1. 1-7 of 7
    1. Predict, Resect, Identify and Discard Strategy with Full-field Optical Coherence Tomography: Two Steps Forward, One Step Back

      Predict, Resect, Identify and Discard Strategy with Full-field Optical Coherence Tomography: Two Steps Forward, One Step Back

      Dear editor, We read with great interest the recently published technique presentation reported by Camus M et al.1 on a rapid on-site evaluation of resected colorectal polyps using full-field optical coherence tomography (FFOCT). We concur that this “predict, resect, identify and discard” paradigm indicated a new way of balancing colonoscopy screening efficacy and pathologic burden as well as shortening the distances among endoscopists, pathologists and patients. While nearly all resected colonic polyps are retrieved for histological analysis in America and Europe, polyp retrieval rate is suboptimal in China due to limited pathologic resources and cost-effectiveness considerations, even in some ...

      Read Full Article
    2. Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy1 and narrow band imaging (NBI)2 have been used to investigate vascular changes as hallmarks of early cancer in the gastrointestinal tract. However, the limited frame rate and field of view make confocal laser endomicroscopy imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high-speed volumetric imaging of subsurface features at near-microscopic resolution,3, 4 and can image microvasculature without exogenous contrast agents,5 such as fluorescein, which obliterates the image in areas of bleeding, or after ...

      Read Full Article
    3. Endoscopic Optical Coherence Angiography Enables 3-Dimensional Visualization of Subsurface Microvasculature

      Endoscopic Optical Coherence Angiography Enables 3-Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy 1 and narrow band imaging (NBI) 2 have been used to investigate vascular changes as hallmarks of early cancer in the gastrointestinal tract. However, the limited frame rate and field of view make confocal laser endomicroscopy imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high-speed volumetric imaging of subsurface features at near-microscopic resolution, 3,4 and can image microvasculature without exogenous contrast agents, 5 such as fluorescein, which obliterates the image in areas of bleeding, or after ...

      Read Full Article
    4. Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy

      Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy

      Background and Aims In order to overcome limitations of endoscopy, we have integrated a microscopic imaging technology into a tethered capsule that can be swallowed. This new technology, which we term tethered capsule endomicroscopy, provides microscopic information from the entire of esophagus as the pill passes through gastrointestinal (GI) tract. Methods Our tethered capsule endomicroscope implements a second-generation, high-speed form of optical coherence tomography termed optical frequency domain imaging that produces microstructural images with a resolution of 30x30x10μm. The capsule has a dimension of 11x25mm and is connected to 160mm long and 0.8mm thin, flexible tether. Unsedated subjects ...

      Read Full Article
    5. Functions and Imaging of Mast Cell and Neural Axis of the Gut

      Functions and Imaging of Mast Cell and Neural Axis of the Gut

      Close association between nerves and mast cells in the gut wall provides the microanatomic basis for functional interactions between these elements, supporting the hypothesis that a mast cell–nerve axis influences gut functions in health and disease. Advanced morphology and imaging techniques are now available to assess structural and functional relationships of the mast cell–nerve axis in human gut tissues. Morphologic techniques including co-labeling of mast cells and nerves serve to evaluate changes in their densities and anatomic proximity. Calcium (Ca ++ ) and potentiometric dye imaging provide novel insights into functions such as mast cell–nerve signaling in the human ...

      Read Full Article
    6. Detection of Dysplasia in Barrett's Esophagus With In Vivo Depth-Resolved Nuclear Morphology

      Detection of Dysplasia in Barrett's Esophagus With In Vivo Depth-Resolved Nuclear Morphology
      Background & Aims Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements to detect dysplasia. We assessed the clinical utility of a/LCI in the endoscopic surveillance of patients with BE. Methods Consecutive patients undergoing routine surveillance upper endoscopy for BE were recruited at 2 endoscopy centers. A novel, endoscope-compatible a/LCI system measured the mean diameter and refractive index of cell nuclei in esophageal epithelium at 172 biopsy sites in ...
      Read Full Article
    1-7 of 7
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks