1. 1-24 of 436 1 2 3 4 ... 17 18 19 »
    1. Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV. Design: Prospective cross-sectional study. Methods: Consecutive CSC patients were recruited from retina clinic. The reference standard for CNV was determined by interpretation of multimodal imaging with OCTA, structural OCT line scan, fluorescein angiography (FA), indocyanine green angiography (ICGA), ultra-widefield fundus photography and fundus autofluorescence (FAF). Two independent masked graders examined OCTA without FA and ICGA to diagnose CNV. Univariate and multivariate analyses were performed to evaluate factors associated with CNV. Results ...

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    2. Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Purpose Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes. Methods Design : Longitudinal cohort study. Setting : Tertiary glaucoma clinic. Patients : 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Observation Procedures : Macular volume scans from 2 OCT devices were exported, co-registered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0 mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the ...

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    3. Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Purpose To compare dynamic ranges and steps to measurement floors of peripapillary and macular metrics from a complex signal-based optical microangiography (OMAG C ) optical coherence tomography angiography (OCTA) device for glaucoma with those of OCT measurements. Design Cross-sectional study. Methods Imaging of 252 eyes from 173 glaucoma subjects and 123 eyes from 92 non-glaucoma subjects from a glaucoma clinic was quantified using custom and commercial software. Metrics from OCT (retinal nerve fiber layer [RNFL], ganglion cell-inner plexiform layer [GCIPL]) and OCTA (custom: peripapillary vessel area density [pVAD], macular vessel area density [mVAD], macular vessel skeleton density [mVSD]; commercial: peripapillary perfusion ...

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    4. Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Purpose To assess the effect of changing anterior eye refractive power with contact lenses on the transverse magnification of enface images and associated vascular indices from optical coherence tomography angiography (OCT-A). Design Prospective cross-over study. Methods Spherical soft contact lenses (-6D to +6D in 2D steps) were used to induce anterior eye refractive power changes in 11 healthy young adults and 3 × 3mm macular scans were captured using OCT-A (Zeiss AngioPlex, software version 11.0; Cirrus HD-OCT 5000, Carl Zeiss Meditec Inc.). Image transverse magnification was predicted based on refraction and biometry measurements and compared with empirical changes in the ...

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    5. The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      Purpose : To assess the additive value of foveal swept-source optical coherence tomography (SS-OCT) based biometry to the preoperative fundus examinations for diagnosing macular abnormalities in patients scheduled for cataract surgery. Design : Diagnostic testing evaluation. Methods : Consecutive patients 50 years of age and older planned for cataract surgery from one institution were retrospectively enrolled. All patients underwent foveal SS-OCT, and macular spectral-domain (SD)-OCT scans before pupil dilation as well as dilated fundus biomicroscopy examination. The effectiveness of fundus biomicroscopy examinations, foveal SS-OCT scans, and the combination of both in identifying macular diseases was analyzed with macular SD-OCT scans as reference ...

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    6. Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study

      Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study

      Purpose : To investigate retinal vessel density changes in macular and papillary regions in post SARS-CoV-2 pneumonia patients by means of optical coherence tomography angiography (OCTA). Design : Prospective, observational, cohort study. Methods : Forty eyes of 40 patients (mean age 49.7 ± 12.6) post SARS-CoV-2 infection and 40 healthy subjects were enrolled in this study. Covid-19 patients had to be fully recovered from Covid-19 pneumonia and were evaluated 6 months after Covid-19 infection. The primary outcome was the results of the OCTA study of the following vascular structures: vessel density (VD) in the retinal superficial capillary plexus (SCP), deep capillary plexus ...

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      Mentions: Optovue
    7. Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma

      Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma

      Purpose To investigate the relationship between the rate of retinal nerve fiber layer (RNFL) loss during initial follow-up and the magnitude of associated visual field loss during an extended follow-up period. Design Retrospective cohort study. Methods A total of 1,150 eyes of 839 glaucoma patients extracted from the Duke Glaucoma Registry. Rates of RNFL loss were obtained from global RNFL thickness values of the first 5 optical coherence tomography (OCT) scans. Rates of visual field loss were assessed using standard automated perimetry mean deviation (SAP MD) during the entire follow-up period. Joint longitudinal mixed effects models were used to ...

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      Mentions: Duke University
    8. Identification and Characterization of Epivascular Glia using En Face OCT

      Identification and Characterization of Epivascular Glia using En Face OCT

      Purpose : To describe the clinical features of epivascular glia (EVG) using en face optical coherence tomography (OCT). Design : Retrospective cross-sectional study. Methods : Single institution en face OCT images were reviewed. Eyes displaying EVG were captured with manual internal limiting membrane segmentation and analysis with customized segmentation was performed. A random age- and gender-matched control group was selected to determine relative epiretinal membrane (ERM) prevalence. Results : Characteristic hyper-reflective internal limiting membrane (ILM) plaques with dendritic-like radiations were identified with en face OCT and displayed vascular predilection. 161 eyes with EVG (EVG group) and 2315 eyes without EVG (control group) were identified ...

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    9. Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Purpose To assess the in vivo physiology of retinal reattachment in humans using swept-source optical coherence tomography (SS-OCT) in real-time. Design Prospective case series. Methods Fifteen consecutive patients with fovea-involving rhegmatogenous retinal detachment undergoing pneumatic retinopexy (PnR). SS-OCT was performed at presentation and frequent intervals immediately following PnR. Primary outcome was longitudinal assessment of early post-operative SS-OCT to establish stages of reattachment. Results 93.3% (14/15) achieved successful reattachment at the median follow-up duration of 13 weeks (IQR 7.5-18.0). Reattachment occurred in five specific stages: Stage 1, redistribution of fluid and approach of the neurosensory retina towards ...

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    10. Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      PURPOSE : To compare the achieved vault using the conventional manufacturer's nomogram and the predicted vault using machine learning, in a large cohort of eyes undergoing posterior chamber phakic intraocular lens (EVO ICL, STAAR Surgical) implantation. DESIGN : Reliability and validity assessment and comparison. METHODS : Our study comprised a total of 1745 eyes of 1745 consecutive patients (mean age ± standard deviation, 26.2 ± 6.8 years) undergoing ICL implantation. At 1-month postoperatively, we quantitatively measured the actual vault, and compared it with the predicted vault using machine leaning of anterior segment optical coherence tomography (CASIA 2, Tomey) metrics. RESULTS : All machine ...

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    11. A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      Cataract surgery with intraocular lens (IOL) implantation is generally a safe procedure with a very low complication rate.1 Where complications occur that are related to the IOL biomaterial, these can cause partial or complete lens opacification, and we categorize them according to the water-content of the IOL: “Glistenings,” microvacuole inclusions in the polymer are most commonly found in hydrophobic acrylic IOLs,2,3 while the pathology most associated with hydrophilic acrylic IOLs is calcification, an opacification resulting from Calcium compound depositions.

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    12. Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Purpose To report a multi-disease deep-learning diagnostic network (MDDN) of common corneal diseases: dry eye syndrome (DES), Fuchs’ endothelial dystrophy (FED), and keratoconus (KCN) using anterior segment optical coherence tomography (AS-OCT) images. Study Design Development of a deep learning neural network diagnosis algorithm Methods A total of 158,220 AS-OCT images from 879 eyes of 478 subjects were used to develop and validate a classification deep network. After a quality check, the network was trained and validated using 134,460 images. We tested the network using a test set of consecutive patients involving 23,760 AS-OCT images of 132 eyes ...

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    13. Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Purpose: Test the hypothesis that visual field (VF) progression can be predicted from baseline and longitudinal optical coherence tomography (OCT) structural measures. Design: Prospective cohort study. Methods: 104 eyes (104 patients) with ≥3 years of follow-up and ≥5 VF exams were enrolled. We defined VF progression based on pointwise linear regression on 24-2 VF (≥3 locations with slope ≤–1.0 dB/year and p<0.01). We used elastic net logistic regression (ENR) and machine learning (ML) to predict VF progression with demographics, baseline circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell/inner plexiform layer (GCIPL) thickness and ...

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    14. Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level segmentation of the 13 most common abnormalities (features). For evaluation, 112 B-scans from 112 patients with a diagnosis of neovascular AMD were annotated by four independent observers. Main outcome measures ...

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    15. Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Purpose To identify genetic, systemic and biological factors associated with the occurrence of sickle cell maculopathy (SCM). To evaluate microvascular macular alterations using optical coherence tomography angiography (OCTA) in sickle cell disease (SCD). Design Cross-sectional study. Methods One hundred fifty-one eyes of 78 adult SCD patients (43 HbSS, 30 HbSC, 4 S/β + and 1 HbSLepore) and 40 eyes of 20 healthy controls underwent spectral domain optical coherence tomography (SD-OCT) and OCTA using Spectralis. We analyzed the occurrence of SCM, the foveal avascular zone (FAZ) area and the severity of macular ischemia and studied their relationships with genetic, systemic and biological ...

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    16. Correlation of Intraoperative Optical Coherence Tomography of Crystalline Lens Diameter, Thickness and Volume with Biometry and Age

      Purpose To characterize crystalline lens dimensions derived from in-vivo spectral-domain optical coherence tomography (SD-OCT) and identify associations between these parameters, ocular biometry and age. Methods In this retrospective study, lens thickness (LT), lens diameter (LD) and lens volume (LV) were measured intraoperatively with SD-OCT in 293 eyes undergoing lens surgery. Correlations among LT, LD, LV, age, axial length (AL) and anterior chamber depth (ACD) were analyzed. Multiple regression analysis was performed to determine whether a combination of biometric data could predict LD and LV. Results Wide variation was observed in LT (3.6 to 5.7mm), LD (7.5 to ...

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    17. Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Purpose The correlations between enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design Retrospective review of prospective, observational case series. Methods Eyes with GA from AMD were imaged with SS-OCT (PLEX® Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA) using 6x6 mm scan pattern. GA lesions were identified and measured using custom en face structural images and annual square root ERs of GA were calculated. At baseline, CC FDs from different regions ...

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    18. Comparison Between Graders in Detection of Diabetic Neovascularization with Swept Source OCT Angiography and Fluorescein Angiography

      Comparison Between Graders in Detection of Diabetic Neovascularization with Swept Source OCT Angiography and Fluorescein Angiography

      Purpose To compare the ability of ophthalmologists to identify neovascularization (NV) in patients with proliferative diabetic retinopathy (PDR) using swept source optical coherence tomography angiography (SS-OCTA) and fluorescein angiography (FA). Design Retrospective study comparing diagnostic instruments. Methods Eyes with PDR or severe non-proliferative diabetic retinopathy and a high suspicion of NV based on clinical examination were imaged using SS-OCTA and FA at the same visit. Two separate grading sets consisting of scrambled, anonymized SS-OCTA and FA images were created. The ground truth for presence of NV was established by consensus of two graders with OCTA experience who did not participate ...

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    19. Determinants of Optical Coherence tomography parameters in a population-based study.

      Determinants of Optical Coherence tomography parameters in a population-based study.

      Purpose To study the effects of age, gender, intraocular pressure, corneal thickness, axial length, disc area and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS), a population-based study. Design Cross-sectional study Methods 1100 eyes (1100 subjects) of normal adults aged between 40-80 years from LVPEI-GLEAMS underwent macular and optic nerve head imaging with spectral-domain OCT (SD-OCT). Effect of age, gender, intraocular pressure (IOP), central corneal thickness (CCT) and axial length (AXL), disc area and signal strength of the OCT scan on ...

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    20. Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Purpose To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-VEGF through pixel-mapping analysis of baseline OCT. Design Cross-sectional analysis. Setting Multicenter clinical trial. Patient population 68 eyes from the Comparison of Age-Related Macular Degeneration Treatments Trials. Intervention Treatment with anti-VEGF agents. Main outcome measure The percentage of MA or FS pixels with each OCT feature at baseline, and the odds ratio (OR) for baseline pixels with an OCT feature to develop MA or FS. Results RPE atrophy and photoreceptor loss on OCT were highly predictive of MA at that location at years ...

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      Mentions: Duke University
    21. OCT Risk Factors for 3-Year Development of Macular Complications in eyes with “Resolved” Chronic Central Serous Chorioretinopathy

      OCT Risk Factors for 3-Year Development of Macular Complications in eyes with “Resolved” Chronic Central Serous Chorioretinopathy

      Purpose To assess the relationship of demographics, clinical characteristics and structural optical coherence tomography (OCT) findings to development of sight-threatening macular complications (choroidal neovascularization [CNV], large areas of retinal pigment epithelium [RPE] atrophy and cystoid macular degeneration [CMD]) in a cohort of eyes with “resolved” chronic central serous chorioretinopathy (CSC) at inclusion (study baseline). Design Retrospective cohort study. Methods In this study, a total of 71 participants (71 eyes) with “resolved” (absence of subretinal fluid) chronic CSC at baseline and 3 years (36 months) of regular follow-ups were retrospectively enrolled. Structural OCT scans were reviewed. Baseline OCT qualitative features reflecting ...

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    22. Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis

      Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis

      Purpose To evaluate microvascular impairments with optical coherence tomography angiography (OCTA) in the eyes of diabetic patients with no diabetic retinopathy (NDR). Design Systematic review and meta-analysis. Methods The PubMed and Embase databases were comprehensively searched to identify studies comparing the microvascular changes between diabetic eyes without clinical retinopathy and healthy controls using OCTA. Data of interest were extracted and analyzed by Review Manager V.5.3 and Stata V.14.0. The weighted mean differences and their 95% confidence intervals were used to assess the strength of the association. Results Forty-four cross-sectional studies involving 2221 diabetic and 1838 healthy ...

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    23. Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions

      Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions

      Purpose Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGC) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. Design Perspective with review of relevant literature. Methods Review of challenges and issues related to detection of change on macular OCT images in glaucoma eyes. Setting NA. Patient or Study Population NA. Intervention or Observation Procedure(s) NA. Main Outcome Measure Confounding factors affecting detection of change on macular OCT images. Results The main ...

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      Mentions: UCLA
    24. Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

      Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

      Purpose To study the feasibility and diagnostic value of vascular imaging using OCT-Angiography (OCTA) of melanocytic lesions of the conjunctiva and iris. Design; Cross-sectional study. Methods Twenty-five patients with an untreated conjunctival lesion (5 melanoma, 13 nevus, 7 primary acquired melanosis (PAM) and 52 patients with an untreated iris lesion (10 melanoma, 42 nevus) were included. Patients were imaged using a commercially-available OCTA device, with addition of an anterior segment lens and manual focussing. Tumor vessel presence, vascular patterns and vascular density were assessed. Results Good OCTA images were obtained in 18/25 conjunctival lesions, and 42/52 iris lesions ...

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