Purpose To evaluate the level of agreement between ANTERION (Heidelberg Engineering, Heidelberg, Germany), OA-2000 (Tomey, Nagoya, Japan), and IOL Master 500 (Carl Zeiss Meditec AG, Jena, Germany). Methods Fifty-one eyes of 51 patients were included in the study. Flat and steep keratometry (K), vector component of astigmatism (J0 and J45), anterior chamber depth (ACD), and axial length (AL) were compared using the three devices. Repeated-measures analysis of variance was conducted to compare the mean values of the biometrics. Pearson’s correlation test was conducted to analyze the correlations of the measured values, and a Bland–Altman plot was used to ...

Purpose To evaluate the clinical availability of a multifunctional ocular biometric unit, MR-6000 (Tomey Corporation, Nagoya, Japan), for simultaneous keratometry, tonometry, topography, and pachymetry evaluation, and compare anterior segment measurements with five other devices: autokeratometer (KR-1, Topcon, Tokyo, Japan), Scheimpflug camera (Pentacam HR, Oculus, Wetzlar, Germany), swept-source optical coherence tomography (IOLMaster 700, Carl Zeiss, Oberkochen, Germany), Placido disk scanning-slit topography (Orbscan II, Bausch & Lomb, NY, USA), and noncontact tonometry (FT-1000, Tomey Corporation). Methods Thirty patients (30 eyes) who visited our clinic for cataract surgery were examined using MR-6000 and the other devices. The mean keratometry (Km), central corneal thickness (CCT ...

Purpose: The aim of the present study is to evaluate the effects of uncomplicated cataract surgery on microvascular structure of fovea, parafovea, optic disc and peripapillary area with optical coherence tomography angiography (OCTA). Methods: The study included 53 eyes of 53 patients, who undergone uncomplicated cataract surgery. The day before cataract surgery and at the first week, first month, third month after surgery, best corrected visual acuity, foveal avascular zone (FAZ), acircularity index (AI), superficial and deep foveal density (SFD and DFD), superficial and deep parafoveal density (SPD and DPD), central macular thickness (CMT), peripapillary retinal nerve fiber layer (PPRNFL ...

Purpose: Macular edema including cystoid macular edema is one of the main causes of unfavorable visual outcomes after cataract surgery. The macular thickness and the occurrence of macular edema after uncomplicated cataract surgery was evaluated using optical coherence tomography (OCT) in this study. Methods: Macular map images were taken by OCT before surgery and at 1 week, 1 month, and 2 months post-surgery. The subjects were classified into two groups (group 1: no macular edema group; group 2: macular edema) Macular edema (group II) was defined as increase in central macular thickness (CMT) by 30% compared with that before surgery ...

Purpose: To compare anterior biometry measurements using placido-scanning-slit topography, rotating Scheimpflug tomography, and swept-source optical coherence tomography. Methods: A retrospective review consisted of 80 eyes of 49 participants who underwent anterior chamber depth (ACD), central corneal thickness (CCT), and keratometry examination on the same day. We used placido-scanning-slit topography (ORBscan II), rotating Scheimpflug tomography (Pentacam HR), and swept-source optical coherence tomography (CASIA ss-1000). The intraclass correlation coefficients (ICCs) and Bland-Altman plots were used to evaluate the agreement and differences between measurements. Results: The mean ACD values were 2.88±0.43 mm, 2.82±0.50 mm, and 2.68 ...

Purpose To establish and validate optical coherence tomography (OCT) based diagnostic criteria of high myopia. Methods This was a cross-sectional study including 100 eyes of high myopia with axial length larger than 26.5 mm and 100 control eyes, which were examined by spectral-domain OCT. Vertical and horizontal OCT of 9 mm scanning across fovea were analyzed. OCT characteristics including mirror artifact, scleral sink due to steep inclination of posterior sclera, scleral visibility, abnormality of outer retinal layer, foveoschisis, and dome-shaped macula were assessed in each group. Results The mean axial length was 28.65 ± 2.07 mm (range, 26 ...

Purpose To investigate the effect of age- and gender-related differences on macular and choroidal perfusion in healthy Turkish individuals by optical coherence tomography angiography (OCTA). Methods Two hundred-eight eyes of 116 healthy Turkish individuals (60 females and 56 males, mean age 40.35 ± 12.64 years) were included in this study. OCTA was performed on a 3 × 3 mm region on the macula. The superficial macula whole-image vessel density (wiVD), foveal-VD and parafoveal-VD vessel density, foveal avascular zone (FAZ) as well as choriocapillaris flow index (CFI) were quantified. Results The mean vessel density was 53.1 ± 2.8% in superficial ...

Purpose: To evaluate the compatibility of corneal curvature and astigmatism, and higher-order aberrations (HOAs) measured by the Scheimpflug camera Pentacam HR and the swept-source optical coherence tomography ANTERION. Method: This prospective study included normal subjects with no ophthalmic history. Steep keratometry (K), flat K, astigmatism and its axis of the anterior and posterior surfaces, total corneal power, and HOAs using the two instruments were compared. To compare the mean values of the measurements, a paired t-test was used. Bland-Altman analysis was applied to assess the agreement between the two devices. Results: Fifty-three eyes of 53 subjects were evaluated. There were ...

No abstract available

Purpose: To analyze the repeatability of vessel density (VD) measurements and manual foveal avascular zone (FAZ) measure-ments using optical coherence tomography angiography (OCTA) in patients with retinal vein occlusion (RVO) without macular edema.Methods: The study population consisted of patients with RVO and central macular thickness <300 μm. For each subject, measurements were performed twice with a 5-minute interval. The intraclass correlation coefficient (ICC) and coefficient of variation (CV) were calculated to analyze the repeatability of results obtained with the OCTA device. To identify factors relat-ed to repeatability, we performed Pearson correlation analyses based on the CV of potential factors ...

ear Editor, Since traumatic macular hole (TMH) was first described in 1869, there have been hypotheses to explain its pathophysiology and MH closure. Previously suggested mechanisms for macular hole (MH) closure were glial or retinal pigment epithelium (RPE) cell proliferation [ 1 ], contraction of the epiretinal membrane or operculum around the edge [ 2 , 3 ]. Recently, we experienced a spontaneously closed TMH accompanied by macular choriovitreal membrane (MCVM) formation in a young patient. A 34-year-old man without significant medical history was admitted to the emergency room with decreased vision in his right eye after being hit by a baseball one day previously ...

Purpose To investigate the foveal avascular zone (AVZ), superficial and deep foveal and parafoveal vessel density (VD) changes related to diabetic retinopathy. Methods Forty-nine type 2 diabetes mellitus (DM) and 45 healthy control subjects were included in this study. The demographic data (age and sex), disease duration, and level of glycated hemoglobin were collected. Superficial VD (%), superficial AVZ area (mm 2 ), deep VD (%) and deep AVZ area (mm 2 ) were evaluated via optic coherence tomography angiography. Results Superficial AVZ was 0.438 ± 0.05 mm 2 in the DM group, 0.246 ± 0.022 mm 2 in the control group ...

Purpose This study compared the glaucoma diagnostic abilities of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In addition, the possibility of enhancing diagnostic capability by combining the two modalities was investigated. Methods A total of 131 healthy eyes and 113 glaucomatous eyes were imaged by both OCT and OCTA. In OCT, glaucoma was defined as when the color of the superior or inferior quadrant of the peripapillary retinal nerve fiber layer thickness map was yellow (borderline, <5%) or red (outside normal limits, <1%). In OCTA, glaucoma was determined using the cut-off value of the superior or inferior ...

Purpose This study investigated visual acuity (VA) values and differences depending on optical coherence tomography (OCT) findings in patients with acute central retinal artery occlusion (CRAO). Methods A retrospective chart review was performed on patients with acute CRAO who underwent macular and disc OCT. We evaluated changes in macular thickness and retinal nerve fiber layer (RNFL) thickness after acute CRAO onset based on OCT. We also determined the association of thickness changes with VA improvement. Results This study involved both eyes in a total of 12 patients with acute CRAO. A significant increase was observed in foveal (1 mm) thickness ...

Purpose To evaluate the agreement between optical biometry with swept-source optical coherence tomography-based optical biometry (IOLMaster 700) and other devices. Methods A total of 137 eyes (78 patients) with cataracts were included in this retrospective study. Axial length (AL), anterior chamber depth (ACD), keratometry, and white-to-white (WTW) distance measured using IOLMaster 700 were compared with results for the following five different biometers: IOLMaster 500, A-scan, automated refractor, manual keratometry, and Galilei G4. Differences and correlations among the devices were assessed using the Bland-Altman plot and intraclass correlation coefficient (ICC). Results For AL values, the IOLMaster 700, IOLMaster 500, and A-scan ...

Purpose To assess choroidal thickness (CT) variation according to refractive errors using enhanced-depth imaging optical coherence tomography. Methods Eighty-nine eyes (in 89 children) <±6 diopter were categorized into three groups: hyperopia, emmetropia, and myopia, according to refractive error, and underwent choroidal scans using enhanced-depth imaging-optical coherence tomography. CT was measured at the fovea and at 1 mm and 3 mm nasal (N1 and N3), temporal (T1 and T3), superior (S1 and S3), and inferior (I1 and I3) from the fovea. Results Mean foveal CTs were 346.86 µm, 301.97 µm, and 267.46 µm in the hyperopia, emmetropia, and ...

Purpose To investigate the retinal nerve fiber layer (RNFL) thickness concordance when measured by spectral domain (SD) and swept source (SS) optical coherence tomography (OCT), and to compare glaucoma-discriminating capability. Methods RNFL thicknesses were measured with the scan circle, centered on the optic nerve head, in 55 healthy, 41 glaucoma suspected, and 87 glaucomatous eyes. The RNFL thickness measured by the SD-OCT (sdRNFL thickness) and SS-OCT (ssRNFL thickness) were compared using the t -test. Bland-Altman analysis was performed to examine their agreement. We compared areas under the receiver operating characteristics curve and examined sdRNFL and ssRNFL thickness for discriminating glaucomatous ...

Dear Editor, Mucopolysaccharidosis is an inheritable storage disease with deficiency of lysosomal enzymes that degrade glycosaminoglycans [ 1 ]. Mucopolysaccharidosis type II, also known as Hunter syndrome, is an X-linked inherited deficiency of enzyme iduronate 2-sulfatase, resulting in progressive accumulation of dermatan sulfate and heparin sulfate [ 1 ]. In many mucopolysaccharidoses, glycosaminoglycans accumulate in the retinal pigment epithelial (RPE) cells, resulting in pronounced lysosomal distension [ 2 ]. Previous studies have revealed outer nuclear layer thinning and the absence of outer segments, as well as reduced inner segments from the anterior midperipheral retina [ 2 , 3 ]. However, structural changes of the retina determined by high-resolution spectral ...

Dear Editor, We experienced a case of sub-internal limiting membrane (ILM) hemorrhage successfully treated with an argon green laser (AGL) posterior hyaloidotomy. We could not identify any report in the ophthalmic literature describing spectral domain optic coherence tomography (OCT) localization of AGL spots or preoperative exact anatomic localization in valsalva retinopathy. A 35-year-old man presented with sudden blurred vision in the right eye that occurred one day before examination. Dilated fundus examination of the right eye showed a well-circumscribed large sub-ILM hemorrhage in the temporal macular area ( Fig. 1A ). Fluid was noted in the upper part of the hemorrhage. OCT ...

Purpose To compare the foveal thickness (FT) parameters measured by Stratus optical coherence tomography (OCT) and Spectralis OCT in various retinal diseases and to construct conversion formulas between the two types of OCT devices. Methods We examined 366 consecutive patients (475 eyes) with retinal diseases and 13 normal controls (13 eyes). The patients were categorized into eight retinal disease groups. The mean amount and distribution of foveal thickness differences (FTD) measured by Stratus and Spectralis OCT were determined, and conversion formulas were constructed for Stratus OCT FT from Spectralis OCT FT for each retinal disease group. Results Among retinal diseases ...

PURPOSE: To investigate correlations between preoperative and postoperative foveal microstructures in patients with macula-off rhegmatogenous retinal detachment (RRD). METHODS: We reviewed the records of 31 eyes from 31 patients with macula-off RRD who had undergone successful re-attachment surgery. We analyzed data obtained from complete ophthalmologic examinations and optical coherence tomography (OCT) before and 9 to 12 months after surgery. All postoperative OCT measurements were taken with spectral-domain OCT, but a subset of preoperative OCT measurements were taken with time-domain OCT. RESULTS: The mean duration of macular detachment was 15.5 ± 15.2 days, and mean preoperative best-corrected visual acuity (BCVA ...

Purpose To evaluate a simplified method to measure peripapillary choroidal thickness using commercially available, three-dimensional optical coherence tomography (3D-OCT). Methods 3D-OCT images of normal eyes were consecutively obtained from the 3D-OCT database of Korea University Medical Center On the peripapillary images for retinal nerve fiber layer (RNFL) analysis, choroidal thickness was measured by adjusting the segmentation line for the retinal pigment epithelium to the chorioscleral junction using the modification tool built into the 3D-OCT image viewer program. Variations of choroidal thickness at 12 sectors of the peripapillary area were evaluated. Results We were able to measure the peripapillary choroidal thickness ...

A 5-year-old girl was diagnosed with neurofibromatosis type 2 (NF-2) due to multiple neurofibromas, cafe-au-lait spots, and schwannomas of the brain. During ophthalmologic evaluation, a posterior subcapsular cataract and a gray-green colored subretinal lesion were found in right eye. Fluorescein angiography (FA) revealed a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). At age 9, she underwent cataract surgery. At this time FA and spectral-domain optical coherence tomography (SD-OCT) were taken. The SD-OCT showed an elevated hyperreflective mass in the retina with prominent attenuation of the inner and outer retina, but minimal attenuation in the photoreceptor layers. The ...

PurposeTo determine the lowest limit of signal strength that is still effective for accurate analysis of optic coherence tomography (OCT) values, we investigated the reproducibility of OCT scans by signal strength (SS). MethodsA total of 668 subjects were scanned for measurements of retinal nerve fiber layer (RNFL) thickness using the Stratus OCT twice on the same day. The variability of overall RNFL thickness parameters obtained at different SS was analyzed and compared by repeated-measures of ANOVA and Spearman's correlation coefficient. Values of the intraclass correlation coefficient (ICC) and variability (standard deviation) of RNFL thickness were obtained. The false positive ...