Articles from Nature Publishing Group

1. A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT + HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

   Explore Article Nature Publishing Group (Feb 10 2010) Ophthalmology

   Purpose: To acquire high definition spectral domain optical coherence tomography (SD-OCT) images of supine, non-anesthetized infants in the office by a novel modification of a commercially available table-top, chin rest system. Method: Spectralis, a combined HRA+OCT device (Heidelberg Engineering, Heidelberg, Germany) was modified to convert the table-top system into a hand-held device using a two-step modification of the existing system. This device was used to obtain high-resolution OCT images of four infants with aggressive posterior retinopathy of prematurity (APROP) who required no general anesthesia. Results: Serial imaging at two time periods of the exact area of clinical interest were obtained ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

2. Bladder cancer: Optical coherence tomography improves UCC detection

   Explore Article Nature Publishing Group (Jan 13 2010) Oncology , Urology

   Targeted optical coherence tomography (OCT) in combination with hexaminolevulinate (HAL) fluorescence cystoscopy improves diagnostic accuracy in detecting urothelial cell carcinoma (UCC) of the bladder, report Schmidbauer and colleagues from the Medical University of Vienna.Fluorescence cystoscopy has been shown to significantly improve detection of UCC when used as an adjunct to white-light cystoscopy. (Read Full Article)
   

   Comment on Article Mentions:   Medical University of Vienna

3. A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT + HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

   Explore Article Nature Publishing Group (Jan 7 2010) Ophthalmology

   Purpose: To acquire high definition spectral domain optical coherence tomography (SD-OCT) images of supine, non-anesthetized infants in the office by a novel modification of a commercially available table-top, chin rest system. Method: Spectralis, a combined HRA+OCT device (Heidelberg Engineering, Heidelberg, Germany) was modified to convert the table-top system into a hand-held device using a two-step modification of the existing system. This device was used to obtain high-resolution OCT images of four infants with aggressive posterior retinopathy of prematurity (APROP) who required no general anesthesia. Results: Serial imaging at two time periods of the exact area of clinical interest were obtained ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

4. Neovascular age-related macular degeneration: decision making and optimal management

   Explore Article Nature Publishing Group (Jan 7 2010) Ophthalmology

   Methods Review of literature and presentation of illustrative cases. Results Guidelines are available to aid commissioners and providers of services but with important gaps in advice. Increasing awareness of variants and diseases that mimic nAMD means that clinicians need to carefully assess lesions at presentation, using stereo imaging, fluorescein and indocyanine green angiography, and new generation optical coherence tomography. Current evidence supports the use of ranibizumab as first-line therapy. Evidence is unclear on the most appropriate treatment regime, especially in protocols relying on clinician-determined re-treatment. Current consensus recommends initiation with monthly injections for 3 months followed by maintenance comprising regular ... (Read Full Article)
   

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5. Imaging chorioretinal vascular disease

   Explore Article Nature Publishing Group (Dec 11 2009) Ophthalmology

   Since its first description more than 40 years ago, fluorescein angiography had a crucial role in the diagnosis and management of chorioretinal vascular disorders such as neovascular age-related macular degeneration. Although fluorescein angiography permits visualization of the retinal microcirculation in exquisite detail, visualization of the choroidal circulation is more limited. Moreover, fluorescein angiography provides only minimal information regarding the functional consequences of vascular disease and allows, at best, only semi-quantitative assessment of retinal thickness. In recent years, the development of other chorioretinal imaging modalities, such as indocyanine green angiography, fundus autofluorescence, and optical coherence tomography (OCT), has addressed many of ... (Read Full Article)
   

   Comment on Article Mentions:   Keck School of Medicine   Srinivas R. Sadda

6. Fourier Domain Optical Coherence Tomography integrated into a slit lamp; a novel technique combining anterior and posterior segment OCT

   Explore Article Nature Publishing Group (Nov 13 2009) Ophthalmology

   Purpose Fourier Domain Optical Coherence Tomography (FD-OCT) provides high resolution cross-sectional images of the retina and the anterior segment. It has become an important tool in ophthalmology in the examination, diagnosis, and treatment of important and common diseases. Present OCT imaging systems are stand-alone devices. The aim of this paper is to show the quality of images made with a prototype of a Fourier Domain (FD-) OCT imaging system (SLSCAN-1) integrated into a slit lamp. Methods Different representative pathologies of the posterior and anterior segment were observed with the slit lamp and simultaneously scanned with a prototype of the slit ... (Read Full Article)
   

   Comment on Article Mentions:   Topcon Medical Systems   Academic Medical Center at the University of Amsterdam   Topcon 3D OCT-1000

7. Myopic pre-foveoschisis: an earlier stage of myopic foveoschisis documented by optical coherence tomography

   Explore Article Nature Publishing Group (Oct 15 2009) Ophthalmology

   Correspondence. (Read Full Article)
   

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8. Diagnostic ability of a linear discriminant function for optic nerve head parameters measured with optical coherence tomography for perimetric glaucoma

   Explore Article Nature Publishing Group (Oct 8 2009) Ophthalmology

   Background/aims To calculate and validate a linear discriminant function (LDF) for optical coherence tomography (OCT) to improve the diagnostic ability of isolated optic nerve head (ONH) parameters to discriminate between healthy individuals and glaucoma patients. Methods Two independent samples (teaching and validating sets) were prospectively selected. The teaching set (54 normal eyes and 73 glaucoma patients) was used to calculate the LDF. The validating set (70 healthy individuals and 67 glaucoma patients) was used to test the performance of the LDF in an independent population. Receiver operating characteristic (ROC) curves were plotted and compared with the ONH parameters measured using ... (Read Full Article)
   

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9. Post-doctoral position in Optical Coherence Technology : Joensuu, Finland and Kuopio, Finland

   Explore Article Nature Publishing Group (Oct 8 2009) Jobs & Studentships

   The Department of Physics and Mathematics, University of Eastern Finland, invites applications for a post-doctoral position in Optical Coherence Technology. The appointed person is to carry out mainly experimental research in Optical Coherence Tomography (OCT) and its application to characterization of tissues. QUALIFICATIONS: Doctoral degree required in physics, medical physics, optics, or related field; specialization in OCT or its medical applications is an advantage. The doctoral degre… (Read Full Article)
   

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10. Structural changes of fovea during remission of Behçet's disease as imaged by spectral domain optical coherence tomography

    Explore Article Nature Publishing Group (Sep 25 2009) Ophthalmology

    Purpose To acquire the image of the fovea during remission of ocular Behçet's disease using spectral domain optical coherence tomography (SD-OCT) and to further assess the correlation between best-corrected visual acuity (BCVA) and SD-OCT findings. Methods A total of 24 eyes of 14 patients with ocular Behçet's disease were examined with SD-OCT. The relationships between BCVA and other clinical characteristics, including foveal thickness and status of external limiting membrane (ELM) or the junction between photoreceptor inner and outer segments (IS/OS), were analysed for statistical significance. Results BCVA in eyes with intact IS/OS was significantly better than that in eyes with ... (Read Full Article)
    

    Comment on Article Mentions:   Nagahisa Yoshimura   Kyoto University Graduate School of Medicine

11. Spectral-domain optical coherence tomography findings in a case of frosted retinal branch angiitis

    Explore Article Nature Publishing Group (Sep 5 2009) Ophthalmology

    No Abstract Available (Read Full Article)
    

    Comment on Article Mentions:   Harvard University   Massachusetts Eye and Ear Infirmary   University of Milan

12. Quantification of Dental Erosions in Patients With GERD Using Optical Coherence Tomography Before and After Double-Blind, Randomized Treatment With Esomeprazole or Placebo

    Explore Article Nature Publishing Group (Aug 6 2009) Dentistry

    OBJECTIVES: Dental erosion, the chemical dissolution of enamel without bacterial involvement, is a rarely reported manifestation of gastroesophageal reflux disease (GERD), as well as of recurrent vomiting and dietary habits. It leads to loss of tooth substance, hypersensitivity, functional impairment, and even tooth fracture. To date, dental erosions have been assessed using only very basic visual methods, and no evidence-based guidelines or studies exist regarding the prevention or treatment of GERD-related dental erosions. METHODS: In this randomized, double-blind study, we used optical coherence tomography (OCT) to quantify dental tissue demineralization and enamel loss before and after 3 weeks of acid-suppressive ... (Read Full Article)
    

    Comment on Article Mentions:   UC Irvine   Petra Wilder-Smith

13. Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy

    Explore Article Nature Publishing Group (Jul 30 2009) Ophthalmology

    Purpose To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC). Methods Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Amod Gupta   Zeiss Cirrus HD-OCT

14. Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

    Explore Article Nature Publishing Group (Jul 27 2009) Ophthalmology

    Purpose To elucidate changes in the neurosensory retina in the macular area, using spectral domain OCT and correlate with functional loss on fundus-related microperimetry, in patients with diabetes and no diabetic retinopathy compared with age-matched healthy volunteers. Methods This was a prospective study enroling 39 patients in each group. All patients underwent comprehensive dilated eye examination. The foveal thickness and the photoreceptor layer thickness at the foveal centre were measured using spectral domain OCT, and the mean retinal sensitivity of central 20 degrees was measured using microperimetry. Results The mean age of the patients with diabetes was 50.924.75 years, and ... (Read Full Article)
    

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15. Optical coherence tomography-based decision making in exudative age-related macular degeneration: comparison of time- vs spectral-domain devices

    Explore Article Nature Publishing Group (Jul 20 2009) Ophthalmology

    Purpose To determine whether optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD). Methods Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus OCT system and the spectral-domain Cirrus OCT system at the same visit. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analysed. Results Cirrus OCT generated a higher ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   National Eye Institute   Zeiss Cirrus HD-OCT

16. OCT measurements on the foveal and perifoveal retinal thickness on diabetic patients after phacoemulsification and IOL implantation

    Explore Article Nature Publishing Group (Jul 11 2009) Ophthalmology

    Purpose The first aim (I.) was to measure the change of macular thickness in diabetic (DM group) and nondiabetic patients (NORMAL group), the values of operated eye (OP) were compared I.A.) to the fellow, non-operated eye (CONTROL) and I.B.) to preoperative baseline value of the operated eye (PRE). The second aim (II.) was to compare postoperative macular thickening of DM group to NORMAL group eyes. Methods Retinal thickness values of the foveal and perifoveal (fovea+3.0 mm, fovea+6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 18 eyes of 18 diabetic ... (Read Full Article)
    

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17. Spectral-domain optical coherence tomography visualisation of retinal oxalosis in primary hyperoxaluria

    Explore Article Nature Publishing Group (Jul 9 2009) Ophthalmology

    No Abstract Provided. (Read Full Article)
    

    Comment on Article Mentions:   Centre Hospitalier Intercommunal de Créteil   Gisèle Soubrane   Eric H. Souied

18. Effects of photodynamic therapy on subfoveal blood flow in neovascular age-related macular degeneration patients

    Explore Article Nature Publishing Group (Jun 20 2009) Ophthalmology

    Aim To assess the short-term changes in choroidal blood flow (ChBF) after photodynamic therapy (PDT) in patients with neovascular age-related macular degeneration (AMD). Methods Fourteen patients with exudative AMD were included after a complete ophthalmological examination, fluorescein and indocyanine green angiography and optical coherence tomography. Subfoveal ChBF was assessed using laser Doppler flowmetry (LDF) in both treated (n=14) and nontreated contralateral (n=8) eyes, 1 h and 1 week after PDT. Ocular perfusion pressure was calculated. Results The detection sensitivity of the LDF measurements at 2-min intervals before PDT in treated eyes was 7.4% for volume, 6.3% for velocity, and 10.4% ... (Read Full Article)
    

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19. Comparison of Visante and slit-lamp anterior segment optical coherence tomography in imaging the anterior chamber angle

    Explore Article Nature Publishing Group (Jun 13 2009) Ophthalmology

    Aims To compare the diagnostic performance of two anterior segment optical coherence tomography (AS-OCT) devices in assessing the anterior chamber angle (ACA). Methods Visante-OCT and slit-lamp-OCT (SL-OCT) were performed on 101 patients by a single operator. The AS-OCT images were processed by customised 'dewarping' software and assessed by two glaucoma specialists masked to clinical findings. A closed ACA was defined by the presence of contact between the iris and angle anterior to the scleral spur. Measurements of the ACA, anterior chamber depth (ACD), and pupil diameter were analysed. Gonioscopy was performed by another examiner masked to AS-OCT findings. Results Qualitative ... (Read Full Article)
    

    Comment on Article Mentions:   National University of Singapore   Hon-Tym Wong   Carl Zeiss Meditec

20. Prospective comparison of ultrasound biomicroscopy and anterior segment optical coherence tomography for evaluation of anterior chamber dimensions in European eyes with primary angle closure

    Explore Article Nature Publishing Group (May 17 2009) Ophthalmology

    Purpose To compare the accuracy in measurement of the anterior chamber (AC) angle by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in European patients with suspected primary angle closure (PACS), primary angle closure (PAC), or primary angle-closure glaucoma (PACG). Design Cross-sectional study. Methods In all, 55 eyes of 33 consecutive patients presenting with PACS, PAC, or PACG were examined with AS-OCT, followed by UBM. The trabecular-iris angle (TIA) was measured in all four quadrants. The angle-opening distance (AOD) was measured at 500 m from the scleral spur. The Bland–Altman method was used for assessing agreement between the ... (Read Full Article)
    

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21. Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

    Explore Article Nature Publishing Group (May 11 2009) Neurology , Ophthalmology

    Multiple sclerosis (MS) is commonly regarded as an inflammatory disease, but it also has a neurodegenerative component, which represents an additional target for treatment. The use of MRI to evaluate the inflammatory disease component in 'proof-of concept' clinical trials is well established, but no systematic assessment of imaging outcomes to evaluate neuroprotection or repair in MS has been performed. In this Review, we examine the potential of traditional and novel imaging parameters to serve as primary outcomes in phase II clinical trials of neuroprotective and reparative strategies in MS. We present the conclusions of an international meeting of imaging, clinical ... (Read Full Article)
    

    Comment on Article Mentions:   Peter A. Calabresi   Johns Hopkins University   University College London

22. Interpretation of the outer retina with high-resolution optical coherence tomography

    Explore Article Nature Publishing Group (May 3 2009) Ophthalmology

    No Abstract Provided (Read Full Article)
    

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23. Performance of GDx and HRT in the Finnish Evidence-Based Guideline for Open-Angle Glaucoma

    Explore Article Nature Publishing Group (Apr 30 2009) Ophthalmology

    Aim To compare the performance of Heidelberg retina tomograph (HRT) and scanning laser polarimetry (GDx) with photographic evaluation of the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) in the application of the Finnish Evidence-Based Guideline for Open-Angle Glaucoma. Methods A total of 41 control participants and 312 patients referred for glaucoma evaluation were included in the study. All the participants underwent ophthalmic evaluation, ONH stereophotography, monochromatic RNFL photography, HRT, optical coherence tomography, and GDx evaluation. Participants were classified on the basis of stereophotographic or imaging device results based by applying the Finnish Guideline. Results Agreement between the ... (Read Full Article)
    

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24. Correlation in foveal thickness measurements between spectral-domain and time-domain optical coherence tomography in normal individuals

    Explore Article Nature Publishing Group (Apr 23 2009) Ophthalmology

    Purpose To compare a time-domain (Stratus) and a spectral-domain (Spectralis) optical coherence tomography (OCT) device in assessing foveal thickness in healthy subjects. Methods In this observational study 40 healthy subjects (40 eyes) underwent Stratus OCT and Spectralis OCT measurements of foveal thickness using three consecutive horizontal and vertical B-scan. Paired samples t-test was used to compare means between Stratus and Spectralis OCT measurements. Coefficient of variation (CoV) was used to compare dispersion in datasets. Pearson's correlation coefficient was used to quantify linear relation between Spectralis and Stratus OCT measurements. To assess agreement between Spectralis and Stratus OCT foveal thickness measurements, ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Heidelberg Spectralis   Heidelberg Engineering

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