1. 1-24 of 456 1 2 3 4 ... 17 18 19 »
    1. Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      Diagnostic accuracy of macular thickness map and texture en-face images for detecting glaucoma in eyes with axial high myopia

      To evaluate the diagnostic accuracy of a novel optical coherence tomography (OCT) texture-based en-face image analysis, called SALSA-Texture, that requires segmentation of only one retinal layer for glaucoma detection in eyes with axial high myopia, and to compare to standard macular ganglion cell-inner plexiform layer (GCIPL) thickness, macular retinal nerve fiber layer (mRNFL) thickness, and ganglion cell complex (GCC) thickness maps.

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      Mentions: UCSD
    2. The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker

      The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker

      Purpose : To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVT&B) could be used as a diagnostic marker for glaucoma. Design : Retrospective, deep-learning approach diagnosis study. Method : We trained a deep learning network to automatically segment the CRVT&B from the B-scans of the optical coherence tomography (OCT) volume of the optic nerve head (ONH). Subsequently, two different approaches were used for glaucoma diagnosis using the structural configuration of the CRVT&B as extracted from the OCT volumes. In the first approach, we aimed to provide a diagnosis using only 3D ...

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    3. Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

      Predicting visual fields from optical coherence tomography via an ensemble of deep representation learners

      Purpose To develop and validate a deep learning (DL) method of predicting visual function from spectral domain optical coherence tomography (SDOCT) derived retinal nerve fiber layer thickness (RNFLT) measurements and corresponding SDOCT images. Design Development and evaluation of diagnostic technology. Methods Two DL ensemble models to predict pointwise VF sensitivity from SDOCT images (model 1 – RNFLT profile only; model 2 – RNFLT profile plus SDOCT image), and two reference models were developed. All models were tested in an independent test-retest dataset comprising 2181 SDOCT/VF pairs; the median of ∼10 VFs per eye was taken as the best available estimate (BAE ...

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    4. Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis

      Purpose To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images. Design Meta-analysis. Methods PubMed and EMBASE were searched on August 11, 2021. Bivariate random-effects model was used to pool ML's diagnostic sensitivity, specificity, and area under the curve (AUC). Subgroup analyses were performed based on ML classifier categories and dataset types. Results 105 (3.3%) studies were retrieved. 73 (69.5%), 30 (28.6%), and 2 (1.9%) studies tested ML using fundus, OCT, and both image types, respectively. Total testing data size was 197174 for fundus and ...

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      Mentions: UCSD
    5. Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Optical microangiography and progressive ganglion cell-inner plexiform layer loss in primary open angle glaucoma

      Purpose To evaluate the association between optical microangiography (OMAG) measurements and progressive ganglion cell-inner plexiform layer (GCIPL) loss in primary open angle glaucoma (POAG). Design Prospective case-series Methods Sixty-three eyes of 38 POAG patients were studied for at least 2 years and with at least 3 optical coherence tomography (OCT) examinations. Only those hemifields with mild to moderate functional damage at baseline (106 hemifields) were included in the analysis. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure), baseline mean deviation (MD ...

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    6. ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      ADVANCED OCT ANALYSIS OF BIOPSY PROVEN VITREORETINAL LYMPHOMA: OCT findings in vitreo-retinal lymphoma

      Importance: Although the diagnosis of vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. Objective: To analyze the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters. Design: Retrospective cross-sectional study SETTING: Multicenter chart review from 13 retina, uveitis and ocular oncology clinics worldwide over an 11-year period (2008-2019). Participants: Patients with a diagnosis of biopsy-proven VRL imaged with OCT at presentation EXPOSURE: The ocular information, systemic information and multimodal retinal imaging findings were collected and studied. Main outcome measure: Characteristics of VRL on OCT RESULTS ...

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    7. Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Deep learning image analysis of optical coherence tomography angiography measured vessel density improves classification of healthy and glaucoma eyes

      Purpose : To compare convolutional neural network (CNN) analysis of en face vessel density images to gradient boosting classifier (GBC) analysis of instrument provided, feature-based optical coherence tomography angiography (OCTA) vessel density measurements and OCT RNFL thickness measurements for classifying healthy and glaucomatous eyes. Design : Comparison of diagnostic approaches Methods : 130 eyes of 80 healthy individuals and 275 eyes of 185 glaucoma patients with optic nerve head (ONH) OCTA and OCT imaging were included. Classification performance of a VGG16 CNN trained and tested on entire en face 4.5 mm x 4.5 mm radial peripapillary capillary OCTA ONH images was ...

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      Mentions: UCSD
    8. Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography

      Purpose To assess the clinical utility of swept-source optical coherence tomography angiography (SS-OCTA) in detecting optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) eyes. Design Cross sectional study. Methods One hundred and ninety-seven eyes of 197 POAG patients with acceptable-quality SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA, USA) images were enrolled. A whole-signal-mode 6.0 × 6.0-mm optic disc cube was obtained with projection artifact removal. Three groups were categorized: no MvD-D (Group 1), MvD-D (Group 2, complete loss of microvasculature within the optic disc), and indiscernible MvD-D (Group 3, poor visualization of the anterior lamina ...

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    9. OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

      OCT Anatomic and Temporal Biomarkers in Uveitic Macular Edema

      Purpose To assess the relationship between best corrected visual acuity (BCVA) and central subfield optical coherence tomography (OCT) features in noninfectious uveitis (NIU)-related macular edema (ME). Design Clinical cohort study from post hoc analysis of two phase 3 clinical trials’ data. Methods Correlation and longitudinal treatment analyses were performed. Of 198 patients with NIU, 134 received suprachoroidally administered CLS-TA (Clearside Biomedical, Inc. proprietary formulation of a triamcinolone acetonide injectable suspension) and 64 received sham, with 12.9% and 72% respectively receiving rescue therapy. Results At baseline, mean BCVA progressively worsened with each ordinal drop in ellipsoid zone (EZ) integrity ...

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    10. Longitudinal Assessment of Ellipsoid Zone Recovery using En Face Optical Coherence Tomography after Retinal Detachment Repair

      Longitudinal Assessment of Ellipsoid Zone Recovery using En Face Optical Coherence Tomography after Retinal Detachment Repair

      Purpose Suboptimal functional outcomes following rhegmatogenous retinal detachment (RRD) repair may be related to photoreceptor abnormalities including alterations of the ellipsoid zone (EZ) which may not be apparent on cross-sectional optical coherence tomography (OCT). This study assessed EZ recovery using en face OCT following RRD repair and its association with visual acuity. Design Post hoc analysis of a randomized controlled trial. Methods Patients with macula-off RRD were followed at 3, 6, 12 and 24 months post-operatively and annually thereafter. En face OCT of the EZ slab were analyzed. Hyporeflective areas were co-localized with EZ abnormalities on cross-sectional OCT B-Scans and ...

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      Mentions: UCLA
    11. Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      Comment on Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography

      We read with interest the manuscript by Bansal and associates 1 regarding optical coherence tomography (OCT) to assess retinal reattachment following successful pneumatic retinopexy (PnR). The authors propose that retinal reattachment occurs through 5 specific stages: approach of the neurosensory retina towards the retinal pigment epithelium (RPE, stage 1), improvement of outer retinal corrugations (stage 2), contact of the neurosensory retina to the RPE (stage 3), deturgescence of the photoreceptors (stage 4) and recovery of photoreceptor integrity (stage 5). An incomplete resolution of outer retinal corrugations before retinal reattachment may lead, according to the authors, to the formation of outer ...

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    12. Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Identification of Sex and Age from Macular Optical Coherence Tomography and Feature Analysis Using Deep Learning

      Purpose To develop deep learning models for identification of sex and age from macular optical coherence tomography (OCT), and to analyze the features for differentiation of sex and age. Design Algorithm development using database of macular OCT. Setting One eye center in Taiwan. Study Population 6147 sets of macular optical coherence tomography (OCT) images from the healthy eyes of 3134 persons. Main Outcome Measures Deep learning based algorithms were used to develop models for identification of sex and age, and 10-fold cross-validation was applied. Gradient-weighted class activation mapping (Grad-CAM) was used for feature analysis. Results The accuracy for sex prediction ...

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    13. Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Choriocapillaris Flow Deficits in Normal Chinese Imaged by Swept-Source Optical Coherence Tomographic Angiography

      Purpose To evaluate the ocular and systemic determinants of the choriocapillaris flow deficits percentage (CC FD%) in normal eyes. Design Observational cross-sectional study. Methods Healthy Chinese participants without ocular or systemic diseases underwent detailed ophthalmic evaluations, including swept-source optical coherence tomography angiography (SS-OCTA) with 6 × 6 mm macular choriocapillaris images. The CC FD% was assessed in circular regions with diameters of 1.0 and 5.0 mm, rings with 1.0–2.5-mm and 2.5–5.0-mm diameters. Results The study included 830 individuals (mean age: 58.66±8.75 years). CC FD% (mean: 22.05%±1.13%) was ...

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    14. Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      We observed that retinal reattachment mediated by the retinal pigment epithelium (RPE) occurs in 5 specific stages and 20% of patients had delayed progression through Stage 2, characterized by outer retinal folds (ORFs). 1 dell'Omo et al hypothesized that “persisting undulations play a role in the formation of pockets of subretinal fluid, later evolving into ORFs” 2 . We demonstrated how improvement of outer retinal corrugations (ORCs) occurs during the slow and natural reattachment process mediated by the RPE in Stage 2 and how if parts of the retina remain in Stage 2 without sufficient improvement of ORCs while adjacent ...

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    15. Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Purpose To investigate the occurrence and risk factors of clinically significant intraocular lens (IOL) decentration and tilt in highly myopic eyes using swept-source anterior segment optical coherence tomography (SS-AS-OCT). Design Cross-sectional study. Methods This study included 334 participants (334 eyes) with high myopia (axial length (AL) ≥26 mm) who underwent phacoemulsification with IOL implantation. Decentration and tilt of IOL were assessed by SS-AS-OCT. Clinically significant IOL decentration and tilt was defined as decentration ≥ 0.4mm and tilt ≥7°. Routine pre- and post-operative examinations were performed, including visual acuity, refraction, biometric measurement using IOL master700, and objective visual quality evaluated by ...

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    16. Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Purpose This is the first study that evaluates the prevalence of retinal thinning and the correlation with papilledema and visual acuity (VA) in a large craniosynostosis population. Design Prospective clinical cohort study Methods All syndromic and complex craniosynostosis patients who visited the only national referral center between 2018-2020 were included. Retinal layers were segmented using optical coherence tomography (OCT). Patients were seen by an ophthalmologist for VA assessment and fundoscopy. Multivariate regression models were developed to evaluate correlations between retinal thickness, papilledema and VA. Results 127 patients were included. Retinal thinning was most prevalent in the peripapillary retinal nerve fiber ...

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    17. Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography

      Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography

      Purpose To compare anterior segment and angle parameters between pseudoexfoliation syndrome(PEX) and pseudoexfoliation glaucoma (PEXG) and normal control subjects by using anterior segment optical coherence tomography (AS-OCT) imaging. Design cross- sectional study Methods One hundred and two subjects with PEXG, PEX and normal eyes as the control group were recruited from academic referral institution. All subjects underwent complete ophthamologic examination, axial length measurement, AS-OCT imaging (CASIA SS-1000, Tomey). The anterior segment and angle parameters were evaluated. Results After excluding 4 eyes due to poor imaging of scleral spur, data from 34 eyes with pseudoexfoliation glaucoma (PEXG), 33 eyes with ...

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    18. Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Purpose : To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). Design : Prospective case series Methods : Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD ...

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    19. Ocular Biometric Characteristics Measured by Swept-Source Optical Coherence Tomography in Individuals Undergoing Cataract Surgery

      Ocular Biometric Characteristics Measured by Swept-Source Optical Coherence Tomography in Individuals Undergoing Cataract Surgery

      Purpose To study the distribution of ocular biometric parameters utilizing a swept-source optical coherence tomography (SS-OCT) biometer in adult candidates for cataract surgery. Design A retrospective cross-sectional study. Methods: Setting A single-center analysis of consecutive eyes measured with the IOLMaster 700 SS-OCT biometer at a large tertiary medical center between February 2018 and June 2020. Results 3836 eyes of 3836 patients were included in the study. The mean age was 72.3±12.8 years and 53% were females. The mean biometric values were: total corneal power (44.17±1.70D), total corneal astigmatism (TCA) (1.11±0.87D), mean ...

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    20. Evaluation of the diagnostic performance of swept-source anterior segment optical coherence tomography in primary angle closure disease

      Evaluation of the diagnostic performance of swept-source anterior segment optical coherence tomography in primary angle closure disease

      Purpose To evaluate the diagnostic performance of swept-source anterior segment optical coherence tomography (SS-OCT) in differentiating primary angle closure diseases (PACD) from control eyes, as well as primary angle closure (PAC) and primary angle closure glaucoma (PACG) from primary angle closure suspect (PACS) eyes. Design Multi-center cross-sectional study. Methods Chinese patients were classified into control, PACS and PAC/PACG groups. Area under the receiving operating characteristics curve (AUC) from logistic regression models was used to evaluate discriminating ability. Sensitivity and specificity were calculated and performance of the models was validated using an independent dataset. Results A total of 2,928 ...

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    21. Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV. Design: Prospective cross-sectional study. Methods: Consecutive CSC patients were recruited from retina clinic. The reference standard for CNV was determined by interpretation of multimodal imaging with OCTA, structural OCT line scan, fluorescein angiography (FA), indocyanine green angiography (ICGA), ultra-widefield fundus photography and fundus autofluorescence (FAF). Two independent masked graders examined OCTA without FA and ICGA to diagnose CNV. Univariate and multivariate analyses were performed to evaluate factors associated with CNV. Results ...

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    22. Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Purpose Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes. Methods Design : Longitudinal cohort study. Setting : Tertiary glaucoma clinic. Patients : 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Observation Procedures : Macular volume scans from 2 OCT devices were exported, co-registered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0 mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the ...

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    23. Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Purpose To compare dynamic ranges and steps to measurement floors of peripapillary and macular metrics from a complex signal-based optical microangiography (OMAG C ) optical coherence tomography angiography (OCTA) device for glaucoma with those of OCT measurements. Design Cross-sectional study. Methods Imaging of 252 eyes from 173 glaucoma subjects and 123 eyes from 92 non-glaucoma subjects from a glaucoma clinic was quantified using custom and commercial software. Metrics from OCT (retinal nerve fiber layer [RNFL], ganglion cell-inner plexiform layer [GCIPL]) and OCTA (custom: peripapillary vessel area density [pVAD], macular vessel area density [mVAD], macular vessel skeleton density [mVSD]; commercial: peripapillary perfusion ...

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    24. Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Purpose To assess the effect of changing anterior eye refractive power with contact lenses on the transverse magnification of enface images and associated vascular indices from optical coherence tomography angiography (OCT-A). Design Prospective cross-over study. Methods Spherical soft contact lenses (-6D to +6D in 2D steps) were used to induce anterior eye refractive power changes in 11 healthy young adults and 3 × 3mm macular scans were captured using OCT-A (Zeiss AngioPlex, software version 11.0; Cirrus HD-OCT 5000, Carl Zeiss Meditec Inc.). Image transverse magnification was predicted based on refraction and biometry measurements and compared with empirical changes in the ...

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