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    1. Automated Detection of the Stromal Demarcation Line using Optical Coherence Tomography in Keratoconus Eyes after Corneal Crosslinking

      Automated Detection of the Stromal Demarcation Line using Optical Coherence Tomography in Keratoconus Eyes after Corneal Crosslinking

      Purpose To evaluate the role of a novel automated detection software as compared to human operators in assessing the presence and depth of stromal demarcation line on optical coherence tomography (OCT) in keratoconus eyes post cross-linking Design: This was a reliability analysis study. Methods Two independent operators and an automated detection software examined corneal OCTs of 25 eyes of 25 patients post corneal cross-linking using the Dresden protocol, at 3 months postoperatively. Operators evaluated the presence of the demarcation line and measured its depth by looking at OCT images (128 cuts) on two separate occasions one week apart. The automated ...

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    2. Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Objective To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. Design Retrospective, cross-sectional study. Methods A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2). Macular 3 × 3 mm angiography was acquired using the Zeiss Cirrus 5000 OCT instrument. Vessel density (VD), perfusion density (PD), and foveal avascular zone ...

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    3. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged ≥50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed by a single trained ophthalmologist. SS-OCT angle scans, which obtain radial scans for the entire circumference of the angle, were analyzed by a single examiner, masked to the subject’s ...

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    4. En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      Objective To investigate the application of en face optical coherence tomography (OCT) imaging in eyes with hydroxychloroquine (HCQ) retinopathy. Design Retrospective case series Methods: Setting Institutional Patient Population Sixty-two eyes of 31 Asian patients with HCQ retinopathy. Observation Procedures Macular volume scanning using swept-source OCT was performed in 6 × 6 and 9 × 9 mm areas centered on the fovea. Segmentation of the photoreceptor layers was automatically performed between the inner border of the ellipsoid zone and that of the retinal pigment epithelium-Bruch’s membrane complex to obtain en face OCT images. Findings from the en face images were qualitatively and ...

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    5. Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Purpose To assess glaucoma specialists’ detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative to the axis between Bruch’s membrane opening (BMO) centroid and the fovea. For each clinician, the distance from BMO centroid to their DM (DM radius) and RM (RM radius ...

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    6. Incorporating Optical Coherence Tomography in the Cataract Preoperative Armamentarium: Additional Need or Additional Burden?

      Incorporating Optical Coherence Tomography in the Cataract Preoperative Armamentarium: Additional Need or Additional Burden?

      Purpose To determine the usefulness of preoperative OCT examination to detect asymptomatic macular abnormalities in patients scheduled for cataract surgery Methods Design : Prospective, interventional case series Setting : Iladevi Cataract and Visakha Eye Center, Ahmedabad, India Study Population : Patients undergoing cataract surgery and intraocular lens(IOL) implantation for senile cataracts. Preoperatively no retinal/macular pathology was identified on clinical evaluation. Intervention All eyes underwent Macular 5-Line Raster evaluation using Spectral Domain OCT before and after cataract surgery(monthly for 3 months). Central Subfield Thickness(CST) analysis was done. Outcome Measures The primary outcome measure was determining the incidence of asymptomatic retinal ...

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    7. Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Purpose To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. Design AI diagnostic tool development, evaluation, and comparison Methods Setting: multiple institutional practices. Study population Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes. Training data included OCT-1000/2000 (Topcon) from 94 eyes of 94 early OAG patients (mean deviation: MD >-5.0 dB) and 84 eyes of 84 normal subjects. Testing data included OCT-1000/2000 from 114 eyes of ...

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    8. Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

      Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

      Purpose To evaluate the performance of the epithelial thickness mapping (ETM) of the iVue spectral domain optical coherence tomography (SD-OCT) (Optovue Inc., Fremont, CA) in normal and diseased cornea eyes. Design Reliability and validity analysis. Methods Sixty eyes of 60 subjects were recruited for the study that included normal subjects (n=12) and patients with corneal diseases (12 each with dry eye syndrome (DES), contact lens (CL) wear, post laser refractive surgery (LRS), and keratoconus (KCN)). Three repeated scans were acquired on 3 iVue SD-OCTs with device-designated operators from consented subjects. Each subject was scanned on each device. Repeatability (based ...

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    9. Iris microhemangiomatosis: Clinical, fluorescein angiography, and optical coherence tomography angiography in 14 consecutive patients

      Iris microhemangiomatosis: Clinical, fluorescein angiography, and optical coherence tomography angiography in 14 consecutive patients

      Purpose To describe the clinical and imaging findings and treatment options in a series of patients with iris microhemangiomatosis. Design: Retrospective observational case series. Methods Setting : Single institution. Study Population : Twenty-two eyes of 14 consecutive patients with iris microhemangiomatosis were reviewed. Observation Procedures : Clinical examination and slit lamp photography were performed on every patient. Anterior segment optical coherence tomography (AS-OCT), anterior segment optical coherence tomography angiography (AS-OCTA), anterior segment intravenous fluorescein angiography (AS-IVFA) and ultrasound biomicroscopy were performed when possible. Main Outcome Measures : Clinical and imaging features and treatment strategies. Results Twenty-two eyes of 14 patients with iris microhemangiomatosis were ...

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    10. Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Purpose To investigate conjunctival and intrascleral vasculatures using anterior-segment (AS) optical coherence tomography angiography (OCTA) in normal eyes. Design Cross-sectional study. Methods AS-OCTA images of the corneal limbus were acquired circumferentially using a swept-source OCT system in 10 eyes of 10 healthy subjects. AS-OCTA flow patterns with en face maximum projection were compared between the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The OCTA images were also compared with fluorescein scleral angiography and indocyanine green aqueous angiography images. Quantitative parameters (vessel density, vessel length ...

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    11. Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Purpose To use spectral domain-optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NAION). Design Retrospective cohort study. Methods.Setting Single academic center. Patient or study population Eighty eyes in 74 subjects presenting within 2 weeks of symptom onset of NAION. Intervention or observation procedures SD-OCT imaging of the optic nerve head, macula, and peripapillary retinal nerve fiber layer (pRNFL) were reviewed for PVD and vitreopapillary traction (VPT). Main Outcome Measures Prevalence and incidence of PVD and VPT, logMAR best-corrected visual ...

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      Mentions: Duke University
    12. Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Purpose To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. Design Case-control study. Settings Clinical Practice. Study Population Thirty patients and thirty age-matched controls. Observation Procedures Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan). The one-way ANOVA test with Bonferroni correction was used to assess statistical significance and ...

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    13. Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Purpose To evaluate the difference in anterior segment optical coherence tomography (AS-OCT) parameters among ethnic Vietnamese, Chinese, and Caucasians Design Cross-sectional study Methods We prospectively recruited phakic non-glaucomatous participants (based on intraocular pressure <21 mmHg, normal optic nerve head and retinal nerve fiber, and cup-to-disc ratio <0.6) of three ethnic groups— Vietnamese, Chinese, and Caucasians. AS-OCT parameters including angle (angle opening distance, trabecular-iris space area, and angle recess area), iris (iris thickness, iris area, and iris curvature (Icurv)), and anterior chamber parameters (anterior chamber depth, width (ACW), area, and lens vault (LV)) were obtained. A linear regression model with ...

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      Mentions: Shan C. Lin UCSF
    14. OCT-Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

      OCT-Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

      Purpose To investigate choriocapillaris (CC) blood flow in unaffected fellow eyes of patients with central serous chorioretinopathy (CSC) using quantitative optical coherence tomography angiography (OCTA) analysis. Design Case-control study. Methods Patients with acute, recurrent or persistent CSC, along with healthy gender- and age-matched subjects were included. Objective assessment of CC blood flow was performed using OCTA measurements. Total area of flow signal voids was quantified at baseline, 3 months, and 6 months. Active serous retinal detachment (SRD) was considered as a potential source of false positive flow impairment, affected eyes were therefore excluded at onset and during follow-up, if this ...

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    15. Optical coherence tomography angiography in intermediate uveitis

      Optical coherence tomography angiography in intermediate uveitis

      Purpose To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A) Design Case-control study Methods Patients and age-matched controls were imaged with swept-source OCT-A (PLEX Elite 9000, Zeiss). Using ImageJ superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI) and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal intensity, signal intensity standard deviation, kurtosis of signal intensity distribution and flow-signal-voids. Results Twentynine intermediate uveitis eyes and 30 control eyes were included. Both superficial and deep retinal layers showed ...

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    16. Reproducibility of Vessel Density, Fractal Dimension, and Foveal Avascular Zone Using 7 Different Optical Coherence Tomography Angiography Devices

      Reproducibility of Vessel Density, Fractal Dimension, and Foveal Avascular Zone Using 7 Different Optical Coherence Tomography Angiography Devices

      We applaud Corvi and associates for their well-powered study entitled “Reproducibility of vessel density, fractal dimension, and foveal avascular zone using 7 different optical coherence tomography angiography devices.”1 In this paper the authors compared quantitative retinal vascular parameters obtained with 7 different optical coherence tomography angiography (OCT-A) devices. Although we certainly appreciate this study, the authors failed to comment on some technical aspects that should be kept in mind when interpreting these results.

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    17. Characteristics of Neovascularization in Early Stages of Proliferative Diabetic Retinopathy by Optical Coherence Tomography Angiography

      Characteristics of Neovascularization in Early Stages of Proliferative Diabetic Retinopathy by Optical Coherence Tomography Angiography

      Purpose To classify retinal neovascularization in untreated early stages of proliferative diabetic retinopathy (PDR) based on optical coherence tomography angiography (OCTA). Design A cross-sectional study. Methods Thirty-five eyes were included. They underwent color fundus photography, fluorescein angiography (FA), and OCTA examinations. Neovascularizations elsewhere (NVEs), neovascularizations of the optic disc (NVDs), and intraretinal microvascular abnormalities (IRMAs) were scanned by OCTA. The origin and morphology of NVE/NVD/IRMA on OCTA were evaluated. Retinal nonperfusion areas (NPAs) were measured using Image J software. Results In 35 eyes successfully imaged, 75 NVEs, 35 NVDs and 12 IRMAs were captured. Three proposed subtypes of ...

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    18. Color Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography in Diagnosing Polypoidal Choroidal Vasculopathy

      Color Fundus Photography, Optical Coherence Tomography, and Fluorescein Angiography in Diagnosing Polypoidal Choroidal Vasculopathy

      Purpose To determine sensitivity and specificity of polypoidal choroidal vasculopathy (PCV) diagnosis using color fundus photography (CFP), optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) without indocyanine-green angiography (ICGA). Design Validity analysis. Methods Treatment-naïve eyes with serous/serosanguinous maculopathy undergoing CFP, OCT, FFA and ICGA imaging before treatment at a university-hospital in Thailand (January 2013 to June 2015) were identified. Images of each subject were categorized into 4 sets (set A: CFP; set B: CFP+OCT; set C: CFP+FFA; set D: CFP+OCT+FFA). Six graders, 3 from Thailand (PCV endemic area) and 3 from U.S ...

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    19. Optical Coherence Tomography Angiography in Optic Disc Swelling

      Optical Coherence Tomography Angiography in Optic Disc Swelling

      Purpose To compare optical coherence tomography angiography (OCT-A) of peripapillary total vasculature and capillaries in patients with optic disc swelling. Design Cross-sectional study. Methods Twenty nine eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION), 44 eyes with papilledema, 8 eyes with acute optic neuritis, and 48 eyes of normal subjects were imaged using OCT-A. Peripapillary total vasculature information was recorded using a commercial vessel density map. Customized image analysis with major vessel removal was also used to measure whole-image capillary density and peripapillary capillary density (PCD). Results Mixed models showed that the peripapillary total vasculature density values were significantly ...

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    20. Automated segmentation of lesions including subretinal hyperreflective material in neovascular age-related macular degeneration

      Automated segmentation of lesions including subretinal hyperreflective material in neovascular age-related macular degeneration

      Purpose To evaluate an automated segmentation algorithm with a convolutional neural network (CNN) to quantify and detect intraretinal fluid (IRF), subretinal fluid (SRF), pigment epithelial detachment (PED), and subretinal hyperreflective material (SHRM) through analyses of spectral domain optical coherence tomography (SD-OCT) images from patients with neovascular age-related macular degeneration (nAMD). Design Reliability and validity analysis of a diagnostic tool. Methods We constructed a dataset including 930 B-scans from 93 eyes of 93 patients with nAMD. A CNN-based deep neural network was trained using 11550 augmented images derived from 550 B-scans. The performance of the trained network was evaluated using a ...

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    21. Spectral Domain Optical Coherence Tomography in Limbal Stem Cell Deficiency. A Case Control Study

      Spectral Domain Optical Coherence Tomography in Limbal Stem Cell Deficiency. A Case Control Study

      Purpose To evaluate the efficacy of optical coherence tomography as a non-contact method for imaging the ocular surface in limbal stem cell deficiency (LSCD) and normal eyes. Design Retrospective case-control study. Methods: Setting Institutional. Study population 22 eyes with LSCD (study group, 22 patients) and 10 normal eyes (control group, 10 patients). Observation procedures SD-OCT and confocal microscopy in both the limbal and central corneal zones. Main outcome measures Pachymetry data from the central cornea, presence of the palisades of Vogt, limbal crypts and clear transition between the hyporeflective corneal epithelium and the hyperreflective conjunctival epithelium assessed on cross-sections parallel ...

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      Mentions: Kate Grieve
    22. Dense B-scan Optical Coherence Tomography Angiography

      Dense B-scan Optical Coherence Tomography Angiography

      Purpose To describe a novel imaging technique, we call “dense B-scan optical coherence tomography angiography” (DB OCTA) in which thin dense raster scans are used to produce highly resolved structural B-scans with superimposed flow signal that provide precise correlation between retinal microstructure and blood flow. Design Observational case series Methods Normal eyes and eyes with macular findings of interest were imaged with DB OCTA in which 150-400 OCT B-scans were acquired within a narrow area (from a single line to 1°) with a width of 10 to 30°. B-scans containing 5-7 consecutive frames were processed for OCTA signal and then ...

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      Mentions: K. Bailey Freund
    23. Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes

      Inter-eye Asymmetry of Optical Coherence Tomography Angiography Vessel Density in Bilateral Glaucoma, Glaucoma Suspect, and Healthy Eyes

      Purpose To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. Design Cross-sectional study. Methods 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans. Thickness of peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (mGCC) was measured with spectral-domain optical coherence tomography (SD-OCT) scans. Inter-eye asymmetry was calculated by taking the absolute ...

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    24. Analysis of Retinal Thinning Using Spectral-domain Optical Coherence Tomography Imaging of Sickle Cell Retinopathy Eyes Compared to Age- and Race-Matched Control Eyes

      Analysis of Retinal Thinning Using Spectral-domain Optical Coherence Tomography Imaging of Sickle Cell Retinopathy Eyes Compared to Age- and Race-Matched Control Eyes

      Purpose To determine whether the retina is thinner in sickle cell patients than in race- and age-matched controls, and, if it is thinner, whether there is any association with systemic diseases. Methods Sickle cell and control (age- and race-matched) patients were prospectively enrolled from a university retina clinic into this observational study. Participants underwent visual acuity testing, slit-lamp biomicroscopy, dilated ophthalmoscopy, and spectral-domain optical coherence tomography imaging. Sickle cell retinal lesions, degree of vascular tortuosity, caliber of arteriovenous anastomosis, and stage of retinopathy were noted. Early Treatment Diabetic Retinopathy Study (ETDRS) subfield measurements were compared between sickle cell and control ...

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