1. 1-24 of 428 1 2 3 4 ... 16 17 18 »
    1. Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Purpose To assess the in vivo physiology of retinal reattachment in humans using swept-source optical coherence tomography (SS-OCT) in real-time. Design Prospective case series. Methods Fifteen consecutive patients with fovea-involving rhegmatogenous retinal detachment undergoing pneumatic retinopexy (PnR). SS-OCT was performed at presentation and frequent intervals immediately following PnR. Primary outcome was longitudinal assessment of early post-operative SS-OCT to establish stages of reattachment. Results 93.3% (14/15) achieved successful reattachment at the median follow-up duration of 13 weeks (IQR 7.5-18.0). Reattachment occurred in five specific stages: Stage 1, redistribution of fluid and approach of the neurosensory retina towards ...

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    2. Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      PURPOSE : To compare the achieved vault using the conventional manufacturer's nomogram and the predicted vault using machine learning, in a large cohort of eyes undergoing posterior chamber phakic intraocular lens (EVO ICL, STAAR Surgical) implantation. DESIGN : Reliability and validity assessment and comparison. METHODS : Our study comprised a total of 1745 eyes of 1745 consecutive patients (mean age ± standard deviation, 26.2 ± 6.8 years) undergoing ICL implantation. At 1-month postoperatively, we quantitatively measured the actual vault, and compared it with the predicted vault using machine leaning of anterior segment optical coherence tomography (CASIA 2, Tomey) metrics. RESULTS : All machine ...

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    3. A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      Cataract surgery with intraocular lens (IOL) implantation is generally a safe procedure with a very low complication rate.1 Where complications occur that are related to the IOL biomaterial, these can cause partial or complete lens opacification, and we categorize them according to the water-content of the IOL: “Glistenings,” microvacuole inclusions in the polymer are most commonly found in hydrophobic acrylic IOLs,2,3 while the pathology most associated with hydrophilic acrylic IOLs is calcification, an opacification resulting from Calcium compound depositions.

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    4. Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Purpose To report a multi-disease deep-learning diagnostic network (MDDN) of common corneal diseases: dry eye syndrome (DES), Fuchs’ endothelial dystrophy (FED), and keratoconus (KCN) using anterior segment optical coherence tomography (AS-OCT) images. Study Design Development of a deep learning neural network diagnosis algorithm Methods A total of 158,220 AS-OCT images from 879 eyes of 478 subjects were used to develop and validate a classification deep network. After a quality check, the network was trained and validated using 134,460 images. We tested the network using a test set of consecutive patients involving 23,760 AS-OCT images of 132 eyes ...

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    5. Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Purpose: Test the hypothesis that visual field (VF) progression can be predicted from baseline and longitudinal optical coherence tomography (OCT) structural measures. Design: Prospective cohort study. Methods: 104 eyes (104 patients) with ≥3 years of follow-up and ≥5 VF exams were enrolled. We defined VF progression based on pointwise linear regression on 24-2 VF (≥3 locations with slope ≤–1.0 dB/year and p<0.01). We used elastic net logistic regression (ENR) and machine learning (ML) to predict VF progression with demographics, baseline circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell/inner plexiform layer (GCIPL) thickness and ...

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    6. Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level segmentation of the 13 most common abnormalities (features). For evaluation, 112 B-scans from 112 patients with a diagnosis of neovascular AMD were annotated by four independent observers. Main outcome measures ...

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    7. Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Purpose To identify genetic, systemic and biological factors associated with the occurrence of sickle cell maculopathy (SCM). To evaluate microvascular macular alterations using optical coherence tomography angiography (OCTA) in sickle cell disease (SCD). Design Cross-sectional study. Methods One hundred fifty-one eyes of 78 adult SCD patients (43 HbSS, 30 HbSC, 4 S/β + and 1 HbSLepore) and 40 eyes of 20 healthy controls underwent spectral domain optical coherence tomography (SD-OCT) and OCTA using Spectralis. We analyzed the occurrence of SCM, the foveal avascular zone (FAZ) area and the severity of macular ischemia and studied their relationships with genetic, systemic and biological ...

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    8. Correlation of Intraoperative Optical Coherence Tomography of Crystalline Lens Diameter, Thickness and Volume with Biometry and Age

      Purpose To characterize crystalline lens dimensions derived from in-vivo spectral-domain optical coherence tomography (SD-OCT) and identify associations between these parameters, ocular biometry and age. Methods In this retrospective study, lens thickness (LT), lens diameter (LD) and lens volume (LV) were measured intraoperatively with SD-OCT in 293 eyes undergoing lens surgery. Correlations among LT, LD, LV, age, axial length (AL) and anterior chamber depth (ACD) were analyzed. Multiple regression analysis was performed to determine whether a combination of biometric data could predict LD and LV. Results Wide variation was observed in LT (3.6 to 5.7mm), LD (7.5 to ...

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    9. Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Purpose The correlations between enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design Retrospective review of prospective, observational case series. Methods Eyes with GA from AMD were imaged with SS-OCT (PLEX® Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA) using 6x6 mm scan pattern. GA lesions were identified and measured using custom en face structural images and annual square root ERs of GA were calculated. At baseline, CC FDs from different regions ...

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    10. Comparison Between Graders in Detection of Diabetic Neovascularization with Swept Source OCT Angiography and Fluorescein Angiography

      Comparison Between Graders in Detection of Diabetic Neovascularization with Swept Source OCT Angiography and Fluorescein Angiography

      Purpose To compare the ability of ophthalmologists to identify neovascularization (NV) in patients with proliferative diabetic retinopathy (PDR) using swept source optical coherence tomography angiography (SS-OCTA) and fluorescein angiography (FA). Design Retrospective study comparing diagnostic instruments. Methods Eyes with PDR or severe non-proliferative diabetic retinopathy and a high suspicion of NV based on clinical examination were imaged using SS-OCTA and FA at the same visit. Two separate grading sets consisting of scrambled, anonymized SS-OCTA and FA images were created. The ground truth for presence of NV was established by consensus of two graders with OCTA experience who did not participate ...

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    11. Determinants of Optical Coherence tomography parameters in a population-based study.

      Determinants of Optical Coherence tomography parameters in a population-based study.

      Purpose To study the effects of age, gender, intraocular pressure, corneal thickness, axial length, disc area and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS), a population-based study. Design Cross-sectional study Methods 1100 eyes (1100 subjects) of normal adults aged between 40-80 years from LVPEI-GLEAMS underwent macular and optic nerve head imaging with spectral-domain OCT (SD-OCT). Effect of age, gender, intraocular pressure (IOP), central corneal thickness (CCT) and axial length (AXL), disc area and signal strength of the OCT scan on ...

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    12. Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Localized Optical Coherence Tomography Precursors of Macular Atrophy and Fibrotic Scar in the Comparison of Age-Related Macular Degeneration Treatments Trials

      Purpose To identify precursors of macular atrophy (MA) and of fibrotic scar (FS) in eyes treated with anti-VEGF through pixel-mapping analysis of baseline OCT. Design Cross-sectional analysis. Setting Multicenter clinical trial. Patient population 68 eyes from the Comparison of Age-Related Macular Degeneration Treatments Trials. Intervention Treatment with anti-VEGF agents. Main outcome measure The percentage of MA or FS pixels with each OCT feature at baseline, and the odds ratio (OR) for baseline pixels with an OCT feature to develop MA or FS. Results RPE atrophy and photoreceptor loss on OCT were highly predictive of MA at that location at years ...

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    13. OCT Risk Factors for 3-Year Development of Macular Complications in eyes with “Resolved” Chronic Central Serous Chorioretinopathy

      OCT Risk Factors for 3-Year Development of Macular Complications in eyes with “Resolved” Chronic Central Serous Chorioretinopathy

      Purpose To assess the relationship of demographics, clinical characteristics and structural optical coherence tomography (OCT) findings to development of sight-threatening macular complications (choroidal neovascularization [CNV], large areas of retinal pigment epithelium [RPE] atrophy and cystoid macular degeneration [CMD]) in a cohort of eyes with “resolved” chronic central serous chorioretinopathy (CSC) at inclusion (study baseline). Design Retrospective cohort study. Methods In this study, a total of 71 participants (71 eyes) with “resolved” (absence of subretinal fluid) chronic CSC at baseline and 3 years (36 months) of regular follow-ups were retrospectively enrolled. Structural OCT scans were reviewed. Baseline OCT qualitative features reflecting ...

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    14. Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis

      Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis

      Purpose To evaluate microvascular impairments with optical coherence tomography angiography (OCTA) in the eyes of diabetic patients with no diabetic retinopathy (NDR). Design Systematic review and meta-analysis. Methods The PubMed and Embase databases were comprehensively searched to identify studies comparing the microvascular changes between diabetic eyes without clinical retinopathy and healthy controls using OCTA. Data of interest were extracted and analyzed by Review Manager V.5.3 and Stata V.14.0. The weighted mean differences and their 95% confidence intervals were used to assess the strength of the association. Results Forty-four cross-sectional studies involving 2221 diabetic and 1838 healthy ...

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    15. Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions

      Detection of Glaucoma Deterioration in The Macular Region with Optical Coherence Tomography: Challenges and Solutions

      Purpose Macular imaging with optical coherence tomography (OCT) measures the most critical retinal ganglion cells (RGC) in the human eye. The goal of this perspective is to review the challenges to detection of glaucoma progression with macular OCT imaging and propose ways to enhance its performance. Design Perspective with review of relevant literature. Methods Review of challenges and issues related to detection of change on macular OCT images in glaucoma eyes. Setting NA. Patient or Study Population NA. Intervention or Observation Procedure(s) NA. Main Outcome Measure Confounding factors affecting detection of change on macular OCT images. Results The main ...

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      Mentions: UCLA
    16. Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

      Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

      Purpose To study the feasibility and diagnostic value of vascular imaging using OCT-Angiography (OCTA) of melanocytic lesions of the conjunctiva and iris. Design; Cross-sectional study. Methods Twenty-five patients with an untreated conjunctival lesion (5 melanoma, 13 nevus, 7 primary acquired melanosis (PAM) and 52 patients with an untreated iris lesion (10 melanoma, 42 nevus) were included. Patients were imaged using a commercially-available OCTA device, with addition of an anterior segment lens and manual focussing. Tumor vessel presence, vascular patterns and vascular density were assessed. Results Good OCTA images were obtained in 18/25 conjunctival lesions, and 42/52 iris lesions ...

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    17. Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion

      Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion

      Purpose To develop geometric perfusion deficits (GPD), an optical coherence tomography angiography (OCTA) biomarker based on oxygen diffusion, and to evaluate its utility in a pilot study of healthy subjects and patients with diabetic retinopathy (DR). Design Retrospective cross-sectional study. Methods Commercial spectral-domain OCTA instruments were used to acquire repeated 3×3 mm 2 and 6×6 mm 2 motion-corrected macular OCTA volumes. En face OCTA images corresponding to the superficial capillary plexus (SCP), deep capillary plexus (DCP), and full retinal projections were obtained using automatic segmentation. For each projection, the GPD percentage and the vessel density percentage, the control ...

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    18. Validity and reliability of semiautomatic ocular cycloposition measurement with Spectralis optical coherence tomography.

      Validity and reliability of semiautomatic ocular cycloposition measurement with Spectralis optical coherence tomography.

      PURPOSE Disc-fovea angle quantification in fundus photography (P-DFA) is considered the gold standard for cycloposition assessment. The FoDi software of the SD-OCT Spectralis also measures the DFA (O-DFA) based on subject fixation and offers important clinical advantages. This study aimed to analyze the validity and reliability of OCT measuring cycloposition and to determine its performance in eyes with poor foveal definition. DESIGN Validity and reliability analysis. METHODS In 60 eyes with normal foveal definition and 32 eyes with poorly defined fovea, ocular cycloposition was assessed by two observers with five fundus photographs and five FoDi analyses each. The patients were ...

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    19. Aqueous Cytokine Expression and Higher-Order OCT Biomarkers: Assessment of the Anatomic-Biologic Bridge in the Imagine Dme Study

      Aqueous Cytokine Expression and Higher-Order OCT Biomarkers: Assessment of the Anatomic-Biologic Bridge in the Imagine Dme Study

      Purpose To identify biomarkers for predicting response to anti-VEGF therapy in diabetic macular edema (DME) and evaluate any links between cytokine expression and OCT phenotype. Design IMAGINE DME is a post-hoc image analysis and cytokine expression assessment of the DAVE randomized clinical trial. Methods Subjects were categorized as anatomical Responders or Nonresponders,and within the Responder group as Rebounders and Nonrebounders based on quantitative, longitudinal optical coherence tomography (OCT) criteria. Retinal layer and fluid features were extracted using an OCT machine-learning augmented segmentation platform. Responders were further sub-classified by rapidity of response. Aqueous concentrations of 54 cytokines at multiple timepoints ...

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    20. Guidelines for imaging the choriocapillaris using OCT angiography

      Guidelines for imaging the choriocapillaris using OCT angiography

      Purpose To provide guidance on how to appropriately quantitate various choriocapillaris (CC) parameters with optical coherence tomography angiography (OCTA). Design Evidence-based perspective. Methods Review of literature and experience of authors. Results Accurate and reliable quantification of the CC using OCTA requires that the CC can be visualized and that the measurements of various CC parameters are validated. For accurate visualization, the selected CC slab must be physiologically sound, must produce images consistent with histology, and must yield qualitatively similar images when viewing repeats of the same scan or scans of different sizes. For accurate quantification, the measured inter-capillary distances (ICDs ...

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    21. Association between sleep apnoea risk score and retinal microvasculature using optical coherence tomography angiography

      Association between sleep apnoea risk score and retinal microvasculature using optical coherence tomography angiography

      Purpose To investigate the retinal vessel changes at peripapillary and parafoveal regions using optical coherence tomography angiography in patients with varying obstructive sleep apnoea syndrome (OSAS) risk, identified by the STOP-BANG questionnaire. Design Prospective, hospital-based cross-sectional study. Methods Participants were divided into 3 groups based on the OSAS risk score. Flow areas and vessel densities were calculated at peripapillary and parafoveal regions using optical coherence tomography angiography. Microvasculature changes between the 3 groups and correlation between OSAS risk score and vascular changes were calculated. Results Six hundred and six eyes of 303 patients were included in groups 1 (n=96 ...

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      Mentions: Rohit Shetty
    22. Impact of artifacts from optical coherence tomography retinal nerve fiber layer and macula scans on detection of glaucoma progression

      Impact of artifacts from optical coherence tomography retinal nerve fiber layer and macula scans on detection of glaucoma progression

      Purpose To determine the prevalence of artifacts on segmented SDOCT images and assess their impact on the interpretation of glaucomatous progression in the retinal nerve fiber layer (RNFL) profile and macular thickness map. Design Retrospective reliability analysis Methods Retrospective review of glaucoma and glaucoma suspect eyes imaged with SDOCT during a one-month period. All cases had at least 4 sets of RNFL and macular images at 6-month intervals. SDOCT raw B-scans were examined to determine true progression and whether artifacts impacted the original interpretation of progression based on auto-segmented change maps. The co-prevalence of artifacts in the RNFL and macula ...

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      Mentions: Sanjay G. Asrani
    23. Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography

      Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography

      Purpose Assessment of anterior segment–optical coherence tomography angiography (AS-OCTA) to determine severity of corneal neovascularization (CoNV). Design Retrospective, cross-sectional, single-center study. Methods Patients of various CoNV etiologies were selected and classified into mild, moderate and severe. Their AS-OCTA images were measured for CoNV anterior limit, CoNV posterior limit, CoNV thickness, CoNV depth%, CoNV vessel density, CoNV area and CoNV volume. Further, AS-OCTA parameters were correlated to clinical parameters, such as classification, a numerical severity scale, vascular clock hours and best corrected visual acuity (BCVA). Results Total 19 mild, 10 moderate and 6 severe CoNV eyes were included with no ...

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    24. Role of Microscope-Intraoperative Optical Coherence Tomography in paediatric keratoplasty: A comparative Study

      Role of Microscope-Intraoperative Optical Coherence Tomography in paediatric keratoplasty: A comparative Study

      Purpose To evaluate role of Microscope-Integrated Intraoperative Optical Coherence Tomography (i-OCT) in paediatric keratoplasty. Design Combined prospective and retrospective, comparative, interventional study Setting Dr Rajendra Prasad Centre for Ophthalmic Sciences, India Methods Seventy-five children aged ≤16 years planned for keratoplasty were divided into two groups and compared for intraoperative course and postoperative outcome. In Group-1 (prospective group, n=56), pre-operative anterior segment visualization was performed clinically, with ultrasound biomicroscopy (UBM) and i-OCT and keratoplasty was commenced under i-OCT microscope. In Group-2 (retrospective group, n=19), conventional microscope was employed during keratoplasty. Results In Group-1, i-OCT, UBM and clinical examination detected ...

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