1. Articles from uspto.gov

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    1. Monitoring dissolution of a dosage form in progress during dissolution by low coherence interferometry

      Monitoring dissolution of a dosage form in progress during dissolution by low coherence interferometry

      A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.

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      Mentions: Corning Optores
    2. Systems, methods, and media for multiple reference arm spectral domain optical coherence tomography

      Systems, methods, and media for multiple reference arm spectral domain optical coherence tomography

      In some embodiments, systems, methods, and media for multiple reference arm spectral domain optical coherence tomography are provided which, in some embodiments, includes: a sample arm coupled to a light source; a first reference arm having a first path length; a second reference arm having a longer second path length; a first optical coupler that combines light from the sample arm and the first reference arm; a second coupler that combines light from the sample arm and the second reference arm; and an optical switch comprising: a first input port coupled to the first optical coupler; a second input coupled ...

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    3. Systems for coherent light detection and related methods

      Systems for coherent light detection and related methods

      Systems for coherent light detection are provided, including a system comprising a light source configured to generate light; a first optical assembly configured to split the light into a reference arm and a sample arm; a second optical assembly configured to illuminate a sample with light of the sample arm, thereby generating a sample signal; a third optical assembly configured to combine the sample signal with light of the reference arm, thereby generating an interference signal; and a detector assembly comprising an array of carrier injection photodetectors, the array arranged to collect the interference signal. Methods of using the systems ...

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    4. Imaging catheter system

      Imaging catheter system

      Disclosed is an imaging catheter system that utilizes optical coherence tomography and autofluorescence lifetime imaging microscopy. The disclosed imaging catheter system may include: an autofluorescence light source; an OCT device; a catheter device configured to receive rays inputted from the autofluorescence light source and an OCT light source of the OCT device and scan a specimen; an optical detector unit configured to detect autofluorescence generated from the specimen; and a first optics system configured to transfer the autofluorescence to the optical detector unit and transfer a ray of the OCT light source reflected from the specimen to the OCT device.

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    5. Apparatus and method for assessment of interstitial tissue

      Apparatus and method for assessment of interstitial tissue

      A handheld optical coherence tomography imaging and tissue sampling system and method of imaging and sampling a tissue is disclosed. The method includes inserting a catheter probe into a biopsy needle. The biopsy needle can be attached to a hand-held scanning and sampling device. The biopsy needle is maneuvered to an investigation site. A three-dimensional image of the tissue at the investigation site is captured with the catheter probe.

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    6. Laser beam welding of geometric figures using OCT seam tracking

      Laser beam welding of geometric figures using OCT seam tracking

      A measuring device for monitoring a laser welding process that is connectable to a machining device for machining a workpiece by a high-energy processing beam that is displaceable on the workpiece along a main machining path that corresponds to a contour of a closed geometric figure. The measuring device includes an optical coherence tomography unit having a measuring beam source for generating an optical measuring beam that is displaceable on the workpiece by at least one movable deflection unit. The optical measuring beam is displaceable on the workpiece along a first discrete measuring line, along a second discrete measuring line ...

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    7. Detection of early stage alzheimer's disease and mild cognitive impairment

      Detection of early stage alzheimer's disease and mild cognitive impairment

      Systems and methods are described herein for determining that a patient has indications mild cognitive impairment (MCI) or early stage Alzheimer's disease (AD). Microperimetry is used to assess the functional integrity of the patient's retina. Optical Coherence Tomography is used to assess the structural integrity of the patient's retina. Reductions in the size and function of the patient's retina indicate that the patient may have MCI or early stage AD.

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    8. Three dimensional corneal imaging with gabor-domain optical coherence microscopy

      Three dimensional corneal imaging with gabor-domain optical coherence microscopy

      A system for non-contact imaging of corneal tissue stored in a viewing chamber using Gabor-domain optical coherence microscopy (GDOCM), wherein a 3D numerical flattening procedure is applied to the image data to produce an at least substantially artifact-free en face view of the endothelium.

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    9. Microresonator-frequency-comb-based platform for clinical high-resolution optical coherence tomography

      Microresonator-frequency-comb-based platform for clinical high-resolution optical coherence tomography

      A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source.

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    10. Source module and optical system for line-field imaging

      Source module and optical system for line-field imaging

      A source module suitable for an optical coherence tomography system. The source module comprises a source operable to emit a divergent, source output beam either of circular cross-section (e.g. as output by a vertical cavity surface emitting laser) or of elliptical cross-section (e.g. as output by an edge-emitting semiconductor laser or diode). Collimation optics are provided to convert the source output beam into a non-divergent, collimated beam of elliptical cross-section having a major axis and a minor axis. A cylindrical lens is arranged with its plano axis aligned with the major axis of the elliptical collimated beam and ...

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      Mentions: Exalos
    11. Handheld device for identification of microbiological constituents in the middle ear

      Handheld device for identification of microbiological constituents in the middle ear

      Methods and apparatus for identifying microbiological constituents in the middle ear. A spectrometer receives Raman-scattered light from the region of the tympanic membrane and resolves spectral features of the Raman-scattered light. A processor receives the interferometry signal and the Raman signal, and generates a Raman spectrum of the tympanic membrane and material adjacent thereto. In some embodiments of the invention, low-coherence light and substantially monochromatic excitation light are directed onto a tympanic membrane of the ear of a person via an otoscopic tip that abuts the ear canal. An interferometer combines scattered low-coherence light from the ear tissue with a ...

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    12. Space division multiplexing optical coherence tomography using an integrated photonic device

      Space division multiplexing optical coherence tomography using an integrated photonic device

      Integrated photonic chips and related systems and methods suitable for space-division multiplexing optical coherence tomography scanning are disclosed. In one embodiment, the photonic chip comprises a substrate, an optical input port which receives an incident sampling beam from an external light source, a plurality of optical output ports configured to transmit a plurality of sampling beams from the chip to a sample to capture scanned images of the sample, and a plurality of interconnected and branched waveguide channels formed in the substrate. Waveguide channels in a splitter region divide the sampling beam into the plurality of sampling beams at the ...

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      Mentions: Thorlabs
    13. Image processing apparatus, optical coherence tomography apparatus, image processing method, and computer-readable medium

      Image processing apparatus, optical coherence tomography apparatus, image processing method, and computer-readable medium

      An image processing apparatus includes an acquisition unit that acquires a plurality of pieces of tomographic data indicating tomographic information on substantially the same part of a subject to be inspected, a threshold calculation unit that calculates a threshold from tomographic data associated with a target pixel for which motion contrast data is to be calculated of the plurality of pieces of tomographic data, and a pixel value calculation unit that calculates the pixel value of the target pixel of a motion contrast image based on the threshold and the motion contrast data calculated from the tomographic data associated with ...

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    14. OCT measurement device with back-reflection

      OCT measurement device with back-reflection

      An optical system comprising an optical coherence tomography (OCT) measuring device and a beam deflection unit for laterally deflecting the position or angle of a beam path of the OCT measuring device. There is an optical component in the beam path, said optical component being embodied in such a way that a back-reflection of the optical component has a different configuration in terms of its longitudinal location along the beam path depending on the lateral position of the deflected beam path on the optical component. The optical system comprises an evaluation unit which is embodied in such a way that ...

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    15. Optical coherence tomography device, optical coherence tomography calculation method, and optical coherence tomography calculation program

      Optical coherence tomography device, optical coherence tomography calculation method, and optical coherence tomography calculation program

      The present disclosure relates to an optical coherence tomography (OCT) including: an OCT device, an OCT calculation method, and an OCT calculation program, enabling correlation between images to be easily performed; more specifically it relates to a case where a functional OCT image such as a motion contrast is acquired by using the OCT; acquiring the functional OCT image through a calculation process of an OCT signal is a time-consuming process, for this reason, a long time elapses until the point that a functional OCT image can be observed after OCT imaging is completed, and thus this causes stress to ...

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      Mentions: Nidek
    16. Method and apparatus for optical coherence tomography scanning

      Method and apparatus for optical coherence tomography scanning

      A method and system provide an optical coherence tomography system including a light source, an interferometric system, a processor and a memory. The interferometric system is optically coupled with the light source and includes at least one movable scanning mirror. The processor and memory are coupled with the interferometric system. The processor executes instructions stored in the memory to cause the movable scanning mirror to scan a plurality of points in a sample in at least one pattern. The at least one pattern is based on at least one of at least one Lissajous curve and at least one Spirograph ...

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      Mentions: Alcon
    17. Holoscopic, optical coherence tomography

      Holoscopic, optical coherence tomography

      A method for holoscopic, optical coherence tomography for an object, wherein the method includes providing source radiation and splitting the source radiation into illumination radiation and reference radiation, illuminating an illumination field on the object with illumination radiation, said illumination field having an areal extent transverse to the direction of incidence, collecting illumination radiation scattered back from the object as measurement radiation, separating the measurement radiation collected from the object from the illumination radiation, and overlaying the measurement radiation with reference radiation and detecting an interference signal of the overlaid radiations with at least one areal detector with a two-dimensional ...

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    18. Phase-decorrelation optical coherence tomography-based parameter measurement

      Phase-decorrelation optical coherence tomography-based parameter measurement

      One example includes a scanning system. The system includes a phase-decorrelation optical coherence tomography (PhD-OCT) scanner configured to implement a scanning sequence via an optical signal on a sample medium. The system also includes a scanning controller configured to provide control signals to the PhD-OCT scanner to implement the scanning sequence and to obtain phase and amplitude information associated with a reflected version of the optical signal. The phase and amplitude information can be indicative of microscale dynamics of the sample medium. The scanning controller can also implement an algorithm to calculate a quantitative parameter of the sample medium based ...

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    19. 1060 nm wavelength range-based optical coherence tomography (OCT) system for anterior/posterior segment imaging of an eye

      1060 nm wavelength range-based optical coherence tomography (OCT) system for anterior/posterior segment imaging of an eye

      An OCT system for generating images of an anterior or posterior segment of an eye is described. The system includes a light source, a controller, optics, a detector, and a processor. The light source generates a beam of light and is capable of operating in a posterior or an anterior segment imaging mode. In the posterior segment imaging mode, light source outputs light with a first spectral bandwidth of less than 120 nm and including wavelengths between about 1060 to 1070 nm. In the anterior segment imaging mode the light source outputs light with a second spectral bandwidth that is ...

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    20. Ophthalmologic image display device and ophthalmologic imaging device

      Ophthalmologic image display device and ophthalmologic imaging device

      A storage device of an ophthalmologic image display device of an embodiment stores a three dimensional data set acquired by scanning a subject's eye using OCT. An image processor forms, based on the three dimensional data set, a B-mode image, front images, and composite front image obtained from the front images. A display controller displays the B-mode image, front images and composite front image in a predetermined layout. The display controller displays distinguishment color information for distinguishment between the front images by colors and slice area information that indicates a partial region of the B-mode image corresponding to a ...

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    21. Apparatus and method for maintaining precise end-to-end relative position between two optical fibers

      Apparatus and method for maintaining precise end-to-end relative position between two optical fibers

      According to at least one embodiment of the present disclosure, there is provided an apparatus comprising: a first optical fiber in communication with a light source; a second optical fiber in communication with an imaging probe; and a fiber optic rotary joint (FORJ) where a distal end of the first optical fiber and a proximal end of the second optical fiber are positioned coaxially with a gap between the fibers' end faces. The FORJ is adapted to transmit light between the fibers' end faces, and to rotate at least one of first and second optical fibers relative to the other ...

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    22. Electronic device for automatic calibration of swept-source optical coherence tomography systems

      Electronic device for automatic calibration of swept-source optical coherence tomography systems

      A circuit for generating a swept source optical coherence tomography (SS-OCT) imaging calibration clock. The circuit comprises a first photodetector configured to convert an SS-OCT optical calibration signal to an SS-OCT electrical calibration signal, a first analog-to-digital converter (ADC) coupled to the first photodetector and configured to convert the SS-OCT electrical calibration signal to a sequence of SS-OCT calibration signal digital values, a processing unit coupled to the first ADC that, when initiated, is configured to demodulate the sequence of SS-OCT calibration signal digital values to obtain a sequence of SS-OCT wave number digital values, where each SS-OCT wave number ...

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    23. Forward looking RGB/optical coherence tomography duplex imager

      Forward looking RGB/optical coherence tomography duplex imager

      Systems, methods, and devices for directed to duplex imaging techniques for combining high-resolution surface images obtained with a Scanning Fiber Endoscope (SFE), and high-resolution penetrating OCT images obtained through Optical Coherence Tomography (OCT), from a SFE, and interleaving frames to improve resolution and identify below surface information of biological structures.

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    1-24 of 2252 1 2 3 4 ... 92 93 94 »
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