1. 1-14 of 14
    1. Rapid ex vivo examination of Mohs specimens using optical coherence tomography

      Rapid ex vivo examination of Mohs specimens using optical coherence tomography

      Background Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo . Objective : The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes. Methods Seventy-three subjects with biopsy-proven ...

      Read Full Article
    2. Optical Coherence Tomography Imaging of Basal Cell Carcinoma Undergoing Photodynamic Therapy: A Pilot Study

      Optical Coherence Tomography Imaging of Basal Cell Carcinoma Undergoing Photodynamic Therapy: A Pilot Study

      The conversion of hyporeflective basal cell carcinoma nodules into hyperreflective ovoid structures was remarked with optical coherence tomography (OCT) as a sign of tumor regression under photodynamic therapy (PDT). OCT presented a higher accuracy in identifying residual and non-residual lesions after PDT treatment compared to clinical inspection alone.  OCT might be used in the future as a standard procedure for detecting non-melanoma skin cancer sparing patients invasive procedures.

      Read Full Article
    3. Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone

      Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone

      Background Basal cell carcinoma (BCC) is a locally destructive form of skin cancer, mainly affecting Caucasians. In the last few years non-surgical treatments of BCC have become widely used and non-invasive methods for treatment monitoring and follow-up are therefore becoming increasingly warranted. The objective of this study was to investigate the utility of adjunct use of non-invasive optical coherence tomography (OCT) imaging for the detection of recurrent BCC over clinical and dermoscopic examination alone, in a real-world setting. Methods A total of 58 patients, previously treated with curettage and/or MAL-PDT for BCC, were included in the study. The patients ...

      Read Full Article
    4. Photodynamic therapy in VEGF inhibition non-responders—pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography

      Photodynamic therapy in VEGF inhibition non-responders—pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography

      Background Treatment of neovascular age-related macular degeneration (nAMD) remains a major challenge in ophthalmology. It is essential to determine which of VEGF inhibition non-responders can benefit from photodynamic therapy (PDT). As AMD is strongly related to gene polymorphisms, genetic factors can modify efficacy of treatment. Swept-source optical coherence tomography (SS-OCT) gives exceptional insight into the retina and choroid. SS-OCT usefulness needs to be evaluated in nAMD patients. Methods Prospective 6-month study included consecutive 110 patients (110 eyes) with predominantly classic neovascular AMD treated with photodynamic therapy. Only non-responders to anti-VEGF were included in the study. Greatest linear dimension (GLD) of ...

      Read Full Article
    5. VECSELs: Innovative light sources for PDT - Photodiagnosis and Photodynamic Therapy

      VECSELs: Innovative light sources for PDT - Photodiagnosis and Photodynamic Therapy

      Photodynamic therapy (PDT) with porphyrins and red light (610–630 nm) is finding increasing clinical application for both the eradication of relatively small tumors and the palliation of inoperable or obstructive tumors. PDT also shows some promise for the sterilization of the tumor bed after surgical removal of neoplastic masses. Optically pumped vertical external-cavity surface-emitting lasers (VECSELs) appear to be a very innovative and efficient technology in this specific wavelength range. Furthermore, VECSELs are power scalable and wavelength tunable, and are an appealing light source for PDT.

      Read Full Article
      Mentions: Mircea Guina
    6. Optical coherence tomography in the assessment of oral squamous cell carcinoma resection margins

      Optical coherence tomography in the assessment of oral squamous cell carcinoma resection margins

      Background Incomplete surgical removal of cancer is believed to be the main cause of local recurrence and high mortality. This study assessed the use of optical technology (namely optical coherence tomography [OCT]) in examining oral squamous cell carcinoma (OSCC) resection margins to assess if this modality could guide the surgeon during surgical resections. Materials and methods Twenty-eight T1-T2 N0M0 oral squamous cell carcinoma patients participated in this study. Nineteen patients were males and nine were females. The majority of lesions were in the ventro-lateral tongue, floor of mouth, retromolar trigone and the buccal mucosa. Following tumour resection, the specimen resection ...

      Read Full Article
    7. Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Background Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. Objectives The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesions, (2) to determine the inter-observer agreement in the analysis of specific image parameters, and (3) to find out the oral epithelial thickness for different pathology groups. Materials and methods This prospective study involved 125 suspicious oral lesions from 125 patients. The lesions were surgically biopsied and subjected to ...

      Read Full Article
    8. Optical coherence tomography of the tongue papillae for patients suffering from taste disorders following chemoradiotherapy

      Optical coherence tomography of the tongue papillae for patients suffering from taste disorders following chemoradiotherapy
      Background: In vivo optical coherence tomography (OCT) is a relatively new, non-invasive method for assessment of the oral cavity epithelium. The penetration depth of approximately 2mm allows visualization of tongue papillae structures and assesses their geometry.
      Read Full Article
    9. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series
      Background: Guiding and monitoring treatment during and after photodynamic therapy (PDT) of skin cancer is often difficult. Objectives: We investigated the applicability of in vivo optical coherence tomography (OCT) in guiding and monitoring PDT in patients with skin cancer.
      Read Full Article
    10. Optical coherence tomography for classification of oral mucosal lesions

      Optical coherence tomography for classification of oral mucosal lesions

      Introduction: Not having to take a biopsy of oral mucosal lesions can be a great relief for patients. Optical coherence tomography (OCT) allows non-invasive imaging of epithelial layers and subsequently of epithelial lesions. The aim of this study is to establish whether OCT can aid in clinical diagnosis and in the decision of taking a biopsy or not.

      Read Full Article
    11. Longitudinal oral mucosal tissue imaging using co-localised optical coherence tomography and micro-vascular imaging

      Longitudinal oral mucosal tissue imaging using co-localised optical coherence tomography and micro-vascular imaging
      Background: Optical Coherence Tomography (OCT) is a non-invasive, non-contact high resolution imaging technology, utilising near infra-red rather than ionising radiation or ultrasound to image biological tissues at millimetre depths. In vivo Head & Neck applications are developing, challenges include the ability to analyse images and capture reproducible imaging data. Oral splints were designed and trailed to allow reproducible imaging of the same gingival region of interest, following patterns of volumetric change and facilitating co-localised micro-vascular assessment over a three-month period.
      Read Full Article
    12. Optical coherence tomography in the evaluation of tongue papillae in healthy individuals

      Optical coherence tomography in the evaluation of tongue papillae in healthy individuals
      Although there have been several investigations involving the morphological features and the pathological changes in tongue papillae, highly accurate and sensitive tools in which morphology, volume and geometry of tongue papillae can be easily identified have not been developed yet.
      Read Full Article
    13. Optical coherence tomography (OCT) for early diagnosis of tumors and online-control of photodynamic therapy (PDT)

      Optical coherence tomography (OCT) for early diagnosis of tumors and online-control of photodynamic therapy (PDT)
      Introduction: Optical coherence tomography is a non-invasive imaging modality, which uses backscattered infrared light for the reconstruction of anatomical structures. Doppler imaging can add functional information on tissue perfusion. With an imaging depth of a few millimeters OCT is able to visualize superficial tumors, which may be treated by PDT. In addition OCT has the potential to control the effect of photodynamic treatment.
      Read Full Article
    14. Qualitative optical coherence tomography for normal and pathologic skin lesions

      Qualitative optical coherence tomography for normal and pathologic skin lesions
      The pre-clinical application of optical coherence tomography (OCT) on ex vivo skin lesions has validated this tool structurally and metrically. However, knowledge of in vivo normal and pathological skin architectural and morphological properties would be of significant interest in dermatological practice.
      Read Full Article
    1-14 of 14
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks