1. 1-24 of 464 1 2 3 4 ... 18 19 20 »
    1. Objective quantification of posterior segment inflammation: Measuring vitreous cells and haze using optical coherence tomography

      Objective quantification of posterior segment inflammation: Measuring vitreous cells and haze using optical coherence tomography

      Purpose : To objectively grade posterior segment inflammation by measuring vitreous cells and haze on Optical Coherence Tomography (OCT) scans and to compare OCT-based results with clinical grading. Design : Evaluation of a diagnostic test Methods : OCT scans of patients with uveitis were collected at 3 time-points: with active (T0), clinically improving (T1) and resolved (T2) inflammation. At each visit visual acuity and clinical grading of the vitreous haze (National Eye Institute (NEI) scale) were assessed. Vitreous cells density was calculated on each OCT scan manually and automatically through a bespoken algorithm. Vitreous haze was indirectly measured on OCT scans by calculating ...

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    2. The 10000 eyes study: Analysis of Keratometry, Abulafia-Koch-Regression, and Biometric Eye Parameters Obtained with Swept Source OCT

      The 10000 eyes study: Analysis of Keratometry, Abulafia-Koch-Regression, and Biometric Eye Parameters Obtained with Swept Source OCT

      : To analyze Abulafia-Koch-Regression (AKRT), anterior and posterior astigmatism (K and TK), and evaluate biometry data in a large population. Design : Retrospective cross-sectional study. Methodology : Multicenter (two tertiary care centers). Data sets acquired between 2017 and 2020 were analyzed. Axial length (AL), corneal front and back radii(including meridians for K and TK conversion), horizontal corneal diameter (W2W), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness were measured using telecentric keratometry and swept source OCT based biometry (IOLMaster700). Cooke-modified axial length (CMAL) and AKRT were calculated. Difference vectors (DV) between K and TK astigmatism and between AKRT and TK ...

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    3. Intra-Operative Mounted Optical Coherence Tomography Findings Following Reversal of Optic Nerve Head Cupping in Childhood Glaucoma

      Intra-Operative Mounted Optical Coherence Tomography Findings Following Reversal of Optic Nerve Head Cupping in Childhood Glaucoma

      Purpose To examine the structural changes occurring in the optic nerve head (ONH) and macula in infants with childhood glaucoma and clinically observed ONH cupping reversal following intraocular pressure (IOP)-reducing glaucoma surgery, as captured by intra-operative spectral-domain optical coherence tomography (SD-OCT). Design Retrospective observational case series from an ongoing prospective cohort study. Methods Included were 18 eyes of 14 patients with childhood glaucoma. All eyes had SD-OCT imaging pre- and post-glaucoma intervention and clinically identified ONH cupping reversal. Patients with poor quality images or persistent optic nerve swelling following IOP reduction were excluded. Outcome measurements included IOP, cup-to-disc ratio ...

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      Mentions: Duke University
    4. Corneal Biometric Features and Their Association With Axial Length in High Myopia

      Corneal Biometric Features and Their Association With Axial Length in High Myopia

      Purpose To characterize the morphologic features of corneal parameters and their correlation with axial length (AL) elongation in patients with high axial myopia. Design Cross-sectional comparative study. Methods A total of 299 eyes with high myopia (299 patients) and 266 eyes of age- and sex-matched control subjects (266 patients) were examined by anterior segment swept-source optical coherence tomography (SS-OCT) and an IOL Master. Central corneal thickness (CCT), thinnest corneal thickness (TCT), corneal volume (CV), and anterior corneal curvature (CC), posterior CC, and total CC were obtained, and their correlation with AL was investigated using multiple linear regression model. Results The ...

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    5. Comparison of FAF versus OCT-based evaluation of the therapeutic response to pegcetacoplan in Geographic Atrophy

      Comparison of FAF versus OCT-based evaluation of the therapeutic response to pegcetacoplan in Geographic Atrophy

      Purpose To perform an optical coherence tomography (OCT)-based analysis of geographic atrophy (GA) progression in patients treated with pegcetacoplan. Design Post-hoc analysis of a phase 2 multicenter, randomized, sham-controlled trial Methods Manual annotation of retinal pigment epithelium (RPE), ellipsoid zone (EZ) and external limiting membrane (ELM) loss was performed on OCT volumes from baseline and month 12 from the phase 2 FILLY trial of intravitreal pegcetacoplan for the treatment of GA secondary to age-related macular degeneration. Main Outcome Measures Correlation of GA areas measured on fundus autofluorescence (FAF) and OCT. Difference in square root transformed growth rates of RPE ...

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    6. Peripapillary Microvasculature Predicts the Incidence and Development of Diabetic Retinopathy: An SS-OCTA Study

      Peripapillary Microvasculature Predicts the Incidence and Development of Diabetic Retinopathy: An SS-OCTA Study

      Purpose : To examine the associations of peripapillary microvascular metrics with diabetic retinopathy (DR) incidence and development using swept-source optical coherence tomography angiography (SS-OCTA). Design : Prospective cohort study. Methods : 1033 eyes from 1033 type II diabetes mellitus (T2D) patients were included with 2-year follow-up. The peripapillary microvascular metrics at the superficial capillary plexus (SCP) were measured by SS-OCTA at the baseline, including peripapillary vascular density (pVD) and vascular length density (pVLD). The DR incidence and progression were evaluated with seven standard fields of stereoscopic color fundus photographs. The associations were tested with logistic regression models after adjusting established risk factors and ...

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    7. Fourier analysis on irregular corneal astigmatism using optical coherence tomography in various severity stages of keratoconus

      Fourier analysis on irregular corneal astigmatism using optical coherence tomography in various severity stages of keratoconus

      Design : Prospective cross-sectional study Methods : The study included 126 eyes with clinical KC (50 KC without any corneal scar, 50 KC with anterior corneal scar, and 26 KC with posterior scar having a history of acute corneal hydrops), 50 with topographic KC (without clinical signs), 50 with pre-topographic KC (normal topography without clinical signs), and 50 controls. Corneal tomographic data were obtained using anterior segment optical coherence tomography (OCT). Fourier analysis decomposed dioptric data from both anterior and posterior corneal surface into spherical, regular astigmatism, asymmetry, and higher-order irregularity components. The discriminating ability of the Fourier indices of pre-topographic KC ...

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      Mentions: Osaka University
    8. Quantification of Anterior Chamber Cells in Children with Uveitis Using Anterior Segment Optical Coherence Tomography

      Quantification of Anterior Chamber Cells in Children with Uveitis Using Anterior Segment Optical Coherence Tomography

      Purpose : To evaluate the feasibility of anterior segment optical coherence tomography (AS-OCT) for measuring anterior chamber (AC) cells in children with uveitis and to compare different AS-OCT acquisition modes. Design : Validity and reliability analysis. Methods : We enrolled children younger than 18 years of age who had uveitis involving the anterior segment and children without eye disease as controls. All underwent clinical grading of AC cells. AC images of each eye were obtained using the Optovue Avanti RTVue XR AS-OCT. Two acquisition modes were used: a single cross-sectional line scan and an 8-line radial scan in an asterisk pattern. Two independent ...

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      Mentions: Visionix UCLA
    9. Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      To evaluate the diagnostic accuracy of a novel optical coherence tomography (OCT) texture-based en-face image analysis, called SALSA-Texture, that requires segmentation of only one retinal layer for glaucoma detection in eyes with axial high myopia, and to compare to standard macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fiber layer (mRNFL) thickness, and ganglion cell complex (GCC) thickness maps.

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      Mentions: UCSD
    10. The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker

      The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker

      Purpose : To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVT&B) could be used as a diagnostic marker for glaucoma. Design : Retrospective, deep-learning approach diagnosis study. Method : We trained a deep learning network to automatically segment the CRVT&B from the B-scans of the optical coherence tomography (OCT) volume of the optic nerve head (ONH). Subsequently, two different approaches were used for glaucoma diagnosis using the structural configuration of the CRVT&B as extracted from the OCT volumes. In the first approach, we aimed to provide a diagnosis using only 3D ...

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    11. Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

      Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

      Purpose To develop and validate a deep learning (DL) method of predicting visual function from spectral domain optical coherence tomography (SDOCT) derived retinal nerve fiber layer thickness (RNFLT) measurements and corresponding SDOCT images. Design Development and evaluation of diagnostic technology. Methods Two DL ensemble models to predict pointwise VF sensitivity from SDOCT images (model 1 – RNFLT profile only; model 2 – RNFLT profile plus SDOCT image), and two reference models were developed. All models were tested in an independent test-retest dataset comprising 2181 SDOCT/VF pairs; the median of ∼10 VFs per eye was taken as the best available estimate (BAE ...

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    12. Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Purpose To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images. Design Meta-analysis. Methods PubMed and EMBASE were searched on August 11, 2021. Bivariate random-effects model was used to pool ML's diagnostic sensitivity, specificity, and area under the curve (AUC). Subgroup analyses were performed based on ML classifier categories and dataset types. Results 105 (3.3%) studies were retrieved. 73 (69.5%), 30 (28.6%), and 2 (1.9%) studies tested ML using fundus, OCT, and both image types, respectively. Total testing data size was 197174 for fundus and ...

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      Mentions: UCSD
    13. Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Purpose To evaluate the association between optical microangiography (OMAG) measurements and progressive ganglion cell-inner plexiform layer (GCIPL) loss in primary open angle glaucoma (POAG). Design Prospective case-series Methods Sixty-three eyes of 38 POAG patients were studied for at least 2 years and with at least 3 optical coherence tomography (OCT) examinations. Only those hemifields with mild to moderate functional damage at baseline (106 hemifields) were included in the analysis. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure), baseline mean deviation (MD ...

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    14. ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      Importance: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. Objective: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. Design: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). Participants: Patients with a diagnosis of biopsy-proven VRL imaged with OCT at presentation EXPOSURE: The ocular information, systemic information and multimodal retinal imaging findings were collected and studied. Main outcome measure: Characteristics of VRL on OCT RESULTS ...

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    15. Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Purpose : To compare convolutional neural network (CNN) analysis of en face vessel density images to gradient boosting classifier (GBC) analysis of instrument provided, feature-based optical coherence tomography angiography (OCTA) vessel density measurements and OCT RNFL thickness measurements for classifying healthy and glaucomatous eyes. Design : Comparison of diagnostic approaches Methods : 130 eyes of 80 healthy individuals and 275 eyes of 185 glaucoma patients with optic nerve head (ONH) OCTA and OCT imaging were included. Classification performance of a VGG16 CNN trained and tested on entire en face 4.5 mm x 4.5 mm radial peripapillary capillary OCTA ONH images was ...

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      Mentions: UCSD
    16. Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Purpose To assess the clinical utility of swept-source optical coherence tomography angiography (SS-OCTA) in detecting optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) eyes. Design Cross sectional study. Methods One hundred and ninety-seven eyes of 197 POAG patients with acceptable-quality SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA, USA) images were enrolled. A whole-signal-mode 6.0 × 6.0-mm optic disc cube was obtained with projection artifact removal. Three groups were categorized: no MvD-D (Group 1), MvD-D (Group 2, complete loss of microvasculature within the optic disc), and indiscernible MvD-D (Group 3, poor visualization of the anterior lamina ...

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    17. OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

      OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

      Purpose To assess the relationship between best corrected visual acuity (BCVA) and central subfield optical coherence tomography (OCT) features in noninfectious uveitis (NIU)-related macular edema (ME). Design Clinical cohort study from post hoc analysis of two phase 3 clinical trials’ data. Methods Correlation and longitudinal treatment analyses were performed. Of 198 patients with NIU, 134 received suprachoroidally administered CLS-TA (Clearside Biomedical, Inc. proprietary formulation of a triamcinolone acetonide injectable suspension) and 64 received sham, with 12.9% and 72% respectively receiving rescue therapy. Results At baseline, mean BCVA progressively worsened with each ordinal drop in ellipsoid zone (EZ) integrity ...

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    18. Longitudinal Assessment of Ellipsoid Zone Recovery using En Face Optical Coherence Tomography after Retinal Detachment Repair

      Longitudinal Assessment of Ellipsoid Zone Recovery using En Face Optical Coherence Tomography after Retinal Detachment Repair

      Purpose Suboptimal functional outcomes following rhegmatogenous retinal detachment (RRD) repair may be related to photoreceptor abnormalities including alterations of the ellipsoid zone (EZ) which may not be apparent on cross-sectional optical coherence tomography (OCT). This study assessed EZ recovery using en face OCT following RRD repair and its association with visual acuity. Design Post hoc analysis of a randomized controlled trial. Methods Patients with macula-off RRD were followed at 3, 6, 12 and 24 months post-operatively and annually thereafter. En face OCT of the EZ slab were analyzed. Hyporeflective areas were co-localized with EZ abnormalities on cross-sectional OCT B-Scans and ...

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      Mentions: UCLA
    19. Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      We read with interest the manuscript by Bansal and associates 1 regarding optical coherence tomography (OCT) to assess retinal reattachment following successful pneumatic retinopexy (PnR). The authors propose that retinal reattachment occurs through 5 specific stages: approach of the neurosensory retina towards the retinal pigment epithelium (RPE, stage 1), improvement of outer retinal corrugations (stage 2), contact of the neurosensory retina to the RPE (stage 3), deturgescence of the photoreceptors (stage 4) and recovery of photoreceptor integrity (stage 5). An incomplete resolution of outer retinal corrugations before retinal reattachment may lead, according to the authors, to the formation of outer ...

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    20. Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Purpose To develop deep learning models for identification of sex and age from macular optical coherence tomography (OCT), and to analyze the features for differentiation of sex and age. Design Algorithm development using database of macular OCT. Setting One eye center in Taiwan. Study Population 6147 sets of macular optical coherence tomography (OCT) images from the healthy eyes of 3134 persons. Main Outcome Measures Deep learning based algorithms were used to develop models for identification of sex and age, and 10-fold cross-validation was applied. Gradient-weighted class activation mapping (Grad-CAM) was used for feature analysis. Results The accuracy for sex prediction ...

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    21. Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Purpose To evaluate the ocular and systemic determinants of the choriocapillaris flow deficits percentage (CC FD%) in normal eyes. Design Observational cross-sectional study. Methods Healthy Chinese participants without ocular or systemic diseases underwent detailed ophthalmic evaluations, including swept-source optical coherence tomography angiography (SS-OCTA) with 6 × 6 mm macular choriocapillaris images. The CC FD% was assessed in circular regions with diameters of 1.0 and 5.0 mm, rings with 1.0–2.5-mm and 2.5–5.0-mm diameters. Results The study included 830 individuals (mean age: 58.66±8.75 years). CC FD% (mean: 22.05%±1.13%) was ...

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    22. Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      We observed that retinal reattachment mediated by the retinal pigment epithelium (RPE) occurs in 5 specific stages and 20% of patients had delayed progression through Stage 2, characterized by outer retinal folds (ORFs). 1 dell'Omo et al hypothesized that “persisting undulations play a role in the formation of pockets of subretinal fluid, later evolving into ORFs” 2 . We demonstrated how improvement of outer retinal corrugations (ORCs) occurs during the slow and natural reattachment process mediated by the RPE in Stage 2 and how if parts of the retina remain in Stage 2 without sufficient improvement of ORCs while adjacent ...

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    23. Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Purpose To investigate the occurrence and risk factors of clinically significant intraocular lens (IOL) decentration and tilt in highly myopic eyes using swept-source anterior segment optical coherence tomography (SS-AS-OCT). Design Cross-sectional study. Methods This study included 334 participants (334 eyes) with high myopia (axial length (AL) ≥26 mm) who underwent phacoemulsification with IOL implantation. Decentration and tilt of IOL were assessed by SS-AS-OCT. Clinically significant IOL decentration and tilt was defined as decentration ≥ 0.4mm and tilt ≥7°. Routine pre- and post-operative examinations were performed, including visual acuity, refraction, biometric measurement using IOL master700, and objective visual quality evaluated by ...

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    24. Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Purpose This is the first study that evaluates the prevalence of retinal thinning and the correlation with papilledema and visual acuity (VA) in a large craniosynostosis population. Design Prospective clinical cohort study Methods All syndromic and complex craniosynostosis patients who visited the only national referral center between 2018-2020 were included. Retinal layers were segmented using optical coherence tomography (OCT). Patients were seen by an ophthalmologist for VA assessment and fundoscopy. Multivariate regression models were developed to evaluate correlations between retinal thickness, papilledema and VA. Results 127 patients were included. Retinal thinning was most prevalent in the peripapillary retinal nerve fiber ...

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