1. 1-22 of 22
    1. Detection of Localized Retinal Nerve Fiber Layer Defects in Glaucoma Using Enhanced Spectral-Domain Optical Coherence Tomography

      Detection of Localized Retinal Nerve Fiber Layer Defects in Glaucoma Using Enhanced Spectral-Domain Optical Coherence Tomography

      Objective:To compare retinal nerve fiber layer (RNFL) defects on fundus photographs with circumpapillary RNFL (cpRNFL) thinning or disruption on images obtained by speckle-noise–reduced spectral-domain optical coherence tomography (enhanced SD OCT), single-scan SD OCT, and single-scan time-domain OCT (TD OCT).Design:Retrospective, comparative case series.Participants:Forty-four eyes of 44 patients with open-angle glaucoma with localized, wedge-shaped RNFL defects on red-free photographs and 35 normal eyes of 35 volunteers.Methods:Cross-sectional images of the cpRNFL and cpRNFL thinning, compared with the confidence interval limit of the normative database where the RNFL defect was photographically identified, were compared between the ...

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    2. Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography

      Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography
      Purpose: To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT).Design: Prospective, noncomparative, interventional case series.Participants: Seven eyes of 7 consecutive patients with CCIN treated using topical interferon alfa-2b or 5-fluorouracil and 7 eyes of 6 consecutive patients with history of surgically excised pterygia.Intervention: Ultra high-resolution OCT imaging of the ocular surface at primary diagnosis of CCIN and during the follow-up period until resolution of the lesion. Ultra high-resolution OCT images of sites of excised pterygia also ...
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    3. A Systematic Comparison of Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence in Patients with Geographic Atrophy

      A Systematic Comparison of Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence in Patients with Geographic Atrophy

      PurposeTo evaluate spectral-domain optical coherence tomography (SD-OCT) in providing reliable and reproducible parameters for grading geographic atrophy (GA) compared with fundus autofluorescence (FAF) images acquired by confocal scanning laser ophthalmoscopy (cSLO).DesignProspective observational study.ParticipantsA total of 81 eyes of 42 patients with GA.MethodsPatients with atrophic age-related macular degeneration (AMD) were enrolled on the basis of total GA lesion size ranging from 0.5 to 7 disc areas and best-corrected visual acuity of at least 20/200. A novel combined cSLO-SD-OCT system (Spectralis HRA-OCT, Heidelberg Engineering, Heidelberg, Germany) was used to grade foveal involvement and to manually measure disease ...

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    4. Choroidal Thickness Measured by Spectral Domain Optical Coherence Tomography: Factors Affecting Thickness in Glaucoma Patients

      Choroidal Thickness Measured by Spectral Domain Optical Coherence Tomography: Factors Affecting Thickness in Glaucoma Patients
      Purpose: To measure choroidal thickness and to determine parameters associated with it.Design: Cross-sectional study.Participants: Seventy-four glaucoma patients and glaucoma suspects.Methods: Spectral domain optical coherence tomography (SD-OCT) scans were obtained to estimate average choroidal thickness in a group of glaucoma suspects and glaucoma patients. The average thickness was calculated from enhanced depth SD-OCT images and manually analyzed with Image J software. Open-angle glaucoma, open-angle glaucoma suspect, primary angle-closure glaucoma, primary angle closure, and primary angle-closure suspect were defined by published criteria. Glaucoma suspects had normal visual fields bilaterally. Glaucoma was defined by specific criteria for optic disc damage ...
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    5. Influence of Disc Size on Optic Nerve Head versus Retinal Nerve Fiber Layer Assessment for Diagnosing Glaucoma

      Influence of Disc Size on Optic Nerve Head versus Retinal Nerve Fiber Layer Assessment for Diagnosing Glaucoma
      Purpose: To explore and compare the influence of optic disc size on the diagnostic accuracy of retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) quantitative assessment.Design: Observational, cross-sectional evaluation of diagnostic tests.Participants: We included 120 eyes from 50 normal subjects and 70 glaucomatous patients classified by the presence of a repeatable visual field defect for the analysis.Testing: The RNFL thickness was measured by scanning laser polarimetry with variable corneal compensator (GDx-VCC, Carl-Zeiss Meditec, Dublin, CA) and spectral-domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Inc). We obtained ONH imaging by means of confocal ...
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    6. Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Evaluation of Anterior Corneal Dystrophies and Degenerations

      Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Evaluation of Anterior Corneal Dystrophies and Degenerations
      Purpose: To evaluate the clinical usefulness of a spectral-domain ultra high-resolution anterior segment optical coherence tomography (UHR OCT) in examination, diagnosis, and management of various anterior corneal dystrophies and degenerations.Design: Noncomparative case series.Participants: Fifty-nine eyes of 38 consecutive patients were enrolled in the study and included 28 eyes of 14 patients with anterior corneal dystrophies, 21 eyes of 19 patients with anterior corneal degenerations or neoplasia, and 10 eyes of 5 patients with normal corneas.Methods: Subjects were imaged using a novel custom-built UHR OCT. Images were used to evaluate and describe the characteristics of anterior corneal dystrophies ...
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    7. Comparison of Automated Analysis of Cirrus HD OCT Spectral-Domain Optical Coherence Tomography with Stereo Photographs of the Optic Disc

      Comparison of Automated Analysis of Cirrus HD OCT Spectral-Domain Optical Coherence Tomography with Stereo Photographs of the Optic Disc
      Objective To evaluate a new automated analysis of optic disc images obtained by spectral-domain optical coherence tomography (SD OCT). Areas of the optic disc, cup, and neural rim in SD OCT images were compared with these areas from stereoscopic photographs to represent the current traditional optic nerve evaluation. The repeatability of measurements by each method was determined and compared. Design Evaluation of diagnostic technology. Participants One hundred nineteen healthy eyes, 23 eyes with glaucoma, and 7 glaucoma suspect eyes. Methods Optic disc and cup margins were traced from stereoscopic photographs by 3 individuals independently. Optic disc margins and rim widths ...
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    8. Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration

      Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration
      Purpose: To measure drusen area and volume in eyes with nonexudative age-related macular degeneration (AMD) using spectral domain optical coherence tomography imaging (SD-OCT). Design: Evaluation of diagnostic technology. Participants: One hundred three eyes from 74 patients with drusen. Methods: Patients with drusen secondary to nonexudative AMD were enrolled in this study. Five separate SD-OCT scans, each consisting of 40 000 uniformly spaced A-scans organized as 200 A-scans in each B-scan and 200 horizontal B-scans, were performed on each eye. Each scan covered a retinal area of 6 × 6 mm centered on the fovea. A novel algorithm was used to quantitatively ...
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    9. High-Resolution In Vivo Imaging in Achromatopsia

      High-Resolution In Vivo Imaging in Achromatopsia
      Purpose:: To characterize the retinal changes in patients with achromatopsia using an ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (OCT) to examine how human achromatopsia corresponds to its animal model.Design:: Comparative case series.Participants and Controls:: Ultrahigh-resolution OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland; 3-μm axial resolution) was used to obtain scans from 13 patients (26 eyes) with achromatopsia and from 20 controls (40 eyes).Methods:: A 3-dimensional scan program (743×75; A×B scan) sampling a 7×7-mm retinal area centered at the fovea was used to obtain tomograms of the fovea. Individual B-scans at the fovea were ...
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    10. Differentiation of Optic Nerve Head Drusen and Optic Disc Edema with Spectral-Domain Optical Coherence Tomography

      Differentiation of Optic Nerve Head Drusen and Optic Disc Edema with Spectral-Domain Optical Coherence Tomography

      Purpose: To evaluate the efficacy of spectral-domain optical coherence tomography (SD-OCT) in differentiating optic disc edema (ODE) and optic nerve head drusen (ONHD) and to reveal the differential points. Design: Comparative case series. Participants: Forty-five patients with ONHD, 15 patients with ODE, and 32 normal controls. Methods: Spectral-domain optical coherence tomography was performed with scans on the optic nerve head and measurements of retinal nerve fiber layer thickness. Main Outcome Measures: Qualitative findings of optic nerve head scans and retinal nerve fiber layer thickness profiles on SD-OCT. Results: Optic nerve head drusen was visualized as a focal, hyperreflective, subretinal mass ...

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    11. Anterior Segment Optical Coherence Tomography of Conjunctival Nevus

      Anterior Segment Optical Coherence Tomography of Conjunctival Nevus
      Purpose:: To evaluate conjunctival nevi using anterior segment optical coherence tomography (AS-OCT).Design:: Retrospective interventional case series.Participants:: There were 22 eyes of 21 patients with conjunctival nevus imaged with AS-OCT for evaluation and detection of cysts within conjunctival nevi.Intervention:: Anterior segment OCT.Main Outcome Measures:: Evaluation and detection of intralesional cysts.Results:: All margins of the nevus, including the deep margin, could be visualized on AS-OCT with high resolution of the anterior margin in 100% of cases, posterior margin in 82% of cases, and lateral margin in 86% of cases. The nevus was optically dense with homogeneous pattern ...
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    12. Documentation of Intraretinal Retinal Pigment Epithelium Migration via High-Speed Ultrahigh-Resolution Optical Coherence Tomography

      Documentation of Intraretinal Retinal Pigment Epithelium Migration via High-Speed Ultrahigh-Resolution Optical Coherence Tomography

      Purpose: To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral-domain, high-speed, ultrahigh-resolution optical coherence tomography (OCT) device in a group of patients with early to intermediate dry age-related macular degeneration (AMD) and to correlate intraretinal RPE migration on OCT to RPE pigment clumping on fundus photographs. Design: Retrospective, noncomparative, noninterventional case series. Participants: Fifty-five eyes of 44 patients seen at the New England Eye Center between December 2007 and June 2008 with early to intermediate dry AMD. Methods: Three-dimensional OCT scan sets from all patients were analyzed for the presence of intraretinal RPE ...

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    13. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans
      Objective: To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal nerve fiber layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design: Retrospective, longitudinal study. Participants: One hundred twenty-nine eyes from 72 glaucoma patients. Methods: All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL ...
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    14. High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy

      High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy
      Objective: To compare, in eyes with an idiopathic epiretinal membrane (ERM), photoreceptor cell structural abnormalities identified on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO-SLO) with the severity of metamorphopsia and anatomic findings on spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: Twenty-five eyes of 24 patients with idiopathic ERM and 20 normal eyes of 20 volunteer subjects. Methods: All participants underwent a full ophthalmologic examination, SD-OCT, and imaging with an original prototype AO-SLO system that incorporated liquid crystal-on-silicon technology. In eyes with ERM, M-CHARTS results were used to quantify metamorphopsia. Main Outcome Measures: Cone mosaic ...
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    15. Progression of Geographic Atrophy in Age-Related Macular Degeneration Imaged with Spectral Domain Optical Coherence Tomography

      Progression of Geographic Atrophy in Age-Related Macular Degeneration Imaged with Spectral Domain Optical Coherence Tomography
      Purpose:: To determine the area and enlargement rate (ER) of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) using the spectral domain optical coherence tomography (SD-OCT) fundus image.Design:: Prospective, longitudinal, natural history study.Participants:: Eighty-six eyes of 64 patients with ≥6 months of follow-up.Methods:: Patients with GA secondary to AMD were enrolled in this study. Macular scans were performed using the Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA). The areas of GA identified on the SD-OCT fundus images were quantified using a digitizing tablet. Reproducibility of these measurements was assessed and the ER of GA was ...
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    16. Analysis of Peripapillary Atrophy Using Spectral Domain Optical Coherence Tomography

      Analysis of Peripapillary Atrophy Using Spectral Domain Optical Coherence Tomography
      Participants: A total of 103 eyes of 73 patients with PPA and 21 eyes of 12 normal patients seen at the New England Eye Center, Tufts Medical Center, between January 2007 and August 2009. Methods: Spectral domain optical coherence tomography images taken through the region of PPA were quantitatively and qualitatively analyzed. Inclusion criteria included eyes with at least 300 μm of temporal PPA as detected on color fundus photographs. The study population was divided into subgroups according to the following clinical diagnoses: glaucoma (n=13), age-related macular degeneration (n=11), high myopia (n=11), glaucoma and high myopia (n ...
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    17. Quantitative Assessment of Diffuse Retinal Nerve Fiber Layer Atrophy Using Optical Coherence Tomography: Diffuse Atrophy Imaging Study

      Quantitative Assessment of Diffuse Retinal Nerve Fiber Layer Atrophy Using Optical Coherence Tomography: Diffuse Atrophy Imaging Study

      Purpose To evaluate quantitatively the degree of diffuse retinal nerve fiber layer (RNFL) atrophy using Stratus optical coherence tomography (OCT). Design Prospective, cross-sectional study. Participants One hundred two eyes of 102 patients with diffuse RNFL atrophy and 102 healthy eyes of 102 age-matched subjects were enrolled in the Diffuse Atrophy Imaging Study. Methods Two experienced observers graded RNFL photographs of diffuse RNFL atrophy eyes using a previously reported standardized protocol with a 4-level grading system. Readings were taken from the superior and inferior RNFL areas. The OCT-measured RNFL thickness parameters were compared among normal eyes and diffuse atrophy subgroups. Area ...

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    18. Outer Retinal Hyperreflective Spots on Spectral-Domain Optical Coherence Tomography in Macular Telangiectasia Type 2

      Outer Retinal Hyperreflective Spots on Spectral-Domain Optical Coherence Tomography in Macular Telangiectasia Type 2
      Purpose: To analyze focal hyperreflective morphologic alterations in outer retinal layers in patients with type 2 idiopathic macular telangiectasia (MacTel type 2) using spectral-domain optical coherence tomography (SD OCT).Design: Cross-sectional case-control study.Participants: Forty-one patients with MacTel type 2.Methods: Anatomic layers were evaluated and compared with those of controls of similar age. Simultaneous SD OCT scans were obtained with a combined confocal scanning laser ophthalmoscope for simultaneous tomographic and topographic in vivo imaging (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany).Main Outcome Measures: Morphologic alterations in the retinal layers secondary to MacTel type 2.Results: Hyperreflective spots in ...
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    19. High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      PurposeTo characterize the morphologic changes in vitreomacular traction (VMT) before and after surgery using spectral-domain optical coherence tomography (SD OCT) and to identify patterns relevant to visual function.DesignProspective, interventional case series.ParticipantsThirty eyes of 30 consecutive patients with visual acuity of less than 20/32 resulting from idiopathic VMT.MethodsA conventional 20-gauge 3-port vitrectomy was performed, including removal of the epiretinal membrane (ERM) and internal limiting membrane. Examinations were performed 1 day before surgery and 1 and 3 days as well as 1, 3, 6, 12, and 24 months after surgery. The SD OCT scan sets were analyzed with ...

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    20. Application of Visante Optical Coherence Tomography Tear Meniscus Height Measurement in the Diagnosis of Dry Eye Disease

      Application of Visante Optical Coherence Tomography Tear Meniscus Height Measurement in the Diagnosis of Dry Eye Disease
      rpose To investigate the applicability of tear meniscus height (TMH) measurement using Visante optical coherence tomography (OCT) in the diagnosis of dry eye disease. Design Prospective, controlled, single-center study. Participants Twenty-four right eyes of 24 patients (6 males, 18 females; mean age, 63.14±13.4 years) with definite dry eye according to the Japanese dry eye diagnostic criteria and 27 right eyes of 27 control subjects (12 males, 15 females; mean age, 56.04±14.22 years) were recruited. Methods All subjects underwent slit-lamp TMH measurement, OCT upper and lower TMH measurements, tear film breakup time (BUT) measurements, vital ...
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    21. Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography

      Sutureless Vitrectomy Incision Architecture in the Immediate Postoperative Period Evaluated In Vivo Using Optical Coherence Tomography
      Purpose: To investigate the in vivo sutureless vitrectomy incision architecture using optical coherence tomography (OCT) in the immediate postoperative period.Design: Prospective, observational case series.Participants: Thirty-five patients underwent 3-port pars plana vitrectomy using 23-gauge instrumentation combined with 25-gauge infusion at the Wenzhou Eye Hospital.Methods: All incisions were evaluated using the Carl Zeiss Visante (Dublin, CA) anterior segment OCT imaging system within 5 hours postoperatively.Main Outcome Measures: Wound architecture (e.g., the length and angle of the incision, presence of gaping), and presence of ciliochoroidal detachment and vitreous incarceration. Seidel test and intraocular pressure (IOP) measurements were performed ...
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    22. Comparison of Different Spectral Domain Optical Coherence Tomography Scanning Areas for Glaucoma Diagnosis

      Comparison of Different Spectral Domain Optical Coherence Tomography Scanning Areas for Glaucoma Diagnosis

      Purpose To evaluate retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular thickness measurements for glaucoma detection using the RTVue spectral domain optical coherence tomograph. Design Diagnostic, case-control study. Participants One hundred forty eyes of 106 glaucoma patients and 74 eyes of 40 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS). Methods All patients underwent ocular imaging with the commercially available RTVue. Optic nerve head, RNFL thickness, and macular thickness scans were obtained during the same visit. Receiver operating characteristic (ROC) curves and sensitivities at fixed specificities (80% and 95%) were calculated for each parameter. Main ...

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