1. Articles from osa-opn.org

  2. 1-16 of 16
    1. Forensic Problems, Optical Solutions

      Forensic Problems, Optical Solutions

      Since first hitting the scene in 1991, optical coherence tomography (OCT) has become a leviathan among biomedical imaging techniques, due to the method’s nondestructive ability to resolve layers of tissue. In ophthalmology, especially, OCT has been revolutionary, imaging retinal layers noninvasively through an approximately one-inch-thick watery window—the human eye. Now, U.K. researchers in applied optics, forensic science and the document-examination industry have joined forces to apply OCT to the high-resolution subsurface analysis of multilayered identification documents (Sci. Justice, doi: 10.1016/j.scijus.2020.12.001 ). The method can reportedly detect forged passports or national ID cards ...

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    2. OCT Captures Impressionistic Brushstrokes

      OCT Captures Impressionistic Brushstrokes

      Art conservators have enlisted a bevy of imaging techniques, including optical coherence tomography (OCT), to study valuable paintings and ensure their long-term preservation. Even though OCT can generate 3D images of scattering media with micrometer resolution and without destroying its subject, the method’s narrow field of view limits its ability to examine broad regions of an artist’s canvas. Researchers at two U.S. universities have built a hybrid scanning platform that couples OCT with a sampling algorithm to create 3D reconstructions of impressionist oil paintings (Appl. Opt., doi: 10.1364/AO.390326 ). Besides helping art historians to understand ...

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    3. Toward an All-Optical Biopsy

      Toward an All-Optical Biopsy

      Combining multiple photonic imaging techniques could allow for new, noninvasive approaches to tumor detection and assessment, meeting clinical challenges at a time of rising global cancer incidence. [Getty Images] A compact experimental setup for multimodal nonlinear microscopy in clinical settings. [Leibniz-IPHT, S. Döring] Aging populations, exposure to environmental contamination in developing countries, and other factors are driving significant increases in cancer worldwide. The World Health Organization estimates that globally, the number of cancer cases will reach 21.6 million by 2030, nearly double the 14 million patients in 2012. In Germany alone, malignant tumors are responsible for a quarter ...

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    4. Using OCT to Watch an Ear Hear

      Using OCT to Watch an Ear Hear

      A research team led by OSA Fellow Seok-Hyun Yun at the Wellman Center for Photomedicine at Massachusetts General Hospital, USA, reports using a form of optical coherence tomography (OCT) to capture 3-D anatomical and vibrational images of ossicles—tiny bones within the middle ear—as they move in response to sound (Biomed. Opt. Express, doi: 10.1364/BOE.9.005489 ). The imaging method, which they named OCT vibrography, uses OCT phase-synchronized with a range of high-frequency sound stimuli. In demonstrations with a chinchilla ear model, the researchers used OCT vibrography to observe a previously unknown mode of ossicular motion at ...

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    5. Study Reveals the Hazards of Laser Pointers

      Study Reveals the Hazards of Laser Pointers

      A research team from the University of Bonn, Germany, and the University of Oxford, U.K., has investigated the severity of injuries that can be caused by common laser pointers. The researchers report that the retinal trauma can sometimes be grave and result in irreversible vision impairment (Dtsch. Arztebl. Int., doi: 10.3238/arztebl.2017.0831 ). They conclude that “In view of the practically unimpeded access to laser pointers (even high-performance ones) over the Internet, society at large now needs to be more aware of the danger posed by these devices, particularly to children and adolescents.”

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    6. Imaging the Whole Human Eye

      Imaging the Whole Human Eye

      Getting the whole picture of the human eye—from front to retina—has required multiple investigations. Now, researchers at two European universities have combined optical coherence tomography (OCT) with an electrically tunable lens to make a system for imaging the entire eye at once (Optica, doi:10.1364/OPTICA.5.000052 ). A new instrument According to the team led by physicist Ireneusz Grulkowski of Nicolaus Copernicus University (Poland), the new adaptive-focusing, non-invasive instrument can provide more detailed images of ocular structures than other systems and could speed up ophthalmic examinations by eliminating the need for physicians to use separate instruments ...

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    7. A Better View of Blood-Vessel Development

      A Better View of Blood-Vessel Development

      A research team in China has exploited photoacoustic imaging to track development of the circulatory system in zebrafish embryos, without the use of labels or contrast agents that can gum up the view of sensitive biological processes (Biomed. Opt. Express, doi: 10.1364/BOE.8.002359 ). The researchers believe that this proof of concept in one of biomedicine’s central model organisms could open a path in the future toward using the technique to study human cardiovascular diseases, as well as brain diseases tied to blood-flow issues.

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    8. Macro-Scale OCT-on-a-Chip

      Macro-Scale OCT-on-a-Chip

      A U.S. industry-academic collaboration, led by OSA Fellow James Fujimoto, Massachusetts Institute of Technology (MIT; USA), reports a proof-of-principle demonstration of cubic-meter volume optical coherence tomography (OCT). The researchers used advanced photonics integrated circuits (PICs) and MEMS technology to boost OCT performance on multiple scales over long ranges. Specifically, the team demonstrated 3-D subsurface tomographic imaging on a meter scale at a 100-kHz axial scan rate with 15-µm depth resolution ( Optica , doi: 10.1364/OPTICA.3.001496 ). OCT is a 3-D imaging technology commonly used in ophthalmology to get micron-scale images of small structures in the human eye ...

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    9. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging

      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a detailed comparison of OCT and another modality, optical projection tomography (OPT), in murine-embryo studies. 2 Most commonly used for ophthalmological imaging, 3 OCT has proved a powerful embryonic-imaging modality as ...

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    10. A 4-D OCT Engine with 1 GVoxel/s

      A 4-D OCT Engine with 1 GVoxel/s

      Optical coherence tomography (OCT) is a depth-resolved imaging modality that provides micrometer-scale cross-sectional and 3-D information on the scattering properties of biological samples. 1 Video rate real-time 3-D volumetric OCT (4-D-OCT) could generate a new class of optical tools in clinical practice, like surgical guidance. 2 This challenge requires us to combine a high-speed OCT imaging setup, ultrafast data acquisition and adequate real-time data processing to process and visualize the vast amount of data. Although 4-D-OCT has long been a dream for researchers, only a few groups have successfully implemented 4-D volumetric OCT imaging with real-time visualization—usually with low ...

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    11. MR-OCT: Affordable Tomographic Imaging Applications

      MR-OCT: Affordable Tomographic Imaging Applications

      The application of optical coherence tomography (OCT) in the field of biomedical imaging has increased rapidly in recent years and may continue on this trajectory with growth potential in clinical diagnostics. 1 Integration of OCT for affordable point-of-care (POC) diagnostic applications and personal-care monitoring should lead to miniature, inexpensive, portable, robust optical instrumentation that is accurate and simple to use. However, the current embodiments of OCT systems are highly expensive, utilize large-form-factor optical design, and require accurate alignment of complex optics, making them impractical for the POC environment. In recent years, there has been an increasing interest in the development ...

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    12. Expanding OCT: Quanitifying the Cornea’s Optical Performance

      Expanding OCT: Quanitifying the Cornea’s Optical Performance

      Optical coherence tomography, a well-known method for imaging the retina, may allow physicians to perform quantitative metrology of the eye’s own optics. Swept-source OCT allows for simultaneous imaging of the cornea, iris and retina in living patients. Laser refractive surgeries such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) have brought better vision to tens of millions worldwide. But these techniques also exact a cost: because they work by reshaping the eye’s cornea, they make accurate measurement of the cornea’s optical parameters after surgery unreliable using conventional tools. That’s important, not only because inaccurate ...

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    13. U.S. Patent Reform and Photonics Companies

      U.S. Patent Reform and Photonics Companies

      A new law represents the most significant patent reform that the United States has seen in over 50 years. Joseph Gortych explains what optical entrepreneurs need to know about the America Invents Act. As those familiar with the patent process know, the U.S. Patent and Trademark Organization (USPTO) has until recently employed a “first-to-invent” system. That means that different inventors who filed patent applications on the same invention at different times could find themselves embroiled in an “interference proceeding” to determine who was first to invent and thus entitled to the patent. That changed on 16 March of this ...

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    14. Optics in 2012: The Best of the Best from Optics and Photonics News (VIDEO)

      Optics in 2012: The Best of the Best from Optics and Photonics News (VIDEO)

      This special issue of Optics & Photonics News highlights the most exciting peer-reviewed optics research to have emerged over the past 12 months. Our panel of editors reviewed close to 80 submitted summaries from scientists all over the globe. They selected for publication the 30 stories that they felt most clearly communicated breakthroughs of interest to the optics community.

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    15. U.S. Science Funding in Jeopardy

      U.S. Science Funding in Jeopardy

      The U.S. Office of Management and Budget (OMB) released a report in mid-September detailing the potential funding reductions of the automatic across-the-board $1.2 trillion spending cuts slated to go into effect 2 January 2013, barring an agreement in Congress on deficit reduction. The decreases were mandated under the Budget Control Act of 2011. The report was meant to encourage Congress to reach an agreement in 2012 on reducing the deficit, since the cuts will only go into effect if a deal is not made. To date, no legislation has been passed to prevent these reductions, which the OMB ...

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    16. OPN Talks with Dr. James Fujimoto - OCT Pioneer and CLEO:2011 Plenary Speaker

      OPN Talks with Dr. James Fujimoto - OCT Pioneer and CLEO:2011 Plenary Speaker
      Optical coherence tomography (OCT) is a relatively new technology, but is it having a significant impact in biomedical research. It was first demonstrated just 20 years ago, and it has already emerged as a powerful imaging tool in the biomedical world. In fact, OCT has become so widespread in the medical field that a journal keyword search on "optical coherence tomography" retrieves more than 10,000 references. The commercial market is estimated at several hundred million dollars. OPN recently caught up with James G. Fujimoto of the Massachusetts Institute of Technology, whose group and collaborators developed OCT. Fujimoto will deliver ...
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    1-16 of 16
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