1. 1-5 of 5
    1. In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops

      Exposure to noise trauma, such as that from improvised explosive devices, can lead to sensorineural hearing loss and a reduced quality of life. In order to elucidate the mechanisms underlying noise-induced hearing loss, we have adapted optical coherence tomography (OCT) for real-time cochlear visua lization in live mice after blast exposure. We demonstrated that endolymphatic hydrops develops following blast injury, and that this phenomenon may be associated with glutamate excitotoxicity and cochlear synaptopathy. Additionally, osmotic stabilization of endolymphatic hydrops partially rescues cochlear synapses after blast trauma. OCT is thus a valuable research tool for investigating the mechanisms underlying acoustic trauma ...

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    2. An enhanced OCT image captioning system to assist ophthalmologists detecting and classifying eye diseases

      An enhanced OCT image captioning system to assist ophthalmologists detecting and classifying eye diseases

      Human eye is affected by the different eye diseases including choroidal neovascularization (CNV), diabetic macular edema (DME) and age-related macular degeneration (AMD). This work aims to design an artificial intelligence (AI) based clinical decision support system for eye disease detection and cl assification to assist the ophthalmologists more effectively detecting and classifying CNV, DME and drusen by using the Optical Coherence Tomography (OCT) images depicting different tissues. The methodology used for designing this system involves different deep learning convolutional neural network (CNN) models and long short-term memory networks (LSTM). The best image captioning model is selected after performance analysis by ...

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    3. A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue

      A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue

      Background:There is a significant current interest in combining multiple modalities in a single optical system for a more complete characterization of tissue for improved diagnosis. Objective:We report development of a dual-modal optical system combing the depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analysis of layered biological tissues. Methods:A time-domain, real-time OCT system, assembled in-house, was used as the platform for developing the dual-modal system. It involved appropriate modification of the sample arm of the OCT for making the LIF excitation beam (337 nm) collinear with the OCT illumination beam (1310 nm) and ...

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    4. A time delay correction technique for SS-OCT

      A time delay correction technique for SS-OCT

      BACKGROUND: K-trigger signals from light source or external Mach-Zehnder interferometer are commonly used in swept source optical coherence tomography (SS-OCT) to achieve interference signal sampling and resolution enhancement. But extra signal transmission time is required due to the increased complexity of interference system using k-trigger signals, resulting in a misalignment (a.k.a., time delay) between the k-trigger and the interference signals. OBJECTIVE: The objective of this paper is to propose a numerical technique to correct the time delay between these two signals. METHODS: The time delay is iterated in this technique and each iterated correction result is evaluated through ...

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      Mentions: Yi Wang
    5. Lateral resolution enhancement using programmable phase modulator in optical coherence tomography

      Lateral resolution enhancement using programmable phase modulator in optical coherence tomography

      Adaptive optics plays an important role in the correction of high-order aberrations to enhance lateral resolution. An OCT system coupled with a programmable phase modulator is designed to verify lateral resolution improvement. The Hamamatsu high-resolution, non-pixelized, optically addressed light modulator (PAL-SLM) PPM X7550 series is used to correct aberrations, utilizing a simple method based on phase information from OCT images. The advantages of this method are its high simplicity and low cost. A raster scanning technique is adopted to scan samples covered with scattering suspension. Metal lines covered with scattering suspension are imaged, and a respective correction is applied to ...

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    1-5 of 5
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