Articles from Nature Publishing Group

1. Post Doctoral Fellow in Biomedical Optics : University of Texas Southwestern Medical Center

   Explore Article Nature Publishing Group (Jun 4 2010) Jobs & Studentships

   A Postdoctoral Research Fellow position is available immediately at the Optical Medical Imaging Laboratories of the University of Texas at Arlington that are located in the Advanced Imaging Research Center (AIRC) in Dallas. The AIRC at the University of Texas Southwestern Medical Center at Dallas (UTSW) is the hub of collaborative research on medical imaging between UTSW, UT Arlington, and UT Dallas. Research focus of our group is in the development of optical techniques (interferometry and spectroscopy) and instrumentation for high resolution structural imaging, molecular imaging, multifunctional image guided surgery, neuro-optical engineering and point-of-care devices. Applicants are expected to have ... (Read Full Article)
   

   Comment on Article Mentions:   UT Southwestern Medical Center   University of Texas at Arlington

2. Vitreous traction and epiretinal membranes in diabetic macular oedema using spectral-domain optical coherence tomography

   Explore Article Nature Publishing Group (Jun 4 2010) Ophthalmology

   Purpose The purpose of this study was to present an association between diabetic macular oedema (DME) and vitreoretinal interface abnormalities using 3D spectral domain optical coherence tomography (SD-OCT). Methods In a retrospective study, charts and SD-OCT of consecutive patients with diffuse or focal DME were reviewed. Only one randomly chosen eye per patient with DME was included, and eyes that had another retinopathy that could affect the study analysis or that underwent vitreoretinal surgery were excluded. Results Out of 58 eyes (58 patients) with DME, 11 eyes (19.0%) had vitreofoveal traction (Group A), either unifocally (n=6) or multifocally; that is, ... (Read Full Article)
   

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3. Influence of pupil dilation on retinal nerve fibre layer measurements with spectral domain OCT

   Explore Article Nature Publishing Group (May 28 2010) Ophthalmology

   Purpose To evaluate the influence of pupil dilation on retinal nerve fibre layer (RNFL) measurements with spectral domain optical coherence tomography (OCT). Patients and Methods In total, 29 healthy individuals and 26 glaucoma patients underwent RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl Zeiss Meditec Inc.) before and 30–40 min after pupil dilation with one drop of tropicamide 1%. Average thickness, quadrant thickness, and clock-hour thickness measurements were compared with the paired Student's t-test. We also compared the quality scores of the images obtained pre- and post-pupil dilation. Results Mean ages in the glaucoma and control groups were 58.3±13.4 ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Cirrus HD-OCT   Carl Zeiss Meditec

4. Postdoctoral Position in Drosophila Genetics at Washington University in St. Louis

   Explore Article Nature Publishing Group (May 24 2010) Jobs & Studentships

   A postdoctoral position is available in the laboratory of Gerald W. Dorn II MD at Washington University School of Medicine in St. Louis, MO to study mitochondrial fission and fusion in heart failure using cardiac gene manipulation and phenotyping in Drosophila melanogaster. The successful candidate will breed and maintain stocks of D. melanogaster with cardiac expression of transgenes or shRNA that modulate mitochondrial fusion and fission. Additional responsibilities include performing microscopic analysis of D. melanogaster cardiac phenotypes, including optical coherence tomography of heart tube contraction, fluorescence analysis of calcium and ATP/ADP signals in heart tubes in situ, and confocal analysis ... (Read Full Article)
   

   Comment on Article Mentions:   Washington University in St. Louis   Gerald W. Dorn

5. Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT

   Explore Article Nature Publishing Group (May 21 2010) Ophthalmology

   Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT Eye advance online publication, May 21, 2010. doi:10.1038/eye.2010.66 Authors: G Savini, M Carbonelli, V Parisi & P Barboni (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Cirrus HD-OCT   Carl Zeiss Meditec

6. Correlation between macular and retinal nerve fibre layer Fourier-domain OCT measurements and visual field loss in chiasmal compression

   Explore Article Nature Publishing Group (Apr 30 2010) Ophthalmology

   Purpose The aim of this study was to test the correlation between Fourier-domain (FD) optical coherence tomography (OCT) macular and retinal nerve fibre layer (RNFL) thickness and visual field (VF) loss on standard automated perimetry (SAP) in chiasmal compression. Methods A total of 35 eyes with permanent temporal VF defects and 35 controls underwent SAP and FD-OCT (3D OCT-1000; Topcon Corp.) examinations. Macular thickness measurements were averaged for the central area and for each quadrant and half of that area, whereas RNFL thickness was determined for six sectors around the optic disc. VF loss was estimated in six sectors of ... (Read Full Article)
   

   Comment on Article Mentions:   Topcon Medical Systems   University of São Paulo   Topcon 3D OCT-1000

7. A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT + HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

   Explore Article Nature Publishing Group (Feb 10 2010) Ophthalmology

   Purpose: To acquire high definition spectral domain optical coherence tomography (SD-OCT) images of supine, non-anesthetized infants in the office by a novel modification of a commercially available table-top, chin rest system. Method: Spectralis, a combined HRA+OCT device (Heidelberg Engineering, Heidelberg, Germany) was modified to convert the table-top system into a hand-held device using a two-step modification of the existing system. This device was used to obtain high-resolution OCT images of four infants with aggressive posterior retinopathy of prematurity (APROP) who required no general anesthesia. Results: Serial imaging at two time periods of the exact area of clinical interest were obtained ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

8. Bladder cancer: Optical coherence tomography improves UCC detection

   Explore Article Nature Publishing Group (Jan 13 2010) Oncology , Urology

   Targeted optical coherence tomography (OCT) in combination with hexaminolevulinate (HAL) fluorescence cystoscopy improves diagnostic accuracy in detecting urothelial cell carcinoma (UCC) of the bladder, report Schmidbauer and colleagues from the Medical University of Vienna.Fluorescence cystoscopy has been shown to significantly improve detection of UCC when used as an adjunct to white-light cystoscopy. (Read Full Article)
   

   Comment on Article Mentions:   Medical University of Vienna

9. A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT + HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

   Explore Article Nature Publishing Group (Jan 7 2010) Ophthalmology

   Purpose: To acquire high definition spectral domain optical coherence tomography (SD-OCT) images of supine, non-anesthetized infants in the office by a novel modification of a commercially available table-top, chin rest system. Method: Spectralis, a combined HRA+OCT device (Heidelberg Engineering, Heidelberg, Germany) was modified to convert the table-top system into a hand-held device using a two-step modification of the existing system. This device was used to obtain high-resolution OCT images of four infants with aggressive posterior retinopathy of prematurity (APROP) who required no general anesthesia. Results: Serial imaging at two time periods of the exact area of clinical interest were obtained ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

10. Neovascular age-related macular degeneration: decision making and optimal management

    Explore Article Nature Publishing Group (Jan 7 2010) Ophthalmology

    Methods Review of literature and presentation of illustrative cases. Results Guidelines are available to aid commissioners and providers of services but with important gaps in advice. Increasing awareness of variants and diseases that mimic nAMD means that clinicians need to carefully assess lesions at presentation, using stereo imaging, fluorescein and indocyanine green angiography, and new generation optical coherence tomography. Current evidence supports the use of ranibizumab as first-line therapy. Evidence is unclear on the most appropriate treatment regime, especially in protocols relying on clinician-determined re-treatment. Current consensus recommends initiation with monthly injections for 3 months followed by maintenance comprising regular ... (Read Full Article)
    

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11. Imaging chorioretinal vascular disease

    Explore Article Nature Publishing Group (Dec 11 2009) Ophthalmology

    Since its first description more than 40 years ago, fluorescein angiography had a crucial role in the diagnosis and management of chorioretinal vascular disorders such as neovascular age-related macular degeneration. Although fluorescein angiography permits visualization of the retinal microcirculation in exquisite detail, visualization of the choroidal circulation is more limited. Moreover, fluorescein angiography provides only minimal information regarding the functional consequences of vascular disease and allows, at best, only semi-quantitative assessment of retinal thickness. In recent years, the development of other chorioretinal imaging modalities, such as indocyanine green angiography, fundus autofluorescence, and optical coherence tomography (OCT), has addressed many of ... (Read Full Article)
    

    Comment on Article Mentions:   University of Southern California   Srinivas R. Sadda

12. Fourier Domain Optical Coherence Tomography integrated into a slit lamp; a novel technique combining anterior and posterior segment OCT

    Explore Article Nature Publishing Group (Nov 13 2009) Ophthalmology

    Purpose Fourier Domain Optical Coherence Tomography (FD-OCT) provides high resolution cross-sectional images of the retina and the anterior segment. It has become an important tool in ophthalmology in the examination, diagnosis, and treatment of important and common diseases. Present OCT imaging systems are stand-alone devices. The aim of this paper is to show the quality of images made with a prototype of a Fourier Domain (FD-) OCT imaging system (SLSCAN-1) integrated into a slit lamp. Methods Different representative pathologies of the posterior and anterior segment were observed with the slit lamp and simultaneously scanned with a prototype of the slit ... (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Academic Medical Center at the University of Amsterdam   Topcon 3D OCT-1000

13. Myopic pre-foveoschisis: an earlier stage of myopic foveoschisis documented by optical coherence tomography

    Explore Article Nature Publishing Group (Oct 15 2009) Ophthalmology

    Correspondence. (Read Full Article)
    

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14. Diagnostic ability of a linear discriminant function for optic nerve head parameters measured with optical coherence tomography for perimetric glaucoma

    Explore Article Nature Publishing Group (Oct 8 2009) Ophthalmology

    Background/aims To calculate and validate a linear discriminant function (LDF) for optical coherence tomography (OCT) to improve the diagnostic ability of isolated optic nerve head (ONH) parameters to discriminate between healthy individuals and glaucoma patients. Methods Two independent samples (teaching and validating sets) were prospectively selected. The teaching set (54 normal eyes and 73 glaucoma patients) was used to calculate the LDF. The validating set (70 healthy individuals and 67 glaucoma patients) was used to test the performance of the LDF in an independent population. Receiver operating characteristic (ROC) curves were plotted and compared with the ONH parameters measured using ... (Read Full Article)
    

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15. Post-doctoral position in Optical Coherence Technology : Joensuu, Finland and Kuopio, Finland

    Explore Article Nature Publishing Group (Oct 8 2009) Jobs & Studentships

    The Department of Physics and Mathematics, University of Eastern Finland, invites applications for a post-doctoral position in Optical Coherence Technology. The appointed person is to carry out mainly experimental research in Optical Coherence Tomography (OCT) and its application to characterization of tissues. QUALIFICATIONS: Doctoral degree required in physics, medical physics, optics, or related field; specialization in OCT or its medical applications is an advantage. The doctoral degre… (Read Full Article)
    

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16. Structural changes of fovea during remission of Behçet's disease as imaged by spectral domain optical coherence tomography

    Explore Article Nature Publishing Group (Sep 25 2009) Ophthalmology

    Purpose To acquire the image of the fovea during remission of ocular Behçet's disease using spectral domain optical coherence tomography (SD-OCT) and to further assess the correlation between best-corrected visual acuity (BCVA) and SD-OCT findings. Methods A total of 24 eyes of 14 patients with ocular Behçet's disease were examined with SD-OCT. The relationships between BCVA and other clinical characteristics, including foveal thickness and status of external limiting membrane (ELM) or the junction between photoreceptor inner and outer segments (IS/OS), were analysed for statistical significance. Results BCVA in eyes with intact IS/OS was significantly better than that in eyes with ... (Read Full Article)
    

    Comment on Article Mentions:   Nagahisa Yoshimura   Kyoto University Graduate School of Medicine

17. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

    Explore Article Nature Publishing Group (Sep 13 2009) Microscopy

    Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, limit the ability to investigate substantial tissue volumes or to probe dynamic changes repeatedly over prolonged periods. Here we introduce optical frequency domain imaging (OFDI) as an intravital microscopy that circumvents the technical limitations of multiphoton microscopy and, as a result, provides unprecedented access to previously unexplored, crucial aspects of tissue biology. Using unique OFDI-based approaches and entirely intrinsic mechanisms of contrast, we ... (Read Full Article)
    

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts General Hospital

18. Spectral-domain optical coherence tomography findings in a case of frosted retinal branch angiitis

    Explore Article Nature Publishing Group (Sep 5 2009) Ophthalmology

    No Abstract Available (Read Full Article)
    

    Comment on Article Mentions:   Harvard University   Massachusetts Eye and Ear Infirmary   University of Milan

19. Quantification of Dental Erosions in Patients With GERD Using Optical Coherence Tomography Before and After Double-Blind, Randomized Treatment With Esomeprazole or Placebo

    Explore Article Nature Publishing Group (Aug 6 2009) Dentistry

    OBJECTIVES: Dental erosion, the chemical dissolution of enamel without bacterial involvement, is a rarely reported manifestation of gastroesophageal reflux disease (GERD), as well as of recurrent vomiting and dietary habits. It leads to loss of tooth substance, hypersensitivity, functional impairment, and even tooth fracture. To date, dental erosions have been assessed using only very basic visual methods, and no evidence-based guidelines or studies exist regarding the prevention or treatment of GERD-related dental erosions. METHODS: In this randomized, double-blind study, we used optical coherence tomography (OCT) to quantify dental tissue demineralization and enamel loss before and after 3 weeks of acid-suppressive ... (Read Full Article)
    

    Comment on Article Mentions:   UC Irvine   Petra Wilder-Smith

20. Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy

    Explore Article Nature Publishing Group (Jul 30 2009) Ophthalmology

    Purpose To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC). Methods Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Amod Gupta   Zeiss Cirrus HD-OCT

21. Is neuronal dysfunction an early sign of diabetic retinopathy? Microperimetry and Spectral Domain Optical Coherence Tomography (SD-OCT) Study in individuals with diabetes, but no diabetic retinopathy

    Explore Article Nature Publishing Group (Jul 27 2009) Ophthalmology

    Purpose To elucidate changes in the neurosensory retina in the macular area, using spectral domain OCT and correlate with functional loss on fundus-related microperimetry, in patients with diabetes and no diabetic retinopathy compared with age-matched healthy volunteers. Methods This was a prospective study enroling 39 patients in each group. All patients underwent comprehensive dilated eye examination. The foveal thickness and the photoreceptor layer thickness at the foveal centre were measured using spectral domain OCT, and the mean retinal sensitivity of central 20 degrees was measured using microperimetry. Results The mean age of the patients with diabetes was 50.924.75 years, and ... (Read Full Article)
    

    Comment on Article Mentions:   Sankara Nethralaya

22. Optical coherence tomography-based decision making in exudative age-related macular degeneration: comparison of time- vs spectral-domain devices

    Explore Article Nature Publishing Group (Jul 20 2009) Ophthalmology

    Purpose To determine whether optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD). Methods Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus OCT system and the spectral-domain Cirrus OCT system at the same visit. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analysed. Results Cirrus OCT generated a higher ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   National Eye Institute   Zeiss Cirrus HD-OCT

23. OCT measurements on the foveal and perifoveal retinal thickness on diabetic patients after phacoemulsification and IOL implantation

    Explore Article Nature Publishing Group (Jul 11 2009) Ophthalmology

    Purpose The first aim (I.) was to measure the change of macular thickness in diabetic (DM group) and nondiabetic patients (NORMAL group), the values of operated eye (OP) were compared I.A.) to the fellow, non-operated eye (CONTROL) and I.B.) to preoperative baseline value of the operated eye (PRE). The second aim (II.) was to compare postoperative macular thickening of DM group to NORMAL group eyes. Methods Retinal thickness values of the foveal and perifoveal (fovea+3.0 mm, fovea+6.0 mm) sectors and the minimum values were measured in a prospective study using optical coherence tomography (OCT) in 18 eyes of 18 diabetic ... (Read Full Article)
    

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24. Spectral-domain optical coherence tomography visualisation of retinal oxalosis in primary hyperoxaluria

    Explore Article Nature Publishing Group (Jul 9 2009) Ophthalmology

    No Abstract Provided. (Read Full Article)
    

    Comment on Article Mentions:   Centre Hospitalier Intercommunal de Créteil   Gisèle Soubrane   Eric H. Souied

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