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    1. Classification of Neural Tissue Types for an Endoscopic Full-field Optical Coherence Tomography Imaging System (Thesis)

      Classification of Neural Tissue Types for an Endoscopic Full-field Optical Coherence Tomography Imaging System (Thesis)

      Optical coherence tomography is a volumetric imaging technique that can differentiate brain regions with micron-scale resolution. Our group has previously developed an endoscopic full-field swept-source OCT system with the aim to provide real-time surgical guidance for the implantation of electrodes for deep brain stimulation. This thesis builds on our prior work. Due to the limitations in the resolution and contrast due to scattering from the tissue, to identify different types of neural tissues, we developed an image classification algorithm that use texture features and optical attenuation. The algorithm could classify three different brain regions in the ex vivo data set ...

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    2. Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)

      Investigating the reliability and clinical utility of minimally invasive portable electroretinography and optical coherence tomography techniques in children undergoing vigabatrin therapy (Thesis)

      The antiepileptic drug for Infantile Spasms – vigabatrin, has been associated with retinal toxicity in over one third of children treated. Young and non-verbal children cannot cooperate with conventional adult-oriented monitoring devices, therefore a safe and reliable technique to monitor for vigabatrin retinal toxicity is missing. This study evaluated the tolerability, reliability and clinical feasibility of two alternative, handheld systems for assessment of retinal function: the RETeval ERG and Envisu OCT. We found that non-sedated children showed poor tolerability on the RETeval ERG. Under sedation the same children showed high tolerability on the handheld OCT. Responses from both techniques demonstrated good ...

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    3. Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography (Thesis)

      Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography (Thesis)

      Optical Coherence Tomography (OCT) is an emerging optical imaging modality that is capable of imaging biological tissues with micron resolution and millimeter penetration depth. In clinical diagnostic imaging and pathology, OCT has helped fill a gap in terms of both resolution and imaging depth, in between traditional fluoroescence based microscopes and non-invasive organ level imaging. In this domain, OCT can be used both as an ex vivo pathological examination tool or in vivo imaging modality.OCT has been successful in ophthalmology owing to its excellent in vivo optical sectioning ability and penetration depth. Over the years, OCT has seen substantial ...

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