1. Articles from scirp.org

  2. 1-14 of 14
    1. Advances in Optical Imaging Technique (Textbook)

      Advances in Optical Imaging Technique (Textbook)

      Optical imaging is a pillar in biomedical research from super-resolution microscopy to whole-body imaging in animal models. Optical imaging covers such a large field that it is difficult to decide what was the first medical application .Could it be said that the introduction of spectacles in 1270, in Florence, Italy was the first use of optical imaging in medicine? Or the introduction in 1590 of the compound microscope by the father and son team of Hans and Zacharias Janssen in the Netherlands? It is more likely that optical imaging (as understood by the general scientific community) and the application of ...

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    2. Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

      Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report

      Coronary artery vasospasm is an infrequent cause of acute coronary syndrome (ACS). A 50-year-old female developed persistent chest discomfort related to anterior STEMI. After an unsuccessful thrombolysis attempt, due to delay concern, the patient was then sent to the catheterization laboratory for rescue PCI. The coronary angiogram revealed a TIMI 3 flow proximal LAD significant stenosis with spastic appearance of the coronary arteries which has improved after intracoronary nitrates administration. Optical Coherence Tomography (OCT) excluded coronary artery dissection and haematoma also revealed thrombus on moderate atherosclerotic plaque. The patient was then pain-free; she was managed medically and discharged after few ...

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    3. Optical Coherence Tomography’s Contribution to the Diagnosis of the Pathologies of the Vitreoretinal Interface in Lomé

      Optical Coherence Tomography’s Contribution to the Diagnosis of the Pathologies of the Vitreoretinal Interface in Lomé

      Purpose: To identify the pathologies of the vitreoretinal interface by Optical Coherence Tomography OCT of the retina in Lomé. Methodology: This is a retrospective analytical study, carried out in a specialized liberal center in Lomé. It was based on the analysis of OCT images of the retina, carried out with patients between October 2012 and October 2014. The variables collected were the socio-demographic characteristics, which were the various pathologies of the vitreoretinal interface. Results: 303 eyes of 164 patients were analyzed. The population was predominantly female (sex ratio = 0.95) aged 9 to 84 years with an average of 52 ...

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    4. Quantitative Assessment of Foveal Avascular Zone in Patients with Early and Intermediate Nonexudative Age-Related Macular Degeneration Using Optical Coherence Tomography-Angiography

      Quantitative Assessment of Foveal Avascular Zone in Patients with Early and Intermediate Nonexudative Age-Related Macular Degeneration Using Optical Coherence Tomography-Angiography

      Optical coherence tomography-angiography (OCT-A) is a relatively new non-invasive imaging technique which provides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). Purpose: To compare 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), perimeter (Pm), and circularity (C) in patients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine patients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were compared with sex- and age-matched control group of 66 healthy subjects (n = 66 eyes). The patients with nonexudative AMD ...

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    5. Non-Invasive and Non-Destructive Determination of Corneal and Scleral Biomechanics Using Vibrational Optical Coherence Tomography: Preliminary Observations

      Non-Invasive and Non-Destructive Determination of Corneal and Scleral Biomechanics Using Vibrational Optical Coherence Tomography: Preliminary Observations

      Experimental measurements made in this study on human and porcine eyes suggest that the resonant frequency for both cornea and sclera varies from 130 to 150 Hz and increases slightly with increasing intraocular pressure. The values of the moduli calculated using the experimental values of the thickness are close to 2 MPa. Similar values of the modulus for cornea and sclera suggest that there is very little stress concentration at the cornea-scleral junction and that any stress concentration that occurs probably resides at the scleral attachment laterally and posteriorly. These moduli are close to those measured in vivo on human ...

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    6. Flatly Broadened and Highly Coherent Supercontinuum Generation by Induced Modulation Instability in ANDi-PCF

      Flatly Broadened and Highly Coherent Supercontinuum Generation by Induced Modulation Instability in ANDi-PCF

      In this paper, a flatly broadened and highly coherent supercontinuum generation by induced modulation instability in ANDi-PCF is proposed. The numerical results show that the bandwidth of supercontinuun can be increased by increasing the modulation depth and the coherence property of supercontinuum can be improved with the optimal modulation frequency. A highly coherent supercontinuum with the 10 dB bandwidth of 1305 nm and the flatness of less than 10 dB can be obtained when seeding at the modulation depth of 0.3 and modulation frequency of 24 THz.

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    7. Analysis of Mechanical Behavior of Composite Tissues Using Vibrational Optical Coherence Tomography

      Analysis of Mechanical Behavior of Composite Tissues Using Vibrational Optical Coherence Tomography

      Extracellular matrices (ECMs) found in vertebrate tissues are fiber reinforced composite materials that prevent premature mechanical failure, store, transmit, and dissipate mechanical energy generated by the musculoskeletal system. We have developed a new method using optical cohesion tomography and vibrational analysis to non-destructively and non-invasively measure the mechanical properties of composite tissues and polymeric materials. In addition, this method can be used to measure the moduli of individual components of composite materials and perform “mechanical spectroscopy” on materials. In addition, we propose that measurement of the resonant frequency of a material minimizes the viscoelastic behavior of a composite material. This ...

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    8. Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

      Anterior Segment Parameters Associated to  Acute Glaucoma with Slit Lamp Optical  Coherence Tomography

      Purpose: To identify the anterior segment parameters associated to acute primary angle closure. Patients and Methods: Case-control study in 58 primary angle closure suspect eyes (PACS, control group) and in 19 acute primary angle closure fellow eyes, case group. All subjects underwent SL OCT imaging in a dark room. Results: The SS, ACD and ACV measures were significantly smaller in case group than in control group (p = 0.011; p < 0.001; p = 0.007 respectively); while the IT was significantly greater (at 500 and 750 μm) (p = 0.038 and p = 0.050). The difference between qua- drants were ...

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    9. Dynamic Analysis of Mental Sweating by the Time-Sequential Piled-Up En-Face OCT Images

      Dynamic Analysis of Mental Sweating by the Time-Sequential Piled-Up En-Face OCT Images

      In this paper, the dynamic analysis of mental sweating for sound stimulus of a few tens of eccrine sweat glands is per- formed by the time-sequential piled-up en-face optical coherence tomography (OCT) images with the frame spacing of 3.3 sec. In the experiment, the amount of excess sweat can be evaluated simultaneously for a few tens of sweat glands by piling up of all the en-face OCT images. Strong non-uniformity is observed in mental sweating where the amount of sweat in response to sound stimulus is different for each sweat gland. Furthermore, the amount of sweat is significantly increased ...

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      Mentions: Osaka University
    10. High-Speed Optical Coherence Tomography System Using a 200-kHz Swept Light Source with a KTN Deflector

      High-Speed Optical Coherence Tomography System Using a 200-kHz Swept Light Source with a KTN Deflector

      We demonstrate a high-speed swept-source optical coherence tomography (SS-OCT) system, which is based on a high- speed swept light source and a Mach-Zehnder interferometer with a high-speed photodetector. The light source is an external-cavity laser tuned by a KTN electro-optic deflector, which exhibits a very fast response and large deflection. The scanning wavelength range is almost 80 nm up to 200 kHz with a ±400-V deflector driving voltage. The system acquires 1 mm × 1 mm images consisting of 200 × 200 pixels within few milliseconds. We present preliminary SS-OCT images of an in-vitro human nail and an in-vivo finger pad.

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    11. Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      OCT is a powerful tool for detection of physiological functions of micro organs underneath the human skin surface, besides the clinical application to ophthalmology, as recently demonstrated by the authors’ group. In particular, dynamics of peripheral vessels can be observed clearly in the time-sequential OCT images. Among the vascular system, only the small artery has two physiological functions both for the elastic artery and for muscle-controlled one. It, therefore, is important for dynamic analysis of blood flow and circulation. In the time-sequential OCT images obtained with 25 frames/sec, it is found that the small artery makes a sharp ...

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      Mentions: Osaka University
    12. Optical Coherence Tomography Findings in a Case of Unilateral Acute Idiopathic Maculopathy

      Optical Coherence Tomography Findings in a Case of Unilateral Acute Idiopathic Maculopathy

      Purpose: To describe the clinical, angiographic, and Optical Coherence Tomography (OCT) findings in a patient with Unilateral Acute Idiopathic Maculopathy (UAIM) and to discuss a possible pattern of OCT findings in patients with this disease. Methods: Case report. Results: A 34-year-old man with UAIM was evaluated. During the acute phase fundus examination revealed a yellow thickening in the macular area of the right eye, Fluorescein Angiography (FA) showed early alternating patches of hypofluorescence and hyperfluorescence and late hyperfluorescence and OCT showed thickening of the outer retina in the foveal zone. Six weeks later, the macula had pigmentary mottling, FA showed ...

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    13. Investigation of changes in thickness and reflectivity from layered retinal structures of healthy and diabetic eyes with optical coherence tomography

      Investigation of changes in thickness and reflectivity from layered retinal structures of healthy and diabetic eyes with optical coherence tomography
      OCT is usually employed for the measurement of retinal thickness. However, coherent reflected light carries more information characterizing the optical properties of tissue. Therefore, optical property changes may provide further information regarding cellular layers and early damage in ocular diseases. We investigated the possibility of OCT in detecting changes in the optical backscattered signal from layered retinal structures. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) or mild diabetic retinopathy (MDR, n = 43 eyes) and normal healthy subjects (n = 74 eyes). The thickness and reflectivity of various layered structures were assessed using a custom-built algorithm ...
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    14. Anti-Spoof Reliable Biometry of Fingerprints Using En-Face Optical Coherence Tomography

      Anti-Spoof Reliable Biometry of Fingerprints Using En-Face Optical Coherence Tomography
      Optical coherence tomography (OCT) is a relatively new imaging technology which can produce high resolution images of three-dimensional structures. OCT has been mainly used for medical applications such as for ophthalmology and dermatology. In this study we demonstrate its capability in providing much more reliable biometry identification of fingerprints than conventional methods. We prove that OCT can serve secure control of genuine fingerprints as it can detect if extra layers are placed above the finger. This can prevent with a high probability, intruders to a secure area trying to foul standard systems based on imaging the finger surface. En-Face OCT ...
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    1-14 of 14
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