1. Articles from oto.sagepub.com

  2. 1-5 of 5
    1. Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue

      Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue

      Objective Vocal fold scarring, a condition defined by increased collagen content, is challenging to treat without a method of noninvasively assessing vocal fold structure in vivo. The goal of this study was to observe the effects of vocal fold collagen content on optical coherence tomography imaging to develop a quantifiable marker of disease. Study Design Excised specimen study. Setting Massachusetts Eye and Ear Infirmary. Subjects and Methods Porcine vocal folds were injected with collagenase to remove collagen from the lamina propria. Optical coherence tomography imaging was performed preinjection and at 0, 45, 90, and 180 minutes postinjection. Mean pixel intensity ...

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    2. Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Visualization of Maculae and Membranous Semicircular Ducts in the Otic Capsule by Optical Coherence Tomography

      Objectives: (1) Show the possibility of using optical coherence tomography (OCT) to visualize the internal structure of the vestibule and semicircular canals with the bony capsule intact. (2) Study the effect of the decalcification. OCT is a nondestructive imaging modality that uses infrared light as it penetrates turbid biological tissue. Previously, OCT has been successfully used to visualize inside the cochlea in normal and abnormal inner ears. Methods: The OCT system, OCS-1300SS (Thorlabs, Inc, NJ) with a central wavelength of 1300 nm and a theoretical axial resolution of 9 µm, was employed for image acquisition. Normal and Slc26a4 mutant mice ...

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    3. First Use of Long-Range Optical Coherence Tomography to Image Airway Structure in Awake Children

      First Use of Long-Range Optical Coherence Tomography to Image Airway Structure in Awake Children

      Objectives: Identifying the appropriate operation(s) for children with sleep-disordered breathing (SDB) remains a challenge, and current imaging modalities have major shortcomings. We have pioneered the use of long-range optical coherence tomography (LR-OCT) to provide real-time images of the upper airway (UA) during sleep and wakefulness. Here we present our first use of LR-OCT to image the UA of awake children. (1) Understand how LR-OCT produces high-resolution structural images by acting as an optical range-finder. (2) Recognize how LR-OCT can identify strictures and real-time collapse of the airway. Methods: This study builds upon our experience using LR-OCT to image 58 ...

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    4. Endoscopic Anatomy of the Pediatric Middle Ear

      Endoscopic Anatomy of the Pediatric Middle Ear

      Traditionally, otologists have aimed to produce a clean, dry, safe ear with the best possible hearing result. More recently, “less invasively” has been added to this list of goals. The development of small-diameter, high-quality rigid endoscopes and high-definition video systems has made totally endoscopic, transcanal surgery a reality in adult otology and a possibility in pediatric otology. This article reviews the anatomy of the pediatric middle ear and its surrounding airspaces and structures based on the work of dozens of researchers over the past 50 years. It will focus on the developmental changes in ear anatomy from birth through the ...

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    5. Polarization-Sensitive Optical Coherence Tomography Imaging of Benign and Malignant Laryngeal Lesions: An In Vivo Study

      Polarization-Sensitive Optical Coherence Tomography Imaging of Benign and Malignant Laryngeal Lesions: An In Vivo Study
      Objective. Optical coherence tomography (OCT), an imaging technology that provides cross-sectional subsurface tissue structure images using back-scattered light, is a promising noninvasive imaging modality for in vivo assessment of vocal fold layered microstructure. Polarization-sensitive OCT (PS-OCT) augments conventional OCT by detecting changes in the polarization state of reflected light. This study imaged various benign and malignant laryngeal pathologies in patients undergoing direct laryngoscopy under general anesthesia to determine whether PS-OCT would provide useful additional information about vocal fold microstructure and glottic surface pathology. Study Design. Prospective clinical trial. Setting. Tertiary care center. Subjects and Methods. Twenty-three patients who were undergoing ...
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    1-5 of 5
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