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    1. Diagnostic Capability of Peripapillary 3D Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans

      Diagnostic Capability of Peripapillary 3D Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans

      Purpose To determine the diagnostic capability of peripapillary 3-dimensional (3D) retinal nerve fiber layer (RNFL) volume measurements from spectral domain optical coherence tomography (OCT) volume scans for open angle glaucoma (OAG). Design Assessment of diagnostic accuracy. Methods Setting: Academic clinical setting. Study population : 180 patients (113 OAG and 67 normal subjects). Observation procedures : One eye per subject was included. Peripapillary 3D RNFL volumes were calculated for global, quadrant, and sector regions, using four different sized annuli. Peripapillary 2D RNFL thickness circle scans were also obtained. Main outcome measures : Area under the receiver operating characteristic curve (AUROC) values, sensitivity, specificity, positive ...

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    2. En Face Optical Coherence Tomography Analysis to Assess the Spectrum of Perivenular Ischemia and Paracentral Acute Middle Maculopathy in Retinal Vein Occlusion

      En Face Optical Coherence Tomography Analysis to Assess the Spectrum of Perivenular Ischemia and Paracentral Acute Middle Maculopathy in Retinal Vein Occlusion

      Using en face optical coherence tomography (OCT), Falavarjani and associates recently illustrated the variability in the area of macular middle-retinal infarction (MMRI) exhibited in eyes with subtotal central retinal venous or arterial occlusion (CRVO or CRAO).1 The severity spectrum from narrow perivenular MMRI to diffuse MMRI with periarteriolar sparing was thought to reflect the extent of circulatory failure during infarct evolution. This chimes with funduscopic observations going back 40 years.

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    3. Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma

      Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma

      Purpose To measure the change of peripapillary retinal vessel density (VD) in eyes with a history of acute primary angle closure glaucoma (PACG). Design Case-control study. Methods Twenty-one consecutive Chinese patients with history of unilateral acute PACG were enrolled. Eyes with acute PACG constituted the case group, while the contralateral eyes without attack constituted the control. All patients underwent ophthalmic examinations including best-corrected visual acuity, intraocular pressure, and visual field (VF). Spectral-domain optical coherence tomography (SD-OCT) was used to obtain both structural OCT and OCT angiography (OCTA). Structural OCT scans provided thickness measurements of the peripapillary retinal nerve fiber layer ...

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    4. Combined Hamartoma of the Retina and Retinal Pigment Epithelium: An Optical Coherence Tomography-Based Reappraisal

      Combined Hamartoma of the Retina and Retinal Pigment Epithelium: An Optical Coherence Tomography-Based Reappraisal

      Purpose To analyze the optical coherence tomography (OCT) characteristics of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) involving the macula. Design Retrospective, observational case series. Methods Setting: Single institutional. Study population: Fourteen consecutive patients of CHRRPE were included. Observation procedures: The authors analyzed the clinical features, color fundus photography, and swept source or spectral domain OCT of all the involved eyes. Main outcome measures: OCT characteristics, especially the involvement of the retinal pigment epithelium (RPE). Results Total 16 eyes of 5 female and 9 male patients were analyzed. The mean age (±SD) was 17.9 ± 6.4 ...

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    5. Optical Coherence Tomography-Angiography of Macular Features after Proton Beam Radiotherapy for Small Choroidal Melanoma

      Optical Coherence Tomography-Angiography of Macular Features after Proton Beam Radiotherapy for Small Choroidal Melanoma

      Purpose To describe the macular features of patients treated with proton beam therapy for choroidal melanoma (CM), using the optical coherence tomography-angiography (OCTA). Design Retrospective case-control study. Methods This study included patients treated with proton beam radiotherapy (PBR) for a small CM. Only patients that had received 100% of the dose 60 GyEBR to the macular area were included in the analysis. All the patients have undergone a full ophthalmological examination including: visual acuity, OCT B-scan and OCTA. Qualitative and quantitative vascular features of the retinal plexus and the choriocapillaris were analyzed on OCTA and compared to healthy subjects matched ...

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    6. Choroidal Changes Associated with Subretinal Drusenoid Deposits in Age-related Macular Degeneration using Swept-source OCT

      Choroidal Changes Associated with Subretinal Drusenoid Deposits in Age-related Macular Degeneration using Swept-source OCT

      Purpose To compare choroidal vascular features of eyes with and without subretinal drusenoid deposits (SDD), using swept-source optical coherence tomography (SS-OCT). Design Multicenter, cross-sectional study. Methods We prospectively recruited patients with intermediate age-related macular degeneration (AMD), without other vitreoretinal pathology. All participants underwent complete ophthalmic exam, color fundus photography (used for AMD staging), and spectral-domain OCT (to evaluate the presence of SDD). SS-OCT was used to obtain automatic macular choroidal thickness (CT) maps, according to the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. For data analysis, we considered mean choroidal thickness as the arithmetic mean value of the 9 ETDRS ...

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    7. Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy

      Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy

      Purpose To quantify retinal structure and progression using spectral-domain optical coherence tomography (SDOCT) in patients with retinitis pigmentosa (RP) associated with retinitis pigmentosa GTPase regulator gene ( RPGR ) mutations. Design Retrospective observational case series. Methods Setting : Moorfields Eye Hospital, London, United Kingdom. Subjects : Both eyes of 32 patients. SDOCT follow-up period of >1 year (3.1 ± 1.4 years). Main Outcome Measures : Ellipsoid zone (EZ) width (EZW) and outer nuclear layer (ONL) and inner retinal layer (IRL) thickness measurements. Progression rates, interocular symmetry, and association with age and genotype were investigated. Results Significant differences were observed between baseline and final measurements ...

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      Mentions: Joseph Carroll
    8. Pseudophakic Macular Edema in Primary Open-Angle Glaucoma: a Prospective Study Using Spectral-Domain Optical Coherence Tomography

      Pseudophakic Macular Edema in Primary Open-Angle Glaucoma: a Prospective Study Using Spectral-Domain Optical Coherence Tomography

      Purpose To determine the incidence of and risk factors for pseudophakic macular edema (PME) after uncomplicated cataract surgery in primary open-angle glaucoma (POAG) using spectral-domain optical coherence tomography (SD-OCT). Design Cohort study Methods Macular retinal thickness was evaluated using SD-OCT at 1-week before surgery and at 1-, 3-, 6-, and 12-months postoperatively, in 70 POAG and 68 control eyes. Forty-three healthy subjects without impaired vision or cystoid PME were recruited separately as pilot samples to define significant PME. Significant PME was defined as an increase in the average thickness exceeding the mean+three standard deviations of the increase shown in ...

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    9. Relationship between internal reflectivity of diabetic microaneurysms on SD-OCT and detection on OCT Angiography

      Relationship between internal reflectivity of diabetic microaneurysms on SD-OCT and detection on OCT Angiography

      Purpose To correlate the appearance of Microaneurysms (MAs) on structural spectral-domain optical coherence tomography (SD-OCT) with their detection on OCT angiography (OCTA) in patients with non-proliferative diabetic retinopathy (NPDR). Design Inter-instrument reliability study. Methods Sixteen patients with NPDR without macular edema underwent SD-OCT and OCTA. To compare MAs seen on OCTA to those on SD-OCT, we superimposed the OCTA superficial capillary plexus (SCP) vascular landmarks onto those of the near infrared. Two observers blinded to patient groupings evaluated reflectivity of MAs on SD-OCT scans, graded as hypo-, moderate, or hyper-reflective, and their visualization at the level of SCP and deep ...

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    10. Comparison of Axial Length, Corneal Curvature, and Anterior Chamber Depth Measurements of 2 Recently Introduced Devices to a Known Biometer

      Comparison of Axial Length, Corneal Curvature, and Anterior Chamber Depth Measurements of 2 Recently Introduced Devices to a Known Biometer

      Purpose Evaluate agreement and repeatability of axial length (AL), corneal curvature, and anterior chamber depth measurements of 2 new devices, 1 using Scheimpflug technology combined with partial coherence interferometry (Pentacam AXL) and 1 using swept-source optical coherence tomography (IOL Master 700) to a widely used optical biometer (IOL Master 500). Design Prospective, instrument reliability analysis. Methods This study was conducted in the Department of Ophthalmology at Goethe-University, Frankfurt, Germany. Seventy-nine eyes in 79 patients were measured with the IOL Master 500, the IOL Master 700, and with the Pentacam AXL. All eyes were measured twice with each device. The results ...

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    11. Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Characteristics of Peripapillary Staphylomas Associated with High Myopia Determined by Swept-source Optical Coherence Tomography

      Purpose To analyze the morphological features of peripapillary staphylomas associated with high myopia by swept-source optical coherence tomography (OCT). Design Validity analysis. Methods Highly myopic patients (refractive error >8.0 diopters or axial length >26.5 mm) with a peripapillary staphyloma who had undergone swept-source OCT were studied. The non-highly myopic fellow eyes in patients with unilateral high myopia were also studied. The presence of a peripapillary staphyloma was determined by stereoscopic ophthalmoscopic examinations. The OCT features of the peripapillary staphylomas and other peripapillary lesions were evaluated. Results Twenty-five eyes of 16 patients were studied. Twenty-two eyes were highly myopic ...

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    12. Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography

      Determination and Validation of Thresholds of Anterior Chamber Parameters by Dedicated Anterior Segment Optical Coherence Tomography

      Purpose To determine and validate thresholds of anterior chamber angle (ACA) parameters in discriminating open versus narrow angle eyes using images from dedicated anterior segment optical coherence tomography (DASOCT). Design Reliability analysis Methods Eyes imaged by DASOCT and examined with gonioscopy were reviewed. By gonioscopy, eyes were classified as narrow if posterior trabecular meshwork was not visible and open if the angle was open to scleral spur and beyond. Imaging was performed in the dark with the CASIA SS-1000 (Tomey, Nagoya, Japan). ACA parameters angle opening distance (AOD), trabecular-iris space area (TISA), trabecular-iris circumference volume (TICV), length of irido-trabecular contact ...

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    13. Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Purpose The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts which might help to distinguish SHRM subtypes. Design Validity analysis. Methods Patients with age-related macular degeneration (AMD), myopia, pachychoroid disease and macular dystrophy, manifesting SHRM on optical coherence tomography (OCT), were recruited. Clinical chart review and multimodal imaging established ...

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    14. Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis with Active Lesions

      Spectral-Domain Optical Coherence Tomography Angiography Findings in Multifocal Choroiditis with Active Lesions

      Purpose To describe optical coherence tomography angiography (OCTA) findings in multifocal choroiditis (MFC) with active lesions and to characterize the concordance between the OCTA and other traditional imaging modalities. Design Reliability and validity analysis. Methods Patients with suspected choroidal neovascularization (CNV) or acute inflammatory lesions associated with MFC were assessed in this study. All participants underwent preliminary traditional multimodal imaging including color fundus photography, fundus autofluorescence, near-infrared reflectance imaging, spectral-domain optical coherence tomography, and fluorescence angiography (FA). The participants were prospectively recruited to perform OCTA. OCTA findings of active lesions were compared with other traditional imaging results. Vascular flow signal ...

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    15. Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Diagnostic performance of a novel 3D neuroretinal rim parameter for glaucoma using high-density volume scans

      Purpose To describe optical coherence tomography angiography (OCTA) findings in multifocal choroiditis (MFC) with active lesions and to characterize the concordance between the OCTA and other traditional imaging modalities. Design Reliability and validity analysis. Methods Patients with suspected choroidal neovascularization (CNV) or acute inflammatory lesions associated with MFC were assessed in this study. All participants underwent preliminary traditional multimodal imaging including color fundus photography, fundus autofluorescence, near-infrared reflectance imaging, spectral-domain optical coherence tomography, and fluorescence angiography (FA). The participants were prospectively recruited to perform OCTA. OCTA findings of active lesions were compared with other traditional imaging results. Vascular flow signal ...

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    16. Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries

      Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries

      Purpose To assess the reliability of manual choroidal thickness measurements by comparing different posterior boundary definitions of the choroidal-scleral junction on enhanced depth imaging optical coherence tomography (EDI-OCT). Design Reliability analysis Methods Two graders marked the choroidal-scleral junction with segmentation software using different posterior boundaries: 1) the outer border of the choroidal vessel lumen, 2) the outer border of the choroid stroma, and 3) the inner border of the sclera, to measure the vascular choroidal thickness (VCT), stromal choroidal thickness (SCT), and total choroidal thickness (TCT), respectively. Measurements were taken at 0.5 mm intervals from 1.5 mm nasal ...

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    17. Microvascular Density in Glaucomatous Eyes with Hemifield Visual Field Defects: An Optical Coherence Tomography Angiography Study

      Microvascular Density in Glaucomatous Eyes with Hemifield Visual Field Defects: An Optical Coherence Tomography Angiography Study

      Purpose To investigate microcirculation of peripapillary retina and optic disc in eyes with primary open-angle glaucoma (POAG) and hemifield visual field (VF) defects. Design Prospective observational case series with normal comparison group. Methods Sixty eyes with POAG (41 with superior and 19 with inferior hemifield VF defects) and 21 normal eyes were included in this study. Optical coherence tomography (OCT) angiography was used to acquire 3 × 3 mm optic disc cubes, and circumpapillary retinal nerve fiber layer thickness was also measured using OCT. Vessel densities in the peripapillary superficial retina and whole-signal mode optic disc were individually analyzed based on ...

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    18. Automated Quantitative Analysis of Retinal Microvasculature In Normal Eyes On Optical Coherence Tomography Angiography

      Automated Quantitative Analysis of Retinal Microvasculature In Normal Eyes On Optical Coherence Tomography Angiography

      Purpose To describe a new automated quantitative technique for displaying and analyzing macular vascular perfusion using optical coherence tomography angiography (OCT-A) and to determine a normative data set, which might be used as reference in identifying progressive changes due to different retinal vascular diseases. Design Reliability study. Methods A retrospective review of forty-seven eyes of 47 consecutive healthy subjects imaged with a spectral domain OCT-A device was performed in a single institution. Full-spectrum amplitude-decorrelation angiography generated OCT-angiograms of the retinal superficial and deep capillary plexuses. A fully-automated custom built software was used to provide quantitative data on the foveal avascular ...

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    19. Choroidal and Retinal Thickness in Children with Different Refractive Status Measured by Swept-Source Optical Coherence Tomography

      Choroidal and Retinal Thickness in Children with Different Refractive Status Measured by Swept-Source Optical Coherence Tomography

      Purpose To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography. Design Cross-sectional study. Methods Two-hundred-and-seventy-six school children aged 7−13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed. Results Compared to emmetropes, myopes had a significantly thinner choroid in all regions (p < 0.01), and ...

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    20. Vascular Density in Retina and Choriocapillaris As Measured by Optical Coherence Tomography Angiography

      Vascular Density in Retina and Choriocapillaris As Measured by Optical Coherence Tomography Angiography

      Purpose To measure the density of the superficial retinal small vessel network (SRSVN), superficial retinal capillary network (SRCN), deep retinal capillary network (DRCN) and choriocapillaris, and the size of the foveal avascular zone (FAZ) in the superficial retinal layer in normal eyes. Design Prospective observational cross-sectional study. Methods In healthy Chinese volunteers, the retinal and choroidal vasculature was visualized by split-spectrum amplitude decorrelation angiography associated optical coherence tomography (RTVueXR Avanti device; Optovue Inc., Fremont, CA, USA). Results Among 105 healthy participants (age:35.9±13.8 years) mean FAZ measured 0.35±0.12mm 2 , and mean density of SRSVN ...

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    21. Microarchitecture of the Vitreous Body: A High-Resolution Optical Coherence Tomography Study

      Microarchitecture of the Vitreous Body: A High-Resolution Optical Coherence Tomography Study

      Purpose To report novel vitreous body microarchitecture findings using high-resolution spectral-domain OCT (HR-SD-OCT). Design Prospective, cross-sectional study. Methods Horizontal and vertical retinal cross-sectional images that were 10 mm long were acquired from 17 eyes of 17 young healthy volunteers using HR-SD-OCT with enhanced vitreous imaging (EVI). Images were acquired through the fovea, upper vessel arcade, and lower vessel arcade. Results Three new findings on vitreous body microarchitecture were found. First, material located between the retina and posterior vitreous cortex was easily detected in 90% of upper and lower vessel arcade scans. Most scans contained hyper-reflective dots and multilayered hyper-reflective lines ...

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    22. Macular telangiectasia type 1: capillary density and microvascular abnormalities assessed by optical coherence tomography angiography

      Macular telangiectasia type 1: capillary density and microvascular abnormalities assessed by optical coherence tomography angiography

      Purpose To describe microvascular abnormalities and capillary density in macular telangiectasia type 1 (MT1) using optical coherence tomography angiography (OCTA), and correlate them with fluorescein angiography (FA). Design; Observational case series. Methods Seven patients with MT1 and 12 age-matched controls were included. Focal microvascular dilations were identified on 3×3-mm OCTA and early-frame FA images. OCTA images were processed to determine the global capillary density after subtraction of larger vessels and cystoid edema cavities. Local capillary densities were calculated inside 100-μm circles around telangiectasias, projected over superficial (SCP) and deep capillary plexuses (DCP). They were compared to a random ...

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    23. Central Corneal Thickness after Cross-linking Using High Definition Optical Coherence Tomography, Ultrasound, Dual Scheimpflug Tomography: A Comparative Study Over One Year

      Central Corneal Thickness after Cross-linking Using High Definition Optical Coherence Tomography, Ultrasound, Dual Scheimpflug Tomography: A Comparative Study Over One Year

      Purpose To assess central corneal thickness (CCT) and corneal haze in keratoconus eyes following corneal cross-linking (CXL). Design Prospective non-comparative case series. Methods Forty patients (44 eyes) with keratoconus that had serial evaluation for CCT, following CXL, using high definition optical coherence tomography (HD-OCT), ultrasound pachymetry (USP), and dual Scheimpflug tomography. CCT was measured at baseline, then at 2 weeks, 1, 3, 6, and 12 months postoperatively. Results The mean baseline CCT measurements were 470.02 μm, 469.79 μm and 466.66 μm using the HD-OCT, the USP, and dual Scheimpflug tomography respectively (P=0.91). Following CXL, the ...

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