1. 1-5 of 5
    1. Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

      Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo

      The inability to visualize airway smooth muscle (ASM) cells in vivo is a major obstacle in understanding their role in normal physiology and diseases. At present, there is no imaging modality available to assess ASM in vivo. Confocal endomicroscopy lacks the penetration depth and field of view, and conventional optical coherence tomography (OCT) does not have sufficient contrast to differentiate ASM from surrounding tissues. We have developed a birefringence microscopy platform that leverages the micro-organization of tissue to add further dimension to traditional OCT. We have used this technology to validate ASM measurements in ex vivo swine and canine studies ...

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    2. Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

      Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography

      More complete brain cancer resection can prolong survival and delay recurrence. However, it is challenging to distinguish cancer from noncancer tissues intraoperatively, especially at the transitional, infiltrative zones. This is especially critical in eloquent regions (for example, speech and motor areas). This study tested the feasibility of label-free, quantitative optical coherence tomography (OCT) for differentiating cancer from noncancer in human brain tissues. Fresh ex vivo human brain tissues were obtained from 32 patients with grade II to IV brain cancer and 5 patients with noncancer brain pathologies. On the basis of volumetric OCT imaging data, pathologically confirmed brain cancer tissues ...

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    3. Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

      Point-of-care and point-of-procedure optical imaging technologies for primary care and global health

      Leveraging advances in consumer electronics and wireless telecommunications, low-cost, portable optical imaging devices have the potential to improve screening and detection of disease at the point of care in primary health care settings in both low- and high-resource countries. Similarly, real-time optical imaging technologies can improve diagnosis and treatment at the point of procedure by circumventing the need for biopsy and analysis by expert pathologists, who are scarce in developing countries. Although many optical imaging technologies have been translated from bench to bedside, industry support is needed to commercialize and broadly disseminate these from the patient level to the population ...

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    4. Setting Sights on a Silent Killer

      Setting Sights on a Silent Killer
      Coronary artery disease is a killer that works at the cellular level. Heart attacks occur when the endothelium of a vulnerable atherosclerotic plaque is disrupted. The ability to determine which patient has a “vulnerable” plaque that is going to rupture—causing a deadly heart attack—is determined by the pathologist, through a microsope, after the rupture has occurred. Clearly, it would benefit the patient to track down these vulnerable plaques before rupture. To this end, Liu and colleagues present a new form of optical coherence tomography (OCT), called micro-optical coherence tomography (µOCT). µOCT boasts 1- to 2-µm resolution, which allows ...
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    5. Femtosecond Laser–Assisted Cataract Surgery with Integrated Optical Coherence Tomography

      Femtosecond Laser–Assisted Cataract Surgery with Integrated Optical Coherence Tomography
      Abstract About one-third of people in the developed world will undergo cataract surgery in their lifetime. Although marked improvements in surgical technique have occurred since the development of the current approach to lens replacement in the late 1960s and early 1970s, some critical steps of the procedure can still only be executed with limited precision. Current practice requires manual formation of an opening in the anterior lens capsule, fragmentation and evacuation of the lens tissue with an ultrasound probe, and implantation of a plastic intraocular lens into the remaining capsular bag. The size, shape, and position of the anterior capsular ...
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    1-5 of 5
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