1. 1-24 of 48 1 2 »
    1. Spectral-Domain Optical Coherence Tomography in Lightning-induced Maculopathy

      Spectral-Domain Optical Coherence Tomography in Lightning-induced Maculopathy

      The authors report a case of lightning-induced chorioretinal burn accompanied by mild anterior segment injuries. Spectral-domain optical coherence tomography images were used to document the progressive retinal and choroidal changes. As evidenced by this report, despite being sight-threatening, such injuries may allow for a significant functional recovery

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    2. SD-OCT Patterns of the Different Stages of Choroidal Metastases

      SD-OCT Patterns of the Different Stages of Choroidal Metastases

       A diagnosis of choroidal metastasis is based on the patient’s clinical history, the tumor’s ophthalmoscopic appearance, and instrumental imaging results such as ultrasonography, fluorescein angiography, fundus autofluorescence, indocyanine green angiography, and optical coherence tomography. Spectral-domain optical coherence tomography (SD-OCT) has provided additional useful information for clinical diagnosis: a pattern of hyperintense irregular spots in the context of the photoreceptor layer and in the retinal pigment epithelium, subretinal fluid, and marked irregularity of the retinal pigment epithelium with thickening and gross undulation. The authors describe a case of bilateral choroidal metastasis presenting peculiar SD-OCT features acquired at different stages ...

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    3. Evaluation of Clear Corneal Wound Dynamics With Contrast-Enhanced Spectral-Domain Optical Coherence Tomography

      Evaluation of Clear Corneal Wound Dynamics With Contrast-Enhanced Spectral-Domain Optical Coherence Tomography

      Please wait Close Window BACKGROUND AND OBJECTIVE:To evaluate wound morphology and integrity using contrast-enhanced spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS:Eighteen patients (18 eyes) undergoing unilateral routine cataract surgery were enrolled. SD-OCT imaging of the corneal wound was performed immediately following cataract surgery and on postoperative day 1. A topical contrast agent, prednisolone acetate 1%, was used to help evaluate wound integrity. OCT features of the corneal incision and changes in wound interface reflectivity after administration of topical prednisolone acetate 1% were analyzed. Main outcome measures were quantitative and qualitative description of wound morphology and contrast enhancement ...

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    4. Single-Shot Dimension Measurements of the Mouse Eye Using SD-OCT

      Single-Shot Dimension Measurements of the Mouse Eye Using SD-OCT

      The authors demonstrate the feasibility and advantage of spectral-domain optical coherence tomography (SD-OCT) for single-shot ocular biometric measurement during the development of the mouse eye. A high-resolution SD-OCT system was built for single-shot imaging of the whole mouse eye in vivo. The axial resolution and imaging depth of the system are 4.5 µm (in tissue) and 5.2 mm, respectively. The system is capable of acquiring a cross-sectional OCT image consisting of 2,048 depth scans in 85 ms. The imaging capability of the SD-OCT system was validated by imaging the normal ocular growth and experimental myopia model using ...

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    5. SD-OCT Imaging of Idiopathic Macular Holes With Spontaneous Closure

      SD-OCT Imaging of Idiopathic Macular Holes With Spontaneous Closure

      Please wait Close Window Spectral-domain optical coherence tomography serial changes in three cases of spontaneous closure of idiopathic macular hole at stages II, III, and IV are described. Initial and serial spectral-domain optical coherence tomography images document the progressive closure. Macular holes apparently resolved spontaneously through two different mechanisms: posterior hyaloid detachment in case 1 and a contraction of epiretinal macular membrane in cases 2 and 3. The spontaneous closure of idiopathic full-thickness macular holes may occur in any stage of idiopathic macular hole; the small size of the hole is a common feature in all cases of spontaneous closure ...

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    6. Anterior Segment Dimensions in Asian and Caucasian Eyes Measured by Optical Coherence Tomography

      Anterior Segment Dimensions in Asian and Caucasian Eyes Measured by Optical Coherence Tomography

      Please wait Close Window BACKGROUND AND OBJECTIVE: To compare Asian and Caucasian anterior segment dimensions measured by optical coherence tomography (OCT). PATIENTS AND METHODS: Anterior segment OCT images were obtained in normal subjects. Four line scans were acquired at the 90°, 45°, 0°, and 135° meridians of each eye. Computer calipers acquired anterior segment dimensions of corneal diameter, anterior chamber width, corneal vault, and anterior chamber depth on OCT images. Univariate and multivariate analyses were performed to assess correlations. RESULTS: Corneal diameter was 0.5 mm narrower ( P < .01), anterior chamber width was 0.46 mm narrower ( P < .01), and corneal vault was 0.22 mm lower ( P < .01) in Asian eyes. All anterior segment dimensions decreased with age. CONCLUSION: Asian eyes had smaller anterior segments compared to Caucasian eyes. Regardless of race, anterior segment dimensions were smaller in older subjects. Age-related changes may affect the tolerability of long-term implants such as phakic intraocular lenses.

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    7. High-Penetration Optical Coherence Tomography With Enhanced Depth Imaging of Polypoidal Choroidal Vasculopathy

      High-Penetration Optical Coherence Tomography With Enhanced Depth Imaging of Polypoidal Choroidal Vasculopathy

      Please wait Close Window A combination of high-penetration spectral-domain optical coherence tomography (central wavelength: 1,020 nm) and an enhanced depth imaging protocol (HP-EDI-OCT) was used to evaluate 5 eyes of 5 patients with polypoidal choroidal vasculopathy (PCV). In all eyes, HP-EDI-OCT provided high-contrast images of PCV lesions in the subretinal pigment epithelium (sub-RPE). In the space between the RPE line and Bruch’s membrane, various PCV lesions, including vascular networks, polypoidal lesions, and sub-RPE hemorrhage, were clearly identified. The chorioscleral interface was clearly observed, and the entire structure of the choroid was readily identified. Thus, HP-EDI-OCT was useful for ...

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    8. Reproducibility of Retinal Blood Flow Measurements Derived From Semi-Automated Doppler OCT Analysis

      Reproducibility of Retinal Blood Flow Measurements Derived From Semi-Automated Doppler OCT Analysis
      BACKGROUND AND OBJECTIVE: To evaluate reproducibility and intergrader agreement of total retinal blood flow (TRBF) measurements obtained by semi-automated grading of Doppler Fourier-domain optical coherence tomography (FD-OCT) scans. PATIENTS AND METHODS: Doppler FD-OCT scans were obtained from 20 eyes of 18 subjects (10 glaucomatous, 10 normal). Scans were obtained using a circumpapillary scan protocol and analyzed using the Doppler OCT of Retinal Circulation software (version 2). Two masked, independent human graders manually refined the scans, adding or deleting vessels, changing vessel boundaries, and classifying vessels as veins or arteries. TRBF was calculated automatically by software summing flow in all veins ...
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    9. Optical Coherence Tomography of Radiation Optic Neuropathy

      Optical Coherence Tomography of Radiation Optic Neuropathy
      BACKGROUND AND OBJECTIVE: To quantitatively study morphologic optic disc and retinal changes in patients with radiation optic neuropathy (RON) using optical coherence tomography (OCT). PATIENTS AND METHODS: This study is a retrospective clinical case series of ten patients with acute RON. Each had been treated with palladium-103 ophthalmic plaque therapy for choroidal melanoma. OCT images were taken at the time of the initial RON diagnosis to measure cup depth, cup width, edema, vasculature diameter, and retinal thickness. RESULTS: All patients with acute RON showed optic disc edema, increased optic disc thickness, and decreased optic cup depth. The average papillary retinal ...
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    10. Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking

      Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking

      BACKGROUND AND OBJECTIVE: To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments. PATIENTS AND METHODS: Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration. RESULTS: All instruments had superior rCMT in normal versus pathologic eyes (P < .001). No difference in rCMT was noted among instruments in normal eyes (P = .92), but TD-OCT was superior to SD-OCT (P = .017) in pathologic eyes. Cirrus image registration improved rCMT for normal eyes (P = .04), with borderline improvement in pathologic eyes (P = .06). Spectralis eye tracking improved rCMT in normal (P = .01) and pathologic (P = .004) eyes. CONCLUSION: Higher image resolution with SD-OCT may not improve rCMT, but image registration and eye tracking options may improve rCMT.

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    11. Comparison of Unenhanced and Enhanced Imaging Protocols for Angle Measurements With Anterior Segment Optical Coherence Tomography

      Comparison of Unenhanced and Enhanced Imaging Protocols for Angle Measurements With Anterior Segment Optical Coherence Tomography
      BACKGROUND AND OBJECTIVE: To compare the intraobserver and interobserver agreement of anterior chamber angle measurements using unenhanced and enhanced imaging protocols for anterior segment optical coherence tomography (AS-OCT). PATIENTS AND METHODS: Anterior segments of 30 eyes of 15 healthy subjects (mean age: 33.8 ± 13.0 years, 8 women) were imaged by a single examiner with AS-OCT using unenhanced and enhanced imaging protocol. Two masked observers analyzed each image independently on two separate occasions. The reproducibility of angle parameters was estimated by calculating coefficients of variation separately for each observer. Bland-Altman plots were constructed to assess the intraobserver and interobserver ...
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    12. Comparison of Residual Stromal Bed Thickness Measurement Among Very High-frequency Digital Ultrasound, Intraoperative Handheld Ultrasound, and Optical Coherence Tomography

      Comparison of Residual Stromal Bed Thickness Measurement Among Very High-frequency Digital Ultrasound, Intraoperative Handheld Ultrasound, and Optical Coherence Tomography
      PURPOSE: To compare residual stromal thickness (RST) measurement by three methods: very high-frequency digital ultrasound (VHFDU), intraoperative handheld ultrasound (US), and optical coherence tomography (OCT). METHODS: This was a retrospective analysis of 93 eyes (55 patients) that underwent LASIK retreatment by flap lift where VHFDU and OCT measurements were obtained before the retreatment and intraoperative US RST measurement was performed after lifting the flap. Corneal vertex RST measurements for intraoperative US and OCT were compared with the VHFDU measurement. Linear regression and Bland-Altman analysis were performed. RESULTS: Mean corneal vertex RST was 327±53 µm for VHFDU, 338±54 µm ...
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    13. SD-OCT Features of Laser Pointer Maculopathy Before and After Systemic Corticosteroid Therapy

      SD-OCT Features of Laser Pointer Maculopathy Before and After Systemic Corticosteroid Therapy
      The authors report spectral-domain optical coherence tomography findings of laser pointer-induced maculopathy in a 25-year-old man after accidental laser pointer exposure of less than 1 second. The Class 3R laser pointer (output wavelength 532 nm and output power 3.5 to 4.5 mW [continuous wave]) had U.S. Food and Drug Administration certification. One day after exposure, he had visual blurring and metamorphopsia of his right eye. He was treated with a systemic high-dose corticosteroid. Spectral-domain optical coherence tomography disclosed a hyperreflective band in the foveal region. After 1 week of treatment, disappearance of hyperreflectivity was observed on spectral-domain ...
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    14. Spectral-Domain Optical Coherence Tomography of the Choroid in Choroidal Osteoma

      Spectral-Domain Optical Coherence Tomography of the Choroid in Choroidal Osteoma
      The authors report spectral-domain optical coherence tomography (SD-OCT) findings in a patient with decalcifying choroidal osteoma accompanied by a choroidal neovascular membrane and serous retinal detachment. A 13-year-old girl was found to have a choroidal osteoma in the left eye. The clinical diagnosis was confirmed by B-scan ultrasonography, computed tomography, and fluorescein and indocyanine green angiography. The SD-OCT findings over the decalcified portion included serous retinal detachment, photoreceptor outer segment disorganization, retinal pigment epithelial atrophy, deformed Bruch’s membrane, and choroidal neovascular membrane. In contrast, the retinal structures over the calcified portion appeared to be preserved. SD-OCT showed loss of ...
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    15. Atypical Presentation of Salzmann Nodular Degeneration Diagnosed With Ultra-High–Resolution Optical Coherence Tomography

      Atypical Presentation of Salzmann Nodular Degeneration Diagnosed With Ultra-High–Resolution Optical Coherence Tomography
      A 59-year-old woman presented with bilateral, peripheral, circular corneal infiltrates. There was a clear zone separating the outer margin of the degeneration from the limbus in both eyes. The inner margins were indistinct. Ultra-high-resolution optical coherence tomography (UHR-OCT) imaging demonstrated subepithelial infiltrations with epithelial thinning and corneal surface elevation. The infiltrate was accompanied by significant stromal scarring, which reached deep layers of the corneal stroma. UHR-OCT findings were consistent with Salzmann nodular degeneration. UHR-OCT can be used as an optical biopsy to diagnose atypical corneal degenerations without tissue sampling.
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    16. Optical Coherence Tomography for Retinal Metastasis With Unknown Primary Tumor

      Optical Coherence Tomography for Retinal Metastasis With Unknown Primary Tumor
      The authors describe the optical coherence tomography (OCT) findings and the therapeutic approach of a patient with metastatic neoplastic disease of the retina. A patient with a history of brain cancer of undetermined origin underwent imaging and surgery to investigate a suspected metastatic retinal lesion of the right eye. Retinal thinning with cordon-like hyperreflective structures was seen on OCT. Neoplastic cells consistent with small cell carcinoma were identified in the vitreous sample. Those cells were thought to be similar to the previous biopsied cerebellar tumor specimen. OCT imaging, along with vitrectomy and retinal biopsy, may be useful in the evaluation ...
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      Mentions: UCSF
    17. High-Definition Optical Coherence Tomography Features of Primary Vitreoretinal Lymphoma

      High-Definition Optical Coherence Tomography Features of Primary Vitreoretinal Lymphoma
      Primary vitreoretinal lymphoma is a high-grade intraocular malignancy that presents as a vitritis with creamy subretinal lesions. In cases where the vitritis is dense, the characteristic subretinal lesions can be difficult to see on clinical examination. Novel high-definition imaging techniques that allow for deeper penetration through opaque media could have diagnostic utility in such cases. The authors present a case of a patient who presented with a dense vitritis that precluded visualization of fundus details. Spectral-domain optical coherence tomography using high-definition raster imaging demonstrated subretinal deposits along with outer retinal atrophy. These findings were suggestive of primary vitreoretinal lymphoma and ...
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    18. Clinical Significance of B-Scan Averaging With SD-OCT

      Clinical Significance of B-Scan Averaging With SD-OCT
      Averaging multiple scans is a potential advantage of optical coherence tomography. The authors evaluate the qualitative benefits of B-scan averaging on the visualization of outer retinal structures. A retrospective analysis was performed on Cirrus OCT (Carl Zeiss Meditec, Dublin, CA) B-scans from 1 eye of 35 patients referred to the imaging unit who underwent three types of scan acquisitions: no averaging, 4× averaging, and 20× averaging. Masked assessment of quality was made using a qualitative scale of 0 (worst) to 3 according to the ability to identify structure, brightness, and continuity. Quality scores consistently improved with 4× averaging, but improved ...
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    19. Between-Grader Repeatability of Tear Meniscus Measurements Using Fourier-Domain OCT in Patients With Dry Eye

      Between-Grader Repeatability of Tear Meniscus Measurements Using Fourier-Domain OCT in Patients With Dry Eye
      BACKGROUND AND OBJECTIVE: To examine the between-grader repeatability of height, depth, and cross-sectional area measurements of the lower tear meniscus, using a Fourier-domain optical coherence tomography (OCT) system. PATIENTS AND METHODS: A total of 16 patients with dry eye had the lower tear meniscus of the right eye imaged twice in rapid succession. The tear meniscus height, depth, and cross-sectional area were measured by two masked graders using computer calipers. The between-grader variability, calculated using the pooled coefficient of variation (CV%), assessed the repeatability of the measurements. RESULTS: The between-grader CV% was 12.1%, 15.7%, and 19.5% for ...
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    20. Comparison of Non-Contact Methods for the Measurement of Central Corneal Thickness

      Comparison of Non-Contact Methods for the Measurement of Central Corneal Thickness

      BACKGROUND AND OBJECTIVE:This study examined the repeatability of and agreements between central corneal thickness measurements obtained by four different non-contact pachymetry devices. PATIENTS AND METHODS:Seventy-eight eyes of 39 subjects were included. Central corneal thickness of each eye was measured by Visante optical coherence tomography (OCT) (Carl Zeiss Meditec Inc., Dublin, CA), Pentacam (Oculus Optikgeräte GmbH, Wetzlar, Germany), Orbscan IIz topography (Bausch & Lomb Surgical Inc., San Dimas, CA), and slit-lamp OCT (SL-OCT) (Heidelberg Engineering GmbH, Heidelberg, Germany). Inter-device agreements and correlations and repeatability of each device were examined. RESULTS:All measurement methods correlated well with each other with a ...

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    21. Spectral-Domain Optical Coherence Tomography Features of Mild and Severe Acute Solar Retinopathy

      Spectral-Domain Optical Coherence Tomography Features of Mild and Severe Acute Solar Retinopathy
      Photochemical/thermal retinal damage that results from unprotected solar eclipse viewing has vague presentations and sometimes misleading diagnosis, especially in cases with unclear history. Spectral-domain optical coherence tomography (SD-OCT) is a non-invasive imaging technique useful in differential diagnosis that can reveal characteristic foveal alterations in solar retinopathy to an unprecedented quasi histologic level. The authors present high-resolution SD-OCT findings correlated with clinical findings in three eyes of two cases with acute solar retinopathy. SD-OCT can precisely define the site and extent of damage in acute solar retinopathy. In mild forms, damage may be limited to the outer retina with inner ...
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    22. Spectral-Domain Optical Coherence Tomography as a Screening Technique for Chloroquine and Hydroxychloroquine Retinal Toxicity

      Spectral-Domain Optical Coherence Tomography as a Screening Technique for Chloroquine and Hydroxychloroquine Retinal Toxicity
      BACKGROUND AND OBJECTIVE: To determine the effectiveness of spectral-domain optical coherence tomography (SD-OCT) as a screening tool for the evaluation of chloroquine or hydroxychloroquine retinal toxicity. PATIENTS AND METHODS: This is a prospective, case–control study. Subject eyes were divided into four groups (group I = eyes with bull’s eye maculopathy, group II = eyes with early changes of toxicity, group III = eyes with exposure but no signs of toxicity, and group IV = eyes of age-matched controls). Retinal thickness was measured via SD-OCT 0.5 and 1.0 mm from the foveal center. RESULTS: Mean retinal thickness 1.0 mm from ...
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    23. Intraoperative OCT of Bilateral Macular Coloboma in a Child With Down Syndrome

      Intraoperative OCT of Bilateral Macular Coloboma in a Child With Down Syndrome
      A 3-year-old girl with Down syndrome presented with a macular lesion in both eyes. With intraoperative optical coherence tomography confirmation, the patient was diagnosed as having bilateral macular coloboma. These findings were previously reported in two patients with Down syndrome. The documentation of similar findings in three separate patients suggests that macular coloboma may be a rare ophthalmic pathology associated with Down syndrome. Moreover, optical coherence tomography imaging may be a useful adjunct in diagnosing macular coloboma in the pediatric population.
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    24. Spontaneous Resolution of Macular Fold Following Retinal Reattachment: Morphologic Features on SD-OCT

      Spontaneous Resolution of Macular Fold Following Retinal Reattachment: Morphologic Features on SD-OCT
      Macular fold is an infrequent complication after retinal detachment surgery. In this report, long-term changes of macular fold are demonstrated using spectral-domain optical coherence tomography. Although spontaneous resolution was noted in this study, spectral-domain optical coherence tomography revealed morphologic changes in the photoreceptor layer after resolution of macular fold, hyperreflective photoreceptor outer segment, and distorted Henle’s fiber layer, which might be associated with poor visual outcome even after resolution of the fold.
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