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    1. Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics

      Peripapillary versus macular combined hamartoma of the retina and retinal pigment epithelium: Imaging characteristics

      Purpose To compare clinical, optical coherence tomography (OCT), and fundus autofluorescence (FAF) characteristics of peripapillary versus (vs.) macular variants of combined hamartoma of the retina and retinal pigment epithelium (combined hamartoma). Design Retrospective observational, comparative case series Methods:Setting Multicentre collaborative study Study Population 50 eyes with a clinical diagnosis of combined hamartoma Observational Analysis A comparative analysis of color fundus photographs (CFPs), OCT and FAF was performed for peripapillary and macular variants of combined hamartoma. Main Outcome Measures Pigmentation and OCT features of macular and peripapillary combined hamartoma Results The review of imaging from 50 eyes of 49 patients ...

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    2. A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss from Optic Disc Photographs

      A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss from Optic Disc Photographs

      Purpose To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch’s membrane opening (BMO-MRW) from spectral domain-optical coherence tomography (SDOCT). Design Cross-sectional study Methods 9,282 pairs of optic disc photographs and SDOCT optic nerve head scans from 927 eyes of 490 subjects were randomly divided into the validation plus training (80%) and test sets (20%). A DL convolutional neural network was trained to predict the SDOCT BMO-MRW global and sector values when evaluating optic disc photographs. The predictions of the DL network were compared to ...

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    3. Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

      Earliest Evidence of Preclinical Diabetic Retinopathy Revealed using OCT Angiography (OCTA) Perfused Capillary Density

      Purpose To compare perfused capillary density (PCD) in diabetic patients and healthy controls using optical coherence tomography angiography (OCTA). Methods Forty controls, 36 diabetics without clinical retinopathy (NoDR), 38 with nonproliferative retinopathy (NPDR), and 38 with proliferative retinopathy (PDR) were imaged using SD-OCT. A 3x3 mm full-thickness parafoveal OCTA scan was obtained from each participant. Following manual delineation of the foveal avascular zone (FAZ), FAZ area, perimeter, and acircularity index were determined. Seven consecutive equidistant 200-μm-wide annular segments were drawn at increasing eccentricities from the FAZ margin. Annular PCD (%) was defined as perfused capillary area divided by the corresponding ...

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    4. Macular colobomata: Comparison of clinical and optical coherence tomography features with serological results

      Macular colobomata: Comparison of clinical and optical coherence tomography features with serological results

      Purpose To assess the correlation between the morphological features and serology in eyes with macular colobomata (MC). Design Retrospective comparative case series Methods Setting: Institutional Study population Patients presenting with MC to the retina clinic over a period of two years (January 2016 to December 2017) Interventional/Observational procedure: Color fundus and swept source optical coherence tomography (SS-OCT, Topcon Inc.) features were reviewed and assessed in three groups based on the serum IgG results: positive for Toxoplasma, positive for Cytomegalovirus (CMV), and serology negative. Main outcome measure Morphological features on clinical and OCT-based examination Results A total of 49 eyes ...

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    5. Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography

      Age-Dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source OCT Angiography

      Purpose Swept source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. Design A prospective, cross-sectional study. Methods Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX ® Elite 9000, Carl Zeiss Meditec). Both 3x3 mm and 6x6 mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1 mm circle (C 1 ), 1 ...

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    6. Looking Back: Fluorescein Angiography And Optical Coherence Tomography And The First Century Of The American Journal Of Ophthalmology

      Looking Back: Fluorescein Angiography And Optical Coherence Tomography And The First Century Of The American Journal Of Ophthalmology

      This perspective follows an earlier article by Feibel (1) which reviewed the development of ophthalmic photography as seen in the first one hundred years of the American Journal of Ophthalmology (hereafter: the Journal). Here I will review fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) as presented to the readers of the Journal over the last one hundred years. As in Feibel’s review no effort has been made to analyze every article nor is there any claim to this being a complete history of FFA and OCT.

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    7. Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization

      Advanced Optical Coherence Tomography Angiography Analysis of Age-related Macular Degeneration Complicated by Onset of Unilateral Choroidal Neovascularization

      I read the article by Arrigo and associates 1 on optical coherence tomography angiography (OCTA) analysis of retinal vasculature in cases of unilateral choroidal neovascularization (CNV) using quantitative analytical techniques with great interest. However, I have few concerns.

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    8. Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Vitrectomy for diabetic macular edema: optical coherence tomography criteria and pathology of the vitreomacular interface

      Purpose To correlate spectral-domain optical coherence tomography (SD-OCT) criteria and clinical data with pathology of the vitreomacular interface (VMI) in eyes with diabetic macular edema (DME). Design Retrospective cross-sectional study and laboratory investigation. Methods We included specimens of 27 eyes of 26 patients with center-involved DME that underwent vitrectomy with peeling of the internal limiting membrane (ILM). Selection of specimens was consecutive and in retrospect using our register of the Vitreoretinal Pathology Unit. Clinical data and SD-OCT examinations were correlated to immunocytochemistry and transmission electron microscopy. Classification of DME comprised sponge-like diffuse retinal thickening, cystoid macular edema, and serous retinal ...

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    9. Automated Detection of the Stromal Demarcation Line using Optical Coherence Tomography in Keratoconus Eyes after Corneal Crosslinking

      Automated Detection of the Stromal Demarcation Line using Optical Coherence Tomography in Keratoconus Eyes after Corneal Crosslinking

      Purpose To evaluate the role of a novel automated detection software as compared to human operators in assessing the presence and depth of stromal demarcation line on optical coherence tomography (OCT) in keratoconus eyes post cross-linking Design: This was a reliability analysis study. Methods Two independent operators and an automated detection software examined corneal OCTs of 25 eyes of 25 patients post corneal cross-linking using the Dresden protocol, at 3 months postoperatively. Operators evaluated the presence of the demarcation line and measured its depth by looking at OCT images (128 cuts) on two separate occasions one week apart. The automated ...

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    10. Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study

      Objective To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. Design Retrospective, cross-sectional study. Methods A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2). Macular 3 × 3 mm angiography was acquired using the Zeiss Cirrus 5000 OCT instrument. Vessel density (VD), perfusion density (PD), and foveal avascular zone ...

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    11. Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Assessment of Circumferential Angle Closure with Swept-Source Optical Coherence Tomography: a community based study

      Purpose To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting. Design Reliability analysis. Methods A total of 2027 phakic subjects aged ≥50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Gonioscopy was performed by a single trained ophthalmologist. SS-OCT angle scans, which obtain radial scans for the entire circumference of the angle, were analyzed by a single examiner, masked to the subject’s ...

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    12. En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      En Face Optical Coherence Tomography Imaging of the Photoreceptor Layers in Hydroxychloroquine Retinopathy

      Objective To investigate the application of en face optical coherence tomography (OCT) imaging in eyes with hydroxychloroquine (HCQ) retinopathy. Design Retrospective case series Methods: Setting Institutional Patient Population Sixty-two eyes of 31 Asian patients with HCQ retinopathy. Observation Procedures Macular volume scanning using swept-source OCT was performed in 6 × 6 and 9 × 9 mm areas centered on the fovea. Segmentation of the photoreceptor layers was automatically performed between the inner border of the ellipsoid zone and that of the retinal pigment epithelium-Bruch’s membrane complex to obtain en face OCT images. Findings from the en face images were qualitatively and ...

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    13. Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Purpose To assess glaucoma specialists’ detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative to the axis between Bruch’s membrane opening (BMO) centroid and the fovea. For each clinician, the distance from BMO centroid to their DM (DM radius) and RM (RM radius ...

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    14. Incorporating Optical Coherence Tomography in the Cataract Preoperative Armamentarium: Additional Need or Additional Burden?

      Incorporating Optical Coherence Tomography in the Cataract Preoperative Armamentarium: Additional Need or Additional Burden?

      Purpose To determine the usefulness of preoperative OCT examination to detect asymptomatic macular abnormalities in patients scheduled for cataract surgery Methods Design : Prospective, interventional case series Setting : Iladevi Cataract and Visakha Eye Center, Ahmedabad, India Study Population : Patients undergoing cataract surgery and intraocular lens(IOL) implantation for senile cataracts. Preoperatively no retinal/macular pathology was identified on clinical evaluation. Intervention All eyes underwent Macular 5-Line Raster evaluation using Spectral Domain OCT before and after cataract surgery(monthly for 3 months). Central Subfield Thickness(CST) analysis was done. Outcome Measures The primary outcome measure was determining the incidence of asymptomatic retinal ...

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    15. Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Purpose To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. Design AI diagnostic tool development, evaluation, and comparison Methods Setting: multiple institutional practices. Study population Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes. Training data included OCT-1000/2000 (Topcon) from 94 eyes of 94 early OAG patients (mean deviation: MD >-5.0 dB) and 84 eyes of 84 normal subjects. Testing data included OCT-1000/2000 from 114 eyes of ...

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    16. Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

      Repeatability and Reproducibility of Corneal Epithelial Thickness Mapping with Spectral Domain Optical Coherence Tomography in Normal and Diseased Cornea Eyes

      Purpose To evaluate the performance of the epithelial thickness mapping (ETM) of the iVue spectral domain optical coherence tomography (SD-OCT) (Optovue Inc., Fremont, CA) in normal and diseased cornea eyes. Design Reliability and validity analysis. Methods Sixty eyes of 60 subjects were recruited for the study that included normal subjects (n=12) and patients with corneal diseases (12 each with dry eye syndrome (DES), contact lens (CL) wear, post laser refractive surgery (LRS), and keratoconus (KCN)). Three repeated scans were acquired on 3 iVue SD-OCTs with device-designated operators from consented subjects. Each subject was scanned on each device. Repeatability (based ...

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    17. Iris microhemangiomatosis: Clinical, fluorescein angiography, and optical coherence tomography angiography in 14 consecutive patients

      Iris microhemangiomatosis: Clinical, fluorescein angiography, and optical coherence tomography angiography in 14 consecutive patients

      Purpose To describe the clinical and imaging findings and treatment options in a series of patients with iris microhemangiomatosis. Design: Retrospective observational case series. Methods Setting : Single institution. Study Population : Twenty-two eyes of 14 consecutive patients with iris microhemangiomatosis were reviewed. Observation Procedures : Clinical examination and slit lamp photography were performed on every patient. Anterior segment optical coherence tomography (AS-OCT), anterior segment optical coherence tomography angiography (AS-OCTA), anterior segment intravenous fluorescein angiography (AS-IVFA) and ultrasound biomicroscopy were performed when possible. Main Outcome Measures : Clinical and imaging features and treatment strategies. Results Twenty-two eyes of 14 patients with iris microhemangiomatosis were ...

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    18. Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Conjunctival and Intrascleral Vasculatures Assessed Using Anterior-Segment Optical Coherence Tomography Angiography in Normal Eyes

      Purpose To investigate conjunctival and intrascleral vasculatures using anterior-segment (AS) optical coherence tomography angiography (OCTA) in normal eyes. Design Cross-sectional study. Methods AS-OCTA images of the corneal limbus were acquired circumferentially using a swept-source OCT system in 10 eyes of 10 healthy subjects. AS-OCTA flow patterns with en face maximum projection were compared between the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers. The OCTA images were also compared with fluorescein scleral angiography and indocyanine green aqueous angiography images. Quantitative parameters (vessel density, vessel length ...

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    19. Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Spectral Domain-Optical Coherence Tomography of the Vitreopapillary Interface in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Purpose To use spectral domain-optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NAION). Design Retrospective cohort study. Methods.Setting Single academic center. Patient or study population Eighty eyes in 74 subjects presenting within 2 weeks of symptom onset of NAION. Intervention or observation procedures SD-OCT imaging of the optic nerve head, macula, and peripapillary retinal nerve fiber layer (pRNFL) were reviewed for PVD and vitreopapillary traction (VPT). Main Outcome Measures Prevalence and incidence of PVD and VPT, logMAR best-corrected visual ...

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      Mentions: Duke University
    20. Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Advanced optical coherence tomography angiography analysis of age-related macular degeneration complicated by onset of unilateral choroidal neovascularization.

      Purpose To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. Design Case-control study. Settings Clinical Practice. Study Population Thirty patients and thirty age-matched controls. Observation Procedures Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan). The one-way ANOVA test with Bonferroni correction was used to assess statistical significance and ...

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    21. Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Comparison of anterior segment optical coherence tomography parameters among Vietnamese, Chinese, and Caucasians

      Purpose To evaluate the difference in anterior segment optical coherence tomography (AS-OCT) parameters among ethnic Vietnamese, Chinese, and Caucasians Design Cross-sectional study Methods We prospectively recruited phakic non-glaucomatous participants (based on intraocular pressure <21 mmHg, normal optic nerve head and retinal nerve fiber, and cup-to-disc ratio <0.6) of three ethnic groups— Vietnamese, Chinese, and Caucasians. AS-OCT parameters including angle (angle opening distance, trabecular-iris space area, and angle recess area), iris (iris thickness, iris area, and iris curvature (Icurv)), and anterior chamber parameters (anterior chamber depth, width (ACW), area, and lens vault (LV)) were obtained. A linear regression model with ...

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      Mentions: Shan C. Lin UCSF
    22. OCT-Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

      OCT-Angiography Quantitative Assessment of Choriocapillaris Blood Flow in Central Serous Chorioretinopathy

      Purpose To investigate choriocapillaris (CC) blood flow in unaffected fellow eyes of patients with central serous chorioretinopathy (CSC) using quantitative optical coherence tomography angiography (OCTA) analysis. Design Case-control study. Methods Patients with acute, recurrent or persistent CSC, along with healthy gender- and age-matched subjects were included. Objective assessment of CC blood flow was performed using OCTA measurements. Total area of flow signal voids was quantified at baseline, 3 months, and 6 months. Active serous retinal detachment (SRD) was considered as a potential source of false positive flow impairment, affected eyes were therefore excluded at onset and during follow-up, if this ...

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    23. Optical coherence tomography angiography in intermediate uveitis

      Optical coherence tomography angiography in intermediate uveitis

      Purpose To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A) Design Case-control study Methods Patients and age-matched controls were imaged with swept-source OCT-A (PLEX Elite 9000, Zeiss). Using ImageJ superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI) and fractal dimension (FD). Choriocapillaris layer was automatically graded for mean signal intensity, signal intensity standard deviation, kurtosis of signal intensity distribution and flow-signal-voids. Results Twentynine intermediate uveitis eyes and 30 control eyes were included. Both superficial and deep retinal layers showed ...

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    24. Reproducibility of Vessel Density, Fractal Dimension, and Foveal Avascular Zone Using 7 Different Optical Coherence Tomography Angiography Devices

      Reproducibility of Vessel Density, Fractal Dimension, and Foveal Avascular Zone Using 7 Different Optical Coherence Tomography Angiography Devices

      We applaud Corvi and associates for their well-powered study entitled “Reproducibility of vessel density, fractal dimension, and foveal avascular zone using 7 different optical coherence tomography angiography devices.”1 In this paper the authors compared quantitative retinal vascular parameters obtained with 7 different optical coherence tomography angiography (OCT-A) devices. Although we certainly appreciate this study, the authors failed to comment on some technical aspects that should be kept in mind when interpreting these results.

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