17 »
    1. Retinal Fluorescein, Indocyanine Green Angiography, and Optic Coherence Tomography in Non-Hodgkin Primary Intraocular Lymphoma

      Purpose: To determine the presence of clinicopathological correlations for primary intraocular non-Hodgkin lymphoma (NHL)in fluorescein angiographies (FA), indocyanine green (ICGA) angiographies, and optical coherence tomography (OCT) images. Design: Comparative retrospective interventional case series.Methods: Institutional practice. All serial patients who underwent vitreous sampling for cytological analysis over a 70-month period were reviewed. Clinical, angiographic, and tomographic findings present prior to tissue diagnosis were re-evaluated in a masked fashion.Results: Cytological analysis of 256 vitreous specimens from 244 patients was performed. The final diagnoses were infections in 42 cases (17.2%) and immune-mediated diseases in 34 cases (13.9%). In ...
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    2. A Pilot Study of Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes

      Purpose: To measure macular choroidal thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate the association of choroidal thickness and age.Design: Retrospective, observational case series.Methods: EDI OCT images were obtained in patients without significant retinal or choroidal pathologic features. The images were obtained by positioning a spectral-domain OCT device close enough to the eye to acquire an inverted image. Seven sections were obtained within a 5 × 30-degree area centered at the fovea, with 100 scans averaged for each section. The choroid was measured from the outer border of ...
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    3. The Use of Postoperative Slit-Lamp Optical Coherence Tomography to Predict Primary Failure in Descemet Stripping Automated Endothelial Keratoplasty

      Purpose: To determine if central donor lenticle thickness as measured by slit-lamp optical coherence tomography (SL OCT; Heidelberg Engineering, Heidelberg, Germany) is predictive of primary donor failure in patients undergoing Descemet stripping automated endothelial keratoplasty (DSAEK).Design: Retrospective cross-sectional study.Methods: Eighty-four patients who underwent DSAEK surgery by 2 surgeons (D.C.R. and J.A.S.) were enrolled. At each postoperative visit (postoperative day 1, week 1, month 1, and month 2), an SL OCT scan was obtained. Statistical differences in SL OCT measurements of successful and failed DSAEK procedures were measured using the Student t test. A successful ...
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    4. Comparison of Spectral- and Time-Domain Optical Coherence Tomography for Retinal Thickness Measurements in Healthy and Diseased Eyes

      Purpose: To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses.Design: Retrospective, observational chart review.Methods: Scans of 184 healthy and diseased eyes from 106 patients were included in the study. Pair-wise comparisons of RT measurements from SD-OCT machines from 2 different manufacturers and TD-OCT were performed for all scans and with eyes stratified by disease diagnosis.Results: Foveal thickness measurements obtained from both SD-OCT machines were greater than those measured by TD-OCT, by 51.0 ± 23.8 μm and 72.5 ± 30 ...
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      Mentions: Duke University
    5. Enhanced Depth Imaging Optical Coherence Tomography of Retinal Pigment Epithelial Detachment in Age-related Macular Degeneration

      Purpose: To describe the internal structure of pigment epithelial detachments (PEDs) seen in eyes with age-related macular degeneration (AMD) as imaged with enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT).Design: Retrospective observational case series.Methods: The images were obtained by positioning a spectral-domain OCT device close enough to the eye to obtain an inverted image and 7 sections, each comprised of 100 averaged scans, were obtained within a 5 degrees × 15 degrees or larger rectangle to encompass the PED and accompanying neovascularization if present. The resultant images were reinverted and compared with fluorescein and indocyanine green angiographic findings ...
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    6. Posturing Time after Macular Hole Surgery Modified by Optical Coherence Tomography Images: A Pilot Study

      Purpose: To see the early postoperative stage of macular hole (MH) surgery and to distinguish eyes needing prolonged posturing from those that do not use Fourier-domain optical coherence tomography (FD-OCT).Design: Interventional case series.Methods: Sixteen eyes of 15 patients with MH underwent the protocol at Kagoshima University Hospital. After the pars plana vitrectomy with 16% SF6 gas tamponade followed by posturing, the eyes were examined by FD OCT from 3 hours to the day after surgery. After MH closure was confirmed, posturing was stopped. Follow-up was performed for 4 months or longer. The main outcome measures included time and ...

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      Mentions: Taiji Sakamoto
    7. Associations Between Macular Findings by Optical Coherence Tomography and Visual Outcomes After Epiretinal Membrane Removal

      Purpose: To identify characteristics measured by optical coherence tomography (OCT) that are correlated with visual outcome after epiretinal membrane (ERM) removal by pars plana vitrectomy (PPV).Design: Interventional, prospective, randomized case series.Methods: One hundred and one eyes of 101 patients with idiopathic ERM underwent PPV for ERM removal. Ophthalmic evaluations included best-corrected visual acuity (BCVA) and Stratus OCT preoperatively at 3 and 6 months postoperatively. Relations between three OCT features including integrity of junction between inner and outer segments of photoreceptors (IS/OS junction), macular thickness, foveal contour and the three visual acuity parameters such as preoperative BCVAs, postoperative ...
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    8. High-speed Optical Coherence Tomography for Imaging Anterior Chamber Inflammatory Reaction in Uveitis: Clinical Correlation and Grading

      Purpose: To evaluate the anterior chamber (AC) inflammatory reaction by anterior segment high-speed optical coherence tomography (OCT).Design: A prospective, nonrandomized, observational case series.Methods: Sixty-two eyes of 45 patients were studied for AC reaction clinically and by anterior segment OCT. Hyperreflective spots suggesting the presence of cells in the AC from the OCT images were counted manually and by a custom made automated software using MATLAB (Mathworks, Natick, Massachusetts, USA) and correlated with clinical grading of AC cells using Standardization of Uveitis Nomenclature criteria.Results: In manual method, mean hyperreflective spots were 3 ± 1.8 in grade 1, 12 ...

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    9. Reproducibility of Retinal Thickness Measurements in Healthy Subjects Using Spectralis Optical Coherence Tomography

      Purpose: To test the reproducibility of retinal thickness measurements in healthy volunteers of a new Frequency-domain optical coherence tomography (OCT) device (Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany).Design: Prospective, observational study.Methods: Forty-one eyes of 41 healthy subjects were included into the study. Intraobserver reproducibility was tested with 20 × 15 degree raster scans consisting of 37 high-resolution line scans that were repeated three times by one examiner (M.N.M.). Mean retinal thickness was calculated for nine areas corresponding to the Early Treatment Diabetic Retinopathy Study (ETDRS) areas. Coefficients of variation (COV) were calculated.Results: Retinal thickness measurements were highly ...
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    10. Anterior Segment Optical Coherence Tomography and Ultrasound Biomicroscopy in the Imaging of Anterior Segment Tumors

      Purpose To evaluate the utility of anterior segment optical coherence tomography (OCT) in the imaging of anterior segment tumors and compare the images to ultrasound biomicroscopy (UBM). Design Prospective observational case series. Methods Eighteen eyes of 18 patients with anterior segment tumors were evaluated at Princess Margaret Hospital. The evaluation included clinical examination, clinical photography, anterior segment OCT, and UBM. Comparison of images obtained by both methods was done. Results Anterior segment OCT imaged small hypopigmented tumors with complete penetration. Cysts were incompletely imaged behind the iris pigment epithelium. Highly pigmented tumors, large tumors, and ciliary body tumors were incompletely ...
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    11. Prospective Comparison of Cirrus and Stratus Optical Coherence Tomography for Quantifying Retinal Thickness

      Prospective Comparison of Cirrus and Stratus Optical Coherence Tomography for Quantifying Retinal Thickness

      Purpose: To compare Cirrus Fourier-domain optical coherence tomography (OCT) with Stratus time-domain OCT for imaging retinal diseases and quantifying retinal thickness (RT) of all nine OCT zones, central macular thickness, and average macular thickness in eyes with and without macular edema.Design: Prospective comparison between two OCT systems.Methods: RT measurements were performed in 120 eyes of 60 patients suspected of having increased retina thickness using both Stratus and Cirrus OCT on the same day. Twenty-one eyes had both 512 × 128 and 200 × 200 Cirrus cube scans done.Results: Data from 101 eyes (53 patients) were analyzed; 46 eyes (45 ...

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    12. Imaging the Infant Retina with a Hand-held Spectral-Domain Optical Coherence Tomography Device

      Purpose: To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS).Design: Observational case series.Methods: A novel SD OCT system was optimized and evaluated for infant imaging. An adult eye was imaged with both a standard clinical SD OCT system and the hand-held system. Four eyes of two infants with a history of SBS were imaged with the hand-held system. One infant was imaged again during follow-up examinations. Robust image processing algorithms were developed to create high-quality images. Images were assessed for ...
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    13. Evaluation of Wound Closure in Oblique 23-gauge Sutureless Sclerotomies With Visante Optical Coherence Tomography

      Purpose: To investigate the in vivo real-time wound morphology of fresh 23-gauge sutureless oblique sclerotomy wounds with anterior segment optical coherence tomography (OCT).Design: Prospective, observational case series.Methods: Subjects underwent three-port pars plana vitrectomy with a 23-gauge trocar/cannula microincision surgical system at the Cole Eye Institute. All incisions were created in an oblique (aka beveled or angled) fashion. The incisions were imaged with the Visante OCT (Carl Zeiss Meditec, Dublin, California, USA) device on postoperative days 1 and 8. The main outcome measure was wound structure (eg, presence of gaping) as evaluated with OCT. Surgical and ocular parameters ...
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    14. Inter-device Variability of the Stratus Optical Coherence Tomography

      Purpose: To assess inter-device measurement variability with the Stratus optical coherence tomography (OCT).Design: Evaluation of diagnostic test technology.Methods: Eight eyes of eight healthy subjects were examined with four different Stratus machines in four medical centers during a period of five hours using fast retinal nerve fiber layer (RNFL) and fast macula protocols. Inter-device measurement variability and signal strength was assessed with standard deviation, coefficient of variance, and intraclass correlation coefficient (ICC). Spearman correlation coefficient was calculated between signal strength and thickness measurements.Results: Statistically significant differences were not found for all macular parameters and all but one RNFL ...
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    15. Spectral-Domain Cirrus Optical Coherence Tomography of Choroidal Striations Seen in the Acute Stage of Vogt-Koyanagi-Harada Disease

      Purpose: To describe changes in the retinal pigment epithelium (RPE) corresponding to the choroidal striations in acute-stage Vogt-Koyanagi-Harada (VKH) disease.Design: Prospective, consecutive case series.Methods: Four patients (eight eyes) with acute-stage VKH disease were studied. All underwent fundus fluorescein angiography (FFA), ultrasonography, and spectral-domain optical coherence tomography (SD OCT). The main outcome measure was the correlation of the findings seen on a 3-dimensional (3D) single-layer RPE map constructed on SD OCT with the serous retinal detachment (RD) and choroidal striations.Results: The retina inner to external limiting membrane did not show any structural alteration in any of the eyes ...
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    16. Nanophthalmos and Acquired Retinoschisis

      Purpose: To report three cases of nanophthalmos associated with acquired (senile) retinoschisis.Design: Observational case series.Methods: Complete ophthalmologic evaluation (including funduscopy with scleral indentation, total axial length measurement with A-scan, optical coherence tomography [Stratus 3 OCT; Carl Zeiss Meditec Inc, Dublin, California, USA], and fundus photography) of three consecutive patients presenting with nanophthalmos and acquired retinoschisis.Results: Three patients with nanophthalmos presented with bilateral acquired retinoschisis. One patient underwent a course of systemic steroids to treat concurrent and bilateral uveal effusion with macular edema. In this patient, one eye responded to this course of therapy without recurrence, while the ...
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    17. Time-Domain and Spectral-Domain Optical Coherence Tomography in Uveitic Macular Edema

      Gupta and associates recently reported in the journal on their experience with a new spectral-domain optical coherence tomography (OCT) device for evaluating the features of macular disease in patients with uveitis. We congratulate the authors on their elegantly designed trial in which the advantages of this new diagnostic tool are highlighted. Using an OCT 3, Monnet and associates recently observed that the loss of the third highly reflective band (HRB), which is thought to correspond with the photoreceptors' inner-outer segment (IS/OS) junction, was associated with poor visual acuity (VA) in patients with birdshot chorioretinopathy. As spectral-domain technology offers an ...
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    18. Assessing the Relationship Between Central Corneal Thickness and Retinal Nerve Fiber Layer Thickness in Healthy Subjects

      Purpose: To determine the relationship between central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness obtained by scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Dublin, California, USA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany), and optical coherence tomography (Stratus OCT; Carl Zeiss Meditec).Design: Multicenter clinical trial, retrospective cross-sectional study.Methods: One hundred and nine healthy subjects from the Advanced Imaging in Glaucoma Study were enrolled in this study. All subjects had a standard clinical examination, including visual field (VF) and good-quality scans from all three imaging devices. CCT was measured using an ultrasonic pachymeter ...
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    19. Assessment of the Use of Anterior Segment Optical Coherence Tomography in Microbial Keratitis

      Purpose: To investigate the imaging capabilities of anterior segment optical coherence tomography (AS OCT) in microbial keratitis and to assess whether measurements of the quantitative parameters, infiltrate thickness and corneal thickness, were possible.Design: Prospective, noncomparative, observational case series.Methods: The study was conducted at a university hospital clinical setting. Seven patients (eyes) with suspected microbial keratitis underwent standard clinical examination and treatment based on slit-lamp clinical findings. AS OCT scanning was performed on presentation and at two follow-up appointments. All scans were carried out with the scanning beam passing through the center of the infiltration and at a specific ...
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    20. High-Definition Optical Coherence Tomography Features in Vitelliform Macular Dystrophy

      Purpose: To correlate high-definition optical coherence tomography (HD OCT) and fundus examination findings at different phases of vitelliform macular dystrophy and to determine the anatomic location of vitelliform material.Design: Prospective, noncomparative, observational case series.Methods: A complete ophthalmologic examination, including fundus biomicroscopy and HD OCT, was performed in 11 consecutive patients with a diagnosis of vitelliform macular dystrophy.Results: Using HD OCT, we were able to demonstrate for the first time the presence of previtelliform lesions, characterized by a thicker layer between the retinal pigment epithelium (RPE) and the inner segment and outer segment (IS/OS) interface. At this ...

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    21. Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

      Purpose: To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images.Design: Observational case series.Methods: The images were obtained by positioning the SD OCT device close enough to the eye to obtain an inverted representation of the fundus in healthy volunteers who did not have pupillary dilation. Seven sections, each comprised of 100 averaged scans, were obtained within a 5- × 15-degree rectangle centered on the fovea. The choroidal thickness under the fovea in each image was measured by independent observers.Results: The ...
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    22. Effect of Blinking on Tear Volume After Instillation of Midviscosity Artificial Tears

      To determine by optical coherence tomography (OCT) the effect of blinking on ocular surface tear volume after instillation of artificial tears. Design Experimental study. Methods Normal human eyes (n = 21) were imaged to obtain dimensions of the tear film and menisci during blinking. The imaging was carried out immediately and five minutes after the instillation of 35 μl midviscosity artificial tears (1.0% carboxymethylcellulose; Refresh Liquigel; Allergan, Irvine, California, USA). The exposed ocular surface area and the lid lengths were used to calculate the volumes. Results Immediately after the instillation, total tear volume was increased (P .05). During the blink ...
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    23. Retinal Blood Flow and Nerve Fiber Layer Measurements in Early-Stage Open-Angle Glaucoma

      Purpose: To evaluate the relationship between retinal circulatory abnormalities and retinal nerve fiber layer (RNFL) thinning in early-stage open-angle glaucoma (OAG) to help elucidate the mechanisms underlying the development of glaucomatous optic neuropathy. Design: Prospective cross-sectional.Methods: Twelve patients with early OAG and a known maximum untreated intraocular pressure less than 22 mm Hg (age, 61.4 ± 9.7 years; Humphrey visual field mean deviation −2.7 ± 2.1) and eight age-matched healthy control subjects (age, 58.5 ± 8.3 years) were included in the study. Blood column diameter, centerline blood speed, and retinal blood flow were measured in the ...
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    361-384 of 390 « 1 2 ... 13 14 15 16 17 »
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