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    1. OCT Reveals Regional Differences in Macular Thickness with Age

      Purpose. To assist identification of macular thickness abnormalities by optical coherence tomography (OCT), we use techniques that improve spatial localization across the retina to establish any age-related retinal thickness changes in healthy eyes. Methods. Retinal thickness was measured in 30 eyes of 30 healthy subjects aged 13 to 69 years. Using Stratus OCT 3, 12 radial scans centered at the foveola were acquired and points between scans were interpolated to create a topographic map of the central 20[degrees]. The thickness map was divided into 37 hexagonal regions. A mean retinal thickness for each hexagon was computed. Retinal thickness vs ...
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    2. Accommodative Fluctuations, Lens Tension, and Ciliary Body Thickness in Children.

      Purpose. To investigate the relationship among microfluctuations in accommodation, resting tension on the crystalline lens, ciliary body thickness, and refractive error in children. Methods. Subjects were 49 children, aged 8 to 15 years. Subjects wore habitual correction over their left eye and an infrared filter over the right eye during accommodative measurements. Monocular accommodation was measured continuously for two, 30-second periods using a PowerRef I at a sampling rate of 25 Hz while subjects viewed a high-contrast target at 0.25 m. The high (1.0 to 2.3 Hz) and low- (0 to 0.6 Hz) frequency components of ...
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    3. Correlation Between Myopia and Major Biometric Parameters of the Eye: A Retrospective Clinical Study.

      Purpose. To investigate the relationship between myopia and changes in ocular biometry and macular thickness in young adults. Methods. Two hundred sixteen eyes from 108 adults (23.3 +/- 6.3 years old, mean +/- SD) were measured for refractive status, corneal curvature, and axial components of the eye. Macular thickness was measured in 118 eyes (59 subjects) by optical coherence tomography. All eyes were categorized into emmetropia, low, moderate, or high myopia based on the refractive status. Biometric results from right eyes of all subjects were compared between sub-groups with the linear correlation analyzed between refraction and other parameters for each ...
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    4. Correlation Between Myopia and Major Biometric Parameters of the Eye: A Retrospective Clinical Study

      Purpose. To investigate the relationship between myopia and changes in ocular biometry and macular thickness in young adults.Methods. Two hundred sixteen eyes from 108 adults (23.3+/- 6.3 years old, mean+/- SD) were measured for refractive status, corneal curvature, and axial components of the eye. Macular thickness was measured in 118 eyes (59 subjects) by optical coherence tomography. All eyes were categorized into emmetropia, low, moderate, or high myopia based on the refractive status. Biometric results from right eyes of all subjects were compared between sub-groups with the linear correlation analyzed between refraction and other parameters for each ...
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    5. Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children

      Purpose. To evaluate the validity and repeatability of crystalline lens thickness measurements obtained by anterior segment optical coherence tomography (OCT). Methods. Forty-seven normal children (mean age, 11.06 ± 2.30 yr) had their crystalline lens thickness measured with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and with conventional corneal touch A-scan ultransonography (ultrasound) (Humphrey 820). The subjects' right corneas were anesthetized, and their right eyes were cyclopleged. Five ultrasound measurements were recorded per eye, and three Visante OCT measurements were recorded per eye. Thirty-eight subjects had measurements at a second visit where three additional Visante OCT measurements ...
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    6. Diurnal Variation of Ocular Hysteresis, Corneal Thickness, and Intraocular Pressure.

      Abstract: Purpose. To investigate, in healthy Asian subjects, the diurnal changes of the corneal biomechanical properties of corneal hysteresis (CH) and its relation to fluctuations of intraocular pressure (IOP) and central corneal thickness (CCT) after sleeping. Methods. Forty eyes of 20 healthy Asian volunteers (4 males and 16 females) with a mean age of 19.7 +/- 1.1 years were measured with a modified retinal optical coherence tomography and an ocular response analyzer (ORA). CH, CCT, Goldmann-equivalent intraocular pressure (IOPg), corneal resistance factor (CRF), and corneal compensated intraocular pressure (IOPcc) were obtained. Repeated measurements were conducted on both eyes during ...
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    7. Thickness Mapping of the Cornea and Epithelium Using Optical Coherence Tomography.

      Purpose. To measure corneal and epithelial thickness across four meridians using Optical Coherence Tomography (OCT) and to compare these measurements between normal non-lens wearers (NLW), rigid gas permeable (RGP) lens wearers, and RGP-wearing keratoconics (KC). Methods. Both eyes of 60 subjects were measured (20 NLW, nine female:11 male, 27.6 +/- 5.9 years; 20 RGP, 20 female, 23.9 +/- 7.6 years; and 20 KC, seven female:13 male, 32.4 +/- 8.1 years). A customized fixation target employing LEDs in eight directions of gaze was attached to the OCT and corneal images obtained. Raw OCT scans were analyzed ...
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    8. Corneal, Limbal, and Conjunctival Epithelial Thickness from Optical Coherence Tomography.

      Purpose. To compare human central corneal, limbal and bulbar conjunctival epithelial thickness in vivo using an Optical Coherence Tomographer (OCT). Methods. Thirteen healthy human subjects participated in this study. An OCT (Carl Zeiss, Meditec, Dublin, CA) was used to image central cornea, temporal corneo-scleral limbus and bulbar conjunctiva of the left eye. Two images were taken at each location. Thirty central measurements were averaged from each image for quantifying epithelial thickness. Results. In addition to the central cornea and limbal region, a band corresponding to bulbar conjunctival "epithelium" is apparent in OCT images, with respective thicknesses of 54.7 +/- 1 ...
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    9. Spectral Optical Coherence Tomography in Video-Rate and 3D Imaging of Contact Lens Wear

      Optometry & Vision Science. 84(12):E1104-E1109, December 2007. KALUZNY, BARTLOMIEJ J. MD, PhD; FOJT, WOJCIECH Dipl Ing; SZKULMOWSKA, ANNA MSc; BAJRASZEWSKI, TOMASZ MSc; WOJTKOWSKI, MACIEJ PhD; KOWALCZYK, ANDRZEJ PhD Abstract: Purpose. To present the applicability of spectral optical coherence tomography (SOCT) for video-rate and three-dimensional imaging of a contact lens on the eye surface. Methods. The SOCT prototype instrument constructed at Nicolaus Copernicus University (Torun, Poland) is b
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