Persistent placoid maculopathy is a rare entity characterized by bilateral well-delineated whitish plaque-like lesions in the macula. Secondary choroidal neovascularization and extensive retinal pigment epithelial damage, highlighted by spectral domain optical coherence tomography and autofluorescence imaging, can limit visual prognosis. Aggressive immunosuppression can preserve vision and perhaps delay the onset of choroidal neovascularization.

BACKGROUND AND OBJECTIVE: To investigate the efficacy of anterior-segment optical coherence tomography (AS-OCT) for calculating flap thickness in femtosecond laser-assisted laser in situ keratomileusis.PATIENTS AND METHODS: Fifty-one eyes of 26 patients with myopia and myopic astigmatism were included in this prospective study. High-resolution corneal images were evaluated at 1 week and 1 month postoperatively. Images along the horizontal meridian were measured with the flap tool at seven points.RESULT: Measurements at vertex and at 1 mm nasally and temporally from the vertex were indistinct but easily defined. Although statistically not significant, flaps were found to be thinner in the ...

Drusen are extracellular deposits that accumulate between the retinal pigment epithelium and Bruch’s membrane. They are one of the earliest clinical manifestations of age-related macular degeneration and it is thought that they disrupt the overlying photoreceptors, leading to subsequent vision loss. The purpose of this study was to illustrate how spectral domain optical coherence tomography and adaptive optics fundus imaging can be used to quantitatively analyze the integrity of the overlying photoreceptors in a single subject with macular drusen. This imaging approach and the image analysis metrics introduced may serve as the foundation for valuable imaging-based biomarkers for detecting ...

Spectral domain optical coherence tomography is a useful new technology for imaging and measuring geographic atrophy (GA) and drusen, the hallmarks of dry age-related macular degeneration (AMD). The advantage of using this novel technique over other imaging modalities for dry AMD is that the same scan pattern can be used to image both drusen and GA while obtaining reproducible, quantitative data on both the area of GA and the morphologic features of drusen. Moreover, this strategy enables the clinician to follow the disease as it progresses from drusen to both GA and choroidal neovascularization. No other imaging modality is able ...

An 840-nm wavelength spectral domain optical coherence tomography (SD-OCT) with prolonged scan depth was developed and mounted onto a conventional slit lamp for imaging the anterior segment of the eye. X-Y cross aiming was applied to align the SD-OCT scanning position during imaging. An internal fixation target displayed on a miniature LCD monitor was provided. The SD-OCT instrument had an axial resolution of 6 µm and a prolonged scan depth of 7.2 mm. High-quality SD-OCT images, consisting of 2,048 × 2,048 pixels, were acquired of the entire anterior chamber and entire crystalline lens from a healthy subject. The ...

In this report, spectral-domain optical coherence tomography (OCT) was used to characterize the acute morphologic alterations that occur when photodynamic therapy with verteporfin results in an acute severe visual decrease. The clinical and imaging records of a patient with neovascular age-related macular degeneration who suffered this complication were reviewed. Using spectral-domain OCT, two relatively distinct subretinal fluid compartments were visualized: a sparsely hyperreflective pocket of subretinal fluid overlying the fibrovascular pigment epithelial detachment, consistent with fibrinous exudation, and a more homogenously hyporeflective compartment at the periphery of the choroidal neovascular lesion, consistent with serous exudation. The higher axial resolution, and ...

A middle-aged asymptomatic woman presented with multiple yellow-white flecks in the retinal pigment epithelium (RPE) affecting both fundi in a symmetrical pattern. The lesions were distributed around the posterior pole and midperiphery but sparing the macula, a picture similar to what was defined by Gass as benign fleck retina. Visual acuity, visual fields, full-field electroretinogram, electrooculogram, and dark adaptation were normal. Multifocal electroretinogram [0] (mfERG) was slightly subnormal in the isopters 17° to 20°. In this same area, microperimetry confirmed a mild decrease in sensitivity more patent in the upper temporal sector where some hypoautofluorescent spots were detected. Optical coherence ...