1. 1-7 of 7
    1. An improved algorithm of structural image reconstruction with rapid scanning optical delay line for Optical Coherence Tomography

      An improved algorithm of structural image reconstruction with rapid scanning optical delay line for Optical Coherence Tomography

      A new algorithm of structural image reconstruction in Optical Coherence Tomography is described. The modified rapid scanning optical delay (RSOD) line, low numerical aperture, small angle raster scanning with consecutive averaging and multilevel digital filtering have been used to obtain high quality structural images of an onion and the nail bed of a human thumb. The proposed method significantly improves image contrast and allows visualization of small blood capillaries under the nail plate.

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    2. Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

      Assessing mechanical properties of tissue phantoms with non-contact optical coherence elastography and Michelson interferometric vibrometry

      Purpose : Elastography is an emerging method for detecting the pathological changes in tissue biomechanical properties caused by various diseases. In this study, we have compared two methods of noncontact optical elastography for quantifying Young’s modulus of tissue-mimicking agar phantoms of various concentrations: a laser Michelson interferometric vibrometer and a phase-stabilized swept source optical coherence elastography system. Methods : The elasticity of the phantoms was estimated from the velocity of air-pulse induced elastic waves as measured by these two techniques. Results : The results show that both techniques were able to accurately assess the elasticity of the samples as compared to uniaxial ...

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    3. Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques

      Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques

      Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaques in vivo in patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the applications of IVUS-OCT technology. Results from cadaver specimens are summarized, which indicated the complementary nature of OCT and IVUS for assessment of vulnerable plaques, plaque composition, and stent-tissue ...

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    4. The combination of optical coherence tomography and Raman spectroscopy for tissue characterization

      The combination of optical coherence tomography and Raman spectroscopy for tissue characterization

      The visualization as well as characterization of diseased tissue are of vital diagnostic interest for an early diagnosis to increase patients’ survival rate. In this study we introduce an imaging device combining optical coherence tomography (OCT) and Raman spectroscopy (RS), allowing to record 2D and 3D OCT cross sectional images of bulk tissue samples, as well as the acquisition of Raman spectra from small areas of interest in order to aid the detection process with molecular information. The design of the OCT/RS imaging device consists of commercially available cage components. The probe head involves a CCD camera chip for ...

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    5. 2D fractal analysis in layered retinal structures of healthy and diabetic eyes with optical coherence tomography

      2D fractal analysis in layered retinal structures of healthy and diabetic eyes with optical coherence tomography

      Optical coherence tomography (OCT) is usually employed for the measurement of retinal thickness characterizing the structural changes of tissue. However, fractal dimension (FD) could also character the structural changes of tissue. Therefore, fractal dimension changes may provide further information regarding cellular layers and early damage in ocular diseases. We investigated the possibility of OCT in detecting changes in fractal dimension from layered retinal structures. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) or mild diabetic retinopathy (MDR, n = 43 eyes) and normal healthy subjects (Controls, n = 74 eyes). Fractal dimension was calculated using the differentiate ...

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    6. OCT/LCT monitoring the drug effect on the human cornea structure in vivo

      OCT/LCT	monitoring	the	drug 	effect	on	the	human	cornea	 structure	in	vivo

      The effect of anti-glaucoma drugs on the structure components of human eye cornea are studied. The eye drops Timolol-AKOS 0.5% and Kosopt were used as the object of study. 10 voluntary patients of the Eye Disease Clinic aged from 70 to 75 suffering from glaucoma took part in the studies. The study of cornea in vivo was carried out using the methods of laser scanning confocal tomography (LCT) and optical coherence tomography (OCT) before the application of drugs and at different time moments after the application. The eye cornea thickness values measured using the OCT are presented. From the ...

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    7. Quantification of Mouse Embryonic Eye Development with Optical Coherence Tomography In Utero

      Quantification	of	Mouse	Embryonic	Eye	Development	with	 Optical	Coherence	Tomography	In	Utero

      Mouse models are commonly used as research tools to understand regulatory pathways affected by human diseases and disorders. Live imaging tools for visualization of mouse embryonic ocular tissues would be beneficial in research associated with developmental ocular defects. In this study, in utero quantitative assessment of ocular structures in mouse embryos was performed with a swept-source optical coherence tomography (SSOCT). To define developmental changes in eye morphology in live embryos, the volume of the embryonic eye lens and the globe at different embryonic stages ranging from E13.5 to E18.5 was quantified. It is determined that the major axis ...

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    1-7 of 7
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