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    1. Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      Response to Comment on “Real-Time In Vivo Assessment of Retinal Reattachment in Humans Using Swept-Source Optical Coherence Tomography”

      We observed that retinal reattachment mediated by the retinal pigment epithelium (RPE) occurs in 5 specific stages and 20% of patients had delayed progression through Stage 2, characterized by outer retinal folds (ORFs). 1 dell'Omo et al hypothesized that “persisting undulations play a role in the formation of pockets of subretinal fluid, later evolving into ORFs” 2 . We demonstrated how improvement of outer retinal corrugations (ORCs) occurs during the slow and natural reattachment process mediated by the RPE in Stage 2 and how if parts of the retina remain in Stage 2 without sufficient improvement of ORCs while adjacent ...

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    2. Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Clinically significant intraocular lens decentration and tilt in highly myopic eyes: a swept source optical coherence tomography study

      Purpose To investigate the occurrence and risk factors of clinically significant intraocular lens (IOL) decentration and tilt in highly myopic eyes using swept-source anterior segment optical coherence tomography (SS-AS-OCT). Design Cross-sectional study. Methods This study included 334 participants (334 eyes) with high myopia (axial length (AL) ≥26 mm) who underwent phacoemulsification with IOL implantation. Decentration and tilt of IOL were assessed by SS-AS-OCT. Clinically significant IOL decentration and tilt was defined as decentration ≥ 0.4mm and tilt ≥7°. Routine pre- and post-operative examinations were performed, including visual acuity, refraction, biometric measurement using IOL master700, and objective visual quality evaluated by ...

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    3. Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Quantified retinal morphology and its association with papilledema and visual acuity in syndromic and complex craniosynostosis: an optical coherence tomography study

      Purpose This is the first study that evaluates the prevalence of retinal thinning and the correlation with papilledema and visual acuity (VA) in a large craniosynostosis population. Design Prospective clinical cohort study Methods All syndromic and complex craniosynostosis patients who visited the only national referral center between 2018-2020 were included. Retinal layers were segmented using optical coherence tomography (OCT). Patients were seen by an ophthalmologist for VA assessment and fundoscopy. Multivariate regression models were developed to evaluate correlations between retinal thickness, papilledema and VA. Results 127 patients were included. Retinal thinning was most prevalent in the peripapillary retinal nerve fiber ...

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    4. Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography

      Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography

      Purpose To compare anterior segment and angle parameters between pseudoexfoliation syndrome(PEX) and pseudoexfoliation glaucoma (PEXG) and normal control subjects by using anterior segment optical coherence tomography (AS-OCT) imaging. Design cross- sectional study Methods One hundred and two subjects with PEXG, PEX and normal eyes as the control group were recruited from academic referral institution. All subjects underwent complete ophthamologic examination, axial length measurement, AS-OCT imaging (CASIA SS-1000, Tomey). The anterior segment and angle parameters were evaluated. Results After excluding 4 eyes due to poor imaging of scleral spur, data from 34 eyes with pseudoexfoliation glaucoma (PEXG), 33 eyes with ...

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    5. Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Optical microangiography and progressive retinal nerve fiber layer loss in primary open angle glaucoma

      Purpose : To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). Design : Prospective case series Methods : Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD ...

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    6. Ocular Biometric Characteristics Measured by Swept-Source Optical Coherence Tomography in Individuals Undergoing Cataract Surgery

      Ocular Biometric Characteristics Measured by Swept-Source Optical Coherence Tomography in Individuals Undergoing Cataract Surgery

      Purpose To study the distribution of ocular biometric parameters utilizing a swept-source optical coherence tomography (SS-OCT) biometer in adult candidates for cataract surgery. Design A retrospective cross-sectional study. Methods: Setting A single-center analysis of consecutive eyes measured with the IOLMaster 700 SS-OCT biometer at a large tertiary medical center between February 2018 and June 2020. Results 3836 eyes of 3836 patients were included in the study. The mean age was 72.3±12.8 years and 53% were females. The mean biometric values were: total corneal power (44.17±1.70D), total corneal astigmatism (TCA) (1.11±0.87D), mean ...

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    7. Evaluation of the diagnostic performance of swept-source anterior segment optical coherence tomography in primary angle closure disease

      Evaluation of the diagnostic performance of swept-source anterior segment optical coherence tomography in primary angle closure disease

      Purpose To evaluate the diagnostic performance of swept-source anterior segment optical coherence tomography (SS-OCT) in differentiating primary angle closure diseases (PACD) from control eyes, as well as primary angle closure (PAC) and primary angle closure glaucoma (PACG) from primary angle closure suspect (PACS) eyes. Design Multi-center cross-sectional study. Methods Chinese patients were classified into control, PACS and PAC/PACG groups. Area under the receiving operating characteristics curve (AUC) from logistic regression models was used to evaluate discriminating ability. Sensitivity and specificity were calculated and performance of the models was validated using an independent dataset. Results A total of 2,928 ...

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    8. Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy

      Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV. Design: Prospective cross-sectional study. Methods: Consecutive CSC patients were recruited from retina clinic. The reference standard for CNV was determined by interpretation of multimodal imaging with OCTA, structural OCT line scan, fluorescein angiography (FA), indocyanine green angiography (ICGA), ultra-widefield fundus photography and fundus autofluorescence (FAF). Two independent masked graders examined OCTA without FA and ICGA to diagnose CNV. Univariate and multivariate analyses were performed to evaluate factors associated with CNV. Results ...

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    9. Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices

      Purpose Compare rates of change of macular ganglion cell/inner plexiform (GCIPL) thickness and proportion of worsening and improving rates from two OCT devices in a cohort of glaucoma eyes. Methods Design : Longitudinal cohort study. Setting : Tertiary glaucoma clinic. Patients : 68 glaucoma eyes with ≥2 years of follow-up and ≥4 OCT images. Observation Procedures : Macular volume scans from 2 OCT devices were exported, co-registered, and segmented. Global and sectoral GCIPL data from the central 4.8 × 4.0 mm region were extracted. GCIPL rates of change were estimated with linear regression. Permutation analyses were used to control specificity with the ...

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    10. Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma

      Purpose To compare dynamic ranges and steps to measurement floors of peripapillary and macular metrics from a complex signal-based optical microangiography (OMAG C ) optical coherence tomography angiography (OCTA) device for glaucoma with those of OCT measurements. Design Cross-sectional study. Methods Imaging of 252 eyes from 173 glaucoma subjects and 123 eyes from 92 non-glaucoma subjects from a glaucoma clinic was quantified using custom and commercial software. Metrics from OCT (retinal nerve fiber layer [RNFL], ganglion cell-inner plexiform layer [GCIPL]) and OCTA (custom: peripapillary vessel area density [pVAD], macular vessel area density [mVAD], macular vessel skeleton density [mVSD]; commercial: peripapillary perfusion ...

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    11. Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Induced refractive error changes optical coherence tomography angiography transverse magnification and vascular indices.

      Purpose To assess the effect of changing anterior eye refractive power with contact lenses on the transverse magnification of enface images and associated vascular indices from optical coherence tomography angiography (OCT-A). Design Prospective cross-over study. Methods Spherical soft contact lenses (-6D to +6D in 2D steps) were used to induce anterior eye refractive power changes in 11 healthy young adults and 3 × 3mm macular scans were captured using OCT-A (Zeiss AngioPlex, software version 11.0; Cirrus HD-OCT 5000, Carl Zeiss Meditec Inc.). Image transverse magnification was predicted based on refraction and biometry measurements and compared with empirical changes in the ...

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    12. The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      The Additive Value of Foveal OCT-based Biometry to Fundus Biomicroscopy for Detecting Macular Pathology Prior to Cataract Surgery

      Purpose : To assess the additive value of foveal swept-source optical coherence tomography (SS-OCT) based biometry to the preoperative fundus examinations for diagnosing macular abnormalities in patients scheduled for cataract surgery. Design : Diagnostic testing evaluation. Methods : Consecutive patients 50 years of age and older planned for cataract surgery from one institution were retrospectively enrolled. All patients underwent foveal SS-OCT, and macular spectral-domain (SD)-OCT scans before pupil dilation as well as dilated fundus biomicroscopy examination. The effectiveness of fundus biomicroscopy examinations, foveal SS-OCT scans, and the combination of both in identifying macular diseases was analyzed with macular SD-OCT scans as reference ...

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    13. Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study

      Optical coherence tomography angiography features in post COVID-19 pneumonia patients: a pilot study

      Purpose : To investigate retinal vessel density changes in macular and papillary regions in post SARS-CoV-2 pneumonia patients by means of optical coherence tomography angiography (OCTA). Design : Prospective, observational, cohort study. Methods : Forty eyes of 40 patients (mean age 49.7 ± 12.6) post SARS-CoV-2 infection and 40 healthy subjects were enrolled in this study. Covid-19 patients had to be fully recovered from Covid-19 pneumonia and were evaluated 6 months after Covid-19 infection. The primary outcome was the results of the OCTA study of the following vascular structures: vessel density (VD) in the retinal superficial capillary plexus (SCP), deep capillary plexus ...

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      Mentions: Optovue
    14. Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma

      Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma

      Purpose To investigate the relationship between the rate of retinal nerve fiber layer (RNFL) loss during initial follow-up and the magnitude of associated visual field loss during an extended follow-up period. Design Retrospective cohort study. Methods A total of 1,150 eyes of 839 glaucoma patients extracted from the Duke Glaucoma Registry. Rates of RNFL loss were obtained from global RNFL thickness values of the first 5 optical coherence tomography (OCT) scans. Rates of visual field loss were assessed using standard automated perimetry mean deviation (SAP MD) during the entire follow-up period. Joint longitudinal mixed effects models were used to ...

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      Mentions: Duke University
    15. Identification and Characterization of Epivascular Glia using En Face OCT

      Identification and Characterization of Epivascular Glia using En Face OCT

      Purpose : To describe the clinical features of epivascular glia (EVG) using en face optical coherence tomography (OCT). Design : Retrospective cross-sectional study. Methods : Single institution en face OCT images were reviewed. Eyes displaying EVG were captured with manual internal limiting membrane segmentation and analysis with customized segmentation was performed. A random age- and gender-matched control group was selected to determine relative epiretinal membrane (ERM) prevalence. Results : Characteristic hyper-reflective internal limiting membrane (ILM) plaques with dendritic-like radiations were identified with en face OCT and displayed vascular predilection. 161 eyes with EVG (EVG group) and 2315 eyes without EVG (control group) were identified ...

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    16. Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Real-Time In Vivo Assessment of Retinal Reattachment in Humans using Swept-Source Optical Coherence Tomography

      Purpose To assess the in vivo physiology of retinal reattachment in humans using swept-source optical coherence tomography (SS-OCT) in real-time. Design Prospective case series. Methods Fifteen consecutive patients with fovea-involving rhegmatogenous retinal detachment undergoing pneumatic retinopexy (PnR). SS-OCT was performed at presentation and frequent intervals immediately following PnR. Primary outcome was longitudinal assessment of early post-operative SS-OCT to establish stages of reattachment. Results 93.3% (14/15) achieved successful reattachment at the median follow-up duration of 13 weeks (IQR 7.5-18.0). Reattachment occurred in five specific stages: Stage 1, redistribution of fluid and approach of the neurosensory retina towards ...

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    17. Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      Prediction of Phakic Intraocular Lens Vault Using Machine Learning of Anterior Segment Optical Coherence Tomography Metrics: Phakic lens vault prediction using machine learning

      PURPOSE : To compare the achieved vault using the conventional manufacturer's nomogram and the predicted vault using machine learning, in a large cohort of eyes undergoing posterior chamber phakic intraocular lens (EVO ICL, STAAR Surgical) implantation. DESIGN : Reliability and validity assessment and comparison. METHODS : Our study comprised a total of 1745 eyes of 1745 consecutive patients (mean age ± standard deviation, 26.2 ± 6.8 years) undergoing ICL implantation. At 1-month postoperatively, we quantitatively measured the actual vault, and compared it with the predicted vault using machine leaning of anterior segment optical coherence tomography (CASIA 2, Tomey) metrics. RESULTS : All machine ...

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    18. A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      A novel approach for assessing visual impairment caused by intraocular lens opacification: high-resolution optical coherence tomography: Straylight prediction in locally opacified IOLs

      Cataract surgery with intraocular lens (IOL) implantation is generally a safe procedure with a very low complication rate.1 Where complications occur that are related to the IOL biomaterial, these can cause partial or complete lens opacification, and we categorize them according to the water-content of the IOL: “Glistenings,” microvacuole inclusions in the polymer are most commonly found in hydrophobic acrylic IOLs,2,3 while the pathology most associated with hydrophilic acrylic IOLs is calcification, an opacification resulting from Calcium compound depositions.

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    19. Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Purpose To report a multi-disease deep-learning diagnostic network (MDDN) of common corneal diseases: dry eye syndrome (DES), Fuchs’ endothelial dystrophy (FED), and keratoconus (KCN) using anterior segment optical coherence tomography (AS-OCT) images. Study Design Development of a deep learning neural network diagnosis algorithm Methods A total of 158,220 AS-OCT images from 879 eyes of 478 subjects were used to develop and validate a classification deep network. After a quality check, the network was trained and validated using 134,460 images. We tested the network using a test set of consecutive patients involving 23,760 AS-OCT images of 132 eyes ...

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    20. Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma

      Purpose: Test the hypothesis that visual field (VF) progression can be predicted from baseline and longitudinal optical coherence tomography (OCT) structural measures. Design: Prospective cohort study. Methods: 104 eyes (104 patients) with ≥3 years of follow-up and ≥5 VF exams were enrolled. We defined VF progression based on pointwise linear regression on 24-2 VF (≥3 locations with slope ≤–1.0 dB/year and p<0.01). We used elastic net logistic regression (ENR) and machine learning (ML) to predict VF progression with demographics, baseline circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell/inner plexiform layer (GCIPL) thickness and ...

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    21. Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Quantification of key retinal features in early and late age-related macular degeneration using deep learning

      Purpose To develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD). Design Development and validation of a deep-learning model for feature segmentation Methods Data for model development were obtained from 307 optical coherence tomography volumes. Eight experienced graders manually delineated all abnormalities in 2,712 B-scans. A deep neural network was trained with this data to perform voxel-level segmentation of the 13 most common abnormalities (features). For evaluation, 112 B-scans from 112 patients with a diagnosis of neovascular AMD were annotated by four independent observers. Main outcome measures ...

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    22. Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Sickle Cell Maculopathy: microstructural analysis using OCTA and identification of genetic, systemic and biological risk factors

      Purpose To identify genetic, systemic and biological factors associated with the occurrence of sickle cell maculopathy (SCM). To evaluate microvascular macular alterations using optical coherence tomography angiography (OCTA) in sickle cell disease (SCD). Design Cross-sectional study. Methods One hundred fifty-one eyes of 78 adult SCD patients (43 HbSS, 30 HbSC, 4 S/β + and 1 HbSLepore) and 40 eyes of 20 healthy controls underwent spectral domain optical coherence tomography (SD-OCT) and OCTA using Spectralis. We analyzed the occurrence of SCM, the foveal avascular zone (FAZ) area and the severity of macular ischemia and studied their relationships with genetic, systemic and biological ...

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    23. Correlation of Intraoperative Optical Coherence Tomography of Crystalline Lens Diameter, Thickness and Volume with Biometry and Age

      Purpose To characterize crystalline lens dimensions derived from in-vivo spectral-domain optical coherence tomography (SD-OCT) and identify associations between these parameters, ocular biometry and age. Methods In this retrospective study, lens thickness (LT), lens diameter (LD) and lens volume (LV) were measured intraoperatively with SD-OCT in 293 eyes undergoing lens surgery. Correlations among LT, LD, LV, age, axial length (AL) and anterior chamber depth (ACD) were analyzed. Multiple regression analysis was performed to determine whether a combination of biometric data could predict LD and LV. Results Wide variation was observed in LT (3.6 to 5.7mm), LD (7.5 to ...

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    24. Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy using Swept Source OCT Imaging

      Purpose The correlations between enlargement rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were investigated using swept source optical coherence tomography (SS-OCT) in age-related macular degeneration (AMD). Design Retrospective review of prospective, observational case series. Methods Eyes with GA from AMD were imaged with SS-OCT (PLEX® Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA) using 6x6 mm scan pattern. GA lesions were identified and measured using custom en face structural images and annual square root ERs of GA were calculated. At baseline, CC FDs from different regions ...

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    1-24 of 443 1 2 3 4 ... 17 18 19 »
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