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    1. Improving optical coherence tomography theories and techniques for advanced performance and reduced cost (Thesis)

      Improving optical coherence tomography theories and techniques for advanced performance and reduced cost (Thesis)

      Optical coherence tomography (OCT) has been developed as a high-resolution three-dimensional imaging technique for clinical diagnosis. This thesis proposes several theoretical discoveries and technical improvements to the current OCT systems aiming to drastically reduce system costs while achieving the state-of-the-art performance. Polarization-sensitive OCT (PS-OCT) is a functional extension of conventional OCT which offers the depth-resolved birefringence imaging capability. To resolve local retardation in tissue samples, the current PS-OCT system employs two multiplexed polarization states to illuminate the sample under investigation and detects the backscattered light with two detection channels. We observed that the polarization state of light after round-trip propagation ...

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    2. Development of cellular resolution optical coherence tomography (Thesis)

      Development of cellular resolution optical coherence tomography (Thesis)

      Diagnosis of most mucosal diseases including epithelial cancers relies on white-light endoscopy/visual inspection followed by random biopsy and histologic examination. These current standard-of-care tools are associated with many issues such as sampling errors, tissue destruction, and processing artifacts. In addition, it is too traumatic to take a biopsy from tissues like eyes and coronary arteries. Being high resolution, high speed, and non-invasive, optical coherence tomography (OCT) has emerged as an endoscopic and intravascular imaging tool that provides valuable anatomic information complementary to the standard-of-care techniques. However, it has a typical resolution of 10 μm, which is too coarse to ...

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    3. Investigation of low coherence interferometry techniques for biomedical applications (Thesis)

      Investigation of low coherence interferometry techniques for biomedical applications (Thesis)

      Interferometric techniques have been used as imaging techniques in many applications. In using low coherence sources in interferometry, good axial resolution can be achieved. The objective of this thesis is to investigate the use low coherence interferometry in biomedical applications. Low coherence interferometry (LCI) was incorporated into an optical tweezers system to determine the trapping dynamics. An optical coherence tomography (OCT) system based on LCI principles was designed and implemented to detect virus infection in orchid leaves. The OCT system was then modified to realize a high-speed endoscopic OCT imaging system. A numerical method and a common-path probe design were ...

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